Incidental Mutation 'R8676:Olfr1339'
ID 661372
Institutional Source Beutler Lab
Gene Symbol Olfr1339
Ensembl Gene ENSMUSG00000070820
Gene Name olfactory receptor 1339
Synonyms GA_x6K02T2QD9B-18815145-18814198, MOR258-2
MMRRC Submission
Accession Numbers
Is this an essential gene? Probably non essential (E-score: 0.082) question?
Stock # R8676 (G1)
Quality Score 225.009
Status Validated
Chromosome 4
Chromosomal Location 118732175-118736906 bp(+) (GRCm38)
Type of Mutation missense
DNA Base Change (assembly) C to A at 118735038 bp (GRCm38)
Zygosity Heterozygous
Amino Acid Change Proline to Threonine at position 170 (P170T)
Ref Sequence ENSEMBL: ENSMUSP00000148988 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000094832] [ENSMUST00000217522]
AlphaFold Q8VGB1
Predicted Effect probably damaging
Transcript: ENSMUST00000094832
AA Change: P170T

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000092428
Gene: ENSMUSG00000070820
AA Change: P170T

DomainStartEndE-ValueType
Pfam:7tm_4 34 309 2.7e-53 PFAM
Pfam:7TM_GPCR_Srsx 38 307 4.1e-7 PFAM
Pfam:7tm_1 44 293 3e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000217522
AA Change: P170T

PolyPhen 2 Score 0.995 (Sensitivity: 0.68; Specificity: 0.97)
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.1%
Validation Efficiency 93% (54/58)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 59 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
0610037L13Rik A G 4: 107,895,599 N152D unknown Het
1700021F05Rik A G 10: 43,532,937 L70S probably benign Het
Acsm3 T A 7: 119,775,169 S281R probably damaging Het
Adipor2 G T 6: 119,363,486 probably benign Het
Alk T C 17: 71,897,941 S1079G probably damaging Het
Ankrd27 T C 7: 35,602,584 probably null Het
Anxa6 C A 11: 55,001,282 E283* probably null Het
Bnc2 T C 4: 84,276,313 H858R possibly damaging Het
Btnl6 T C 17: 34,508,069 S496G probably benign Het
Ccdc88a T C 11: 29,460,860 S449P probably benign Het
Cdh23 A T 10: 60,410,910 D916E probably damaging Het
Cfap43 A T 19: 47,748,017 L1345H possibly damaging Het
Cyld A T 8: 88,729,510 H396L probably benign Het
Cyp20a1 A G 1: 60,379,420 T340A possibly damaging Het
Dera A T 6: 137,830,204 I217F probably damaging Het
Dnah11 A G 12: 118,190,804 L247P probably damaging Het
Eftud2 G A 11: 102,868,621 T152M probably damaging Het
Epb41l2 C T 10: 25,443,776 T169M probably benign Het
Fam186a T C 15: 99,947,142 D407G unknown Het
Fam189a2 T C 19: 23,988,494 K214E probably damaging Het
Gli3 T A 13: 15,715,034 C578S probably damaging Het
Gm436 G A 4: 144,670,113 R350C possibly damaging Het
Gm6408 A G 5: 146,482,427 N84S probably benign Het
Heatr5a AGCACACTGCAGGAAGCTCACACAGCACAGCATACCTTCAGGAGTGCACACTGCAGGAAGCTCACACAGCACAGCATACCTTCAGGAGAGCACACTGCAGGAAGCTCA AGCACACTGCAGGAAGCTCACACAGCACAGCATACCTTCAGGAGAGCACACTGCAGGAAGCTCA 12: 51,887,919 probably benign Het
Herc2 C A 7: 56,188,613 T3296K probably damaging Het
Hnf4g A T 3: 3,643,073 probably benign Het
Hyal4 C A 6: 24,755,827 Q15K probably damaging Het
Itpr3 G A 17: 27,118,677 probably benign Het
Kcna3 A G 3: 107,036,592 E57G probably damaging Het
Kcnc3 C A 7: 44,591,596 D237E probably benign Het
Map3k8 A G 18: 4,343,137 V130A probably benign Het
Mpp7 A G 18: 7,440,430 probably null Het
Myh13 T A 11: 67,342,485 L610Q probably damaging Het
Olfr1020 T A 2: 85,849,902 M150K probably benign Het
Olfr917 T C 9: 38,665,768 I25M probably benign Het
Pcdhb5 A T 18: 37,321,076 T170S probably benign Het
Polr3b T A 10: 84,680,387 H626Q probably benign Het
Prkg1 A T 19: 31,764,746 L26Q probably damaging Het
Prob1 T C 18: 35,653,986 N405S possibly damaging Het
Proz T G 8: 13,073,630 S300R probably damaging Het
Psg19 A G 7: 18,794,065 I251T probably benign Het
Rcbtb1 T C 14: 59,229,952 I413T possibly damaging Het
Rnf144b T A 13: 47,228,976 Y103N probably damaging Het
Rspry1 G C 8: 94,632,119 G194R probably benign Het
Scn2b A G 9: 45,125,619 I142V probably damaging Het
Spata20 A T 11: 94,481,781 L588H probably damaging Het
Stk32b T A 5: 37,457,159 H335L probably benign Het
Taar4 A C 10: 23,960,903 D137A possibly damaging Het
Tchh CTCCGCCGGGAGCAAGAGCTCCGCCGGGAGCAAGAGTTCCGCCGGGAGCAAGAGCTCCGCCGGGAGCAAGAGTTCCGCCGGGAGCAAGAGCTCCGCC CTCCGCCGGGAGCAAGAGCTCCGCCGGGAGCAAGAGTTCCGCCGGGAGCAAGAGCTCCGCC 3: 93,446,708 probably benign Het
Tek A T 4: 94,849,837 H708L probably benign Het
Tmem89 C T 9: 108,915,027 L132F unknown Het
Ugt2b38 T C 5: 87,411,822 I404V probably benign Het
Vmn1r16 C T 6: 57,322,829 M269I probably benign Het
Vmn1r201 A G 13: 22,475,252 K212R probably damaging Het
Vmn2r11 A C 5: 109,053,760 F293V probably damaging Het
Zdhhc17 A T 10: 110,962,379 probably benign Het
Zfp423 C A 8: 87,782,710 M335I probably benign Het
Zfp74 T C 7: 29,934,654 Y543C probably damaging Het
Zfp975 A T 7: 42,662,840 S116R probably benign Het
Other mutations in Olfr1339
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02834:Olfr1339 APN 4 118734606 missense probably benign 0.01
R0433:Olfr1339 UTSW 4 118735090 missense probably benign 0.20
R0600:Olfr1339 UTSW 4 118734789 missense probably damaging 0.99
R0737:Olfr1339 UTSW 4 118735224 missense probably benign 0.01
R1167:Olfr1339 UTSW 4 118734632 missense possibly damaging 0.83
R1655:Olfr1339 UTSW 4 118734999 missense probably benign 0.18
R2152:Olfr1339 UTSW 4 118735249 missense possibly damaging 0.90
R3883:Olfr1339 UTSW 4 118734685 missense probably benign 0.38
R4715:Olfr1339 UTSW 4 118734655 missense probably damaging 1.00
R4750:Olfr1339 UTSW 4 118734733 missense possibly damaging 0.66
R4887:Olfr1339 UTSW 4 118734688 missense probably benign 0.20
R4888:Olfr1339 UTSW 4 118734688 missense probably benign 0.20
R5624:Olfr1339 UTSW 4 118735371 missense probably damaging 1.00
R7268:Olfr1339 UTSW 4 118735408 missense probably damaging 1.00
R7783:Olfr1339 UTSW 4 118734902 missense probably damaging 1.00
R7796:Olfr1339 UTSW 4 118734685 missense probably damaging 0.97
Z1177:Olfr1339 UTSW 4 118735456 missense probably damaging 0.99
Predicted Primers PCR Primer
(F):5'- CTGGTGTTAGGCATCACTGAGG -3'
(R):5'- AAGGCCTTCAGTCGACCTTG -3'

Sequencing Primer
(F):5'- AGGCATCACTGAGGGCTGG -3'
(R):5'- CTTCAGTCGACCTTGGGCTGAG -3'
Posted On 2021-03-08