|Institutional Source||Beutler Lab|
|Gene Name||glutamate receptor, metabotropic 5|
|Synonyms||Glu5R, mGluR5, 6430542K11Rik, Gprc1e|
|Essential gene?||Possibly non essential (E-score: 0.302)|
|Stock #||R8671 (G1)|
|Chromosomal Location||87584168-88134907 bp(+) (GRCm38)|
|Type of Mutation||critical splice donor site (2 bp from exon)|
|DNA Base Change (assembly)||T to C at 88116290 bp (GRCm38)|
|Amino Acid Change|
|Ref Sequence||ENSEMBL: ENSMUSP00000114927 (fasta)|
|Gene Model||predicted gene model for transcript(s): [ENSMUST00000107263] [ENSMUST00000125009] [ENSMUST00000155358]|
|Coding Region Coverage||
|Validation Efficiency||100% (48/48)|
FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014]
PHENOTYPE: Homozygous null mice have reduced corticostriatal long term potentiation, do not exhibit hyperactivity after cocaine consumption and do not self-administer cocaine. [provided by MGI curators]
|Allele List at MGI|
|Other mutations in this stock||
|Other mutations in Grm5||
(F):5'- GCTTGCAGTCATGGCTCTTC -3'
(R):5'- GAAACAGCAGCATCTGGGAC -3'
(F):5'- TTCCCCAGCCTGGAGGTTAAG -3'
(R):5'- GGCTCCCATTAGTTGACATGAAG -3'