Incidental Mutation 'R8355:Zfp1005'
| ID |
660262 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Zfp1005
|
| Ensembl Gene |
ENSMUSG00000079008 |
| Gene Name |
zinc finger protein 1005 |
| Synonyms |
Gm10749, EG640962, Gm14124 |
| MMRRC Submission |
067869-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.070)
|
| Stock # |
R8355 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
2 |
| Chromosomal Location |
150099437-150112220 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 150109876 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Cysteine to Serine
at position 189
(C189S)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000105548
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000109922]
|
| AlphaFold |
A2AU83 |
| Predicted Effect |
unknown
Transcript: ENSMUST00000109922
AA Change: C189S
|
| SMART Domains |
Protein: ENSMUSP00000105548
Gene: ENSMUSG00000079008
AA Change: C189S
| Domain | Start | End | E-Value | Type |
|---|
|
KRAB
|
4 |
66 |
9.26e-19 |
SMART |
|
ZnF_C2H2
|
103 |
125 |
7.49e-5 |
SMART |
|
ZnF_C2H2
|
131 |
151 |
9.46e0 |
SMART |
|
ZnF_C2H2
|
159 |
181 |
5.9e-3 |
SMART |
|
ZnF_C2H2
|
187 |
209 |
6.67e-2 |
SMART |
|
ZnF_C2H2
|
215 |
237 |
4.87e-4 |
SMART |
|
ZnF_C2H2
|
243 |
265 |
2.82e0 |
SMART |
|
ZnF_C2H2
|
271 |
293 |
2.2e2 |
SMART |
|
ZnF_C2H2
|
299 |
321 |
1.4e-4 |
SMART |
|
ZnF_C2H2
|
327 |
349 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
355 |
377 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
383 |
405 |
1.38e-3 |
SMART |
|
ZnF_C2H2
|
411 |
433 |
9.56e1 |
SMART |
|
ZnF_C2H2
|
439 |
461 |
6.99e-5 |
SMART |
|
ZnF_C2H2
|
467 |
489 |
2.99e-4 |
SMART |
|
ZnF_C2H2
|
495 |
517 |
7.78e-3 |
SMART |
|
ZnF_C2H2
|
523 |
545 |
1.04e-3 |
SMART |
|
ZnF_C2H2
|
551 |
573 |
1.6e-4 |
SMART |
|
ZnF_C2H2
|
579 |
601 |
1.18e-2 |
SMART |
|
ZnF_C2H2
|
607 |
629 |
4.54e-4 |
SMART |
|
ZnF_C2H2
|
635 |
657 |
4.24e-4 |
SMART |
|
ZnF_C2H2
|
663 |
685 |
1.2e-3 |
SMART |
|
ZnF_C2H2
|
691 |
713 |
8.47e-4 |
SMART |
|
| Meta Mutation Damage Score |
0.8493 |
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
| Validation Efficiency |
98% (48/49) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 53 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Abcc9 |
A |
T |
6: 142,638,478 (GRCm39) |
H145Q |
probably benign |
Het |
| Acsf2 |
A |
T |
11: 94,461,450 (GRCm39) |
M293K |
probably benign |
Het |
| Ak9 |
G |
A |
10: 41,275,700 (GRCm39) |
R1112Q |
|
Het |
| Ano8 |
T |
C |
8: 71,933,210 (GRCm39) |
|
probably benign |
Het |
| Ap3b2 |
A |
T |
7: 81,122,851 (GRCm39) |
V462E |
probably damaging |
Het |
| Arid1a |
T |
C |
4: 133,448,174 (GRCm39) |
Q498R |
unknown |
Het |
| AW011738 |
C |
A |
4: 156,287,837 (GRCm39) |
|
probably benign |
Het |
| Bhlhe41 |
T |
A |
6: 145,811,028 (GRCm39) |
|
probably null |
Het |
| Bnc1 |
A |
C |
7: 81,618,624 (GRCm39) |
S814A |
probably damaging |
Het |
| Bnip5 |
T |
A |
17: 29,122,249 (GRCm39) |
Q414L |
probably damaging |
Het |
| Cage1 |
A |
T |
13: 38,203,225 (GRCm39) |
L613H |
probably damaging |
Het |
| Camk1g |
T |
C |
1: 193,033,355 (GRCm39) |
I231V |
probably damaging |
Het |
| Catspere2 |
T |
C |
1: 177,845,276 (GRCm39) |
Y99H |
possibly damaging |
Het |
| Ccdc50 |
A |
G |
16: 27,236,101 (GRCm39) |
Y145C |
probably benign |
Het |
| Cdcp1 |
A |
G |
9: 123,002,888 (GRCm39) |
S728P |
probably benign |
Het |
| Chrm3 |
A |
T |
13: 9,928,646 (GRCm39) |
M130K |
probably damaging |
Het |
| Csf1r |
T |
C |
18: 61,261,222 (GRCm39) |
F766S |
probably damaging |
Het |
| Dact3 |
A |
G |
7: 16,617,125 (GRCm39) |
D108G |
probably damaging |
Het |
| Dnaaf5 |
ACCCAGCACCTGGAGATCGTCC |
ACC |
5: 139,147,614 (GRCm39) |
|
probably null |
Het |
| Dnah8 |
A |
C |
17: 30,914,152 (GRCm39) |
L1099F |
possibly damaging |
Het |
| Ggnbp2 |
C |
T |
11: 84,728,815 (GRCm39) |
|
probably null |
Het |
| Gk5 |
T |
C |
9: 96,032,839 (GRCm39) |
V274A |
possibly damaging |
Het |
| Gnpat |
T |
C |
8: 125,597,579 (GRCm39) |
F47S |
probably benign |
Het |
| Gsap |
G |
T |
5: 21,456,017 (GRCm39) |
G374* |
probably null |
Het |
| Gtf2h2 |
A |
T |
13: 100,605,503 (GRCm39) |
F368Y |
possibly damaging |
Het |
| Gvin1 |
A |
T |
7: 105,757,312 (GRCm39) |
W2386R |
possibly damaging |
Het |
| Ighe |
A |
T |
12: 113,235,167 (GRCm39) |
L331* |
probably null |
Het |
| Iqank1 |
C |
A |
15: 75,906,073 (GRCm39) |
Q87K |
probably benign |
Het |
| Itch |
T |
A |
2: 155,052,502 (GRCm39) |
|
probably null |
Het |
| Lars2 |
G |
A |
9: 123,283,780 (GRCm39) |
A683T |
probably damaging |
Het |
| Lin7a |
C |
T |
10: 107,218,497 (GRCm39) |
R14C |
probably damaging |
Het |
| Lrp2 |
C |
T |
2: 69,346,828 (GRCm39) |
S806N |
probably damaging |
Het |
| Lrrc8e |
T |
A |
8: 4,284,018 (GRCm39) |
M81K |
probably benign |
Het |
| Mcm3ap |
C |
A |
10: 76,329,335 (GRCm39) |
T1172K |
probably benign |
Het |
| Mrm3 |
A |
T |
11: 76,141,164 (GRCm39) |
M391L |
possibly damaging |
Het |
| Myo9a |
T |
C |
9: 59,817,130 (GRCm39) |
S2278P |
probably damaging |
Het |
| Ncln |
T |
C |
10: 81,323,703 (GRCm39) |
K511E |
probably damaging |
Het |
| Or2y17 |
G |
T |
11: 49,231,592 (GRCm39) |
V78L |
possibly damaging |
Het |
| Or8b101 |
A |
G |
9: 38,020,258 (GRCm39) |
K87R |
probably benign |
Het |
| Pcdhb10 |
G |
T |
18: 37,545,134 (GRCm39) |
G70V |
probably damaging |
Het |
| Phf24 |
A |
G |
4: 42,933,735 (GRCm39) |
E39G |
probably benign |
Het |
| Plat |
C |
A |
8: 23,261,758 (GRCm39) |
S52* |
probably null |
Het |
| Pramel52-ps |
T |
C |
5: 94,531,772 (GRCm39) |
C219R |
probably damaging |
Het |
| Ptpru |
C |
A |
4: 131,535,811 (GRCm39) |
G389C |
probably damaging |
Het |
| Rnpep |
T |
C |
1: 135,195,005 (GRCm39) |
D407G |
probably damaging |
Het |
| Rttn |
G |
A |
18: 89,047,016 (GRCm39) |
V893I |
probably benign |
Het |
| Slit1 |
A |
G |
19: 41,634,473 (GRCm39) |
L428P |
probably damaging |
Het |
| Tet1 |
T |
A |
10: 62,652,229 (GRCm39) |
L1596F |
possibly damaging |
Het |
| Thsd7b |
T |
C |
1: 129,523,616 (GRCm39) |
C140R |
probably damaging |
Het |
| Usp17le |
A |
T |
7: 104,418,752 (GRCm39) |
M130K |
possibly damaging |
Het |
| Vmn2r92 |
T |
G |
17: 18,405,061 (GRCm39) |
I735S |
probably damaging |
Het |
| Zbtb42 |
A |
T |
12: 112,645,969 (GRCm39) |
Y48F |
probably damaging |
Het |
| Zbtb43 |
C |
T |
2: 33,345,120 (GRCm39) |
G35D |
possibly damaging |
Het |
|
| Other mutations in Zfp1005 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01550:Zfp1005
|
APN |
2 |
150,108,363 (GRCm39) |
splice site |
probably benign |
|
|
R0220:Zfp1005
|
UTSW |
2 |
150,110,595 (GRCm39) |
missense |
unknown |
|
|
R0396:Zfp1005
|
UTSW |
2 |
150,109,973 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0402:Zfp1005
|
UTSW |
2 |
150,111,136 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0446:Zfp1005
|
UTSW |
2 |
150,109,993 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R0462:Zfp1005
|
UTSW |
2 |
150,111,122 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
R0507:Zfp1005
|
UTSW |
2 |
150,110,044 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R0605:Zfp1005
|
UTSW |
2 |
150,110,523 (GRCm39) |
missense |
unknown |
|
|
R0838:Zfp1005
|
UTSW |
2 |
150,111,220 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R1327:Zfp1005
|
UTSW |
2 |
150,108,070 (GRCm39) |
missense |
possibly damaging |
0.71 |
|
R1405:Zfp1005
|
UTSW |
2 |
150,109,620 (GRCm39) |
nonsense |
probably null |
|
|
R1405:Zfp1005
|
UTSW |
2 |
150,109,620 (GRCm39) |
nonsense |
probably null |
|
|
R2114:Zfp1005
|
UTSW |
2 |
150,109,819 (GRCm39) |
missense |
unknown |
|
|
R2140:Zfp1005
|
UTSW |
2 |
150,111,281 (GRCm39) |
missense |
probably benign |
0.33 |
|
R3683:Zfp1005
|
UTSW |
2 |
150,109,976 (GRCm39) |
missense |
probably benign |
0.41 |
|
R3917:Zfp1005
|
UTSW |
2 |
150,108,039 (GRCm39) |
splice site |
probably benign |
|
|
R4084:Zfp1005
|
UTSW |
2 |
150,108,122 (GRCm39) |
missense |
possibly damaging |
0.85 |
|
R4499:Zfp1005
|
UTSW |
2 |
150,111,362 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R4683:Zfp1005
|
UTSW |
2 |
150,108,390 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4762:Zfp1005
|
UTSW |
2 |
150,109,549 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4937:Zfp1005
|
UTSW |
2 |
150,110,680 (GRCm39) |
missense |
unknown |
|
|
R5678:Zfp1005
|
UTSW |
2 |
150,110,425 (GRCm39) |
nonsense |
probably null |
|
|
R5696:Zfp1005
|
UTSW |
2 |
150,111,394 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5697:Zfp1005
|
UTSW |
2 |
150,111,394 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5698:Zfp1005
|
UTSW |
2 |
150,111,394 (GRCm39) |
missense |
possibly damaging |
0.52 |
|
R5769:Zfp1005
|
UTSW |
2 |
150,110,198 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R5780:Zfp1005
|
UTSW |
2 |
150,108,139 (GRCm39) |
missense |
probably benign |
0.05 |
|
R5973:Zfp1005
|
UTSW |
2 |
150,109,855 (GRCm39) |
missense |
unknown |
|
|
R6662:Zfp1005
|
UTSW |
2 |
150,108,172 (GRCm39) |
critical splice donor site |
probably null |
|
|
R6878:Zfp1005
|
UTSW |
2 |
150,108,406 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7037:Zfp1005
|
UTSW |
2 |
150,108,376 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7081:Zfp1005
|
UTSW |
2 |
150,110,189 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R7413:Zfp1005
|
UTSW |
2 |
150,108,081 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R7725:Zfp1005
|
UTSW |
2 |
150,110,468 (GRCm39) |
missense |
unknown |
|
|
R7781:Zfp1005
|
UTSW |
2 |
150,109,577 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8197:Zfp1005
|
UTSW |
2 |
150,109,577 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8517:Zfp1005
|
UTSW |
2 |
150,110,043 (GRCm39) |
missense |
probably benign |
0.33 |
|
R8812:Zfp1005
|
UTSW |
2 |
150,109,624 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R9108:Zfp1005
|
UTSW |
2 |
150,109,969 (GRCm39) |
missense |
possibly damaging |
0.61 |
|
R9488:Zfp1005
|
UTSW |
2 |
150,110,477 (GRCm39) |
missense |
unknown |
|
|
R9499:Zfp1005
|
UTSW |
2 |
150,109,856 (GRCm39) |
missense |
unknown |
|
|
R9551:Zfp1005
|
UTSW |
2 |
150,109,856 (GRCm39) |
missense |
unknown |
|
|
R9567:Zfp1005
|
UTSW |
2 |
150,109,517 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9646:Zfp1005
|
UTSW |
2 |
150,110,104 (GRCm39) |
missense |
probably benign |
0.43 |
|
R9709:Zfp1005
|
UTSW |
2 |
150,110,305 (GRCm39) |
missense |
possibly damaging |
0.47 |
|
R9719:Zfp1005
|
UTSW |
2 |
150,111,304 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R9779:Zfp1005
|
UTSW |
2 |
150,108,064 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
X0022:Zfp1005
|
UTSW |
2 |
150,109,578 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
Z1177:Zfp1005
|
UTSW |
2 |
150,110,244 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
Z1177:Zfp1005
|
UTSW |
2 |
150,110,237 (GRCm39) |
missense |
possibly damaging |
0.84 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGCAGCTCTCTGAGTTTATCCAATG -3'
(R):5'- CATATGGTCTCTGTCCAGCATGT -3'
Sequencing Primer
(F):5'- GTGAGAAACCCTATGCGTGTAACC -3'
(R):5'- TGACATACAGAGGCTTTCTCAC -3'
|
| Posted On |
2021-01-18 |
Incidental Mutation