Incidental Mutation 'R8554:Rgl3'
ID 660026
Institutional Source Beutler Lab
Gene Symbol Rgl3
Ensembl Gene ENSMUSG00000040146
Gene Name ral guanine nucleotide dissociation stimulator-like 3
Synonyms 1300003D20Rik
MMRRC Submission 068517-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8554 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 21882475-21900765 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 21900159 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Proline at position 44 (S44P)
Ref Sequence ENSEMBL: ENSMUSP00000148965 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044926] [ENSMUST00000045726] [ENSMUST00000115336] [ENSMUST00000214026] [ENSMUST00000215851]
AlphaFold Q3UYI5
Predicted Effect probably benign
Transcript: ENSMUST00000044926
SMART Domains Protein: ENSMUSP00000041117
Gene: ENSMUSG00000039632

DomainStartEndE-ValueType
coiled coil region 88 286 N/A INTRINSIC
low complexity region 334 345 N/A INTRINSIC
coiled coil region 378 420 N/A INTRINSIC
low complexity region 495 514 N/A INTRINSIC
low complexity region 550 565 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000045726
AA Change: S44P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000035726
Gene: ENSMUSG00000040146
AA Change: S44P

DomainStartEndE-ValueType
low complexity region 28 39 N/A INTRINSIC
RasGEFN 63 201 1.35e-6 SMART
RasGEF 244 504 2.74e-84 SMART
low complexity region 533 579 N/A INTRINSIC
RA 609 699 3.36e-15 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000115336
SMART Domains Protein: ENSMUSP00000110993
Gene: ENSMUSG00000039632

DomainStartEndE-ValueType
coiled coil region 88 286 N/A INTRINSIC
low complexity region 335 346 N/A INTRINSIC
coiled coil region 379 421 N/A INTRINSIC
low complexity region 496 515 N/A INTRINSIC
low complexity region 551 566 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000214026
AA Change: S44P

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
Predicted Effect unknown
Transcript: ENSMUST00000215851
AA Change: S44P
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 52 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adtrp G A 13: 41,969,636 (GRCm39) T89I possibly damaging Het
Aopep T A 13: 63,444,711 (GRCm39) Y94N possibly damaging Het
Apc T C 18: 34,445,999 (GRCm39) V947A probably damaging Het
Apob A C 12: 8,037,830 (GRCm39) K334N probably damaging Het
Camk2d A T 3: 126,564,448 (GRCm39) Q119L possibly damaging Het
Ccdc60 A T 5: 116,328,171 (GRCm39) F98I probably damaging Het
Cd47 A G 16: 49,688,304 (GRCm39) T22A probably benign Het
Crat A G 2: 30,300,035 (GRCm39) V115A probably benign Het
Csmd3 T C 15: 47,507,538 (GRCm39) M2992V probably benign Het
Dsg4 T A 18: 20,586,100 (GRCm39) N263K probably damaging Het
Eln A C 5: 134,738,964 (GRCm39) probably benign Het
Ep300 A G 15: 81,523,228 (GRCm39) E1284G unknown Het
Fam193a T A 5: 34,633,115 (GRCm39) M122K probably benign Het
Fcgr1 A T 3: 96,199,788 (GRCm39) W40R probably damaging Het
Gm3486 T A 14: 41,209,119 (GRCm39) Q84L probably damaging Het
Golga2 G A 2: 32,183,357 (GRCm39) D80N probably damaging Het
Isg20 T C 7: 78,566,425 (GRCm39) Y125H probably benign Het
Kdf1 A G 4: 133,256,188 (GRCm39) I302V probably damaging Het
Kics2 T A 10: 121,575,960 (GRCm39) I27N probably benign Het
Krt33a T A 11: 99,903,209 (GRCm39) T278S possibly damaging Het
Lrp1b T A 2: 41,234,495 (GRCm39) Q1038L probably benign Het
Marchf6 G A 15: 31,482,976 (GRCm39) H476Y probably damaging Het
Myom1 A G 17: 71,343,448 (GRCm39) E215G possibly damaging Het
Or2aa1 A T 11: 59,480,312 (GRCm39) L201Q possibly damaging Het
Or2h15 T A 17: 38,441,489 (GRCm39) Q198L probably damaging Het
Or4c122 T C 2: 89,079,595 (GRCm39) T148A possibly damaging Het
Pate11 A G 9: 36,387,788 (GRCm39) I25V probably benign Het
Pdlim2 T A 14: 70,408,698 (GRCm39) T173S probably benign Het
Pitpnb T C 5: 111,494,372 (GRCm39) M74T probably benign Het
Pou2f2 C A 7: 24,814,981 (GRCm39) probably benign Het
Rab35 A C 5: 115,783,690 (GRCm39) probably null Het
Rasef A T 4: 73,645,844 (GRCm39) D508E probably benign Het
Rev3l T C 10: 39,682,838 (GRCm39) S319P probably benign Het
Rftn1 G T 17: 50,354,408 (GRCm39) A318D probably damaging Het
Rnf214 C A 9: 45,778,797 (GRCm39) probably null Het
Rpsa T C 9: 119,958,317 (GRCm39) V76A possibly damaging Het
Rsf1 CGGCGGCGG CGGCGGCGGGGGCGGCGG 7: 97,229,130 (GRCm39) probably benign Het
Senp7 T C 16: 55,978,973 (GRCm39) V529A probably benign Het
Siglecg C T 7: 43,058,320 (GRCm39) S69L probably benign Het
Sos1 G T 17: 80,705,842 (GRCm39) T1243K probably damaging Het
Tent5a T C 9: 85,208,784 (GRCm39) D13G possibly damaging Het
Tlcd3a A G 11: 76,096,244 (GRCm39) H124R probably damaging Het
Tmc2 A G 2: 130,106,084 (GRCm39) T872A probably benign Het
Tnfrsf8 A C 4: 145,023,511 (GRCm39) C107W probably damaging Het
Tnn T C 1: 159,937,986 (GRCm39) Y913C probably damaging Het
Ttn T C 2: 76,568,376 (GRCm39) T19179A probably damaging Het
Usp42 T A 5: 143,706,137 (GRCm39) K294N probably damaging Het
Vmn1r123 T A 7: 20,896,971 (GRCm39) C288S probably benign Het
Vmn1r29 T A 6: 58,285,191 (GRCm39) *304K probably null Het
Vmn2r1 T C 3: 63,997,334 (GRCm39) I330T probably damaging Het
Vmn2r16 A G 5: 109,511,997 (GRCm39) I735V probably benign Het
Vmn2r65 T C 7: 84,595,960 (GRCm39) I241M probably benign Het
Other mutations in Rgl3
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00706:Rgl3 APN 9 21,888,535 (GRCm39) missense probably damaging 1.00
IGL00770:Rgl3 APN 9 21,899,018 (GRCm39) splice site probably benign
IGL00774:Rgl3 APN 9 21,899,018 (GRCm39) splice site probably benign
IGL02071:Rgl3 APN 9 21,899,559 (GRCm39) missense probably benign 0.00
IGL02172:Rgl3 APN 9 21,888,134 (GRCm39) missense probably damaging 1.00
IGL02190:Rgl3 APN 9 21,893,004 (GRCm39) missense probably benign 0.00
IGL02277:Rgl3 APN 9 21,885,405 (GRCm39) missense probably damaging 1.00
IGL02515:Rgl3 APN 9 21,885,396 (GRCm39) missense possibly damaging 0.93
R0077:Rgl3 UTSW 9 21,885,398 (GRCm39) missense probably benign 0.00
R0126:Rgl3 UTSW 9 21,887,108 (GRCm39) missense probably benign 0.06
R0360:Rgl3 UTSW 9 21,888,153 (GRCm39) missense probably damaging 0.97
R0421:Rgl3 UTSW 9 21,887,328 (GRCm39) missense probably benign 0.06
R0556:Rgl3 UTSW 9 21,887,140 (GRCm39) nonsense probably null
R0751:Rgl3 UTSW 9 21,888,676 (GRCm39) critical splice donor site probably null
R1184:Rgl3 UTSW 9 21,888,676 (GRCm39) critical splice donor site probably null
R1548:Rgl3 UTSW 9 21,892,002 (GRCm39) missense probably benign 0.11
R2176:Rgl3 UTSW 9 21,887,254 (GRCm39) utr 3 prime probably benign
R3154:Rgl3 UTSW 9 21,892,070 (GRCm39) missense probably damaging 1.00
R3607:Rgl3 UTSW 9 21,898,987 (GRCm39) missense probably damaging 0.98
R3803:Rgl3 UTSW 9 21,887,321 (GRCm39) missense probably damaging 1.00
R3958:Rgl3 UTSW 9 21,886,885 (GRCm39) intron probably benign
R4081:Rgl3 UTSW 9 21,898,971 (GRCm39) missense possibly damaging 0.79
R4937:Rgl3 UTSW 9 21,899,004 (GRCm39) nonsense probably null
R5068:Rgl3 UTSW 9 21,899,340 (GRCm39) critical splice donor site probably null
R5070:Rgl3 UTSW 9 21,899,340 (GRCm39) critical splice donor site probably null
R5217:Rgl3 UTSW 9 21,898,944 (GRCm39) makesense probably null
R5772:Rgl3 UTSW 9 21,892,908 (GRCm39) missense probably benign 0.00
R5819:Rgl3 UTSW 9 21,892,898 (GRCm39) critical splice donor site probably null
R6509:Rgl3 UTSW 9 21,883,204 (GRCm39) missense probably benign 0.00
R7425:Rgl3 UTSW 9 21,888,123 (GRCm39) nonsense probably null
R7744:Rgl3 UTSW 9 21,898,866 (GRCm39) missense probably benign 0.00
R7883:Rgl3 UTSW 9 21,892,723 (GRCm39) missense probably benign 0.00
R8339:Rgl3 UTSW 9 21,898,825 (GRCm39) missense probably benign
R8383:Rgl3 UTSW 9 21,888,529 (GRCm39) missense probably damaging 1.00
R8546:Rgl3 UTSW 9 21,899,156 (GRCm39) missense probably benign 0.06
R9189:Rgl3 UTSW 9 21,885,356 (GRCm39) missense possibly damaging 0.65
R9380:Rgl3 UTSW 9 21,888,123 (GRCm39) missense probably damaging 0.99
X0019:Rgl3 UTSW 9 21,892,775 (GRCm39) missense probably benign
Z1176:Rgl3 UTSW 9 21,892,699 (GRCm39) missense possibly damaging 0.91
Predicted Primers PCR Primer
(F):5'- TGGATTCAAACCAAGTCACCTG -3'
(R):5'- CGAGTCTTGAATACTCTGTTCGG -3'

Sequencing Primer
(F):5'- ACCAAGTCACCTGGCCGC -3'
(R):5'- CTTGAATACTCTGTTCGGGAAAG -3'
Posted On 2021-01-18