Incidental Mutation 'R8554:Vmn2r16'
ID 660013
Institutional Source Beutler Lab
Gene Symbol Vmn2r16
Ensembl Gene ENSMUSG00000092080
Gene Name vomeronasal 2, receptor 16
Synonyms EG384220
MMRRC Submission 068517-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.154) question?
Stock # R8554 (G1)
Quality Score 225.009
Status Not validated
Chromosome 5
Chromosomal Location 109478247-109512347 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 109511997 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Valine at position 735 (I735V)
Ref Sequence ENSEMBL: ENSMUSP00000127838 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000165180]
AlphaFold A0A3B2WCY4
Predicted Effect probably benign
Transcript: ENSMUST00000165180
AA Change: I735V

PolyPhen 2 Score 0.131 (Sensitivity: 0.93; Specificity: 0.86)
SMART Domains Protein: ENSMUSP00000127838
Gene: ENSMUSG00000092080
AA Change: I735V

DomainStartEndE-ValueType
signal peptide 1 24 N/A INTRINSIC
Pfam:ANF_receptor 76 425 2.3e-28 PFAM
Pfam:NCD3G 509 563 8.2e-19 PFAM
Pfam:7tm_3 596 831 3.5e-56 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adtrp G A 13: 41,969,636 (GRCm39) T89I possibly damaging Het
Aopep T A 13: 63,444,711 (GRCm39) Y94N possibly damaging Het
Apc T C 18: 34,445,999 (GRCm39) V947A probably damaging Het
Apob A C 12: 8,037,830 (GRCm39) K334N probably damaging Het
Camk2d A T 3: 126,564,448 (GRCm39) Q119L possibly damaging Het
Ccdc60 A T 5: 116,328,171 (GRCm39) F98I probably damaging Het
Cd47 A G 16: 49,688,304 (GRCm39) T22A probably benign Het
Crat A G 2: 30,300,035 (GRCm39) V115A probably benign Het
Csmd3 T C 15: 47,507,538 (GRCm39) M2992V probably benign Het
Dsg4 T A 18: 20,586,100 (GRCm39) N263K probably damaging Het
Eln A C 5: 134,738,964 (GRCm39) probably benign Het
Ep300 A G 15: 81,523,228 (GRCm39) E1284G unknown Het
Fam193a T A 5: 34,633,115 (GRCm39) M122K probably benign Het
Fcgr1 A T 3: 96,199,788 (GRCm39) W40R probably damaging Het
Gm3486 T A 14: 41,209,119 (GRCm39) Q84L probably damaging Het
Golga2 G A 2: 32,183,357 (GRCm39) D80N probably damaging Het
Isg20 T C 7: 78,566,425 (GRCm39) Y125H probably benign Het
Kdf1 A G 4: 133,256,188 (GRCm39) I302V probably damaging Het
Kics2 T A 10: 121,575,960 (GRCm39) I27N probably benign Het
Krt33a T A 11: 99,903,209 (GRCm39) T278S possibly damaging Het
Lrp1b T A 2: 41,234,495 (GRCm39) Q1038L probably benign Het
Marchf6 G A 15: 31,482,976 (GRCm39) H476Y probably damaging Het
Myom1 A G 17: 71,343,448 (GRCm39) E215G possibly damaging Het
Or2aa1 A T 11: 59,480,312 (GRCm39) L201Q possibly damaging Het
Or2h15 T A 17: 38,441,489 (GRCm39) Q198L probably damaging Het
Or4c122 T C 2: 89,079,595 (GRCm39) T148A possibly damaging Het
Pate11 A G 9: 36,387,788 (GRCm39) I25V probably benign Het
Pdlim2 T A 14: 70,408,698 (GRCm39) T173S probably benign Het
Pitpnb T C 5: 111,494,372 (GRCm39) M74T probably benign Het
Pou2f2 C A 7: 24,814,981 (GRCm39) probably benign Het
Rab35 A C 5: 115,783,690 (GRCm39) probably null Het
Rasef A T 4: 73,645,844 (GRCm39) D508E probably benign Het
Rev3l T C 10: 39,682,838 (GRCm39) S319P probably benign Het
Rftn1 G T 17: 50,354,408 (GRCm39) A318D probably damaging Het
Rgl3 A G 9: 21,900,159 (GRCm39) S44P probably benign Het
Rnf214 C A 9: 45,778,797 (GRCm39) probably null Het
Rpsa T C 9: 119,958,317 (GRCm39) V76A possibly damaging Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,229,130 (GRCm39) probably benign Het
Senp7 T C 16: 55,978,973 (GRCm39) V529A probably benign Het
Siglecg C T 7: 43,058,320 (GRCm39) S69L probably benign Het
Sos1 G T 17: 80,705,842 (GRCm39) T1243K probably damaging Het
Tent5a T C 9: 85,208,784 (GRCm39) D13G possibly damaging Het
Tlcd3a A G 11: 76,096,244 (GRCm39) H124R probably damaging Het
Tmc2 A G 2: 130,106,084 (GRCm39) T872A probably benign Het
Tnfrsf8 A C 4: 145,023,511 (GRCm39) C107W probably damaging Het
Tnn T C 1: 159,937,986 (GRCm39) Y913C probably damaging Het
Ttn T C 2: 76,568,376 (GRCm39) T19179A probably damaging Het
Usp42 T A 5: 143,706,137 (GRCm39) K294N probably damaging Het
Vmn1r123 T A 7: 20,896,971 (GRCm39) C288S probably benign Het
Vmn1r29 T A 6: 58,285,191 (GRCm39) *304K probably null Het
Vmn2r1 T C 3: 63,997,334 (GRCm39) I330T probably damaging Het
Vmn2r65 T C 7: 84,595,960 (GRCm39) I241M probably benign Het
Other mutations in Vmn2r16
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01116:Vmn2r16 APN 5 109,488,294 (GRCm39) missense probably damaging 1.00
IGL01374:Vmn2r16 APN 5 109,478,283 (GRCm39) missense probably benign 0.00
IGL01391:Vmn2r16 APN 5 109,511,627 (GRCm39) missense possibly damaging 0.50
IGL01419:Vmn2r16 APN 5 109,510,267 (GRCm39) splice site probably benign
IGL01634:Vmn2r16 APN 5 109,488,177 (GRCm39) missense probably benign 0.00
IGL01845:Vmn2r16 APN 5 109,511,762 (GRCm39) missense probably damaging 1.00
IGL01875:Vmn2r16 APN 5 109,478,277 (GRCm39) missense probably benign 0.01
IGL01910:Vmn2r16 APN 5 109,487,951 (GRCm39) missense probably damaging 1.00
IGL02217:Vmn2r16 APN 5 109,487,676 (GRCm39) missense probably damaging 0.98
IGL02327:Vmn2r16 APN 5 109,487,987 (GRCm39) missense probably benign 0.01
IGL02491:Vmn2r16 APN 5 109,487,703 (GRCm39) nonsense probably null
IGL02531:Vmn2r16 APN 5 109,488,134 (GRCm39) missense probably damaging 0.99
IGL02680:Vmn2r16 APN 5 109,487,948 (GRCm39) missense probably benign 0.44
IGL02884:Vmn2r16 APN 5 109,508,757 (GRCm39) missense possibly damaging 0.94
IGL03084:Vmn2r16 APN 5 109,478,292 (GRCm39) missense probably damaging 0.99
IGL03096:Vmn2r16 APN 5 109,487,751 (GRCm39) missense probably damaging 0.99
IGL03355:Vmn2r16 APN 5 109,511,580 (GRCm39) missense possibly damaging 0.74
R0280:Vmn2r16 UTSW 5 109,488,005 (GRCm39) missense possibly damaging 0.88
R0594:Vmn2r16 UTSW 5 109,511,762 (GRCm39) missense probably damaging 1.00
R1016:Vmn2r16 UTSW 5 109,487,754 (GRCm39) missense probably damaging 1.00
R1109:Vmn2r16 UTSW 5 109,487,652 (GRCm39) missense probably damaging 0.98
R1248:Vmn2r16 UTSW 5 109,508,643 (GRCm39) missense probably benign 0.10
R1626:Vmn2r16 UTSW 5 109,511,443 (GRCm39) missense probably damaging 1.00
R1909:Vmn2r16 UTSW 5 109,511,853 (GRCm39) missense probably benign 0.01
R1929:Vmn2r16 UTSW 5 109,487,124 (GRCm39) missense possibly damaging 0.92
R1982:Vmn2r16 UTSW 5 109,511,890 (GRCm39) missense probably benign 0.01
R3038:Vmn2r16 UTSW 5 109,487,199 (GRCm39) missense probably damaging 1.00
R3437:Vmn2r16 UTSW 5 109,478,362 (GRCm39) missense probably damaging 0.99
R3734:Vmn2r16 UTSW 5 109,478,280 (GRCm39) missense probably benign 0.11
R3820:Vmn2r16 UTSW 5 109,510,143 (GRCm39) missense probably benign 0.36
R3873:Vmn2r16 UTSW 5 109,488,177 (GRCm39) missense probably benign 0.33
R4165:Vmn2r16 UTSW 5 109,478,427 (GRCm39) missense possibly damaging 0.80
R4373:Vmn2r16 UTSW 5 109,511,667 (GRCm39) missense probably damaging 1.00
R4575:Vmn2r16 UTSW 5 109,511,665 (GRCm39) missense possibly damaging 0.81
R4576:Vmn2r16 UTSW 5 109,511,665 (GRCm39) missense possibly damaging 0.81
R4578:Vmn2r16 UTSW 5 109,511,665 (GRCm39) missense possibly damaging 0.81
R4637:Vmn2r16 UTSW 5 109,478,280 (GRCm39) missense probably benign 0.00
R4696:Vmn2r16 UTSW 5 109,487,168 (GRCm39) missense probably benign 0.01
R5026:Vmn2r16 UTSW 5 109,508,722 (GRCm39) nonsense probably null
R5180:Vmn2r16 UTSW 5 109,478,391 (GRCm39) missense probably benign 0.01
R5433:Vmn2r16 UTSW 5 109,511,708 (GRCm39) missense probably damaging 1.00
R5955:Vmn2r16 UTSW 5 109,511,613 (GRCm39) missense possibly damaging 0.78
R5958:Vmn2r16 UTSW 5 109,510,153 (GRCm39) missense possibly damaging 0.81
R6353:Vmn2r16 UTSW 5 109,488,119 (GRCm39) missense probably benign 0.33
R6389:Vmn2r16 UTSW 5 109,478,344 (GRCm39) missense probably benign 0.19
R6819:Vmn2r16 UTSW 5 109,488,412 (GRCm39) missense probably benign 0.04
R6994:Vmn2r16 UTSW 5 109,487,969 (GRCm39) missense probably damaging 1.00
R7061:Vmn2r16 UTSW 5 109,511,620 (GRCm39) missense probably damaging 0.99
R7063:Vmn2r16 UTSW 5 109,511,650 (GRCm39) missense probably damaging 1.00
R7220:Vmn2r16 UTSW 5 109,508,772 (GRCm39) missense probably damaging 0.97
R7268:Vmn2r16 UTSW 5 109,488,331 (GRCm39) nonsense probably null
R7420:Vmn2r16 UTSW 5 109,511,736 (GRCm39) missense probably damaging 0.96
R7591:Vmn2r16 UTSW 5 109,510,223 (GRCm39) missense probably damaging 0.99
R7644:Vmn2r16 UTSW 5 109,487,837 (GRCm39) missense probably damaging 1.00
R7939:Vmn2r16 UTSW 5 109,487,705 (GRCm39) missense possibly damaging 0.79
R7977:Vmn2r16 UTSW 5 109,488,015 (GRCm39) missense probably damaging 1.00
R7987:Vmn2r16 UTSW 5 109,488,015 (GRCm39) missense probably damaging 1.00
R8023:Vmn2r16 UTSW 5 109,488,272 (GRCm39) nonsense probably null
R8427:Vmn2r16 UTSW 5 109,488,138 (GRCm39) missense probably benign 0.03
R8436:Vmn2r16 UTSW 5 109,511,649 (GRCm39) missense probably damaging 1.00
R8475:Vmn2r16 UTSW 5 109,487,073 (GRCm39) missense probably benign 0.01
R8771:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8774:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8774-TAIL:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8775:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8775-TAIL:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8777:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8777-TAIL:Vmn2r16 UTSW 5 109,488,231 (GRCm39) missense probably benign 0.00
R8825:Vmn2r16 UTSW 5 109,487,019 (GRCm39) missense probably benign 0.41
R8865:Vmn2r16 UTSW 5 109,487,910 (GRCm39) missense probably benign 0.33
R8900:Vmn2r16 UTSW 5 109,511,619 (GRCm39) missense probably benign 0.04
R9365:Vmn2r16 UTSW 5 109,488,064 (GRCm39) missense probably damaging 0.99
R9683:Vmn2r16 UTSW 5 109,511,677 (GRCm39) missense probably damaging 1.00
X0027:Vmn2r16 UTSW 5 109,487,175 (GRCm39) missense probably damaging 1.00
Z1088:Vmn2r16 UTSW 5 109,511,779 (GRCm39) frame shift probably null
Z1088:Vmn2r16 UTSW 5 109,488,381 (GRCm39) missense probably benign 0.03
Z1177:Vmn2r16 UTSW 5 109,487,864 (GRCm39) missense possibly damaging 0.79
Predicted Primers PCR Primer
(F):5'- TCAAGCTCACTACTCCAGGAAG -3'
(R):5'- CCTGCACTAGAAGCCAAGATG -3'

Sequencing Primer
(F):5'- CTCACTACTCCAGGAAGAAGGATG -3'
(R):5'- ACCATGACTGTTCCCCTGGTG -3'
Posted On 2021-01-18