Incidental Mutation 'R8356:Neo1'
ID 660345
Institutional Source Beutler Lab
Gene Symbol Neo1
Ensembl Gene ENSMUSG00000032340
Gene Name neogenin
Synonyms 2610028H22Rik, D930014N22Rik, Igdcc2
MMRRC Submission 067870-MU
Accession Numbers
Essential gene? Essential (E-score: 1.000) question?
Stock # R8356 (G1)
Quality Score 225.009
Status Validated
Chromosome 9
Chromosomal Location 58781970-58943724 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) G to A at 58785402 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Methionine at position 1408 (T1408M)
Ref Sequence ENSEMBL: ENSMUSP00000150600 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000068664] [ENSMUST00000214547]
AlphaFold no structure available at present
Predicted Effect probably damaging
Transcript: ENSMUST00000068664
AA Change: T1435M

PolyPhen 2 Score 0.984 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000063656
Gene: ENSMUSG00000032340
AA Change: T1435M

DomainStartEndE-ValueType
signal peptide 1 41 N/A INTRINSIC
IGc2 76 147 9.49e-5 SMART
IGc2 175 239 4.43e-5 SMART
IGc2 272 338 6.15e-13 SMART
IGc2 364 428 7.76e-10 SMART
low complexity region 446 458 N/A INTRINSIC
FN3 470 553 8.23e-12 SMART
FN3 570 649 1.78e-16 SMART
FN3 665 749 1.54e-11 SMART
FN3 770 849 5.27e-10 SMART
FN3 885 970 7.63e-7 SMART
FN3 986 1072 2.78e-9 SMART
transmembrane domain 1136 1158 N/A INTRINSIC
Pfam:Neogenin_C 1189 1492 1.9e-122 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214547
AA Change: T1408M

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (58/58)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]
PHENOTYPE: Mice homozygous for a gene trap allele display perinatal lethality and abnormal trigeminal nerve development. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 61 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700069L16Rik T A 5: 113,861,868 (GRCm39) M1L unknown Het
Abcc9 A T 6: 142,536,096 (GRCm39) M1546K probably benign Het
Acbd3 T C 1: 180,553,881 (GRCm39) M72T probably benign Het
Adam6a T G 12: 113,509,757 (GRCm39) L710R probably benign Het
Aldh4a1 T C 4: 139,365,833 (GRCm39) S275P probably benign Het
Ap3d1 A T 10: 80,568,737 (GRCm39) L47Q probably damaging Het
Arhgap19 G A 19: 41,762,615 (GRCm39) R414C probably damaging Het
Ascc3 T C 10: 50,526,003 (GRCm39) S572P probably benign Het
Cdk10 G A 8: 123,955,096 (GRCm39) R78H probably benign Het
Celsr2 C T 3: 108,320,847 (GRCm39) R655H possibly damaging Het
Cntnap2 T A 6: 47,026,307 (GRCm39) H44Q probably benign Het
Cpped1 A T 16: 11,712,793 (GRCm39) C32* probably null Het
Ddi1 A G 9: 6,266,249 (GRCm39) V40A probably benign Het
Ddx50 T C 10: 62,457,287 (GRCm39) T588A probably benign Het
Degs2 A G 12: 108,658,223 (GRCm39) I252T possibly damaging Het
Dnah1 C T 14: 30,994,972 (GRCm39) V2762I probably benign Het
Dnah5 A G 15: 28,444,313 (GRCm39) D4037G probably benign Het
Dnah5 C T 15: 28,444,469 (GRCm39) A4089V probably null Het
Dthd1 A T 5: 63,007,081 (GRCm39) D594V probably damaging Het
Ehmt1 A T 2: 24,742,781 (GRCm39) M466K probably benign Het
Erich2 A T 2: 70,357,873 (GRCm39) probably null Het
Fam221b T C 4: 43,665,519 (GRCm39) D313G probably benign Het
Fbxl22 T C 9: 66,421,732 (GRCm39) D35G possibly damaging Het
Ggcx A G 6: 72,406,574 (GRCm39) E679G probably benign Het
Gm14295 A G 2: 176,501,307 (GRCm39) T266A probably benign Het
Hnrnpa1 A G 15: 103,150,529 (GRCm39) D160G probably null Het
Hnrnpul1 T C 7: 25,422,247 (GRCm39) probably benign Het
Hydin A G 8: 111,259,756 (GRCm39) E2576G possibly damaging Het
Ifit2 T A 19: 34,550,908 (GRCm39) C149* probably null Het
Il18rap T A 1: 40,564,084 (GRCm39) S67R probably benign Het
Kcnk4 T G 19: 6,903,668 (GRCm39) S294R probably benign Het
Kif21b A G 1: 136,100,683 (GRCm39) H1588R probably damaging Het
Klhl35 A T 7: 99,122,129 (GRCm39) S77C probably damaging Het
Lats2 A T 14: 57,934,867 (GRCm39) M228K probably damaging Het
Lrfn4 T C 19: 4,662,256 (GRCm39) D587G probably benign Het
Lrrd1 C A 5: 3,916,509 (GRCm39) T842K probably benign Het
Mafb G A 2: 160,208,125 (GRCm39) H158Y probably benign Het
Mapk8ip3 T A 17: 25,123,925 (GRCm39) E561D probably damaging Het
Mcemp1 A G 8: 3,717,542 (GRCm39) T158A probably damaging Het
Mst1r A T 9: 107,794,463 (GRCm39) E1214V probably damaging Het
Muc16 A G 9: 18,570,074 (GRCm39) I815T unknown Het
Ncoa6 T A 2: 155,248,172 (GRCm39) I1711L possibly damaging Het
Niban1 T A 1: 151,571,901 (GRCm39) V282D probably damaging Het
Nnt A C 13: 119,476,368 (GRCm39) F632C probably damaging Het
Nup210 G A 6: 91,051,330 (GRCm39) T351I probably benign Het
Or4f59 A G 2: 111,872,943 (GRCm39) S145P probably damaging Het
Or52e18 A G 7: 104,609,934 (GRCm39) S2P probably benign Het
P4ha1 C T 10: 59,191,185 (GRCm39) T364I probably damaging Het
Pcdhb11 T A 18: 37,555,252 (GRCm39) L194Q probably damaging Het
Pramel52-ps A G 5: 94,531,703 (GRCm39) K196E probably damaging Het
Rad51ap1 A G 6: 126,901,879 (GRCm39) probably null Het
Rbm11 G A 16: 75,397,694 (GRCm39) R208K probably benign Het
Rps6ka1 T A 4: 133,587,368 (GRCm39) Q535L possibly damaging Het
Slc26a3 A G 12: 31,516,505 (GRCm39) D621G probably benign Het
Sox10 T G 15: 79,040,652 (GRCm39) E296A probably damaging Het
St3gal4 A C 9: 34,964,438 (GRCm39) V188G probably damaging Het
Trim34a A T 7: 103,910,178 (GRCm39) I327F probably damaging Het
Ttc28 G A 5: 111,381,207 (GRCm39) D1240N probably benign Het
Zc2hc1c A G 12: 85,337,471 (GRCm39) E376G probably damaging Het
Zfp423 G A 8: 88,509,910 (GRCm39) P77S probably damaging Het
Zfp560 A T 9: 20,260,231 (GRCm39) S210R probably benign Het
Other mutations in Neo1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00514:Neo1 APN 9 58,829,202 (GRCm39) splice site probably benign
IGL00885:Neo1 APN 9 58,795,746 (GRCm39) missense probably damaging 1.00
IGL01103:Neo1 APN 9 58,788,082 (GRCm39) missense possibly damaging 0.60
IGL01322:Neo1 APN 9 58,814,368 (GRCm39) missense possibly damaging 0.68
IGL02216:Neo1 APN 9 58,824,336 (GRCm39) missense probably damaging 0.96
IGL02327:Neo1 APN 9 58,810,371 (GRCm39) missense probably benign 0.08
IGL02392:Neo1 APN 9 58,833,094 (GRCm39) missense possibly damaging 0.49
IGL02458:Neo1 APN 9 58,801,150 (GRCm39) splice site probably benign
IGL03057:Neo1 APN 9 58,785,342 (GRCm39) missense probably damaging 1.00
IGL03091:Neo1 APN 9 58,885,951 (GRCm39) missense probably damaging 0.98
IGL03193:Neo1 APN 9 58,815,767 (GRCm39) missense probably damaging 1.00
R0097:Neo1 UTSW 9 58,882,021 (GRCm38) intron probably benign
R0419:Neo1 UTSW 9 58,897,463 (GRCm39) splice site probably benign
R0571:Neo1 UTSW 9 58,893,069 (GRCm39) missense probably benign
R0646:Neo1 UTSW 9 58,838,317 (GRCm39) missense probably damaging 1.00
R0736:Neo1 UTSW 9 58,824,364 (GRCm39) missense possibly damaging 0.78
R0739:Neo1 UTSW 9 58,829,160 (GRCm39) missense probably benign 0.22
R1636:Neo1 UTSW 9 58,820,560 (GRCm39) missense probably damaging 1.00
R1694:Neo1 UTSW 9 58,787,886 (GRCm39) missense probably damaging 1.00
R1827:Neo1 UTSW 9 58,824,314 (GRCm39) nonsense probably null
R1927:Neo1 UTSW 9 58,897,668 (GRCm39) missense probably benign 0.12
R2354:Neo1 UTSW 9 58,892,917 (GRCm39) missense probably benign
R2365:Neo1 UTSW 9 58,863,286 (GRCm39) missense probably benign
R3156:Neo1 UTSW 9 58,796,262 (GRCm39) splice site probably null
R3552:Neo1 UTSW 9 58,801,161 (GRCm39) missense probably damaging 1.00
R3829:Neo1 UTSW 9 58,820,452 (GRCm39) missense possibly damaging 0.58
R4477:Neo1 UTSW 9 58,784,582 (GRCm39) missense probably damaging 0.99
R4613:Neo1 UTSW 9 58,796,324 (GRCm39) missense possibly damaging 0.94
R5023:Neo1 UTSW 9 58,897,554 (GRCm39) missense probably damaging 1.00
R5046:Neo1 UTSW 9 58,801,194 (GRCm39) missense possibly damaging 0.77
R5057:Neo1 UTSW 9 58,897,554 (GRCm39) missense probably damaging 1.00
R5323:Neo1 UTSW 9 58,813,931 (GRCm39) critical splice donor site probably null
R5394:Neo1 UTSW 9 58,897,517 (GRCm39) missense probably benign 0.10
R5470:Neo1 UTSW 9 58,838,350 (GRCm39) missense probably damaging 1.00
R5473:Neo1 UTSW 9 58,788,126 (GRCm39) missense possibly damaging 0.88
R5500:Neo1 UTSW 9 58,824,337 (GRCm39) missense possibly damaging 0.94
R5503:Neo1 UTSW 9 58,892,933 (GRCm39) missense possibly damaging 0.67
R6122:Neo1 UTSW 9 58,824,291 (GRCm39) missense probably benign
R6191:Neo1 UTSW 9 58,796,312 (GRCm39) missense probably damaging 1.00
R6431:Neo1 UTSW 9 58,814,354 (GRCm39) missense probably benign 0.27
R6560:Neo1 UTSW 9 58,787,884 (GRCm39) missense possibly damaging 0.95
R6658:Neo1 UTSW 9 58,829,132 (GRCm39) missense probably benign 0.14
R6772:Neo1 UTSW 9 58,810,259 (GRCm39) missense probably damaging 1.00
R6912:Neo1 UTSW 9 58,824,335 (GRCm39) missense probably benign 0.00
R7061:Neo1 UTSW 9 58,897,724 (GRCm39) missense possibly damaging 0.95
R7145:Neo1 UTSW 9 58,796,462 (GRCm39) missense probably damaging 1.00
R7156:Neo1 UTSW 9 58,810,206 (GRCm39) missense probably damaging 1.00
R7485:Neo1 UTSW 9 58,791,826 (GRCm39) missense probably benign 0.04
R7519:Neo1 UTSW 9 58,785,348 (GRCm39) missense probably benign 0.13
R7615:Neo1 UTSW 9 58,791,786 (GRCm39) missense probably benign 0.07
R7665:Neo1 UTSW 9 58,833,078 (GRCm39) missense probably damaging 1.00
R7695:Neo1 UTSW 9 58,810,212 (GRCm39) missense possibly damaging 0.81
R7753:Neo1 UTSW 9 58,863,288 (GRCm39) missense probably benign 0.00
R7807:Neo1 UTSW 9 58,897,777 (GRCm39) missense probably benign 0.01
R7915:Neo1 UTSW 9 58,838,264 (GRCm39) missense probably benign 0.42
R7973:Neo1 UTSW 9 58,897,476 (GRCm39) missense probably damaging 1.00
R8505:Neo1 UTSW 9 58,820,566 (GRCm39) missense probably benign 0.02
R8700:Neo1 UTSW 9 58,825,913 (GRCm39) missense probably benign 0.28
R8798:Neo1 UTSW 9 58,820,449 (GRCm39) missense probably damaging 1.00
R8952:Neo1 UTSW 9 58,897,545 (GRCm39) missense probably benign 0.01
R9779:Neo1 UTSW 9 58,886,009 (GRCm39) nonsense probably null
R9784:Neo1 UTSW 9 58,889,503 (GRCm39) missense probably benign
R9789:Neo1 UTSW 9 58,801,307 (GRCm39) critical splice acceptor site probably null
X0063:Neo1 UTSW 9 58,897,581 (GRCm39) missense probably damaging 0.98
Predicted Primers PCR Primer
(F):5'- TCCAAGGACACCTGTTTGATG -3'
(R):5'- TCAGAGCAGATCCCTGTCTG -3'

Sequencing Primer
(F):5'- ATCTATGGTGGCAAAGACCTC -3'
(R):5'- GATCCCTGTCTGAGCCTACAAG -3'
Posted On 2021-01-18