Incidental Mutation 'R8348:Vmn2r89'
ID 660452
Institutional Source Beutler Lab
Gene Symbol Vmn2r89
Ensembl Gene ENSMUSG00000070448
Gene Name vomeronasal 2, receptor 89
Synonyms V2r10, V2r11
MMRRC Submission 067732-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.147) question?
Stock # R8348 (G1)
Quality Score 225.009
Status Validated
Chromosome 14
Chromosomal Location 51689419-51698750 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 51692548 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Alanine at position 117 (D117A)
Ref Sequence ENSEMBL: ENSMUSP00000124256 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000159611] [ENSMUST00000159734] [ENSMUST00000161670] [ENSMUST00000162998]
AlphaFold O35199
Predicted Effect possibly damaging
Transcript: ENSMUST00000159611
AA Change: D117A

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000124065
Gene: ENSMUSG00000070448
AA Change: D117A

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:ANF_receptor 76 449 4.8e-30 PFAM
Predicted Effect possibly damaging
Transcript: ENSMUST00000159734
AA Change: D117A

PolyPhen 2 Score 0.901 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000124256
Gene: ENSMUSG00000070448
AA Change: D117A

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Pfam:ANF_receptor 76 420 1.1e-29 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000161670
SMART Domains Protein: ENSMUSP00000124261
Gene: ENSMUSG00000070448

DomainStartEndE-ValueType
signal peptide 1 26 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000162998
SMART Domains Protein: ENSMUSP00000125409
Gene: ENSMUSG00000068399

DomainStartEndE-ValueType
Pfam:Takusan 35 115 2.2e-25 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.4%
Validation Efficiency 100% (59/59)
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1600014C10Rik A G 7: 37,894,384 (GRCm39) Y139C possibly damaging Het
A430033K04Rik A G 5: 138,634,514 (GRCm39) D43G probably damaging Het
Actn3 C A 19: 4,915,361 (GRCm39) V464L possibly damaging Het
Adamts15 C T 9: 30,813,846 (GRCm39) R773Q probably benign Het
Angpt2 G A 8: 18,791,135 (GRCm39) R54* probably null Het
Arhgef28 G T 13: 98,190,375 (GRCm39) P195T possibly damaging Het
Axdnd1 A T 1: 156,245,854 (GRCm39) D107E probably benign Het
Cdh23 C T 10: 60,167,507 (GRCm39) V1828M probably benign Het
Cep95 A G 11: 106,704,593 (GRCm39) T440A possibly damaging Het
Ctdp1 G A 18: 80,493,325 (GRCm39) A390V probably benign Het
Desi2 T A 1: 178,083,906 (GRCm39) probably benign Het
Dnah2 A T 11: 69,320,273 (GRCm39) M3932K possibly damaging Het
Dnah8 A T 17: 30,955,121 (GRCm39) Q2050L probably damaging Het
Etnppl T A 3: 130,423,141 (GRCm39) M274K probably benign Het
Farp2 G T 1: 93,504,614 (GRCm39) probably null Het
Fbxo46 G A 7: 18,870,469 (GRCm39) G363R probably damaging Het
Fiz1 A G 7: 5,015,909 (GRCm39) V27A probably benign Het
Fndc3b T A 3: 27,494,144 (GRCm39) M994L probably benign Het
G3bp1 T G 11: 55,389,457 (GRCm39) D384E possibly damaging Het
Galnt2 C T 8: 125,061,025 (GRCm39) R306* probably null Het
Gle1 T C 2: 29,832,556 (GRCm39) Y304H possibly damaging Het
Gm3415 G A 5: 146,493,407 (GRCm39) R84H probably benign Het
Gm7694 A C 1: 170,129,209 (GRCm39) S107A possibly damaging Het
Gpc6 A G 14: 117,673,232 (GRCm39) D163G probably damaging Het
Gtpbp6 G A 5: 110,251,892 (GRCm39) H514Y possibly damaging Het
Hdgfl2 A G 17: 56,406,370 (GRCm39) E595G possibly damaging Het
Hoxc11 G A 15: 102,863,186 (GRCm39) G76S possibly damaging Het
Hoxc4 T C 15: 102,943,440 (GRCm39) C98R possibly damaging Het
Hydin A T 8: 111,329,878 (GRCm39) I4871F possibly damaging Het
Ifnar1 A G 16: 91,292,187 (GRCm39) D176G probably benign Het
Inafm1 A G 7: 16,007,055 (GRCm39) I54T probably damaging Het
Inpp5b G A 4: 124,678,967 (GRCm39) G458D probably damaging Het
Irs2 A T 8: 11,054,974 (GRCm39) S1153T probably damaging Het
Kcnj15 A G 16: 95,096,609 (GRCm39) Y77C probably damaging Het
Klhl35 C A 7: 99,121,062 (GRCm39) D10E probably damaging Het
Lef1 A T 3: 130,906,461 (GRCm39) M1L probably benign Het
Lima1 T C 15: 99,678,753 (GRCm39) T403A probably benign Het
Magi3 T A 3: 103,958,531 (GRCm39) N518I probably damaging Het
Mcoln3 T C 3: 145,836,974 (GRCm39) C269R probably damaging Het
Mis18a A T 16: 90,523,919 (GRCm39) L81* probably null Het
Mug2 A T 6: 122,049,192 (GRCm39) K903* probably null Het
Nhsl3 G A 4: 129,117,699 (GRCm39) R322C probably damaging Het
Pex6 T C 17: 47,034,039 (GRCm39) S656P probably benign Het
Pgr C A 9: 8,922,602 (GRCm39) Q591K probably benign Het
Phactr3 T C 2: 177,897,935 (GRCm39) S50P probably benign Het
Plscr4 C T 9: 92,372,843 (GRCm39) R322* probably null Het
Sipa1l1 T A 12: 82,443,045 (GRCm39) N778K probably benign Het
Slc22a6 C G 19: 8,599,169 (GRCm39) R267G probably damaging Het
Slc5a7 A G 17: 54,583,655 (GRCm39) V545A possibly damaging Het
Snf8 A G 11: 95,925,877 (GRCm39) K13R probably benign Het
St3gal1 G A 15: 66,985,511 (GRCm39) R48C probably damaging Het
Tacc2 A C 7: 130,225,019 (GRCm39) K568T possibly damaging Het
Tnxb C A 17: 34,929,102 (GRCm39) T2715K possibly damaging Het
Vegfb T C 19: 6,962,856 (GRCm39) I140V probably benign Het
Vps13c C T 9: 67,786,385 (GRCm39) T284I possibly damaging Het
Wnk1 T C 6: 119,906,960 (GRCm39) probably null Het
Wscd2 T A 5: 113,710,371 (GRCm39) H298Q possibly damaging Het
Zfp69 A T 4: 120,787,834 (GRCm39) C494S probably damaging Het
Zfp715 T C 7: 42,949,361 (GRCm39) T200A possibly damaging Het
Other mutations in Vmn2r89
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00433:Vmn2r89 APN 14 51,692,422 (GRCm39) missense probably damaging 1.00
IGL00990:Vmn2r89 APN 14 51,694,950 (GRCm39) missense probably benign
IGL00990:Vmn2r89 APN 14 51,693,428 (GRCm39) missense probably benign 0.14
IGL01991:Vmn2r89 APN 14 51,689,676 (GRCm39) missense probably benign 0.00
IGL03073:Vmn2r89 APN 14 51,693,528 (GRCm39) missense possibly damaging 0.95
IGL03085:Vmn2r89 APN 14 51,689,615 (GRCm39) missense probably damaging 0.99
IGL03278:Vmn2r89 APN 14 51,692,557 (GRCm39) missense probably damaging 0.99
R0115:Vmn2r89 UTSW 14 51,693,577 (GRCm39) missense probably damaging 1.00
R0127:Vmn2r89 UTSW 14 51,693,160 (GRCm39) missense probably damaging 0.98
R0391:Vmn2r89 UTSW 14 51,693,435 (GRCm39) missense probably damaging 0.99
R0481:Vmn2r89 UTSW 14 51,693,577 (GRCm39) missense probably damaging 1.00
R0538:Vmn2r89 UTSW 14 51,695,048 (GRCm39) splice site probably null
R1210:Vmn2r89 UTSW 14 51,692,427 (GRCm39) missense probably benign 0.01
R1332:Vmn2r89 UTSW 14 51,692,559 (GRCm39) missense probably benign 0.00
R1660:Vmn2r89 UTSW 14 51,693,693 (GRCm39) missense possibly damaging 0.48
R1959:Vmn2r89 UTSW 14 51,694,897 (GRCm39) missense probably benign 0.22
R2876:Vmn2r89 UTSW 14 51,692,541 (GRCm39) missense possibly damaging 0.47
R3410:Vmn2r89 UTSW 14 51,693,628 (GRCm39) missense probably damaging 0.98
R4026:Vmn2r89 UTSW 14 51,689,500 (GRCm39) start codon destroyed probably null 1.00
R4398:Vmn2r89 UTSW 14 51,689,551 (GRCm39) missense probably damaging 1.00
R4700:Vmn2r89 UTSW 14 51,694,942 (GRCm39) missense probably damaging 1.00
R4714:Vmn2r89 UTSW 14 51,689,688 (GRCm39) missense probably damaging 0.97
R5162:Vmn2r89 UTSW 14 51,693,620 (GRCm39) missense possibly damaging 0.88
R5294:Vmn2r89 UTSW 14 51,692,570 (GRCm39) missense probably benign 0.00
R5811:Vmn2r89 UTSW 14 51,693,565 (GRCm39) missense probably benign 0.12
R6087:Vmn2r89 UTSW 14 51,695,033 (GRCm39) splice site probably null
R6229:Vmn2r89 UTSW 14 51,693,178 (GRCm39) missense probably benign 0.05
R6246:Vmn2r89 UTSW 14 51,693,503 (GRCm39) missense probably damaging 1.00
R6572:Vmn2r89 UTSW 14 51,693,450 (GRCm39) missense probably damaging 1.00
R7351:Vmn2r89 UTSW 14 51,693,739 (GRCm39) missense probably benign 0.30
R7683:Vmn2r89 UTSW 14 51,692,651 (GRCm39) missense probably benign
R7974:Vmn2r89 UTSW 14 51,693,459 (GRCm39) missense probably damaging 1.00
R8047:Vmn2r89 UTSW 14 51,692,549 (GRCm39) missense probably benign 0.05
R8093:Vmn2r89 UTSW 14 51,693,699 (GRCm39) missense probably benign 0.00
R8723:Vmn2r89 UTSW 14 51,693,910 (GRCm39) missense probably benign
R8737:Vmn2r89 UTSW 14 51,693,722 (GRCm39) missense probably damaging 1.00
R8859:Vmn2r89 UTSW 14 51,693,170 (GRCm39) missense probably benign
R9183:Vmn2r89 UTSW 14 51,692,501 (GRCm39) missense probably benign 0.01
R9197:Vmn2r89 UTSW 14 51,693,596 (GRCm39) missense possibly damaging 0.70
R9377:Vmn2r89 UTSW 14 51,692,601 (GRCm39) missense probably benign 0.02
R9395:Vmn2r89 UTSW 14 51,693,783 (GRCm39) missense probably damaging 1.00
R9452:Vmn2r89 UTSW 14 51,693,288 (GRCm39) missense probably damaging 0.99
R9457:Vmn2r89 UTSW 14 51,693,469 (GRCm39) missense probably damaging 0.99
R9678:Vmn2r89 UTSW 14 51,693,511 (GRCm39) missense probably benign 0.09
X0019:Vmn2r89 UTSW 14 51,693,872 (GRCm39) missense possibly damaging 0.95
Predicted Primers PCR Primer
(F):5'- ATCTAGTTCAAGGATGGCATTGAG -3'
(R):5'- GTTAACCCATTCAGTGTCACATG -3'

Sequencing Primer
(F):5'- TTCAAGGATGGCATTGAGATAAAAC -3'
(R):5'- AGTGTCACATGTTCTTACCATTGG -3'
Posted On 2021-01-18