Mutagenetix > Incidental Mutation

Incidental Mutation 'R8351:Vmn1r128'

660484

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r128

Ensembl Gene

ENSMUSG00000095758

Gene Name

vomeronasal 1 receptor 128

Synonyms

Gm8509

MMRRC Submission

067804-MU

Accession Numbers

Essential gene?

Not available question?

Stock #

R8351 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

21083298-21084221 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 21083597 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Arginine to Serine at position 100 (R100S)

Ref Sequence

ENSEMBL: ENSMUSP00000129433 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169165]

AlphaFold

L7N2B4

Predicted Effect

probably damaging
Transcript: ENSMUST00000169165
AA Change: R100S

PolyPhen 2 Score 0.999 (Sensitivity: 0.14; Specificity: 0.99)

SMART Domains

Protein: ENSMUSP00000129433
Gene: ENSMUSG00000095758
AA Change: R100S

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	299	3.6e-16	PFAM
Pfam:7tm_1	31	288	3.8e-6	PFAM
Pfam:V1R	41	296	8.4e-15	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

100% (41/41)

Allele List at MGI

Other mutations in this stock

Total: 44 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Agpat3	A	T	10: 78,110,086 (GRCm39)	Y288N	probably damaging	Het
Ano5	A	G	7: 51,203,626 (GRCm39)	K225E	probably benign	Het
Apob	A	G	12: 8,056,356 (GRCm39)	T1613A	probably benign	Het
Ascc3	A	G	10: 50,725,693 (GRCm39)	T2139A	probably benign	Het
Asnsd1	A	T	1: 53,386,172 (GRCm39)		probably null	Het
Atp23	C	T	10: 126,723,407 (GRCm39)	A232T	probably damaging	Het
Cd8b1	G	A	6: 71,306,777 (GRCm39)		probably null	Het
Cep295	G	A	9: 15,234,202 (GRCm39)	T2198I	probably damaging	Het
Col12a1	G	T	9: 79,588,694 (GRCm39)	N1140K	probably damaging	Het
Cyp2f2	A	G	7: 26,821,294 (GRCm39)	Y69C	probably damaging	Het
Ep400	C	T	5: 110,887,200 (GRCm39)	A628T	probably damaging	Het
Faxc	A	T	4: 21,932,046 (GRCm39)		probably null	Het
Fpr3	T	C	17: 18,191,436 (GRCm39)	S236P	probably benign	Het
Fsip2	T	C	2: 82,822,239 (GRCm39)	S5991P	possibly damaging	Het
Gm3099	A	T	14: 15,345,347 (GRCm39)	N58Y	probably damaging	Het
Gmps	T	C	3: 63,887,615 (GRCm39)	V29A	probably benign	Het
Gnptab	T	G	10: 88,250,348 (GRCm39)	D153E	probably benign	Het
Kcnh6	A	G	11: 105,911,062 (GRCm39)	H486R	probably damaging	Het
Lama3	T	C	18: 12,673,670 (GRCm39)	Y2571H	probably damaging	Het
Lama5	C	T	2: 179,837,401 (GRCm39)	V995M	probably damaging	Het
Lrrc43	A	G	5: 123,632,328 (GRCm39)	N157S	probably damaging	Het
Mbtps1	G	A	8: 120,272,923 (GRCm39)	S74L	probably benign	Het
Muc16	A	T	9: 18,571,181 (GRCm39)	V446D	unknown	Het
Ncapg2	T	C	12: 116,403,647 (GRCm39)	V853A	possibly damaging	Het
Nkx2-6	T	C	14: 69,409,476 (GRCm39)	S76P	probably benign	Het
Nuak1	T	C	10: 84,229,981 (GRCm39)	I131V	probably damaging	Het
Nup50l	A	C	6: 96,142,655 (GRCm39)	S130A	probably benign	Het
Oas1e	A	T	5: 120,925,008 (GRCm39)		probably null	Het
Or1n2	T	C	2: 36,797,149 (GRCm39)	F64L	probably benign	Het
Pde5a	T	C	3: 122,542,128 (GRCm39)		probably null	Het
Plin4	T	C	17: 56,413,861 (GRCm39)	T255A	probably benign	Het
Pygm	A	G	19: 6,438,117 (GRCm39)	T141A	possibly damaging	Het
Rps2	T	A	17: 24,939,334 (GRCm39)		probably benign	Het
Rptor	A	G	11: 119,783,465 (GRCm39)	D1153G	probably benign	Het
Ryr2	A	G	13: 11,814,718 (GRCm39)	F685L	probably damaging	Het
Slc22a17	A	G	14: 55,146,051 (GRCm39)	I356T	probably benign	Het
Slc29a4	T	G	5: 142,703,584 (GRCm39)	I286S	probably benign	Het
Swap70	T	C	7: 109,821,105 (GRCm39)	S30P	possibly damaging	Het
Tbc1d10c	A	G	19: 4,234,744 (GRCm39)	F439S	probably damaging	Het
Tbx3	T	A	5: 119,818,841 (GRCm39)	L472Q	probably damaging	Het
Tbxas1	A	G	6: 39,004,850 (GRCm39)	R366G	possibly damaging	Het
Ttll8	T	C	15: 88,798,638 (GRCm39)	D699G	probably benign	Het
Wdpcp	A	G	11: 21,698,931 (GRCm39)	D570G	probably damaging	Het
Znfx1	A	G	2: 166,897,575 (GRCm39)	S450P	probably damaging	Het

Other mutations in Vmn1r128

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00972:Vmn1r128	APN	7	21,084,001 (GRCm39)	missense	probably benign	0.01
IGL02169:Vmn1r128	APN	7	21,084,163 (GRCm39)	missense	probably damaging	0.99
IGL02883:Vmn1r128	APN	7	21,083,440 (GRCm39)	missense	probably benign	0.00
R1740:Vmn1r128	UTSW	7	21,083,869 (GRCm39)	missense	probably benign	0.00
R2969:Vmn1r128	UTSW	7	21,084,046 (GRCm39)	missense	probably damaging	1.00
R4583:Vmn1r128	UTSW	7	21,083,644 (GRCm39)	missense	possibly damaging	0.79
R4867:Vmn1r128	UTSW	7	21,083,939 (GRCm39)	missense	possibly damaging	0.53
R5266:Vmn1r128	UTSW	7	21,083,328 (GRCm39)	missense	probably benign	0.14
R5631:Vmn1r128	UTSW	7	21,083,300 (GRCm39)	start codon destroyed	probably null	1.00
R6267:Vmn1r128	UTSW	7	21,084,221 (GRCm39)	makesense	probably null
R7376:Vmn1r128	UTSW	7	21,083,668 (GRCm39)	missense	probably damaging	1.00
R8440:Vmn1r128	UTSW	7	21,083,745 (GRCm39)	missense	probably benign	0.22
R8773:Vmn1r128	UTSW	7	21,083,922 (GRCm39)	missense	probably benign	0.41
R8889:Vmn1r128	UTSW	7	21,083,740 (GRCm39)	missense	possibly damaging	0.61
R9182:Vmn1r128	UTSW	7	21,083,683 (GRCm39)	missense	possibly damaging	0.72
R9200:Vmn1r128	UTSW	7	21,083,316 (GRCm39)	missense	possibly damaging	0.89
R9665:Vmn1r128	UTSW	7	21,083,362 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGTTGGAACTGTGGCCAATG -3'
(R):5'- CAGTGACCTTAATTGGAATGTGG -3'

Sequencing Primer
(F):5'- GAACTGTGGCCAATGTCTTTC -3'
(R):5'- GGAATGTGGATGTTACTTAAGACAC -3'

Posted On

2021-01-18