Incidental Mutation 'R0234:Cdcp3'
| ID |
66017 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Cdcp3
|
| Ensembl Gene |
ENSMUSG00000006204 |
| Gene Name |
CUB domain containing protein 3 |
| Synonyms |
5430419D17Rik |
| MMRRC Submission |
038475-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R0234 (G1)
|
| Quality Score |
187 |
|
Status
|
Not validated
|
| Chromosome |
7 |
| Chromosomal Location |
130776131-130908180 bp(+) (GRCm39) |
| Type of Mutation |
splice site |
| DNA Base Change (assembly) |
T to A
at 130796032 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000150784
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000050586]
[ENSMUST00000124096]
[ENSMUST00000208921]
|
| AlphaFold |
no structure available at present |
| Predicted Effect |
probably null
Transcript: ENSMUST00000050586
|
| SMART Domains |
Protein: ENSMUSP00000061529
Gene: ENSMUSG00000006204
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
low complexity region
|
85 |
105 |
N/A |
INTRINSIC |
|
SR
|
144 |
244 |
3.3e-57 |
SMART |
|
CUB
|
272 |
378 |
1.2e-16 |
SMART |
|
SR
|
428 |
528 |
3.9e-56 |
SMART |
|
low complexity region
|
533 |
548 |
N/A |
INTRINSIC |
|
CUB
|
556 |
667 |
5.1e-38 |
SMART |
|
SR
|
680 |
780 |
1.5e-57 |
SMART |
|
Pfam:CUB
|
795 |
840 |
3.1e-9 |
PFAM |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000124096
|
| SMART Domains |
Protein: ENSMUSP00000130971
Gene: ENSMUSG00000030849
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Pkinase
|
1 |
118 |
4.8e-19 |
PFAM |
|
Pfam:Pkinase_Tyr
|
1 |
118 |
1.7e-50 |
PFAM |
|
low complexity region
|
146 |
160 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably null
Transcript: ENSMUST00000208921
|
| Coding Region Coverage |
- 1x: 98.8%
- 3x: 97.7%
- 10x: 94.1%
- 20x: 83.3%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 71 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| A3galt2 |
A |
G |
4: 128,660,941 (GRCm39) |
R197G |
possibly damaging |
Het |
| Acacb |
A |
T |
5: 114,347,878 (GRCm39) |
H983L |
probably damaging |
Het |
| Adal |
T |
A |
2: 120,978,798 (GRCm39) |
D139E |
probably benign |
Het |
| Adam6b |
G |
A |
12: 113,454,230 (GRCm39) |
R349H |
probably damaging |
Het |
| Agap1 |
A |
G |
1: 89,598,934 (GRCm39) |
K331E |
probably damaging |
Het |
| B3gat1 |
A |
G |
9: 26,667,377 (GRCm39) |
E203G |
probably damaging |
Het |
| Bsn |
T |
C |
9: 107,993,595 (GRCm39) |
E719G |
possibly damaging |
Het |
| Cap2 |
G |
C |
13: 46,791,498 (GRCm39) |
|
probably null |
Het |
| Ccni |
A |
G |
5: 93,350,186 (GRCm39) |
V31A |
probably benign |
Het |
| Clns1a |
T |
A |
7: 97,363,239 (GRCm39) |
Y204N |
possibly damaging |
Het |
| Cox11 |
C |
T |
11: 90,535,326 (GRCm39) |
T259I |
probably damaging |
Het |
| Dsp |
A |
G |
13: 38,371,869 (GRCm39) |
N940S |
probably benign |
Het |
| Erbb2 |
T |
C |
11: 98,327,265 (GRCm39) |
V1181A |
probably benign |
Het |
| Exoc4 |
T |
C |
6: 33,839,022 (GRCm39) |
V686A |
possibly damaging |
Het |
| F830045P16Rik |
A |
G |
2: 129,305,384 (GRCm39) |
V330A |
possibly damaging |
Het |
| Fbf1 |
A |
C |
11: 116,045,860 (GRCm39) |
F245V |
probably damaging |
Het |
| Fut10 |
T |
A |
8: 31,726,225 (GRCm39) |
F327I |
probably damaging |
Het |
| Galnt1 |
C |
T |
18: 24,387,690 (GRCm39) |
P144S |
probably damaging |
Het |
| Garin4 |
T |
C |
1: 190,895,105 (GRCm39) |
S513G |
probably benign |
Het |
| Ghrhr |
A |
T |
6: 55,356,171 (GRCm39) |
D88V |
possibly damaging |
Het |
| Greb1l |
T |
A |
18: 10,560,331 (GRCm39) |
C1864S |
probably damaging |
Het |
| H1f2 |
T |
C |
13: 23,923,106 (GRCm39) |
I92T |
probably benign |
Het |
| Hps1 |
T |
C |
19: 42,750,992 (GRCm39) |
E336G |
probably damaging |
Het |
| Irgc |
C |
A |
7: 24,132,753 (GRCm39) |
E21D |
possibly damaging |
Het |
| Itsn1 |
A |
T |
16: 91,625,168 (GRCm39) |
R590* |
probably null |
Het |
| Katnip |
T |
C |
7: 125,394,557 (GRCm39) |
V211A |
probably benign |
Het |
| Lmln |
T |
C |
16: 32,886,694 (GRCm39) |
V67A |
probably damaging |
Het |
| Lsm14a |
T |
C |
7: 34,065,042 (GRCm39) |
Q179R |
probably damaging |
Het |
| Ltbr |
A |
C |
6: 125,289,836 (GRCm39) |
D119E |
probably benign |
Het |
| Mrc1 |
A |
G |
2: 14,284,705 (GRCm39) |
T565A |
possibly damaging |
Het |
| Muc6 |
A |
C |
7: 141,235,939 (GRCm39) |
N473K |
possibly damaging |
Het |
| Myocd |
A |
T |
11: 65,078,066 (GRCm39) |
D448E |
probably benign |
Het |
| Neil2 |
T |
A |
14: 63,420,975 (GRCm39) |
I239F |
probably damaging |
Het |
| Npnt |
A |
G |
3: 132,620,175 (GRCm39) |
F123S |
possibly damaging |
Het |
| Or2g25 |
T |
A |
17: 37,970,997 (GRCm39) |
I76F |
probably damaging |
Het |
| Or4f15 |
T |
C |
2: 111,813,645 (GRCm39) |
Y258C |
probably damaging |
Het |
| Or52x1 |
C |
A |
7: 104,852,821 (GRCm39) |
C243F |
probably damaging |
Het |
| Or56a5 |
T |
C |
7: 104,793,281 (GRCm39) |
D73G |
probably damaging |
Het |
| Or5d37 |
T |
A |
2: 87,923,366 (GRCm39) |
R305* |
probably null |
Het |
| Or8d1b |
A |
C |
9: 38,887,547 (GRCm39) |
|
probably null |
Het |
| Or9i2 |
C |
T |
19: 13,815,902 (GRCm39) |
V212M |
possibly damaging |
Het |
| Pcnx3 |
T |
C |
19: 5,722,646 (GRCm39) |
T941A |
probably benign |
Het |
| Pitrm1 |
C |
A |
13: 6,625,115 (GRCm39) |
Y864* |
probably null |
Het |
| Plcb4 |
T |
C |
2: 135,823,995 (GRCm39) |
I844T |
probably benign |
Het |
| Ppp1r3b |
T |
A |
8: 35,851,655 (GRCm39) |
F165I |
probably damaging |
Het |
| Prr5 |
T |
A |
15: 84,587,322 (GRCm39) |
F357L |
probably damaging |
Het |
| Rbm15b |
T |
C |
9: 106,762,563 (GRCm39) |
Y535C |
probably damaging |
Het |
| Rbp3 |
A |
T |
14: 33,677,858 (GRCm39) |
E602V |
probably damaging |
Het |
| Rimklb |
T |
C |
6: 122,433,292 (GRCm39) |
N343S |
probably benign |
Het |
| Rrp12 |
A |
G |
19: 41,860,199 (GRCm39) |
L1008P |
probably damaging |
Het |
| Sec63 |
C |
T |
10: 42,674,794 (GRCm39) |
R226C |
probably damaging |
Het |
| Sirpa |
T |
C |
2: 129,457,388 (GRCm39) |
V154A |
probably damaging |
Het |
| Slc22a23 |
G |
A |
13: 34,367,244 (GRCm39) |
T588I |
probably damaging |
Het |
| Slc22a27 |
C |
A |
19: 7,904,156 (GRCm39) |
|
probably benign |
Het |
| Slc4a4 |
A |
C |
5: 89,304,195 (GRCm39) |
H502P |
possibly damaging |
Het |
| Slc5a5 |
A |
T |
8: 71,342,277 (GRCm39) |
M258K |
probably damaging |
Het |
| Spry4 |
A |
G |
18: 38,723,142 (GRCm39) |
I207T |
possibly damaging |
Het |
| Stk11ip |
A |
G |
1: 75,505,711 (GRCm39) |
D460G |
possibly damaging |
Het |
| Syn3 |
T |
A |
10: 86,284,750 (GRCm39) |
I117F |
possibly damaging |
Het |
| Tead4 |
C |
T |
6: 128,220,365 (GRCm39) |
A224T |
probably damaging |
Het |
| Tmtc3 |
A |
T |
10: 100,286,184 (GRCm39) |
N546K |
probably benign |
Het |
| Tnn |
T |
A |
1: 159,916,036 (GRCm39) |
H1227L |
probably damaging |
Het |
| Tor2a |
G |
A |
2: 32,648,716 (GRCm39) |
G62D |
probably damaging |
Het |
| Trf |
T |
C |
9: 103,104,078 (GRCm39) |
|
probably null |
Het |
| Ubr5 |
T |
C |
15: 37,968,737 (GRCm39) |
T2727A |
probably damaging |
Het |
| Vmn2r27 |
T |
A |
6: 124,208,578 (GRCm39) |
T56S |
probably benign |
Het |
| Wipf3 |
T |
G |
6: 54,473,486 (GRCm39) |
L458R |
probably damaging |
Het |
| Zfp236 |
T |
C |
18: 82,648,119 (GRCm39) |
K966R |
probably damaging |
Het |
| Zfp27 |
T |
A |
7: 29,593,532 (GRCm39) |
H811L |
possibly damaging |
Het |
| Zfp366 |
A |
G |
13: 99,370,768 (GRCm39) |
H496R |
probably damaging |
Het |
| Zfp467 |
A |
T |
6: 48,415,689 (GRCm39) |
V321E |
probably damaging |
Het |
|
| Other mutations in Cdcp3 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00226:Cdcp3
|
APN |
7 |
130,839,823 (GRCm39) |
splice site |
probably null |
|
|
IGL00848:Cdcp3
|
APN |
7 |
130,848,453 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL00966:Cdcp3
|
APN |
7 |
130,844,836 (GRCm39) |
nonsense |
probably null |
|
|
IGL01286:Cdcp3
|
APN |
7 |
130,848,432 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01303:Cdcp3
|
APN |
7 |
130,796,060 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL01585:Cdcp3
|
APN |
7 |
130,846,487 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01665:Cdcp3
|
APN |
7 |
130,848,386 (GRCm39) |
nonsense |
probably null |
|
|
IGL01953:Cdcp3
|
APN |
7 |
130,826,709 (GRCm39) |
missense |
probably benign |
0.04 |
|
IGL02427:Cdcp3
|
APN |
7 |
130,846,517 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL02508:Cdcp3
|
APN |
7 |
130,824,559 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL02678:Cdcp3
|
APN |
7 |
130,830,646 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL03092:Cdcp3
|
APN |
7 |
130,803,527 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03122:Cdcp3
|
APN |
7 |
130,798,243 (GRCm39) |
missense |
possibly damaging |
0.68 |
|
IGL03343:Cdcp3
|
APN |
7 |
130,848,420 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0011:Cdcp3
|
UTSW |
7 |
130,831,722 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0011:Cdcp3
|
UTSW |
7 |
130,831,722 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R0234:Cdcp3
|
UTSW |
7 |
130,796,032 (GRCm39) |
splice site |
probably null |
|
|
R0268:Cdcp3
|
UTSW |
7 |
130,839,905 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0383:Cdcp3
|
UTSW |
7 |
130,841,268 (GRCm39) |
missense |
probably benign |
0.05 |
|
R0973:Cdcp3
|
UTSW |
7 |
130,839,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0973:Cdcp3
|
UTSW |
7 |
130,839,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0974:Cdcp3
|
UTSW |
7 |
130,839,911 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1572:Cdcp3
|
UTSW |
7 |
130,846,560 (GRCm39) |
nonsense |
probably null |
|
|
R1911:Cdcp3
|
UTSW |
7 |
130,839,818 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2032:Cdcp3
|
UTSW |
7 |
130,844,781 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2097:Cdcp3
|
UTSW |
7 |
130,783,693 (GRCm39) |
nonsense |
probably null |
|
|
R2221:Cdcp3
|
UTSW |
7 |
130,849,186 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2223:Cdcp3
|
UTSW |
7 |
130,849,186 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R2254:Cdcp3
|
UTSW |
7 |
130,824,634 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2913:Cdcp3
|
UTSW |
7 |
130,783,753 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
R2991:Cdcp3
|
UTSW |
7 |
130,848,429 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3439:Cdcp3
|
UTSW |
7 |
130,790,508 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4418:Cdcp3
|
UTSW |
7 |
130,849,194 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R4916:Cdcp3
|
UTSW |
7 |
130,776,206 (GRCm39) |
splice site |
probably null |
|
|
R5488:Cdcp3
|
UTSW |
7 |
130,848,324 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5594:Cdcp3
|
UTSW |
7 |
130,841,252 (GRCm39) |
missense |
probably benign |
0.12 |
|
R5897:Cdcp3
|
UTSW |
7 |
130,798,280 (GRCm39) |
splice site |
probably null |
|
|
R5898:Cdcp3
|
UTSW |
7 |
130,843,696 (GRCm39) |
splice site |
probably null |
|
|
R5940:Cdcp3
|
UTSW |
7 |
130,839,992 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6170:Cdcp3
|
UTSW |
7 |
130,776,216 (GRCm39) |
splice site |
probably null |
|
|
R6187:Cdcp3
|
UTSW |
7 |
130,872,328 (GRCm39) |
intron |
probably benign |
|
|
R6321:Cdcp3
|
UTSW |
7 |
130,858,735 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6409:Cdcp3
|
UTSW |
7 |
130,863,800 (GRCm39) |
intron |
probably benign |
|
|
R6432:Cdcp3
|
UTSW |
7 |
130,846,601 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6481:Cdcp3
|
UTSW |
7 |
130,858,530 (GRCm39) |
missense |
probably benign |
0.05 |
|
R6750:Cdcp3
|
UTSW |
7 |
130,889,974 (GRCm39) |
intron |
probably benign |
|
|
R6783:Cdcp3
|
UTSW |
7 |
130,828,493 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R6836:Cdcp3
|
UTSW |
7 |
130,798,233 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R6925:Cdcp3
|
UTSW |
7 |
130,824,436 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R6995:Cdcp3
|
UTSW |
7 |
130,824,400 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7199:Cdcp3
|
UTSW |
7 |
130,837,641 (GRCm39) |
nonsense |
probably null |
|
|
R7205:Cdcp3
|
UTSW |
7 |
130,879,352 (GRCm39) |
critical splice donor site |
probably null |
|
|
R7340:Cdcp3
|
UTSW |
7 |
130,879,344 (GRCm39) |
missense |
unknown |
|
|
R7354:Cdcp3
|
UTSW |
7 |
130,873,762 (GRCm39) |
missense |
unknown |
|
|
R7354:Cdcp3
|
UTSW |
7 |
130,858,458 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
R7434:Cdcp3
|
UTSW |
7 |
130,881,212 (GRCm39) |
missense |
unknown |
|
|
R7485:Cdcp3
|
UTSW |
7 |
130,830,562 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R7513:Cdcp3
|
UTSW |
7 |
130,873,800 (GRCm39) |
missense |
unknown |
|
|
R7562:Cdcp3
|
UTSW |
7 |
130,904,426 (GRCm39) |
missense |
unknown |
|
|
R7623:Cdcp3
|
UTSW |
7 |
130,879,295 (GRCm39) |
splice site |
probably null |
|
|
R7782:Cdcp3
|
UTSW |
7 |
130,904,466 (GRCm39) |
splice site |
probably null |
|
|
R7879:Cdcp3
|
UTSW |
7 |
130,844,871 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R7935:Cdcp3
|
UTSW |
7 |
130,852,205 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R7949:Cdcp3
|
UTSW |
7 |
130,895,324 (GRCm39) |
splice site |
probably null |
|
|
R7964:Cdcp3
|
UTSW |
7 |
130,899,963 (GRCm39) |
missense |
unknown |
|
|
R7980:Cdcp3
|
UTSW |
7 |
130,836,506 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R8145:Cdcp3
|
UTSW |
7 |
130,898,045 (GRCm39) |
missense |
unknown |
|
|
R8673:Cdcp3
|
UTSW |
7 |
130,844,846 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R8684:Cdcp3
|
UTSW |
7 |
130,837,688 (GRCm39) |
nonsense |
probably null |
|
|
R8721:Cdcp3
|
UTSW |
7 |
130,879,335 (GRCm39) |
missense |
unknown |
|
|
R8725:Cdcp3
|
UTSW |
7 |
130,875,485 (GRCm39) |
missense |
unknown |
|
|
R8727:Cdcp3
|
UTSW |
7 |
130,875,485 (GRCm39) |
missense |
unknown |
|
|
R8742:Cdcp3
|
UTSW |
7 |
130,783,741 (GRCm39) |
missense |
unknown |
|
|
R8807:Cdcp3
|
UTSW |
7 |
130,846,507 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R8822:Cdcp3
|
UTSW |
7 |
130,843,706 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R8861:Cdcp3
|
UTSW |
7 |
130,861,690 (GRCm39) |
nonsense |
probably null |
|
|
R8897:Cdcp3
|
UTSW |
7 |
130,867,566 (GRCm39) |
missense |
unknown |
|
|
R8900:Cdcp3
|
UTSW |
7 |
130,904,197 (GRCm39) |
intron |
probably benign |
|
|
R9214:Cdcp3
|
UTSW |
7 |
130,824,481 (GRCm39) |
missense |
possibly damaging |
0.89 |
|
R9218:Cdcp3
|
UTSW |
7 |
130,863,728 (GRCm39) |
missense |
unknown |
|
|
R9311:Cdcp3
|
UTSW |
7 |
130,859,490 (GRCm39) |
missense |
unknown |
|
|
R9323:Cdcp3
|
UTSW |
7 |
130,828,401 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R9384:Cdcp3
|
UTSW |
7 |
130,904,404 (GRCm39) |
missense |
unknown |
|
|
R9387:Cdcp3
|
UTSW |
7 |
130,863,620 (GRCm39) |
missense |
unknown |
|
|
R9417:Cdcp3
|
UTSW |
7 |
130,852,218 (GRCm39) |
missense |
possibly damaging |
0.60 |
|
R9502:Cdcp3
|
UTSW |
7 |
130,836,815 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9603:Cdcp3
|
UTSW |
7 |
130,830,643 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R9642:Cdcp3
|
UTSW |
7 |
130,848,257 (GRCm39) |
missense |
probably benign |
0.01 |
|
Z1088:Cdcp3
|
UTSW |
7 |
130,848,362 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Cdcp3
|
UTSW |
7 |
130,867,595 (GRCm39) |
missense |
unknown |
|
|
| Predicted Primers |
|
| Posted On |
2013-08-19 |
Incidental Mutation