Mutagenetix > Incidental Mutations

Incidental Mutation 'R8556:Tcrg-C4'

660129

Institutional Source

Beutler Lab

Gene Symbol

Tcrg-C4

Ensembl Gene

ENSMUSG00000076757

Gene Name

T cell receptor gamma, constant 4

Synonyms

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R8556 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

19344558-19352343 bp(+) (GRCm38)

Type of Mutation

unclassified

DNA Base Change (assembly)

A to G at 19344782 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000143068 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000103564] [ENSMUST00000184430]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000103564

SMART Domains

Protein: ENSMUSP00000100342
Gene: ENSMUSG00000076755

Domain	Start	End	E-Value	Type
IGv	34	113	8.44e-11	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000184430

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.2%

Validation Efficiency

100% (51/51)

Allele List at MGI

Other mutations in this stock

Total: 50 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Acadvl	A	T	11: 70,013,550	M148K	probably benign	Het
Adcy2	T	C	13: 68,630,975	Y982C	possibly damaging	Het
Adgrl4	T	C	3: 151,510,665	I495T	probably damaging	Het
Ankfn1	A	T	11: 89,441,442	I426K	possibly damaging	Het
Birc6	T	G	17: 74,557,954	S236R	probably benign	Het
Cdan1	C	T	2: 120,722,990	V971M	probably damaging	Het
Col6a4	A	G	9: 106,067,053	F1074S	probably damaging	Het
Crk	A	G	11: 75,692,521	K189R	probably benign	Het
Dennd5b	A	G	6: 148,993,770	L1254P	probably damaging	Het
Dlec1	A	G	9: 119,126,221	T658A	probably benign	Het
Dock2	T	C	11: 34,262,457	D1228G	possibly damaging	Het
Dync2h1	T	C	9: 7,113,198	Y209C	probably benign	Het
Edem3	G	A	1: 151,784,835	V283I	possibly damaging	Het
Elavl1	A	G	8: 4,295,388	S202P	possibly damaging	Het
Eprs	G	A	1: 185,420,288		probably null	Het
Esp31	A	T	17: 38,641,051	M1L	probably benign	Het
Eya4	G	A	10: 23,106,258	H601Y	probably damaging	Het
Gm6370	T	C	5: 146,493,892	S296P	probably benign	Het
Helz2	A	G	2: 181,229,557	V2754A	probably damaging	Het
Hgsnat	C	T	8: 25,953,280		probably null	Het
Hoxb6	G	T	11: 96,300,717	R155L	probably damaging	Het
Igkv6-17	T	C	6: 70,371,762	V39A	probably damaging	Het
Iqgap1	G	A	7: 80,726,039	L1363F	probably damaging	Het
Lcor	TCA	T	19: 41,558,424		probably null	Het
Macf1	A	G	4: 123,488,343	S476P	probably damaging	Het
Mdh1b	A	C	1: 63,710,982		probably null	Het
Muc16	T	A	9: 18,640,937	I4687L	probably benign	Het
Mylk3	T	C	8: 85,327,273	M672V	possibly damaging	Het
Nbea	A	G	3: 55,647,386	F2614L	probably benign	Het
Olfr1208	A	T	2: 88,897,038	C186*	probably null	Het
Otop3	T	A	11: 115,344,956	D471E	probably benign	Het
Pds5b	G	A	5: 150,792,608	M1077I	probably benign	Het
Plppr5	T	A	3: 117,672,030	L310Q	probably benign	Het
Ptpn13	G	A	5: 103,559,172	E1416K	probably damaging	Het
Ptprj	A	G	2: 90,440,700	L1228P	probably damaging	Het
Rbm12	T	C	2: 156,096,561	D597G	probably damaging	Het
Ret	A	G	6: 118,169,188	F777L	probably damaging	Het
Rrbp1	A	T	2: 143,989,125	V374D	possibly damaging	Het
Scin	T	C	12: 40,077,594		probably null	Het
Serpina1a	T	A	12: 103,855,970	K234N	probably damaging	Het
Snx20	T	A	8: 88,630,033	M52L	probably benign	Het
Svs6	T	C	2: 164,317,565	S83P	possibly damaging	Het
Tdp1	T	C	12: 99,891,268	S29P	probably benign	Het
Tet1	T	C	10: 62,840,206	N697S	probably benign	Het
Trpv3	A	G	11: 73,287,465	I453V	probably benign	Het
Trrap	T	C	5: 144,825,937	F2407L	probably benign	Het
Tsc22d4	T	C	5: 137,747,587	S158P	probably damaging	Het
Uaca	A	T	9: 60,870,641	K768M	probably damaging	Het
Wdr20rt	G	A	12: 65,226,965	V228I	probably benign	Het
Zbtb7b	T	C	3: 89,393,137		probably null	Het

Other mutations in Tcrg-C4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL03328:Tcrg-C4	APN	13	19352246	missense	unknown
R4633:Tcrg-C4	UTSW	13	19352287	missense	probably benign	0.00
R5035:Tcrg-C4	UTSW	13	19352336	missense	unknown
R5125:Tcrg-C4	UTSW	13	19344762	unclassified	probably benign
R5178:Tcrg-C4	UTSW	13	19344762	unclassified	probably benign
R5556:Tcrg-C4	UTSW	13	19352307	missense	unknown
R7006:Tcrg-C4	UTSW	13	19344825	unclassified	probably benign
R7952:Tcrg-C4	UTSW	13	19349570	missense

Predicted Primers

PCR Primer
(F):5'- TCCTTCTGCTGCTGAAACAAATC -3'
(R):5'- AACATTCTCGGGGACAGAAG -3'

Sequencing Primer
(F):5'- TCTCCATAAGGCTGGGACCTAC -3'
(R):5'- TTCTCGGGGACAGAAGAATATGGTTC -3'

Posted On

2021-01-18