Incidental Mutation 'R8555:Vmn1r174'
ID 660060
Institutional Source Beutler Lab
Gene Symbol Vmn1r174
Ensembl Gene ENSMUSG00000090411
Gene Name vomeronasal 1 receptor 174
Synonyms V1rd22
MMRRC Submission 068518-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.051) question?
Stock # R8555 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 23453336-23454277 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 23453970 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Phenylalanine at position 212 (Y212F)
Ref Sequence ENSEMBL: ENSMUSP00000154506 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000167551] [ENSMUST00000228331]
AlphaFold E9PYW5
Predicted Effect possibly damaging
Transcript: ENSMUST00000167551
AA Change: Y212F

PolyPhen 2 Score 0.842 (Sensitivity: 0.83; Specificity: 0.93)
SMART Domains Protein: ENSMUSP00000126478
Gene: ENSMUSG00000090411
AA Change: Y212F

DomainStartEndE-ValueType
Pfam:TAS2R 8 300 4e-9 PFAM
Pfam:V1R 43 300 5e-19 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000228331
AA Change: Y212F

PolyPhen 2 Score 0.842 (Sensitivity: 0.83; Specificity: 0.93)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.2%
Validation Efficiency 100% (35/35)
Allele List at MGI
Other mutations in this stock
Total: 35 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4933405O20Rik C T 7: 50,250,010 (GRCm39) A348V possibly damaging Het
Alk A T 17: 72,228,869 (GRCm39) V732E probably damaging Het
Ccdc88a T C 11: 29,380,169 (GRCm39) S182P probably benign Het
Cyp2c70 T C 19: 40,172,345 (GRCm39) D99G probably benign Het
Dnah8 G T 17: 30,940,084 (GRCm39) E1677* probably null Het
Dop1b A G 16: 93,568,698 (GRCm39) T797A probably damaging Het
Fam181b A T 7: 92,729,296 (GRCm39) D23V probably damaging Het
Fbxo4 A T 15: 3,995,273 (GRCm39) V357D probably damaging Het
Gm4924 T C 10: 82,213,224 (GRCm39) probably benign Het
Grhl2 A G 15: 37,233,507 (GRCm39) probably benign Het
Magee2 A T X: 103,900,087 (GRCm39) L188H probably damaging Het
Matn2 A G 15: 34,423,951 (GRCm39) K603R probably benign Het
Mfsd6l G A 11: 68,447,898 (GRCm39) V250I probably benign Het
Mroh9 T C 1: 162,899,595 (GRCm39) probably null Het
Ntsr1 A G 2: 180,180,470 (GRCm39) I259V probably benign Het
Ogfr GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG GGCCAGAGGACCCCAAAAGCCAGGTGGAGCCAGAGGACCCCAAAAGCCAGGTGGGGCCAGAGGACCCCCAAAGCCAGGTGG 2: 180,237,059 (GRCm39) probably benign Het
Or14j3 A G 17: 37,900,540 (GRCm39) S235P possibly damaging Het
Or6d14 G T 6: 116,534,289 (GRCm39) R301L probably damaging Het
Pax2 T C 19: 44,750,128 (GRCm39) Y72H probably damaging Het
Pcdh10 A T 3: 45,334,030 (GRCm39) I115F probably benign Het
Pkp4 A T 2: 59,138,379 (GRCm39) R210* probably null Het
Rftn1 G T 17: 50,354,408 (GRCm39) A318D probably damaging Het
Rpa2 A G 4: 132,499,481 (GRCm39) probably null Het
Sec31a T C 5: 100,540,273 (GRCm39) N471S probably benign Het
Serpinb9g A T 13: 33,676,796 (GRCm39) T193S probably benign Het
Sh3pxd2b C T 11: 32,361,469 (GRCm39) T227M probably benign Het
Speg A G 1: 75,378,908 (GRCm39) probably null Het
Suz12 T C 11: 79,922,817 (GRCm39) I653T probably damaging Het
Thsd7b C A 1: 129,523,191 (GRCm39) T75K probably damaging Het
Trav5-1 A C 14: 52,860,276 (GRCm39) Q27P probably damaging Het
Trim5 T C 7: 103,927,330 (GRCm39) probably null Het
Vmn2r110 G A 17: 20,804,618 (GRCm39) P101S probably damaging Het
Vmn2r17 A G 5: 109,600,810 (GRCm39) T703A probably damaging Het
Vmn2r84 A G 10: 130,230,100 (GRCm39) M4T probably benign Het
Zfp709 A G 8: 72,643,476 (GRCm39) T302A probably benign Het
Other mutations in Vmn1r174
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00331:Vmn1r174 APN 7 23,453,958 (GRCm39) missense possibly damaging 0.77
IGL00950:Vmn1r174 APN 7 23,453,911 (GRCm39) missense possibly damaging 0.96
IGL01484:Vmn1r174 APN 7 23,453,749 (GRCm39) nonsense probably null
IGL02014:Vmn1r174 APN 7 23,453,583 (GRCm39) missense probably damaging 1.00
IGL02190:Vmn1r174 APN 7 23,454,252 (GRCm39) missense unknown
IGL03265:Vmn1r174 APN 7 23,453,898 (GRCm39) nonsense probably null
IGL03335:Vmn1r174 APN 7 23,453,937 (GRCm39) missense probably benign 0.41
R0529:Vmn1r174 UTSW 7 23,453,622 (GRCm39) missense probably benign 0.00
R1489:Vmn1r174 UTSW 7 23,453,981 (GRCm39) nonsense probably null
R1645:Vmn1r174 UTSW 7 23,453,777 (GRCm39) missense possibly damaging 0.87
R1691:Vmn1r174 UTSW 7 23,453,337 (GRCm39) start codon destroyed probably null 1.00
R1753:Vmn1r174 UTSW 7 23,453,622 (GRCm39) missense probably benign 0.00
R1939:Vmn1r174 UTSW 7 23,453,532 (GRCm39) missense probably damaging 0.99
R1988:Vmn1r174 UTSW 7 23,454,050 (GRCm39) missense probably damaging 0.98
R2299:Vmn1r174 UTSW 7 23,453,429 (GRCm39) missense probably benign 0.08
R4429:Vmn1r174 UTSW 7 23,453,565 (GRCm39) missense probably benign 0.02
R4516:Vmn1r174 UTSW 7 23,453,768 (GRCm39) missense probably benign 0.01
R4589:Vmn1r174 UTSW 7 23,454,204 (GRCm39) nonsense probably null
R5175:Vmn1r174 UTSW 7 23,454,153 (GRCm39) missense probably benign 0.03
R5392:Vmn1r174 UTSW 7 23,454,227 (GRCm39) missense unknown
R5503:Vmn1r174 UTSW 7 23,453,562 (GRCm39) missense probably benign 0.03
R5568:Vmn1r174 UTSW 7 23,453,919 (GRCm39) missense probably damaging 0.96
R6705:Vmn1r174 UTSW 7 23,453,851 (GRCm39) missense probably benign 0.25
R8168:Vmn1r174 UTSW 7 23,454,096 (GRCm39) missense probably damaging 0.99
R8190:Vmn1r174 UTSW 7 23,453,568 (GRCm39) missense probably damaging 1.00
R8523:Vmn1r174 UTSW 7 23,454,182 (GRCm39) missense probably damaging 1.00
R8913:Vmn1r174 UTSW 7 23,453,375 (GRCm39) missense possibly damaging 0.90
R8979:Vmn1r174 UTSW 7 23,453,892 (GRCm39) missense possibly damaging 0.92
R8990:Vmn1r174 UTSW 7 23,453,956 (GRCm39) missense possibly damaging 0.71
X0011:Vmn1r174 UTSW 7 23,453,906 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- AAATACCTCCACATTTGTGCAC -3'
(R):5'- GCCAAAATTTCACTGACATGCC -3'

Sequencing Primer
(F):5'- GTCTACATCCCTATAAAAATCAGTGG -3'
(R):5'- ATTTCACTGACATGCCTCAACC -3'
Posted On 2021-01-18