Mutagenetix > Incidental Mutation

Incidental Mutation 'R8440:Vmn1r128'

660383

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r128

Ensembl Gene

ENSMUSG00000095758

Gene Name

vomeronasal 1 receptor 128

Synonyms

Gm8509

MMRRC Submission

067884-MU

Accession Numbers

Essential gene?

Not available question?

Stock #

R8440 (G1)

Quality Score

218.009

Status

Not validated

Chromosome

Chromosomal Location

21083298-21084221 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 21083745 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Isoleucine at position 150 (V150I)

Ref Sequence

ENSEMBL: ENSMUSP00000129433 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169165]

AlphaFold

L7N2B4

Predicted Effect

probably benign
Transcript: ENSMUST00000169165
AA Change: V150I

PolyPhen 2 Score 0.220 (Sensitivity: 0.91; Specificity: 0.88)

SMART Domains

Protein: ENSMUSP00000129433
Gene: ENSMUSG00000095758
AA Change: V150I

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	299	3.6e-16	PFAM
Pfam:7tm_1	31	288	3.8e-6	PFAM
Pfam:V1R	41	296	8.4e-15	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

97% (38/39)

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Ak5	G	C	3: 152,209,680 (GRCm39)		probably null	Het
Bbs9	T	A	9: 22,479,046 (GRCm39)	V163E	probably damaging	Het
Bsn	G	A	9: 107,988,651 (GRCm39)	A2367V	probably benign	Het
Cbr3	T	C	16: 93,480,421 (GRCm39)	I70T	probably damaging	Het
Chka	T	C	19: 3,943,375 (GRCm39)	Y426H	probably damaging	Het
Cpq	T	A	15: 33,213,341 (GRCm39)	M120K	possibly damaging	Het
Dcaf1	T	A	9: 106,725,073 (GRCm39)	C520S	possibly damaging	Het
Egfr	T	C	11: 16,859,831 (GRCm39)	Y1018H	probably damaging	Het
Eif3l	T	C	15: 78,961,120 (GRCm39)	Y58H	possibly damaging	Het
Frmd8	T	C	19: 5,915,202 (GRCm39)	Y234C	possibly damaging	Het
Fus	T	C	7: 127,568,998 (GRCm39)	Y50H	unknown	Het
Hmcn1	T	A	1: 150,570,671 (GRCm39)	Q2164L	probably damaging	Het
Hmcn2	C	A	2: 31,281,088 (GRCm39)	L1867I	probably benign	Het
Hsd11b1	T	C	1: 192,904,420 (GRCm39)	K260E	probably benign	Het
Igkv4-91	C	T	6: 68,745,556 (GRCm39)	G114D	probably benign	Het
Inpp4b	G	A	8: 82,768,524 (GRCm39)	E678K	probably damaging	Het
Kifc3	G	T	8: 95,836,422 (GRCm39)	P113Q	possibly damaging	Het
Lgi4	T	A	7: 30,760,049 (GRCm39)		probably null	Het
Map1s	A	G	8: 71,365,163 (GRCm39)	N107D	probably damaging	Het
Meiob	G	T	17: 25,037,302 (GRCm39)	C60F	probably benign	Het
Nedd4l	G	T	18: 65,022,126 (GRCm39)		probably null	Het
Omp	A	G	7: 97,794,253 (GRCm39)	F125L	probably damaging	Het
Or1ad6	T	C	11: 50,860,024 (GRCm39)	Y60H	probably damaging	Het
Or51h1	G	A	7: 102,308,275 (GRCm39)	M82I	probably damaging	Het
Or5a1	C	T	19: 12,097,308 (GRCm39)	C244Y	probably damaging	Het
Pcdha3	T	C	18: 37,080,914 (GRCm39)	V552A	probably damaging	Het
Plek	T	C	11: 16,945,276 (GRCm39)	D18G	possibly damaging	Het
Ppip5k2	T	C	1: 97,675,276 (GRCm39)	T376A	probably damaging	Het
Prkdc	CAAA	CAAAA	16: 15,653,022 (GRCm39)	3833	probably null	Het
Rabgap1	T	C	2: 37,432,692 (GRCm39)		probably null	Het
Rtn1	T	A	12: 72,270,173 (GRCm39)	I113F	probably damaging	Het
Ssu2	T	A	6: 112,364,950 (GRCm39)	D4V	probably benign	Het
St6galnac2	T	C	11: 116,568,374 (GRCm39)	H363R	probably damaging	Het
Stk19	T	C	17: 35,055,456 (GRCm39)	S60G	possibly damaging	Het
Suco	G	A	1: 161,679,907 (GRCm39)	T332I	probably damaging	Het
Trbv20	T	A	6: 41,165,892 (GRCm39)	Y106N	probably damaging	Het
Uck1	C	A	2: 32,150,153 (GRCm39)		probably benign	Het
Vmn2r54	A	T	7: 12,350,013 (GRCm39)	V523E	possibly damaging	Het
Vmn2r61	A	T	7: 41,916,080 (GRCm39)	E231V	probably benign	Het
Xkr9	A	G	1: 13,771,603 (GRCm39)	D373G	probably benign	Het
Zfp592	G	C	7: 80,691,271 (GRCm39)	S1150T	possibly damaging	Het

Other mutations in Vmn1r128

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00972:Vmn1r128	APN	7	21,084,001 (GRCm39)	missense	probably benign	0.01
IGL02169:Vmn1r128	APN	7	21,084,163 (GRCm39)	missense	probably damaging	0.99
IGL02883:Vmn1r128	APN	7	21,083,440 (GRCm39)	missense	probably benign	0.00
R1740:Vmn1r128	UTSW	7	21,083,869 (GRCm39)	missense	probably benign	0.00
R2969:Vmn1r128	UTSW	7	21,084,046 (GRCm39)	missense	probably damaging	1.00
R4583:Vmn1r128	UTSW	7	21,083,644 (GRCm39)	missense	possibly damaging	0.79
R4867:Vmn1r128	UTSW	7	21,083,939 (GRCm39)	missense	possibly damaging	0.53
R5266:Vmn1r128	UTSW	7	21,083,328 (GRCm39)	missense	probably benign	0.14
R5631:Vmn1r128	UTSW	7	21,083,300 (GRCm39)	start codon destroyed	probably null	1.00
R6267:Vmn1r128	UTSW	7	21,084,221 (GRCm39)	makesense	probably null
R7376:Vmn1r128	UTSW	7	21,083,668 (GRCm39)	missense	probably damaging	1.00
R8351:Vmn1r128	UTSW	7	21,083,597 (GRCm39)	missense	probably damaging	1.00
R8773:Vmn1r128	UTSW	7	21,083,922 (GRCm39)	missense	probably benign	0.41
R8889:Vmn1r128	UTSW	7	21,083,740 (GRCm39)	missense	possibly damaging	0.61
R9182:Vmn1r128	UTSW	7	21,083,683 (GRCm39)	missense	possibly damaging	0.72
R9200:Vmn1r128	UTSW	7	21,083,316 (GRCm39)	missense	possibly damaging	0.89
R9665:Vmn1r128	UTSW	7	21,083,362 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- ATTCTTCAGTCACATGGTGGC -3'
(R):5'- AGTGAGGATGTGCTGCATTC -3'

Sequencing Primer
(F):5'- CTTCAGTCACATGGTGGCAAGAAG -3'
(R):5'- TGTCTATGGAGGAGAAGTACCATG -3'

Posted On

2021-01-18