Incidental Mutation 'R8669:Krt87'
ID 661074
Institutional Source Beutler Lab
Gene Symbol Krt87
Ensembl Gene ENSMUSG00000047641
Gene Name keratin 87
Synonyms Krt2-25, Krt83
MMRRC Submission 068524-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.065) question?
Stock # R8669 (G1)
Quality Score 225.009
Status Validated
Chromosome 15
Chromosomal Location 101329371-101336685 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to A at 101385777 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Leucine at position 273 (V273L)
Ref Sequence ENSEMBL: ENSMUSP00000023718 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000023718]
AlphaFold Q6IMF0
Predicted Effect probably benign
Transcript: ENSMUST00000023718
AA Change: V273L

PolyPhen 2 Score 0.002 (Sensitivity: 0.99; Specificity: 0.30)
SMART Domains Protein: ENSMUSP00000023718
Gene: ENSMUSG00000067613
AA Change: V273L

DomainStartEndE-ValueType
Pfam:Keratin_2_head 2 100 5.9e-16 PFAM
Filament 103 414 7.02e-149 SMART
low complexity region 422 436 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 98% (53/54)
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
4930447C04Rik A T 12: 72,949,234 (GRCm39) S305T probably benign Het
Ankrd42 A G 7: 92,268,881 (GRCm39) V154A possibly damaging Het
Apc2 C T 10: 80,149,491 (GRCm39) T1515I probably damaging Het
Blzf1 T A 1: 164,130,113 (GRCm39) N80Y possibly damaging Het
Cacna2d1 T C 5: 16,140,013 (GRCm39) M1T probably null Het
Ccdc125 T C 13: 100,832,683 (GRCm39) L420P probably damaging Het
Ccdc162 T C 10: 41,428,352 (GRCm39) T1976A probably benign Het
Cdc20b C T 13: 113,208,460 (GRCm39) P219S possibly damaging Het
Cep89 A G 7: 35,128,602 (GRCm39) D585G probably benign Het
Crnn A T 3: 93,056,296 (GRCm39) R361* probably null Het
Defb5 A G 8: 19,300,761 (GRCm39) I38V probably benign Het
Defb8 A G 8: 19,495,973 (GRCm39) V29A probably benign Het
Dgkh A G 14: 78,962,459 (GRCm39) V24A probably benign Het
Dhrs13 G C 11: 77,923,492 (GRCm39) R70P possibly damaging Het
Dnah12 A T 14: 26,552,582 (GRCm39) probably benign Het
Dsg2 A G 18: 20,723,132 (GRCm39) N386S probably damaging Het
Dyrk1a G T 16: 94,464,650 (GRCm39) R77L probably damaging Het
Fbxw19 G T 9: 109,313,482 (GRCm39) L239I probably benign Het
Gal3st2b A T 1: 93,868,764 (GRCm39) I332L possibly damaging Het
Gcnt1 T G 19: 17,307,143 (GRCm39) K194T probably benign Het
Gm7298 T C 6: 121,742,002 (GRCm39) W475R probably benign Het
Gpatch1 C A 7: 34,991,204 (GRCm39) W613C probably damaging Het
Gulp1 T A 1: 44,805,270 (GRCm39) S120T probably benign Het
Ift122 C A 6: 115,900,252 (GRCm39) Q946K probably damaging Het
Itpr1 T A 6: 108,370,928 (GRCm39) L1065H probably damaging Het
Kcnq5 T C 1: 21,476,050 (GRCm39) D579G probably damaging Het
Klhl40 T A 9: 121,607,088 (GRCm39) S83T probably benign Het
Krt19 T C 11: 100,031,993 (GRCm39) K320E probably damaging Het
Lgals4 C T 7: 28,540,921 (GRCm39) R282C probably damaging Het
Lrp1b A G 2: 41,172,047 (GRCm39) probably null Het
Lrrk1 G A 7: 65,912,344 (GRCm39) L1739F probably benign Het
Mthfr A G 4: 148,135,934 (GRCm39) N336D probably benign Het
Myo6 T G 9: 80,173,531 (GRCm39) L557R unknown Het
Naip2 T C 13: 100,325,477 (GRCm39) S144G probably benign Het
Nfatc1 T C 18: 80,725,406 (GRCm39) K453E probably damaging Het
Or52ab7 A T 7: 102,978,281 (GRCm39) D196V probably benign Het
Osm A T 11: 4,189,665 (GRCm39) I150L probably benign Het
Phtf1 T A 3: 103,910,792 (GRCm39) N639K probably benign Het
Prpf40b T A 15: 99,201,228 (GRCm39) M1K probably null Het
Rhbdl3 G A 11: 80,244,339 (GRCm39) V349M probably damaging Het
Senp7 T C 16: 55,986,315 (GRCm39) S582P probably damaging Het
Slc16a14 A G 1: 84,900,605 (GRCm39) S127P probably benign Het
Slc22a21 C T 11: 53,870,643 (GRCm39) W14* probably null Het
Slc6a18 T A 13: 73,812,430 (GRCm39) E553D probably benign Het
Speer4a1 T G 5: 26,243,236 (GRCm39) N83T probably damaging Het
Svep1 T A 4: 58,070,119 (GRCm39) S2556C possibly damaging Het
Tc2n T C 12: 101,660,851 (GRCm39) N127S probably damaging Het
Tcstv7b C A 13: 120,702,338 (GRCm39) P45T probably benign Het
Tenm4 C T 7: 96,555,148 (GRCm39) P2618S probably benign Het
Thra T C 11: 98,654,476 (GRCm39) V282A possibly damaging Het
Tmem161b A T 13: 84,420,288 (GRCm39) probably null Het
Tmem218 C T 9: 37,133,815 (GRCm39) A85V probably benign Het
Txnip T C 3: 96,466,252 (GRCm39) Y100H probably damaging Het
Unc5c A G 3: 141,509,704 (GRCm39) D728G possibly damaging Het
Zfp462 T A 4: 55,051,313 (GRCm39) I2262K probably damaging Het
Zfp804a A T 2: 82,088,106 (GRCm39) D645V probably damaging Het
Other mutations in Krt87
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00481:Krt87 APN 15 101,386,092 (GRCm39) missense probably benign 0.17
IGL00987:Krt87 APN 15 101,336,327 (GRCm39) missense probably benign 0.00
IGL01019:Krt87 APN 15 101,336,312 (GRCm39) missense possibly damaging 0.84
IGL01066:Krt87 APN 15 101,336,266 (GRCm39) critical splice donor site probably null
IGL01087:Krt87 APN 15 101,329,706 (GRCm39) missense probably benign 0.27
IGL01315:Krt87 APN 15 101,384,848 (GRCm39) splice site probably benign
IGL01572:Krt87 APN 15 101,334,414 (GRCm39) missense probably benign 0.33
IGL01702:Krt87 APN 15 101,389,099 (GRCm39) missense probably benign 0.18
IGL02123:Krt87 APN 15 101,385,466 (GRCm39) missense possibly damaging 0.49
IGL02353:Krt87 APN 15 101,383,339 (GRCm39) missense probably benign
IGL02360:Krt87 APN 15 101,383,339 (GRCm39) missense probably benign
IGL02395:Krt87 APN 15 101,385,833 (GRCm39) missense probably benign 0.18
IGL02633:Krt87 APN 15 101,389,095 (GRCm39) missense probably damaging 1.00
IGL02716:Krt87 APN 15 101,332,485 (GRCm39) missense possibly damaging 0.52
IGL03287:Krt87 APN 15 101,330,218 (GRCm39) splice site probably benign
R0144:Krt87 UTSW 15 101,336,542 (GRCm39) missense probably benign 0.04
R0357:Krt87 UTSW 15 101,384,900 (GRCm39) missense probably benign 0.17
R0650:Krt87 UTSW 15 101,384,921 (GRCm39) missense probably damaging 0.99
R0928:Krt87 UTSW 15 101,389,161 (GRCm39) missense probably benign 0.00
R1126:Krt87 UTSW 15 101,385,363 (GRCm39) missense probably damaging 0.98
R1196:Krt87 UTSW 15 101,389,314 (GRCm39) missense probably benign 0.03
R1252:Krt87 UTSW 15 101,385,711 (GRCm39) missense probably damaging 1.00
R1513:Krt87 UTSW 15 101,387,538 (GRCm39) missense probably benign 0.30
R1612:Krt87 UTSW 15 101,386,092 (GRCm39) missense probably benign 0.17
R1870:Krt87 UTSW 15 101,385,071 (GRCm39) missense probably benign
R2173:Krt87 UTSW 15 101,385,818 (GRCm39) missense probably damaging 0.98
R2196:Krt87 UTSW 15 101,336,314 (GRCm39) missense probably damaging 0.99
R2209:Krt87 UTSW 15 101,330,989 (GRCm39) missense probably benign 0.42
R2432:Krt87 UTSW 15 101,386,037 (GRCm39) nonsense probably null
R2568:Krt87 UTSW 15 101,385,708 (GRCm39) missense possibly damaging 0.67
R2696:Krt87 UTSW 15 101,384,890 (GRCm39) missense probably benign 0.01
R3508:Krt87 UTSW 15 101,386,039 (GRCm39) missense probably benign 0.04
R4364:Krt87 UTSW 15 101,385,395 (GRCm39) missense probably benign
R4366:Krt87 UTSW 15 101,385,395 (GRCm39) missense probably benign
R4606:Krt87 UTSW 15 101,384,930 (GRCm39) missense probably benign 0.18
R4721:Krt87 UTSW 15 101,385,863 (GRCm39) missense probably damaging 1.00
R4784:Krt87 UTSW 15 101,385,837 (GRCm39) missense probably damaging 1.00
R4987:Krt87 UTSW 15 101,384,890 (GRCm39) missense probably benign
R5008:Krt87 UTSW 15 101,389,105 (GRCm39) missense probably damaging 1.00
R5101:Krt87 UTSW 15 101,385,391 (GRCm39) missense probably benign 0.14
R5367:Krt87 UTSW 15 101,384,875 (GRCm39) missense probably damaging 1.00
R5516:Krt87 UTSW 15 101,385,002 (GRCm39) nonsense probably null
R5651:Krt87 UTSW 15 101,331,910 (GRCm39) missense possibly damaging 0.94
R5949:Krt87 UTSW 15 101,385,476 (GRCm39) missense probably damaging 0.99
R5972:Krt87 UTSW 15 101,385,467 (GRCm39) missense probably benign
R6036:Krt87 UTSW 15 101,385,412 (GRCm39) missense possibly damaging 0.78
R6036:Krt87 UTSW 15 101,385,412 (GRCm39) missense possibly damaging 0.78
R6135:Krt87 UTSW 15 101,385,415 (GRCm39) missense probably damaging 1.00
R6437:Krt87 UTSW 15 101,336,273 (GRCm39) missense possibly damaging 0.95
R6615:Krt87 UTSW 15 101,334,443 (GRCm39) missense probably benign 0.02
R6680:Krt87 UTSW 15 101,331,859 (GRCm39) missense probably damaging 1.00
R7151:Krt87 UTSW 15 101,387,529 (GRCm39) missense probably damaging 1.00
R7186:Krt87 UTSW 15 101,385,083 (GRCm39) splice site probably null
R7297:Krt87 UTSW 15 101,387,528 (GRCm39) missense probably benign 0.42
R7541:Krt87 UTSW 15 101,336,515 (GRCm39) missense probably damaging 1.00
R7617:Krt87 UTSW 15 101,336,426 (GRCm39) missense probably benign 0.38
R7708:Krt87 UTSW 15 101,385,813 (GRCm39) missense probably benign 0.00
R7796:Krt87 UTSW 15 101,383,865 (GRCm39) missense possibly damaging 0.95
R8172:Krt87 UTSW 15 101,383,284 (GRCm39) missense probably benign 0.25
R8463:Krt87 UTSW 15 101,332,506 (GRCm39) missense probably benign 0.05
R8695:Krt87 UTSW 15 101,331,901 (GRCm39) missense probably benign 0.00
R8771:Krt87 UTSW 15 101,385,779 (GRCm39) missense probably benign 0.00
R9478:Krt87 UTSW 15 101,385,449 (GRCm39) missense probably benign 0.06
R9489:Krt87 UTSW 15 101,336,484 (GRCm39) nonsense probably null
R9592:Krt87 UTSW 15 101,386,060 (GRCm39) missense probably benign
R9605:Krt87 UTSW 15 101,336,484 (GRCm39) nonsense probably null
R9629:Krt87 UTSW 15 101,389,048 (GRCm39) missense probably benign 0.01
R9642:Krt87 UTSW 15 101,385,074 (GRCm39) missense probably benign 0.00
Predicted Primers PCR Primer
(F):5'- AAGATGCACAGTGGTCAGGC -3'
(R):5'- TTCCGTGACTGTGAAGTCC -3'

Sequencing Primer
(F):5'- GCCTAGAGCTGTGTGCAATC -3'
(R):5'- CTGTGTGGACCTGGGCAG -3'
Posted On 2021-03-08