Incidental Mutation 'R8555:Vmn1r174'
ID |
660060 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn1r174
|
Ensembl Gene |
ENSMUSG00000090411 |
Gene Name |
vomeronasal 1 receptor 174 |
Synonyms |
V1rd22 |
MMRRC Submission |
068518-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.051)
|
Stock # |
R8555 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
23453336-23454277 bp(+) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to T
at 23453970 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Phenylalanine
at position 212
(Y212F)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000154506
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000167551]
[ENSMUST00000228331]
|
AlphaFold |
E9PYW5 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000167551
AA Change: Y212F
PolyPhen 2
Score 0.842 (Sensitivity: 0.83; Specificity: 0.93)
|
SMART Domains |
Protein: ENSMUSP00000126478 Gene: ENSMUSG00000090411 AA Change: Y212F
Domain | Start | End | E-Value | Type |
Pfam:TAS2R
|
8 |
300 |
4e-9 |
PFAM |
Pfam:V1R
|
43 |
300 |
5e-19 |
PFAM |
|
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000228331
AA Change: Y212F
PolyPhen 2
Score 0.842 (Sensitivity: 0.83; Specificity: 0.93)
|
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.2%
|
Validation Efficiency |
100% (35/35) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 35 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4933405O20Rik |
C |
T |
7: 50,250,010 (GRCm39) |
A348V |
possibly damaging |
Het |
Alk |
A |
T |
17: 72,228,869 (GRCm39) |
V732E |
probably damaging |
Het |
Ccdc88a |
T |
C |
11: 29,380,169 (GRCm39) |
S182P |
probably benign |
Het |
Cyp2c70 |
T |
C |
19: 40,172,345 (GRCm39) |
D99G |
probably benign |
Het |
Dnah8 |
G |
T |
17: 30,940,084 (GRCm39) |
E1677* |
probably null |
Het |
Dop1b |
A |
G |
16: 93,568,698 (GRCm39) |
T797A |
probably damaging |
Het |
Fam181b |
A |
T |
7: 92,729,296 (GRCm39) |
D23V |
probably damaging |
Het |
Fbxo4 |
A |
T |
15: 3,995,273 (GRCm39) |
V357D |
probably damaging |
Het |
Gm4924 |
T |
C |
10: 82,213,224 (GRCm39) |
|
probably benign |
Het |
Grhl2 |
A |
G |
15: 37,233,507 (GRCm39) |
|
probably benign |
Het |
Magee2 |
A |
T |
X: 103,900,087 (GRCm39) |
L188H |
probably damaging |
Het |
Matn2 |
A |
G |
15: 34,423,951 (GRCm39) |
K603R |
probably benign |
Het |
Mfsd6l |
G |
A |
11: 68,447,898 (GRCm39) |
V250I |
probably benign |
Het |
Mroh9 |
T |
C |
1: 162,899,595 (GRCm39) |
|
probably null |
Het |
Ntsr1 |
A |
G |
2: 180,180,470 (GRCm39) |
I259V |
probably benign |
Het |
Ogfr |
GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG |
GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG |
2: 180,237,059 (GRCm39) |
|
probably benign |
Het |
Or14j3 |
A |
G |
17: 37,900,540 (GRCm39) |
S235P |
possibly damaging |
Het |
Or6d14 |
G |
T |
6: 116,534,289 (GRCm39) |
R301L |
probably damaging |
Het |
Pax2 |
T |
C |
19: 44,750,128 (GRCm39) |
Y72H |
probably damaging |
Het |
Pcdh10 |
A |
T |
3: 45,334,030 (GRCm39) |
I115F |
probably benign |
Het |
Pkp4 |
A |
T |
2: 59,138,379 (GRCm39) |
R210* |
probably null |
Het |
Rftn1 |
G |
T |
17: 50,354,408 (GRCm39) |
A318D |
probably damaging |
Het |
Rpa2 |
A |
G |
4: 132,499,481 (GRCm39) |
|
probably null |
Het |
Sec31a |
T |
C |
5: 100,540,273 (GRCm39) |
N471S |
probably benign |
Het |
Serpinb9g |
A |
T |
13: 33,676,796 (GRCm39) |
T193S |
probably benign |
Het |
Sh3pxd2b |
C |
T |
11: 32,361,469 (GRCm39) |
T227M |
probably benign |
Het |
Speg |
A |
G |
1: 75,378,908 (GRCm39) |
|
probably null |
Het |
Suz12 |
T |
C |
11: 79,922,817 (GRCm39) |
I653T |
probably damaging |
Het |
Thsd7b |
C |
A |
1: 129,523,191 (GRCm39) |
T75K |
probably damaging |
Het |
Trav5-1 |
A |
C |
14: 52,860,276 (GRCm39) |
Q27P |
probably damaging |
Het |
Trim5 |
T |
C |
7: 103,927,330 (GRCm39) |
|
probably null |
Het |
Vmn2r110 |
G |
A |
17: 20,804,618 (GRCm39) |
P101S |
probably damaging |
Het |
Vmn2r17 |
A |
G |
5: 109,600,810 (GRCm39) |
T703A |
probably damaging |
Het |
Vmn2r84 |
A |
G |
10: 130,230,100 (GRCm39) |
M4T |
probably benign |
Het |
Zfp709 |
A |
G |
8: 72,643,476 (GRCm39) |
T302A |
probably benign |
Het |
|
Other mutations in Vmn1r174 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00331:Vmn1r174
|
APN |
7 |
23,453,958 (GRCm39) |
missense |
possibly damaging |
0.77 |
IGL00950:Vmn1r174
|
APN |
7 |
23,453,911 (GRCm39) |
missense |
possibly damaging |
0.96 |
IGL01484:Vmn1r174
|
APN |
7 |
23,453,749 (GRCm39) |
nonsense |
probably null |
|
IGL02014:Vmn1r174
|
APN |
7 |
23,453,583 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02190:Vmn1r174
|
APN |
7 |
23,454,252 (GRCm39) |
missense |
unknown |
|
IGL03265:Vmn1r174
|
APN |
7 |
23,453,898 (GRCm39) |
nonsense |
probably null |
|
IGL03335:Vmn1r174
|
APN |
7 |
23,453,937 (GRCm39) |
missense |
probably benign |
0.41 |
R0529:Vmn1r174
|
UTSW |
7 |
23,453,622 (GRCm39) |
missense |
probably benign |
0.00 |
R1489:Vmn1r174
|
UTSW |
7 |
23,453,981 (GRCm39) |
nonsense |
probably null |
|
R1645:Vmn1r174
|
UTSW |
7 |
23,453,777 (GRCm39) |
missense |
possibly damaging |
0.87 |
R1691:Vmn1r174
|
UTSW |
7 |
23,453,337 (GRCm39) |
start codon destroyed |
probably null |
1.00 |
R1753:Vmn1r174
|
UTSW |
7 |
23,453,622 (GRCm39) |
missense |
probably benign |
0.00 |
R1939:Vmn1r174
|
UTSW |
7 |
23,453,532 (GRCm39) |
missense |
probably damaging |
0.99 |
R1988:Vmn1r174
|
UTSW |
7 |
23,454,050 (GRCm39) |
missense |
probably damaging |
0.98 |
R2299:Vmn1r174
|
UTSW |
7 |
23,453,429 (GRCm39) |
missense |
probably benign |
0.08 |
R4429:Vmn1r174
|
UTSW |
7 |
23,453,565 (GRCm39) |
missense |
probably benign |
0.02 |
R4516:Vmn1r174
|
UTSW |
7 |
23,453,768 (GRCm39) |
missense |
probably benign |
0.01 |
R4589:Vmn1r174
|
UTSW |
7 |
23,454,204 (GRCm39) |
nonsense |
probably null |
|
R5175:Vmn1r174
|
UTSW |
7 |
23,454,153 (GRCm39) |
missense |
probably benign |
0.03 |
R5392:Vmn1r174
|
UTSW |
7 |
23,454,227 (GRCm39) |
missense |
unknown |
|
R5503:Vmn1r174
|
UTSW |
7 |
23,453,562 (GRCm39) |
missense |
probably benign |
0.03 |
R5568:Vmn1r174
|
UTSW |
7 |
23,453,919 (GRCm39) |
missense |
probably damaging |
0.96 |
R6705:Vmn1r174
|
UTSW |
7 |
23,453,851 (GRCm39) |
missense |
probably benign |
0.25 |
R8168:Vmn1r174
|
UTSW |
7 |
23,454,096 (GRCm39) |
missense |
probably damaging |
0.99 |
R8190:Vmn1r174
|
UTSW |
7 |
23,453,568 (GRCm39) |
missense |
probably damaging |
1.00 |
R8523:Vmn1r174
|
UTSW |
7 |
23,454,182 (GRCm39) |
missense |
probably damaging |
1.00 |
R8913:Vmn1r174
|
UTSW |
7 |
23,453,375 (GRCm39) |
missense |
possibly damaging |
0.90 |
R8979:Vmn1r174
|
UTSW |
7 |
23,453,892 (GRCm39) |
missense |
possibly damaging |
0.92 |
R8990:Vmn1r174
|
UTSW |
7 |
23,453,956 (GRCm39) |
missense |
possibly damaging |
0.71 |
X0011:Vmn1r174
|
UTSW |
7 |
23,453,906 (GRCm39) |
missense |
probably benign |
0.03 |
|
Predicted Primers |
PCR Primer
(F):5'- AAATACCTCCACATTTGTGCAC -3'
(R):5'- GCCAAAATTTCACTGACATGCC -3'
Sequencing Primer
(F):5'- GTCTACATCCCTATAAAAATCAGTGG -3'
(R):5'- ATTTCACTGACATGCCTCAACC -3'
|
Posted On |
2021-01-18 |