Mutagenetix > Incidental Mutation

Incidental Mutation 'R0234:Greb1l'

66050

Institutional Source

Beutler Lab

Gene Symbol

Greb1l

Ensembl Gene

ENSMUSG00000042942

Gene Name

growth regulation by estrogen in breast cancer-like

Synonyms

AK220484, mKIAA4095

MMRRC Submission

038475-MU

Accession Numbers

Genbank: NM_001083628; MGI: 3576497

Essential gene?

Essential (E-score: 1.000) question?

Stock #

R0234 (G1)

Quality Score

125

Status

Not validated

Chromosome

Chromosomal Location

10325177-10562934 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 10560331 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 1864 (C1864S)

Ref Sequence

ENSEMBL: ENSMUSP00000049003 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000048977]

AlphaFold

B9EJV3

Predicted Effect

probably damaging
Transcript: ENSMUST00000048977
AA Change: C1864S

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000049003
Gene: ENSMUSG00000042942
AA Change: C1864S

Domain	Start	End	E-Value	Type
Pfam:GREB1	1	1172	N/A	PFAM
Pfam:GREB1	1154	1913	N/A	PFAM

Predicted Effect

noncoding transcript
Transcript: ENSMUST00000173261

Coding Region Coverage

1x: 98.8%
3x: 97.7%
10x: 94.1%
20x: 83.3%

Validation Efficiency

Allele List at MGI

All alleles(5) : Targeted, other(2) Gene trapped(3)

Other mutations in this stock

Total: 71 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
5430419D17Rik	T	A	7: 131,194,303		probably null	Het
A3galt2	A	G	4: 128,767,148	R197G	possibly damaging	Het
Acacb	A	T	5: 114,209,817	H983L	probably damaging	Het
Adal	T	A	2: 121,148,317	D139E	probably benign	Het
Adam6b	G	A	12: 113,490,610	R349H	probably damaging	Het
Agap1	A	G	1: 89,671,212	K331E	probably damaging	Het
B3gat1	A	G	9: 26,756,081	E203G	probably damaging	Het
Bsn	T	C	9: 108,116,396	E719G	possibly damaging	Het
Cap2	G	C	13: 46,638,022		probably null	Het
Ccni	A	G	5: 93,202,327	V31A	probably benign	Het
Clns1a	T	A	7: 97,714,032	Y204N	possibly damaging	Het
Cox11	C	T	11: 90,644,500	T259I	probably damaging	Het
D430042O09Rik	T	C	7: 125,795,385	V211A	probably benign	Het
Dsp	A	G	13: 38,187,893	N940S	probably benign	Het
Erbb2	T	C	11: 98,436,439	V1181A	probably benign	Het
Exoc4	T	C	6: 33,862,087	V686A	possibly damaging	Het
F830045P16Rik	A	G	2: 129,463,464	V330A	possibly damaging	Het
Fam71a	T	C	1: 191,162,908	S513G	probably benign	Het
Fbf1	A	C	11: 116,155,034	F245V	probably damaging	Het
Fut10	T	A	8: 31,236,197	F327I	probably damaging	Het
Galnt1	C	T	18: 24,254,633	P144S	probably damaging	Het
Ghrhr	A	T	6: 55,379,186	D88V	possibly damaging	Het
Hist1h1c	T	C	13: 23,739,123	I92T	probably benign	Het
Hps1	T	C	19: 42,762,553	E336G	probably damaging	Het
Irgc1	C	A	7: 24,433,328	E21D	possibly damaging	Het
Itsn1	A	T	16: 91,828,280	R590*	probably null	Het
Lmln	T	C	16: 33,066,324	V67A	probably damaging	Het
Lsm14a	T	C	7: 34,365,617	Q179R	probably damaging	Het
Ltbr	A	C	6: 125,312,873	D119E	probably benign	Het
Mrc1	A	G	2: 14,279,894	T565A	possibly damaging	Het
Muc6	A	C	7: 141,649,674	N473K	possibly damaging	Het
Myocd	A	T	11: 65,187,240	D448E	probably benign	Het
Neil2	T	A	14: 63,183,526	I239F	probably damaging	Het
Npnt	A	G	3: 132,914,414	F123S	possibly damaging	Het
Olfr1164	T	A	2: 88,093,022	R305*	probably null	Het
Olfr117	T	A	17: 37,660,106	I76F	probably damaging	Het
Olfr1309	T	C	2: 111,983,300	Y258C	probably damaging	Het
Olfr1501	C	T	19: 13,838,538	V212M	possibly damaging	Het
Olfr683	T	C	7: 105,144,074	D73G	probably damaging	Het
Olfr686	C	A	7: 105,203,614	C243F	probably damaging	Het
Olfr933	A	C	9: 38,976,251		probably null	Het
Pcnx3	T	C	19: 5,672,618	T941A	probably benign	Het
Pitrm1	C	A	13: 6,575,079	Y864*	probably null	Het
Plcb4	T	C	2: 135,982,075	I844T	probably benign	Het
Ppp1r3b	T	A	8: 35,384,501	F165I	probably damaging	Het
Prr5	T	A	15: 84,703,121	F357L	probably damaging	Het
Rbm15b	T	C	9: 106,885,364	Y535C	probably damaging	Het
Rbp3	A	T	14: 33,955,901	E602V	probably damaging	Het
Rimklb	T	C	6: 122,456,333	N343S	probably benign	Het
Rrp12	A	G	19: 41,871,760	L1008P	probably damaging	Het
Sec63	C	T	10: 42,798,798	R226C	probably damaging	Het
Sirpa	T	C	2: 129,615,468	V154A	probably damaging	Het
Slc22a23	G	A	13: 34,183,261	T588I	probably damaging	Het
Slc22a27	C	A	19: 7,926,791		probably benign	Het
Slc4a4	A	C	5: 89,156,336	H502P	possibly damaging	Het
Slc5a5	A	T	8: 70,889,633	M258K	probably damaging	Het
Spry4	A	G	18: 38,590,089	I207T	possibly damaging	Het
Stk11ip	A	G	1: 75,529,067	D460G	possibly damaging	Het
Syn3	T	A	10: 86,448,886	I117F	possibly damaging	Het
Tead4	C	T	6: 128,243,402	A224T	probably damaging	Het
Tmtc3	A	T	10: 100,450,322	N546K	probably benign	Het
Tnn	T	A	1: 160,088,466	H1227L	probably damaging	Het
Tor2a	G	A	2: 32,758,704	G62D	probably damaging	Het
Trf	T	C	9: 103,226,879		probably null	Het
Ubr5	T	C	15: 37,968,493	T2727A	probably damaging	Het
Vmn2r27	T	A	6: 124,231,619	T56S	probably benign	Het
Wipf3	T	G	6: 54,496,501	L458R	probably damaging	Het
Zfp236	T	C	18: 82,629,994	K966R	probably damaging	Het
Zfp27	T	A	7: 29,894,107	H811L	possibly damaging	Het
Zfp366	A	G	13: 99,234,260	H496R	probably damaging	Het
Zfp467	A	T	6: 48,438,755	V321E	probably damaging	Het

Other mutations in Greb1l

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00485:Greb1l	APN	18	10555962	missense	possibly damaging	0.90
IGL01554:Greb1l	APN	18	10522144	missense	probably benign	0.01
IGL01563:Greb1l	APN	18	10469399	missense	probably damaging	0.99
IGL01944:Greb1l	APN	18	10557280	missense	possibly damaging	0.91
IGL02110:Greb1l	APN	18	10515271	missense	probably damaging	1.00
IGL02249:Greb1l	APN	18	10532961	missense	probably damaging	1.00
IGL02318:Greb1l	APN	18	10469388	missense	possibly damaging	0.91
IGL02340:Greb1l	APN	18	10515200	missense	probably damaging	0.99
IGL02516:Greb1l	APN	18	10537064	missense	probably benign	0.31
IGL02566:Greb1l	APN	18	10503299	missense	probably damaging	0.99
IGL02583:Greb1l	APN	18	10542362	missense	probably damaging	1.00
IGL02838:Greb1l	APN	18	10560430	missense	probably damaging	1.00
A4554:Greb1l	UTSW	18	10532862	missense	possibly damaging	0.58
PIT4453001:Greb1l	UTSW	18	10533031	missense	probably damaging	0.98
PIT4453001:Greb1l	UTSW	18	10533032	missense	probably benign	0.08
R0099:Greb1l	UTSW	18	10509158	missense	probably damaging	1.00
R0226:Greb1l	UTSW	18	10522076	intron	probably benign
R0234:Greb1l	UTSW	18	10560331	missense	probably damaging	1.00
R0239:Greb1l	UTSW	18	10458567	splice site	probably benign
R0316:Greb1l	UTSW	18	10547420	missense	probably damaging	1.00
R0369:Greb1l	UTSW	18	10469375	missense	possibly damaging	0.80
R0394:Greb1l	UTSW	18	10523374	missense	probably damaging	0.99
R0478:Greb1l	UTSW	18	10509281	missense	probably damaging	1.00
R0555:Greb1l	UTSW	18	10458781	splice site	probably benign
R0671:Greb1l	UTSW	18	10474303	missense	probably damaging	1.00
R1282:Greb1l	UTSW	18	10547289	missense	probably benign	0.13
R1574:Greb1l	UTSW	18	10554997	missense	possibly damaging	0.95
R1574:Greb1l	UTSW	18	10554997	missense	possibly damaging	0.95
R1607:Greb1l	UTSW	18	10529703	missense	possibly damaging	0.85
R1666:Greb1l	UTSW	18	10501080	critical splice donor site	probably null
R1666:Greb1l	UTSW	18	10529708	critical splice donor site	probably null
R1720:Greb1l	UTSW	18	10553848	missense	probably benign	0.19
R1808:Greb1l	UTSW	18	10542143	missense	probably benign
R1829:Greb1l	UTSW	18	10509314	missense	probably damaging	1.00
R1897:Greb1l	UTSW	18	10498992	missense	probably benign	0.00
R1967:Greb1l	UTSW	18	10501049	missense	possibly damaging	0.91
R2025:Greb1l	UTSW	18	10515221	missense	possibly damaging	0.71
R2086:Greb1l	UTSW	18	10523281	missense	probably damaging	1.00
R2125:Greb1l	UTSW	18	10511422	missense	probably damaging	0.98
R2139:Greb1l	UTSW	18	10555011	missense	probably damaging	1.00
R2255:Greb1l	UTSW	18	10554857	missense	probably damaging	1.00
R2256:Greb1l	UTSW	18	10503307	missense	possibly damaging	0.91
R2257:Greb1l	UTSW	18	10503307	missense	possibly damaging	0.91
R2880:Greb1l	UTSW	18	10547288	missense	possibly damaging	0.93
R3623:Greb1l	UTSW	18	10542380	missense	probably damaging	0.99
R3778:Greb1l	UTSW	18	10469444	missense	possibly damaging	0.60
R3975:Greb1l	UTSW	18	10522247	missense	possibly damaging	0.71
R4038:Greb1l	UTSW	18	10515209	missense	possibly damaging	0.93
R4062:Greb1l	UTSW	18	10522150	missense	probably damaging	0.99
R4134:Greb1l	UTSW	18	10529708	critical splice donor site	probably null
R4342:Greb1l	UTSW	18	10544561	missense	probably benign	0.12
R4409:Greb1l	UTSW	18	10503182	missense	possibly damaging	0.70
R4600:Greb1l	UTSW	18	10553705	missense	probably damaging	1.00
R4618:Greb1l	UTSW	18	10498965	missense	probably benign	0.00
R4683:Greb1l	UTSW	18	10529563	splice site	probably null
R4686:Greb1l	UTSW	18	10522112	missense	probably damaging	0.98
R4707:Greb1l	UTSW	18	10532922	missense	probably benign	0.02
R4780:Greb1l	UTSW	18	10541792	missense	probably benign	0.00
R4819:Greb1l	UTSW	18	10458358	missense	probably damaging	1.00
R4925:Greb1l	UTSW	18	10547447	missense	possibly damaging	0.79
R4960:Greb1l	UTSW	18	10547306	missense	probably damaging	0.99
R5150:Greb1l	UTSW	18	10555950	frame shift	probably null
R5154:Greb1l	UTSW	18	10458312	missense	probably benign	0.02
R5269:Greb1l	UTSW	18	10511409	missense	probably benign
R5290:Greb1l	UTSW	18	10542427	missense	probably damaging	1.00
R5310:Greb1l	UTSW	18	10542427	missense	probably damaging	1.00
R5328:Greb1l	UTSW	18	10553720	missense	probably damaging	1.00
R5337:Greb1l	UTSW	18	10509143	missense	probably damaging	1.00
R5393:Greb1l	UTSW	18	10458312	missense	probably benign	0.02
R5402:Greb1l	UTSW	18	10537169	missense	probably benign	0.26
R5718:Greb1l	UTSW	18	10542427	missense	probably damaging	1.00
R5719:Greb1l	UTSW	18	10542427	missense	probably damaging	1.00
R5720:Greb1l	UTSW	18	10542427	missense	probably damaging	1.00
R5721:Greb1l	UTSW	18	10542427	missense	probably damaging	1.00
R5902:Greb1l	UTSW	18	10538302	missense	probably benign	0.00
R5993:Greb1l	UTSW	18	10544455	missense	probably benign	0.10
R6035:Greb1l	UTSW	18	10501025	missense	possibly damaging	0.91
R6035:Greb1l	UTSW	18	10501025	missense	possibly damaging	0.91
R6045:Greb1l	UTSW	18	10547068	missense	probably damaging	1.00
R6063:Greb1l	UTSW	18	10557340	missense	probably damaging	1.00
R6297:Greb1l	UTSW	18	10469494	missense	probably damaging	1.00
R6405:Greb1l	UTSW	18	10501076	missense	probably benign	0.30
R6552:Greb1l	UTSW	18	10541814	missense	probably benign	0.00
R6572:Greb1l	UTSW	18	10522131	missense	probably benign	0.07
R6575:Greb1l	UTSW	18	10547347	missense	possibly damaging	0.88
R6922:Greb1l	UTSW	18	10547482	missense	possibly damaging	0.88
R6957:Greb1l	UTSW	18	10558786	missense	probably benign	0.23
R6962:Greb1l	UTSW	18	10547327	missense	probably damaging	1.00
R7012:Greb1l	UTSW	18	10529707	critical splice donor site	probably null
R7179:Greb1l	UTSW	18	10544576	missense	probably benign	0.00
R7251:Greb1l	UTSW	18	10515319	missense	probably damaging	1.00
R7275:Greb1l	UTSW	18	10544561	missense	probably benign	0.12
R7301:Greb1l	UTSW	18	10544970	missense	probably damaging	1.00
R7307:Greb1l	UTSW	18	10538142	missense	probably damaging	0.99
R7455:Greb1l	UTSW	18	10554915	missense	probably damaging	1.00
R7832:Greb1l	UTSW	18	10542056	missense	probably benign	0.38
R7934:Greb1l	UTSW	18	10474371	nonsense	probably null
R8137:Greb1l	UTSW	18	10474357	missense	possibly damaging	0.77
R8138:Greb1l	UTSW	18	10533060	missense	probably benign	0.13
R8208:Greb1l	UTSW	18	10510703	missense	probably damaging	1.00
R8227:Greb1l	UTSW	18	10515371	missense	probably damaging	1.00
R8312:Greb1l	UTSW	18	10511587	intron	probably benign
R8331:Greb1l	UTSW	18	10458706	missense	possibly damaging	0.96
R8364:Greb1l	UTSW	18	10529687	missense	possibly damaging	0.85
R8389:Greb1l	UTSW	18	10529613	missense	probably benign	0.00
R8695:Greb1l	UTSW	18	10544450	missense	probably benign	0.01
R8795:Greb1l	UTSW	18	10553739	missense	probably damaging	0.98
R8836:Greb1l	UTSW	18	10509257	missense	probably benign	0.30
R8862:Greb1l	UTSW	18	10555042	missense	possibly damaging	0.90
R8872:Greb1l	UTSW	18	10529684	missense	probably benign	0.18
R8874:Greb1l	UTSW	18	10544896	missense	probably benign	0.01
R8886:Greb1l	UTSW	18	10553843	missense	probably benign	0.21
R8921:Greb1l	UTSW	18	10541825	missense	probably benign	0.01
R8997:Greb1l	UTSW	18	10510747	missense	probably damaging	1.00
R9015:Greb1l	UTSW	18	10541675	missense	probably benign	0.00
R9018:Greb1l	UTSW	18	10542004	missense	possibly damaging	0.76
R9074:Greb1l	UTSW	18	10532797	missense	probably damaging	1.00
R9074:Greb1l	UTSW	18	10558795	missense	probably damaging	1.00
R9117:Greb1l	UTSW	18	10542422	missense	probably benign	0.31
R9189:Greb1l	UTSW	18	10499983	missense	probably benign
R9332:Greb1l	UTSW	18	10532796	missense	possibly damaging	0.92
R9367:Greb1l	UTSW	18	10522130	missense	probably benign	0.00
R9497:Greb1l	UTSW	18	10458600	missense	probably benign	0.00
R9796:Greb1l	UTSW	18	10538233	missense	possibly damaging	0.69
Z1176:Greb1l	UTSW	18	10515305	missense	probably damaging	1.00

Predicted Primers

Posted On

2013-08-19