Incidental Mutation 'R8553:Sult1a1'
ID 659969
Institutional Source Beutler Lab
Gene Symbol Sult1a1
Ensembl Gene ENSMUSG00000030711
Gene Name sulfotransferase family 1A, phenol-preferring, member 1
Synonyms Stp1, PST
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.263) question?
Stock # R8553 (G1)
Quality Score 225.009
Status Not validated
Chromosome 7
Chromosomal Location 126272037-126275604 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to T at 126273333 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Lysine at position 177 (Q177K)
Ref Sequence ENSEMBL: ENSMUSP00000101980 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000032956] [ENSMUST00000106371] [ENSMUST00000106372] [ENSMUST00000106373] [ENSMUST00000155419] [ENSMUST00000205507] [ENSMUST00000206359]
AlphaFold no structure available at present
Predicted Effect probably benign
Transcript: ENSMUST00000032956
SMART Domains Protein: ENSMUSP00000032956
Gene: ENSMUSG00000030714

DomainStartEndE-ValueType
coiled coil region 66 86 N/A INTRINSIC
Pfam:DUF1325 158 288 5.2e-43 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106371
AA Change: Q170K

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000101979
Gene: ENSMUSG00000030711
AA Change: Q170K

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 256 1.1e-78 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106372
AA Change: Q177K

PolyPhen 2 Score 0.006 (Sensitivity: 0.97; Specificity: 0.75)
SMART Domains Protein: ENSMUSP00000101980
Gene: ENSMUSG00000030711
AA Change: Q177K

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 41 263 1.1e-78 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000106373
AA Change: Q170K

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)
SMART Domains Protein: ENSMUSP00000101981
Gene: ENSMUSG00000030711
AA Change: Q170K

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 284 1.1e-89 PFAM
Pfam:Sulfotransfer_3 36 210 2.9e-10 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000129786
Predicted Effect probably benign
Transcript: ENSMUST00000155419
SMART Domains Protein: ENSMUSP00000121514
Gene: ENSMUSG00000030711

DomainStartEndE-ValueType
Pfam:Sulfotransfer_1 34 121 6e-23 PFAM
Pfam:Sulfotransfer_1 133 181 1.5e-13 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000205507
Predicted Effect probably benign
Transcript: ENSMUST00000206359
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for a knock-out allele exhibit decrease hepatic DNA adduct formation induced by methyleugenol. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 53 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933427I04Rik A G 4: 123,754,327 (GRCm39) I80M probably benign Het
Acsbg3 T A 17: 57,188,021 (GRCm39) D176E probably benign Het
Aga G A 8: 53,973,367 (GRCm39) R255H probably damaging Het
Anapc1 G A 2: 128,461,833 (GRCm39) P1757L possibly damaging Het
Arfgef3 T A 10: 18,479,278 (GRCm39) I1446L probably damaging Het
Auts2 T C 5: 131,468,981 (GRCm39) T779A probably benign Het
Cacna1s T C 1: 136,019,540 (GRCm39) S778P possibly damaging Het
Cep164 A T 9: 45,718,508 (GRCm39) probably benign Het
Cmya5 T C 13: 93,230,304 (GRCm39) T1595A probably benign Het
Csmd3 G T 15: 47,484,724 (GRCm39) T3214K possibly damaging Het
Dpy30 A G 17: 74,622,913 (GRCm39) L23P probably damaging Het
Edrf1 A G 7: 133,252,047 (GRCm39) E391G possibly damaging Het
Egflam A T 15: 7,237,229 (GRCm39) V985E probably damaging Het
Elmo3 T C 8: 106,033,810 (GRCm39) V201A probably benign Het
Entrep3 A C 3: 89,094,153 (GRCm39) D322A possibly damaging Het
Epb41l5 T A 1: 119,477,671 (GRCm39) D700V possibly damaging Het
Esr1 T C 10: 4,947,847 (GRCm39) S467P probably damaging Het
Eya4 G A 10: 22,982,157 (GRCm39) H601Y probably damaging Het
Fancm A C 12: 65,173,469 (GRCm39) N1927T possibly damaging Het
Gcfc2 A G 6: 81,912,944 (GRCm39) T248A probably benign Het
Gm29106 T A 1: 118,128,149 (GRCm39) C614S probably damaging Het
Greb1 T C 12: 16,773,328 (GRCm39) T249A probably benign Het
Hectd4 T C 5: 121,491,661 (GRCm39) S3700P possibly damaging Het
Hr T C 14: 70,804,965 (GRCm39) L950P probably damaging Het
Hsd3b3 T A 3: 98,651,205 (GRCm39) T82S possibly damaging Het
Ifit2 C A 19: 34,550,538 (GRCm39) A26E probably benign Het
Igsf9b A G 9: 27,244,739 (GRCm39) D902G probably damaging Het
Itga4 G A 2: 79,131,405 (GRCm39) R591Q probably damaging Het
Kcnb1 A T 2: 166,946,531 (GRCm39) S772R possibly damaging Het
Klhl32 T A 4: 24,629,343 (GRCm39) I213L probably benign Het
Lcn3 A T 2: 25,656,347 (GRCm39) probably null Het
Lpin2 T A 17: 71,538,232 (GRCm39) S293T probably damaging Het
Magi2 T C 5: 20,856,198 (GRCm39) F840S probably benign Het
Myt1 G A 2: 181,439,344 (GRCm39) E289K possibly damaging Het
Ndst4 A G 3: 125,503,756 (GRCm39) S8G probably damaging Het
Nlrp4f T C 13: 65,343,252 (GRCm39) D109G possibly damaging Het
Or6d14 G T 6: 116,534,289 (GRCm39) R301L probably damaging Het
Pcdhb12 C T 18: 37,570,687 (GRCm39) A611V probably damaging Het
Pcif1 A T 2: 164,728,417 (GRCm39) I225F probably damaging Het
Peli3 A G 19: 4,984,960 (GRCm39) F150L probably damaging Het
Qng1 G A 13: 58,532,694 (GRCm39) T92M probably damaging Het
Rfx7 A G 9: 72,519,086 (GRCm39) T263A probably damaging Het
Rpn1 A G 6: 88,072,539 (GRCm39) Y294C probably damaging Het
Rusc2 T A 4: 43,416,508 (GRCm39) S605T probably benign Het
Sec23ip A C 7: 128,355,777 (GRCm39) Q300P probably damaging Het
Sh2d3c A G 2: 32,635,925 (GRCm39) T98A probably damaging Het
Siah3 T A 14: 75,763,067 (GRCm39) I106K probably benign Het
Spns2 C T 11: 72,348,053 (GRCm39) D305N probably damaging Het
Tas2r109 A G 6: 132,957,171 (GRCm39) I253T probably benign Het
Tcof1 T C 18: 60,964,643 (GRCm39) D661G possibly damaging Het
Tdrd1 A G 19: 56,831,584 (GRCm39) N325S probably damaging Het
Tfcp2l1 C A 1: 118,560,082 (GRCm39) A58E probably damaging Het
Wdcp T C 12: 4,902,024 (GRCm39) probably benign Het
Other mutations in Sult1a1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01521:Sult1a1 APN 7 126,274,451 (GRCm39) missense possibly damaging 0.65
IGL03157:Sult1a1 APN 7 126,274,489 (GRCm39) missense probably damaging 1.00
R6056:Sult1a1 UTSW 7 126,275,624 (GRCm39) splice site probably null
R6407:Sult1a1 UTSW 7 126,272,356 (GRCm39) splice site probably null
R6529:Sult1a1 UTSW 7 126,274,310 (GRCm39) missense probably benign 0.00
R7237:Sult1a1 UTSW 7 126,272,622 (GRCm39) missense probably benign 0.01
R8255:Sult1a1 UTSW 7 126,274,280 (GRCm39) missense possibly damaging 0.87
R9678:Sult1a1 UTSW 7 126,273,536 (GRCm39) missense probably benign 0.01
X0066:Sult1a1 UTSW 7 126,273,578 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- CAGAAGTGCTGTTCTACTGTGG -3'
(R):5'- GCAAAGGATGTGGTTGTCTCC -3'

Sequencing Primer
(F):5'- CTACTGTGGGGCTAGGATAGG -3'
(R):5'- TTCTACAAAATGGCCAAGCTG -3'
Posted On 2021-01-18