Incidental Mutation 'R8348:Zfp715'
ID 660434
Institutional Source Beutler Lab
Gene Symbol Zfp715
Ensembl Gene ENSMUSG00000012640
Gene Name zinc finger protein 715
Synonyms 2610041B18Rik, mszf15
MMRRC Submission 067732-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.088) question?
Stock # R8348 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 42945946-42962724 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 42949361 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Threonine to Alanine at position 200 (T200A)
Ref Sequence ENSEMBL: ENSMUSP00000103620 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000012796] [ENSMUST00000048015] [ENSMUST00000107986] [ENSMUST00000135130] [ENSMUST00000139061] [ENSMUST00000145622]
AlphaFold G3X9T1
Predicted Effect probably benign
Transcript: ENSMUST00000012796
SMART Domains Protein: ENSMUSP00000012796
Gene: ENSMUSG00000012640

DomainStartEndE-ValueType
KRAB 48 108 3.87e-30 SMART
ZnF_C2H2 124 146 3.39e-3 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000048015
AA Change: T200A

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000040282
Gene: ENSMUSG00000012640
AA Change: T200A

DomainStartEndE-ValueType
KRAB 48 108 3.87e-30 SMART
ZnF_C2H2 356 378 1.28e-3 SMART
ZnF_C2H2 384 406 1.03e-2 SMART
ZnF_C2H2 412 434 4.79e-3 SMART
ZnF_C2H2 440 462 1.45e-2 SMART
ZnF_C2H2 468 490 1.12e-3 SMART
ZnF_C2H2 496 518 2.57e-3 SMART
ZnF_C2H2 524 546 4.79e-3 SMART
ZnF_C2H2 552 574 1.92e-2 SMART
ZnF_C2H2 580 602 9.58e-3 SMART
ZnF_C2H2 608 630 8.6e-5 SMART
ZnF_C2H2 636 658 1.13e-4 SMART
ZnF_C2H2 691 713 1.98e-4 SMART
ZnF_C2H2 719 741 8.34e-3 SMART
ZnF_C2H2 747 769 3.95e-4 SMART
ZnF_C2H2 775 797 4.94e-5 SMART
ZnF_C2H2 803 825 3.39e-3 SMART
ZnF_C2H2 831 853 1.95e-3 SMART
ZnF_C2H2 859 881 2.09e-3 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000107986
AA Change: T200A

PolyPhen 2 Score 0.528 (Sensitivity: 0.88; Specificity: 0.90)
SMART Domains Protein: ENSMUSP00000103620
Gene: ENSMUSG00000012640
AA Change: T200A

DomainStartEndE-ValueType
KRAB 48 108 3.87e-30 SMART
ZnF_C2H2 356 378 1.28e-3 SMART
ZnF_C2H2 384 406 1.03e-2 SMART
ZnF_C2H2 412 434 4.79e-3 SMART
ZnF_C2H2 440 462 1.45e-2 SMART
ZnF_C2H2 468 490 1.12e-3 SMART
ZnF_C2H2 496 518 2.57e-3 SMART
ZnF_C2H2 524 546 4.79e-3 SMART
ZnF_C2H2 552 574 1.92e-2 SMART
ZnF_C2H2 580 602 9.58e-3 SMART
ZnF_C2H2 608 630 8.6e-5 SMART
ZnF_C2H2 636 658 1.13e-4 SMART
ZnF_C2H2 691 713 1.98e-4 SMART
ZnF_C2H2 719 741 8.34e-3 SMART
ZnF_C2H2 747 769 3.95e-4 SMART
ZnF_C2H2 775 797 4.94e-5 SMART
ZnF_C2H2 803 825 3.39e-3 SMART
ZnF_C2H2 831 853 1.95e-3 SMART
ZnF_C2H2 859 881 2.09e-3 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000135130
SMART Domains Protein: ENSMUSP00000122812
Gene: ENSMUSG00000012640

DomainStartEndE-ValueType
KRAB 48 88 5.49e-12 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000139061
SMART Domains Protein: ENSMUSP00000114600
Gene: ENSMUSG00000012640

DomainStartEndE-ValueType
KRAB 48 108 3.87e-30 SMART
Predicted Effect probably benign
Transcript: ENSMUST00000145622
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (59/59)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1600014C10Rik A G 7: 37,894,384 (GRCm39) Y139C possibly damaging Het
A430033K04Rik A G 5: 138,634,514 (GRCm39) D43G probably damaging Het
Actn3 C A 19: 4,915,361 (GRCm39) V464L possibly damaging Het
Adamts15 C T 9: 30,813,846 (GRCm39) R773Q probably benign Het
Angpt2 G A 8: 18,791,135 (GRCm39) R54* probably null Het
Arhgef28 G T 13: 98,190,375 (GRCm39) P195T possibly damaging Het
Axdnd1 A T 1: 156,245,854 (GRCm39) D107E probably benign Het
Cdh23 C T 10: 60,167,507 (GRCm39) V1828M probably benign Het
Cep95 A G 11: 106,704,593 (GRCm39) T440A possibly damaging Het
Ctdp1 G A 18: 80,493,325 (GRCm39) A390V probably benign Het
Desi2 T A 1: 178,083,906 (GRCm39) probably benign Het
Dnah2 A T 11: 69,320,273 (GRCm39) M3932K possibly damaging Het
Dnah8 A T 17: 30,955,121 (GRCm39) Q2050L probably damaging Het
Etnppl T A 3: 130,423,141 (GRCm39) M274K probably benign Het
Farp2 G T 1: 93,504,614 (GRCm39) probably null Het
Fbxo46 G A 7: 18,870,469 (GRCm39) G363R probably damaging Het
Fiz1 A G 7: 5,015,909 (GRCm39) V27A probably benign Het
Fndc3b T A 3: 27,494,144 (GRCm39) M994L probably benign Het
G3bp1 T G 11: 55,389,457 (GRCm39) D384E possibly damaging Het
Galnt2 C T 8: 125,061,025 (GRCm39) R306* probably null Het
Gle1 T C 2: 29,832,556 (GRCm39) Y304H possibly damaging Het
Gm3415 G A 5: 146,493,407 (GRCm39) R84H probably benign Het
Gm7694 A C 1: 170,129,209 (GRCm39) S107A possibly damaging Het
Gpc6 A G 14: 117,673,232 (GRCm39) D163G probably damaging Het
Gtpbp6 G A 5: 110,251,892 (GRCm39) H514Y possibly damaging Het
Hdgfl2 A G 17: 56,406,370 (GRCm39) E595G possibly damaging Het
Hoxc11 G A 15: 102,863,186 (GRCm39) G76S possibly damaging Het
Hoxc4 T C 15: 102,943,440 (GRCm39) C98R possibly damaging Het
Hydin A T 8: 111,329,878 (GRCm39) I4871F possibly damaging Het
Ifnar1 A G 16: 91,292,187 (GRCm39) D176G probably benign Het
Inafm1 A G 7: 16,007,055 (GRCm39) I54T probably damaging Het
Inpp5b G A 4: 124,678,967 (GRCm39) G458D probably damaging Het
Irs2 A T 8: 11,054,974 (GRCm39) S1153T probably damaging Het
Kcnj15 A G 16: 95,096,609 (GRCm39) Y77C probably damaging Het
Klhl35 C A 7: 99,121,062 (GRCm39) D10E probably damaging Het
Lef1 A T 3: 130,906,461 (GRCm39) M1L probably benign Het
Lima1 T C 15: 99,678,753 (GRCm39) T403A probably benign Het
Magi3 T A 3: 103,958,531 (GRCm39) N518I probably damaging Het
Mcoln3 T C 3: 145,836,974 (GRCm39) C269R probably damaging Het
Mis18a A T 16: 90,523,919 (GRCm39) L81* probably null Het
Mug2 A T 6: 122,049,192 (GRCm39) K903* probably null Het
Nhsl3 G A 4: 129,117,699 (GRCm39) R322C probably damaging Het
Pex6 T C 17: 47,034,039 (GRCm39) S656P probably benign Het
Pgr C A 9: 8,922,602 (GRCm39) Q591K probably benign Het
Phactr3 T C 2: 177,897,935 (GRCm39) S50P probably benign Het
Plscr4 C T 9: 92,372,843 (GRCm39) R322* probably null Het
Sipa1l1 T A 12: 82,443,045 (GRCm39) N778K probably benign Het
Slc22a6 C G 19: 8,599,169 (GRCm39) R267G probably damaging Het
Slc5a7 A G 17: 54,583,655 (GRCm39) V545A possibly damaging Het
Snf8 A G 11: 95,925,877 (GRCm39) K13R probably benign Het
St3gal1 G A 15: 66,985,511 (GRCm39) R48C probably damaging Het
Tacc2 A C 7: 130,225,019 (GRCm39) K568T possibly damaging Het
Tnxb C A 17: 34,929,102 (GRCm39) T2715K possibly damaging Het
Vegfb T C 19: 6,962,856 (GRCm39) I140V probably benign Het
Vmn2r89 A C 14: 51,692,548 (GRCm39) D117A possibly damaging Het
Vps13c C T 9: 67,786,385 (GRCm39) T284I possibly damaging Het
Wnk1 T C 6: 119,906,960 (GRCm39) probably null Het
Wscd2 T A 5: 113,710,371 (GRCm39) H298Q possibly damaging Het
Zfp69 A T 4: 120,787,834 (GRCm39) C494S probably damaging Het
Other mutations in Zfp715
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00093:Zfp715 APN 7 42,949,173 (GRCm39) missense possibly damaging 0.53
IGL00984:Zfp715 APN 7 42,949,208 (GRCm39) missense probably benign 0.28
IGL03401:Zfp715 APN 7 42,949,160 (GRCm39) missense probably benign 0.18
R0373:Zfp715 UTSW 7 42,948,760 (GRCm39) missense possibly damaging 0.96
R1167:Zfp715 UTSW 7 42,947,861 (GRCm39) missense possibly damaging 0.83
R1943:Zfp715 UTSW 7 42,949,054 (GRCm39) missense possibly damaging 0.86
R1987:Zfp715 UTSW 7 42,948,073 (GRCm39) missense possibly damaging 0.71
R2073:Zfp715 UTSW 7 42,960,544 (GRCm39) missense probably benign 0.01
R2116:Zfp715 UTSW 7 42,947,370 (GRCm39) missense possibly damaging 0.71
R2403:Zfp715 UTSW 7 42,948,692 (GRCm39) missense possibly damaging 0.91
R3707:Zfp715 UTSW 7 42,960,553 (GRCm39) missense probably benign
R3838:Zfp715 UTSW 7 42,949,180 (GRCm39) missense probably benign 0.33
R4059:Zfp715 UTSW 7 42,951,155 (GRCm39) missense probably benign 0.11
R4110:Zfp715 UTSW 7 42,947,304 (GRCm39) missense possibly damaging 0.72
R4426:Zfp715 UTSW 7 42,960,516 (GRCm39) missense probably damaging 0.99
R4675:Zfp715 UTSW 7 42,949,444 (GRCm39) missense probably benign 0.15
R4898:Zfp715 UTSW 7 42,949,106 (GRCm39) missense possibly damaging 0.48
R5007:Zfp715 UTSW 7 42,949,019 (GRCm39) missense possibly damaging 0.53
R5477:Zfp715 UTSW 7 42,949,378 (GRCm39) missense probably damaging 0.99
R5574:Zfp715 UTSW 7 42,960,463 (GRCm39) missense possibly damaging 0.94
R5594:Zfp715 UTSW 7 42,949,116 (GRCm39) missense possibly damaging 0.73
R5967:Zfp715 UTSW 7 42,948,572 (GRCm39) missense probably benign 0.04
R6538:Zfp715 UTSW 7 42,948,573 (GRCm39) missense possibly damaging 0.73
R7322:Zfp715 UTSW 7 42,960,562 (GRCm39) missense possibly damaging 0.53
R7629:Zfp715 UTSW 7 42,951,100 (GRCm39) missense possibly damaging 0.92
R7934:Zfp715 UTSW 7 42,949,308 (GRCm39) nonsense probably null
R7973:Zfp715 UTSW 7 42,949,321 (GRCm39) missense possibly damaging 0.64
R8327:Zfp715 UTSW 7 42,947,482 (GRCm39) missense possibly damaging 0.64
R8532:Zfp715 UTSW 7 42,949,134 (GRCm39) missense probably benign 0.00
R8532:Zfp715 UTSW 7 42,948,829 (GRCm39) missense possibly damaging 0.71
R8835:Zfp715 UTSW 7 42,948,430 (GRCm39) missense
R9150:Zfp715 UTSW 7 42,948,713 (GRCm39) missense possibly damaging 0.85
R9328:Zfp715 UTSW 7 42,947,328 (GRCm39) missense possibly damaging 0.71
R9332:Zfp715 UTSW 7 42,948,847 (GRCm39) missense probably damaging 0.98
R9619:Zfp715 UTSW 7 42,949,104 (GRCm39) nonsense probably null
R9649:Zfp715 UTSW 7 42,950,653 (GRCm39) missense probably benign
Predicted Primers PCR Primer
(F):5'- GGCTGAGAACATCTCCATTCC -3'
(R):5'- TTATAGCAATGTGGCAAGTGAAGTG -3'

Sequencing Primer
(F):5'- GTAACCACACAGTTAGCATTACAGG -3'
(R):5'- GACAAGAGATGGTTCATGGTGTTCC -3'
Posted On 2021-01-18