Incidental Mutation 'R8558:Ces2f'
ID 660855
Institutional Source Beutler Lab
Gene Symbol Ces2f
Ensembl Gene ENSMUSG00000062826
Gene Name carboxylesterase 2F
Synonyms 2310038E17Rik
MMRRC Submission 068521-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8558 (G1)
Quality Score 225.009
Status Not validated
Chromosome 8
Chromosomal Location 105673988-105686679 bp(+) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) T to A at 105679758 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Leucine to Stop codon at position 417 (L417*)
Ref Sequence ENSEMBL: ENSMUSP00000075722 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000076384] [ENSMUST00000212820] [ENSMUST00000212926]
AlphaFold Q08ED5
Predicted Effect probably null
Transcript: ENSMUST00000076384
AA Change: L417*
SMART Domains Protein: ENSMUSP00000075722
Gene: ENSMUSG00000062826
AA Change: L417*

DomainStartEndE-ValueType
Pfam:COesterase 12 540 2.7e-167 PFAM
Pfam:Abhydrolase_3 145 261 1.2e-8 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000212820
AA Change: L417*
Predicted Effect probably null
Transcript: ENSMUST00000212926
AA Change: L286*
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 98.5%
Validation Efficiency
MGI Phenotype PHENOTYPE: Mice homozygous for an ENU-induced mutation exhibit epidermal and follicular hyperkeratosis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 76 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700017N19Rik A T 10: 100,430,497 (GRCm39) R51S probably benign Het
1700067P10Rik G T 17: 48,400,849 (GRCm39) E45* probably null Het
Abcb5 T C 12: 118,841,566 (GRCm39) T960A probably benign Het
Abcc3 A G 11: 94,242,623 (GRCm39) probably null Het
Adamtsl3 A T 7: 82,077,600 (GRCm39) D95V possibly damaging Het
Ash1l T A 3: 88,891,713 (GRCm39) S1197R probably damaging Het
BC034090 T A 1: 155,097,085 (GRCm39) H671L possibly damaging Het
Bltp1 T A 3: 37,102,750 (GRCm39) M1443K Het
Btnl9 T C 11: 49,071,619 (GRCm39) E68G probably benign Het
C1qtnf1 A T 11: 118,339,149 (GRCm39) Y273F probably damaging Het
C4b A T 17: 34,955,541 (GRCm39) C714S probably damaging Het
Carmil1 G A 13: 24,209,863 (GRCm39) T1204I probably benign Het
Cdk12 T C 11: 98,101,915 (GRCm39) L591P unknown Het
Chl1 T A 6: 103,685,390 (GRCm39) S810R probably benign Het
Ckap2 A G 8: 22,658,811 (GRCm39) V644A possibly damaging Het
Ctdsp2 T A 10: 126,829,746 (GRCm39) V126E probably damaging Het
Dok6 G T 18: 89,492,066 (GRCm39) H170Q probably damaging Het
Dynlrb1 T C 2: 155,084,728 (GRCm39) probably null Het
Eif5b T C 1: 38,083,795 (GRCm39) L757S probably damaging Het
Epas1 A C 17: 87,116,896 (GRCm39) T189P possibly damaging Het
Epha10 C A 4: 124,788,777 (GRCm39) N283K Het
Epha5 C A 5: 84,206,975 (GRCm39) G853C probably damaging Het
Gapvd1 A T 2: 34,594,493 (GRCm39) H831Q probably damaging Het
Gcnt3 T A 9: 69,941,996 (GRCm39) K191* probably null Het
Gm14226 T A 2: 154,866,909 (GRCm39) S289T probably benign Het
Gm4846 T A 1: 166,314,674 (GRCm39) D323V probably damaging Het
Golga3 G T 5: 110,356,421 (GRCm39) R1036L possibly damaging Het
Gopc T C 10: 52,229,580 (GRCm39) Q213R probably damaging Het
Hrh1 G A 6: 114,457,564 (GRCm39) V282M probably benign Het
Ighv5-4 T C 12: 113,561,078 (GRCm39) Y114C probably damaging Het
Igkv10-94 A T 6: 68,681,636 (GRCm39) I68N probably damaging Het
Kcnj3 A G 2: 55,336,875 (GRCm39) D247G possibly damaging Het
Lcn6 C A 2: 25,570,718 (GRCm39) S102Y probably damaging Het
Matk C A 10: 81,096,765 (GRCm39) H232N probably benign Het
Mcm9 C T 10: 53,492,068 (GRCm39) V366I probably benign Het
Nadk A G 4: 155,669,844 (GRCm39) I176V probably benign Het
Nlrp12 A G 7: 3,298,111 (GRCm39) L20P probably damaging Het
Oga T C 19: 45,746,511 (GRCm39) S763G probably benign Het
Or10ag56 A T 2: 87,139,583 (GRCm39) Q170L probably benign Het
Or1e21 G A 11: 73,344,309 (GRCm39) S243F probably damaging Het
Or4a72 A G 2: 89,405,329 (GRCm39) L247P probably damaging Het
Pcdhgb6 T A 18: 37,877,237 (GRCm39) D648E probably damaging Het
Pkd1l3 A T 8: 110,362,012 (GRCm39) N1018I probably damaging Het
Plch2 T C 4: 155,083,391 (GRCm39) K516E probably damaging Het
Pmpca G C 2: 26,285,046 (GRCm39) E424Q possibly damaging Het
Pnma2 C T 14: 67,153,972 (GRCm39) A132V probably benign Het
Prkn T C 17: 11,456,472 (GRCm39) S99P probably benign Het
Prune2 A G 19: 17,099,602 (GRCm39) E1702G probably damaging Het
Qars1 T A 9: 108,392,422 (GRCm39) H756Q probably benign Het
Rab5a A G 17: 53,790,877 (GRCm39) probably benign Het
Rars2 A G 4: 34,657,199 (GRCm39) D515G probably damaging Het
Rpe65 T A 3: 159,320,429 (GRCm39) C329S probably damaging Het
Rps6ka2 G A 17: 7,523,316 (GRCm39) V231M possibly damaging Het
Rsf1 GCG GCGACGGCGCCG 7: 97,229,114 (GRCm39) probably benign Het
Scrt1 G T 15: 76,403,843 (GRCm39) S49* probably null Het
Sec23b C G 2: 144,428,308 (GRCm39) D640E possibly damaging Het
Setdb1 C T 3: 95,261,979 (GRCm39) V96M possibly damaging Het
Sik3 C A 9: 46,066,746 (GRCm39) A175E probably damaging Het
Smarcad1 A G 6: 65,060,908 (GRCm39) K463E probably benign Het
Sobp A C 10: 43,003,888 (GRCm39) C154G probably damaging Het
Sox6 A G 7: 115,141,033 (GRCm39) S482P probably benign Het
Spen C T 4: 141,197,681 (GRCm39) A3396T probably benign Het
Spink11 T A 18: 44,324,748 (GRCm39) R75* probably null Het
Sptb T C 12: 76,659,561 (GRCm39) H1113R probably benign Het
Sypl2 A T 3: 108,125,004 (GRCm39) V119E probably damaging Het
Tbc1d24 T C 17: 24,427,903 (GRCm39) S20G unknown Het
Tektl1 T C 10: 78,583,035 (GRCm39) K450E probably damaging Het
Top2a A T 11: 98,912,549 (GRCm39) V106D probably damaging Het
Tspyl4 G C 10: 34,174,261 (GRCm39) R251P probably damaging Het
Ttc21a T A 9: 119,787,835 (GRCm39) L801Q probably damaging Het
Vgll3 A G 16: 65,624,844 (GRCm39) E64G probably damaging Het
Vmn2r30 A G 7: 7,315,655 (GRCm39) I726T possibly damaging Het
Vmn2r81 T C 10: 79,106,467 (GRCm39) S482P possibly damaging Het
Wasf1 T G 10: 40,806,648 (GRCm39) M97R possibly damaging Het
Wdr33 T A 18: 31,962,947 (GRCm39) M98K probably benign Het
Wdr73 G A 7: 80,548,254 (GRCm39) T95I probably damaging Het
Other mutations in Ces2f
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00160:Ces2f APN 8 105,676,604 (GRCm39) missense probably damaging 1.00
IGL00160:Ces2f APN 8 105,676,605 (GRCm39) missense probably damaging 1.00
IGL01680:Ces2f APN 8 105,680,705 (GRCm39) missense probably benign 0.10
IGL01683:Ces2f APN 8 105,679,733 (GRCm39) missense probably benign 0.39
IGL02685:Ces2f APN 8 105,679,730 (GRCm39) nonsense probably null
R0545:Ces2f UTSW 8 105,676,668 (GRCm39) missense possibly damaging 0.66
R0707:Ces2f UTSW 8 105,677,618 (GRCm39) missense possibly damaging 0.88
R1170:Ces2f UTSW 8 105,680,178 (GRCm39) missense probably damaging 0.99
R1476:Ces2f UTSW 8 105,679,134 (GRCm39) missense possibly damaging 0.60
R4105:Ces2f UTSW 8 105,677,824 (GRCm39) splice site probably null
R4394:Ces2f UTSW 8 105,677,586 (GRCm39) missense probably damaging 1.00
R4436:Ces2f UTSW 8 105,679,788 (GRCm39) missense probably benign 0.00
R4601:Ces2f UTSW 8 105,676,596 (GRCm39) missense probably damaging 1.00
R4986:Ces2f UTSW 8 105,678,657 (GRCm39) missense probably benign 0.39
R5502:Ces2f UTSW 8 105,679,155 (GRCm39) missense possibly damaging 0.60
R6610:Ces2f UTSW 8 105,676,738 (GRCm39) critical splice donor site probably null
R7078:Ces2f UTSW 8 105,681,284 (GRCm39) missense probably damaging 0.98
R7357:Ces2f UTSW 8 105,676,595 (GRCm39) missense probably benign 0.03
R7480:Ces2f UTSW 8 105,681,338 (GRCm39) missense possibly damaging 0.49
R7497:Ces2f UTSW 8 105,681,330 (GRCm39) missense probably benign 0.00
R8403:Ces2f UTSW 8 105,674,808 (GRCm39) missense possibly damaging 0.95
R8826:Ces2f UTSW 8 105,679,734 (GRCm39) missense probably benign 0.39
R8869:Ces2f UTSW 8 105,676,704 (GRCm39) missense probably damaging 1.00
R8937:Ces2f UTSW 8 105,677,669 (GRCm39) missense probably damaging 1.00
R8982:Ces2f UTSW 8 105,679,667 (GRCm39) missense probably benign 0.04
R9000:Ces2f UTSW 8 105,677,661 (GRCm39) missense probably benign 0.01
R9057:Ces2f UTSW 8 105,674,744 (GRCm39) missense probably benign 0.21
R9505:Ces2f UTSW 8 105,676,669 (GRCm39) missense probably benign 0.10
R9723:Ces2f UTSW 8 105,677,463 (GRCm39) missense possibly damaging 0.89
R9765:Ces2f UTSW 8 105,676,678 (GRCm39) missense probably damaging 1.00
Z1177:Ces2f UTSW 8 105,674,867 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AGACCTCAATGGCATTCCC -3'
(R):5'- ACAGATACCACTCAGCTGTTTCC -3'

Sequencing Primer
(F):5'- CCCACCCTAAGGATGTCGC -3'
(R):5'- CCTCATCTGTACACAAATAAGATGTC -3'
Posted On 2021-03-08