Incidental Mutation 'R8675:Il20'
ID 661325
Institutional Source Beutler Lab
Gene Symbol Il20
Ensembl Gene ENSMUSG00000026416
Gene Name interleukin 20
Synonyms Zcyto10
MMRRC Submission 068530-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8675 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 130834722-130839033 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 130835172 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tryptophan to Arginine at position 171 (W171R)
Ref Sequence ENSEMBL: ENSMUSP00000027673 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027673] [ENSMUST00000188581]
AlphaFold Q9JKV9
Predicted Effect probably damaging
Transcript: ENSMUST00000027673
AA Change: W171R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027673
Gene: ENSMUSG00000026416
AA Change: W171R

DomainStartEndE-ValueType
IL10 35 176 3.89e-3 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000188581
AA Change: W149R

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000141088
Gene: ENSMUSG00000026416
AA Change: W149R

DomainStartEndE-ValueType
Pfam:IL10 35 154 1.9e-8 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 100% (37/37)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a cytokine structurally related to interleukin 10 (IL10). This cytokine has been shown to transduce its signal through signal transducer and activator of transcription 3 (STAT3) in keratinocytes. A specific receptor for this cytokine is found to be expressed in skin and upregulated dramatically in psoriatic skin, suggesting a role for this protein in epidermal function and psoriasis. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygous mice show an increased inflammatory response in contact hypersensitivity assays. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 40 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1700067P10Rik G T 17: 48,400,849 (GRCm39) E45* probably null Het
Abl2 T C 1: 156,452,909 (GRCm39) V148A probably damaging Het
Cacng7 G A 7: 3,385,221 (GRCm39) V41I probably benign Het
Clrn3 A G 7: 135,115,880 (GRCm39) S157P possibly damaging Het
Dsg2 T A 18: 20,734,975 (GRCm39) N984K possibly damaging Het
Fam83e A G 7: 45,373,293 (GRCm39) T220A probably benign Het
Frk A G 10: 34,484,493 (GRCm39) T489A probably benign Het
Gigyf2 T A 1: 87,331,438 (GRCm39) H195Q unknown Het
Gm49380 C T 9: 44,023,187 (GRCm39) A354T probably benign Het
Igfbpl1 T C 4: 45,813,469 (GRCm39) T249A possibly damaging Het
Il17ra T A 6: 120,458,949 (GRCm39) M700K probably benign Het
Mfsd4a T C 1: 131,986,926 (GRCm39) Y134C probably damaging Het
Mis12 A G 11: 70,916,500 (GRCm39) S178G probably benign Het
Pcdh1 A G 18: 38,332,229 (GRCm39) V397A probably damaging Het
Pcsk4 T C 10: 80,158,896 (GRCm39) Y499C probably damaging Het
Pgbd1 A G 13: 21,607,183 (GRCm39) L337P probably damaging Het
Pigt CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT CCAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGATCTGTAACCACAGGCCAGTGAGTAGGTTTGTCTCTGTCTAGTGTGGAT 2: 164,341,589 (GRCm39) probably null Het
Pih1d1 A G 7: 44,803,806 (GRCm39) K22E unknown Het
Pkd1l1 A G 11: 8,798,916 (GRCm39) probably null Het
Pld2 A G 11: 70,445,713 (GRCm39) D649G probably null Het
Ralgapa1 T C 12: 55,785,002 (GRCm39) T753A possibly damaging Het
Rapgef5 T A 12: 117,547,782 (GRCm39) L141M probably damaging Het
Rasgrp4 G A 7: 28,842,452 (GRCm39) G242D probably damaging Het
Rnf213 T C 11: 119,346,984 (GRCm39) S3682P Het
Scnn1b A G 7: 121,498,474 (GRCm39) K5E probably damaging Het
Smbd1 T C 16: 32,625,340 (GRCm39) *142W probably null Het
Snrnp200 A G 2: 127,074,443 (GRCm39) T1428A possibly damaging Het
Speer1b C T 5: 11,823,973 (GRCm39) R174* probably null Het
Spire1 T C 18: 67,624,378 (GRCm39) T594A possibly damaging Het
Spta1 A G 1: 174,058,249 (GRCm39) T1906A probably benign Het
Stx16 T C 2: 173,934,255 (GRCm39) S152P probably benign Het
Tcp11 T A 17: 28,288,565 (GRCm39) Q331L probably benign Het
Tmem106a T A 11: 101,481,222 (GRCm39) Y243* probably null Het
Tmem268 C T 4: 63,502,108 (GRCm39) T312M probably damaging Het
Ttc9 T G 12: 81,707,379 (GRCm39) V146G probably damaging Het
Ubr3 T A 2: 69,850,865 (GRCm39) I1758N probably damaging Het
Unc13a G A 8: 72,098,359 (GRCm39) T1142I probably benign Het
Vipr1 T C 9: 121,493,732 (GRCm39) L261P probably damaging Het
Vmn1r222 A T 13: 23,416,607 (GRCm39) V202E probably damaging Het
Zfp78 A G 7: 6,381,280 (GRCm39) N110S probably benign Het
Other mutations in Il20
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01979:Il20 APN 1 130,838,839 (GRCm39) missense probably damaging 0.98
IGL02297:Il20 APN 1 130,836,145 (GRCm39) missense probably damaging 0.99
IGL02322:Il20 APN 1 130,837,313 (GRCm39) missense probably damaging 1.00
R0627:Il20 UTSW 1 130,837,476 (GRCm39) splice site probably benign
R0885:Il20 UTSW 1 130,838,518 (GRCm39) missense probably benign 0.21
R1659:Il20 UTSW 1 130,836,086 (GRCm39) splice site probably null
R2037:Il20 UTSW 1 130,836,115 (GRCm39) missense probably damaging 0.99
R2199:Il20 UTSW 1 130,838,476 (GRCm39) missense probably benign 0.01
R5632:Il20 UTSW 1 130,835,165 (GRCm39) missense probably benign 0.19
R6039:Il20 UTSW 1 130,838,478 (GRCm39) missense possibly damaging 0.65
R6039:Il20 UTSW 1 130,838,478 (GRCm39) missense possibly damaging 0.65
R6155:Il20 UTSW 1 130,838,477 (GRCm39) missense probably damaging 0.98
R6340:Il20 UTSW 1 130,836,118 (GRCm39) missense probably benign 0.30
Z1177:Il20 UTSW 1 130,839,124 (GRCm39) unclassified probably benign
Predicted Primers PCR Primer
(F):5'- TTATATCACAAAGGGGTGGTGG -3'
(R):5'- TCCCAAGAGAGTGCTCACTGAC -3'

Sequencing Primer
(F):5'- TATCACAAAGGGGTGGTGGTTTGAG -3'
(R):5'- AACTGGTCCAGTGCTTGATATAGTC -3'
Posted On 2021-03-08