Incidental Mutation 'R8529:Fam149b'
ID 660805
Institutional Source Beutler Lab
Gene Symbol Fam149b
Ensembl Gene ENSMUSG00000039599
Gene Name family with sequence similarity 149, member B
Synonyms
MMRRC Submission 068499-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.287) question?
Stock # R8529 (G1)
Quality Score 130.008
Status Validated
Chromosome 14
Chromosomal Location 20398230-20433559 bp(+) (GRCm39)
Type of Mutation splice site (5465 bp from exon)
DNA Base Change (assembly) T to A at 20408370 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change
Ref Sequence ENSEMBL: ENSMUSP00000153332 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000037698] [ENSMUST00000051915] [ENSMUST00000090499] [ENSMUST00000090503] [ENSMUST00000224721] [ENSMUST00000224930] [ENSMUST00000225597] [ENSMUST00000225834] [ENSMUST00000225942] [ENSMUST00000225991]
AlphaFold Q6NSV7
Predicted Effect probably null
Transcript: ENSMUST00000037698
SMART Domains Protein: ENSMUSP00000045247
Gene: ENSMUSG00000039599

DomainStartEndE-ValueType
Pfam:DUF3719 116 183 2.1e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000051915
SMART Domains Protein: ENSMUSP00000056907
Gene: ENSMUSG00000039599

DomainStartEndE-ValueType
Pfam:DUF3719 116 183 2.2e-25 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000090499
SMART Domains Protein: ENSMUSP00000087985
Gene: ENSMUSG00000039599

DomainStartEndE-ValueType
Pfam:DUF3719 116 181 1.5e-28 PFAM
low complexity region 369 383 N/A INTRINSIC
low complexity region 404 415 N/A INTRINSIC
Predicted Effect probably null
Transcript: ENSMUST00000090503
SMART Domains Protein: ENSMUSP00000087989
Gene: ENSMUSG00000039599

DomainStartEndE-ValueType
Pfam:DUF3719 116 157 5.7e-14 PFAM
low complexity region 276 290 N/A INTRINSIC
low complexity region 311 322 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000224721
Predicted Effect probably benign
Transcript: ENSMUST00000224930
Predicted Effect probably benign
Transcript: ENSMUST00000225597
Predicted Effect probably benign
Transcript: ENSMUST00000225834
Predicted Effect probably benign
Transcript: ENSMUST00000225942
Predicted Effect probably null
Transcript: ENSMUST00000225991
Meta Mutation Damage Score 0.9756 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 98% (52/53)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Acbd5 A G 2: 22,970,704 (GRCm39) Y173C probably benign Het
Ankrd55 A T 13: 112,480,670 (GRCm39) T192S probably benign Het
Apob A T 12: 8,057,353 (GRCm39) H1912L probably damaging Het
Bcl2l11 T C 2: 127,970,796 (GRCm39) S82P possibly damaging Het
Bsn G A 9: 107,988,651 (GRCm39) A2367V probably benign Het
Btnl10 A T 11: 58,813,238 (GRCm39) D289V probably benign Het
Calcoco2 GGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC GGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTCCTCCCAGGAGGCCTTCTCTTTCTCCCAGGAGGCCTTCTCTTCC 11: 95,990,808 (GRCm39) probably benign Het
Cdh11 G A 8: 103,391,387 (GRCm39) P283L probably benign Het
Crybg3 C A 16: 59,376,984 (GRCm39) K1423N probably damaging Het
Dgat1 T A 15: 76,387,237 (GRCm39) Y350F probably damaging Het
Dhx36 TCCGCCGCCGCCGCCGC TCCGCCGCCGCCGC 3: 62,414,277 (GRCm39) probably benign Het
Edc4 A G 8: 106,611,682 (GRCm39) D86G probably damaging Het
Ep400 T C 5: 110,867,102 (GRCm39) Y1014C unknown Het
Erbb3 A G 10: 128,419,069 (GRCm39) V264A probably damaging Het
Foxc1 A G 13: 31,992,520 (GRCm39) S444G unknown Het
Gm2042 G A 12: 87,926,856 (GRCm39) S391N possibly damaging Het
Gnb3 A T 6: 124,814,633 (GRCm39) N88K probably benign Het
Ifnar2 T A 16: 91,188,684 (GRCm39) V157D possibly damaging Het
Il27 A T 7: 126,191,977 (GRCm39) L53Q probably damaging Het
Ints13 T C 6: 146,464,926 (GRCm39) E225G probably damaging Het
Itpr2 G A 6: 146,231,051 (GRCm39) R1167C probably damaging Het
Lrp2 A T 2: 69,330,986 (GRCm39) I1690K probably damaging Het
Lrrc37a T C 11: 103,348,373 (GRCm39) E2774G unknown Het
Lyz2 A T 10: 117,116,568 (GRCm39) N93K probably damaging Het
Mki67 A G 7: 135,315,688 (GRCm39) probably null Het
Mroh1 T C 15: 76,311,832 (GRCm39) F522L probably benign Het
Myo5a A G 9: 75,120,154 (GRCm39) I1626V probably benign Het
Nav3 A T 10: 109,689,192 (GRCm39) S362T probably benign Het
Neurl4 C T 11: 69,799,613 (GRCm39) P972L probably damaging Het
Or11i1 A T 3: 106,729,109 (GRCm39) Y255* probably null Het
Or13p8 A T 4: 118,583,770 (GRCm39) T109S probably benign Het
Or8a1 A T 9: 37,642,252 (GRCm39) V9E probably damaging Het
Potefam3b A G 8: 21,159,174 (GRCm39) D176G possibly damaging Het
Prdm5 C T 6: 65,878,829 (GRCm39) R128C probably damaging Het
Prom1 A T 5: 44,170,369 (GRCm39) probably null Het
Prrc2c T A 1: 162,536,663 (GRCm39) probably benign Het
Prss3b T A 6: 41,009,369 (GRCm39) Y155F probably benign Het
Ptprd T C 4: 76,047,262 (GRCm39) T322A probably damaging Het
Reg3d C G 6: 78,353,382 (GRCm39) G154R probably null Het
Rsf1 A G 7: 97,320,074 (GRCm39) probably benign Het
Ryr1 T A 7: 28,769,509 (GRCm39) T2724S possibly damaging Het
Sec63 A G 10: 42,665,379 (GRCm39) Y103C probably damaging Het
Serpinb9b A T 13: 33,223,543 (GRCm39) D245V probably benign Het
Slc22a28 G A 19: 8,040,778 (GRCm39) T491I probably benign Het
Slc24a2 T C 4: 86,946,517 (GRCm39) N484S possibly damaging Het
Slc44a3 G T 3: 121,319,334 (GRCm39) L136I probably benign Het
Tff3 A G 17: 31,348,460 (GRCm39) probably null Het
Tpp2 T A 1: 44,022,300 (GRCm39) D899E probably benign Het
Tsbp1 G T 17: 34,679,143 (GRCm39) C302F possibly damaging Het
Tsen54 G T 11: 115,711,386 (GRCm39) D268Y possibly damaging Het
Ttbk2 A C 2: 120,604,338 (GRCm39) V220G possibly damaging Het
Uggt1 A G 1: 36,223,513 (GRCm39) V592A possibly damaging Het
Usp49 A T 17: 47,983,037 (GRCm39) Q14L probably damaging Het
Vldlr T A 19: 27,207,656 (GRCm39) L48Q probably benign Het
Zbed6 T C 1: 133,584,706 (GRCm39) Y877C probably benign Het
Zp3 C A 5: 136,016,119 (GRCm39) T282N probably damaging Het
Other mutations in Fam149b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01153:Fam149b APN 14 20,427,949 (GRCm39) missense possibly damaging 0.78
IGL02323:Fam149b APN 14 20,413,369 (GRCm39) missense possibly damaging 0.94
IGL02631:Fam149b APN 14 20,425,614 (GRCm39) missense probably damaging 0.97
IGL03208:Fam149b APN 14 20,401,370 (GRCm39) splice site probably benign
R0334:Fam149b UTSW 14 20,413,492 (GRCm39) missense probably damaging 0.97
R2511:Fam149b UTSW 14 20,428,524 (GRCm39) missense probably damaging 1.00
R2566:Fam149b UTSW 14 20,425,578 (GRCm39) missense probably damaging 0.97
R4659:Fam149b UTSW 14 20,417,941 (GRCm39) missense probably benign 0.16
R5011:Fam149b UTSW 14 20,413,439 (GRCm39) missense possibly damaging 0.92
R5013:Fam149b UTSW 14 20,413,439 (GRCm39) missense possibly damaging 0.92
R5583:Fam149b UTSW 14 20,413,368 (GRCm39) missense possibly damaging 0.66
R5791:Fam149b UTSW 14 20,401,394 (GRCm39) missense probably damaging 0.96
R5905:Fam149b UTSW 14 20,409,978 (GRCm39) missense probably benign 0.30
R6035:Fam149b UTSW 14 20,427,985 (GRCm39) missense probably damaging 1.00
R6035:Fam149b UTSW 14 20,427,985 (GRCm39) missense probably damaging 1.00
R7180:Fam149b UTSW 14 20,431,853 (GRCm39) missense probably benign 0.01
R7210:Fam149b UTSW 14 20,428,540 (GRCm39) missense probably damaging 0.99
R7976:Fam149b UTSW 14 20,427,852 (GRCm39) missense probably damaging 0.98
R8971:Fam149b UTSW 14 20,402,777 (GRCm39) missense probably benign 0.30
R9743:Fam149b UTSW 14 20,413,411 (GRCm39) missense probably benign 0.05
Predicted Primers PCR Primer
(F):5'- CACATGAAGCAACCTTGTCTCAAG -3'
(R):5'- AGGGCCAGCTGCTGTAATAG -3'

Sequencing Primer
(F):5'- CTTGTCTCAAGAAAGAGAGTCTACC -3'
(R):5'- CCAGCTGCTGTAATAGAGCTG -3'
Posted On 2021-03-03