Mutagenetix > Incidental Mutation

Incidental Mutation 'R8676:Vmn1r16'

661379

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r16

Ensembl Gene

ENSMUSG00000115792

Gene Name

vomeronasal 1 receptor 16

Synonyms

V1rc29

MMRRC Submission

068531-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.118) question?

Stock #

R8676 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

57297724-57300620 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 57299814 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Isoleucine at position 269 (M269I)

Ref Sequence

ENSEMBL: ENSMUSP00000154001 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000227168] [ENSMUST00000227283] [ENSMUST00000228356]

AlphaFold

K7N775

Predicted Effect

probably benign
Transcript: ENSMUST00000227168
AA Change: M269I

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

Predicted Effect

probably benign
Transcript: ENSMUST00000227283
AA Change: M269I

PolyPhen 2 Score 0.012 (Sensitivity: 0.96; Specificity: 0.78)

Predicted Effect

probably benign
Transcript: ENSMUST00000228356

Meta Mutation Damage Score

0.0846

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.7%
20x: 99.1%

Validation Efficiency

93% (54/58)

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Aadacl4fm4	G	A	4: 144,396,683 (GRCm39)	R350C	possibly damaging	Het
Acsm3	T	A	7: 119,374,392 (GRCm39)	S281R	probably damaging	Het
Adipor2	G	T	6: 119,340,447 (GRCm39)		probably benign	Het
Alk	T	C	17: 72,204,936 (GRCm39)	S1079G	probably damaging	Het
Ankrd27	T	C	7: 35,302,009 (GRCm39)		probably null	Het
Anxa6	C	A	11: 54,892,108 (GRCm39)	E283*	probably null	Het
Bnc2	T	C	4: 84,194,550 (GRCm39)	H858R	possibly damaging	Het
Btnl6	T	C	17: 34,727,043 (GRCm39)	S496G	probably benign	Het
Ccdc88a	T	C	11: 29,410,860 (GRCm39)	S449P	probably benign	Het
Cdh23	A	T	10: 60,246,689 (GRCm39)	D916E	probably damaging	Het
Cfap43	A	T	19: 47,736,456 (GRCm39)	L1345H	possibly damaging	Het
Cyld	A	T	8: 89,456,138 (GRCm39)	H396L	probably benign	Het
Cyp20a1	A	G	1: 60,418,579 (GRCm39)	T340A	possibly damaging	Het
Czib	A	G	4: 107,752,796 (GRCm39)	N152D	unknown	Het
Dera	A	T	6: 137,807,202 (GRCm39)	I217F	probably damaging	Het
Dnah11	A	G	12: 118,154,539 (GRCm39)	L247P	probably damaging	Het
Eftud2	G	A	11: 102,759,447 (GRCm39)	T152M	probably damaging	Het
Entrep1	T	C	19: 23,965,858 (GRCm39)	K214E	probably damaging	Het
Epb41l2	C	T	10: 25,319,674 (GRCm39)	T169M	probably benign	Het
Fam186a	T	C	15: 99,845,023 (GRCm39)	D407G	unknown	Het
Gli3	T	A	13: 15,889,619 (GRCm39)	C578S	probably damaging	Het
Gm6408	A	G	5: 146,419,237 (GRCm39)	N84S	probably benign	Het
Heatr5a	AGCACACTGCAGGAAGCTCACACAGCACAGCATACCTTCAGGAGTGCACACTGCAGGAAGCTCACACAGCACAGCATACCTTCAGGAGAGCACACTGCAGGAAGCTCA	AGCACACTGCAGGAAGCTCACACAGCACAGCATACCTTCAGGAGAGCACACTGCAGGAAGCTCA	12: 51,934,702 (GRCm39)		probably benign	Het
Herc2	C	A	7: 55,838,361 (GRCm39)	T3296K	probably damaging	Het
Hnf4g	A	T	3: 3,708,133 (GRCm39)		probably benign	Het
Hyal4	C	A	6: 24,755,826 (GRCm39)	Q15K	probably damaging	Het
Itpr3	G	A	17: 27,337,651 (GRCm39)		probably benign	Het
Kcna3	A	G	3: 106,943,908 (GRCm39)	E57G	probably damaging	Het
Kcnc3	C	A	7: 44,241,020 (GRCm39)	D237E	probably benign	Het
Map3k8	A	G	18: 4,343,137 (GRCm39)	V130A	probably benign	Het
Mpp7	A	G	18: 7,440,430 (GRCm39)		probably null	Het
Mtres1	A	G	10: 43,408,933 (GRCm39)	L70S	probably benign	Het
Myh13	T	A	11: 67,233,311 (GRCm39)	L610Q	probably damaging	Het
Or13p5	C	A	4: 118,592,235 (GRCm39)	P170T	probably damaging	Het
Or5ap2	T	A	2: 85,680,246 (GRCm39)	M150K	probably benign	Het
Or8b52	T	C	9: 38,577,064 (GRCm39)	I25M	probably benign	Het
Pcdhb5	A	T	18: 37,454,129 (GRCm39)	T170S	probably benign	Het
Polr3b	T	A	10: 84,516,251 (GRCm39)	H626Q	probably benign	Het
Prkg1	A	T	19: 31,742,146 (GRCm39)	L26Q	probably damaging	Het
Prob1	T	C	18: 35,787,039 (GRCm39)	N405S	possibly damaging	Het
Proz	T	G	8: 13,123,630 (GRCm39)	S300R	probably damaging	Het
Psg19	A	G	7: 18,527,990 (GRCm39)	I251T	probably benign	Het
Rcbtb1	T	C	14: 59,467,401 (GRCm39)	I413T	possibly damaging	Het
Rnf144b	T	A	13: 47,382,452 (GRCm39)	Y103N	probably damaging	Het
Rspry1	G	C	8: 95,358,747 (GRCm39)	G194R	probably benign	Het
Scn2b	A	G	9: 45,036,917 (GRCm39)	I142V	probably damaging	Het
Spata20	A	T	11: 94,372,607 (GRCm39)	L588H	probably damaging	Het
Stk32b	T	A	5: 37,614,503 (GRCm39)	H335L	probably benign	Het
Taar4	A	C	10: 23,836,801 (GRCm39)	D137A	possibly damaging	Het
Tchh	CTCCGCCGGGAGCAAGAGCTCCGCCGGGAGCAAGAGTTCCGCCGGGAGCAAGAGCTCCGCCGGGAGCAAGAGTTCCGCCGGGAGCAAGAGCTCCGCC	CTCCGCCGGGAGCAAGAGCTCCGCCGGGAGCAAGAGTTCCGCCGGGAGCAAGAGCTCCGCC	3: 93,354,015 (GRCm39)		probably benign	Het
Tek	A	T	4: 94,738,074 (GRCm39)	H708L	probably benign	Het
Tmem89	C	T	9: 108,744,095 (GRCm39)	L132F	unknown	Het
Ugt2b38	T	C	5: 87,559,681 (GRCm39)	I404V	probably benign	Het
Vmn1r201	A	G	13: 22,659,422 (GRCm39)	K212R	probably damaging	Het
Vmn2r11	A	C	5: 109,201,626 (GRCm39)	F293V	probably damaging	Het
Zdhhc17	A	T	10: 110,798,240 (GRCm39)		probably benign	Het
Zfp423	C	A	8: 88,509,338 (GRCm39)	M335I	probably benign	Het
Zfp74	T	C	7: 29,634,079 (GRCm39)	Y543C	probably damaging	Het
Zfp975	A	T	7: 42,312,264 (GRCm39)	S116R	probably benign	Het

Other mutations in Vmn1r16

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01350:Vmn1r16	APN	6	57,299,716 (GRCm39)	missense	possibly damaging	0.74
IGL02027:Vmn1r16	APN	6	57,300,044 (GRCm39)	missense	possibly damaging	0.49
IGL02804:Vmn1r16	APN	6	57,300,467 (GRCm39)	missense	probably benign	0.18
IGL03329:Vmn1r16	APN	6	57,300,603 (GRCm39)	missense	probably damaging	0.99
IGL03392:Vmn1r16	APN	6	57,299,879 (GRCm39)	missense	probably damaging	1.00
I1329:Vmn1r16	UTSW	6	57,300,519 (GRCm39)	missense	probably damaging	0.97
PIT4581001:Vmn1r16	UTSW	6	57,299,858 (GRCm39)	missense	probably benign	0.12
R0750:Vmn1r16	UTSW	6	57,299,812 (GRCm39)	missense	probably benign	0.00
R1137:Vmn1r16	UTSW	6	57,300,221 (GRCm39)	missense	probably damaging	1.00
R1239:Vmn1r16	UTSW	6	57,300,618 (GRCm39)	start codon destroyed	probably null	1.00
R1796:Vmn1r16	UTSW	6	57,300,256 (GRCm39)	missense	probably benign	0.03
R1858:Vmn1r16	UTSW	6	57,299,884 (GRCm39)	missense	probably damaging	1.00
R1895:Vmn1r16	UTSW	6	57,299,885 (GRCm39)	missense	probably benign	0.31
R1946:Vmn1r16	UTSW	6	57,299,885 (GRCm39)	missense	probably benign	0.31
R3832:Vmn1r16	UTSW	6	57,300,212 (GRCm39)	missense	probably benign	0.00
R4801:Vmn1r16	UTSW	6	57,300,175 (GRCm39)	missense	probably benign	0.03
R4802:Vmn1r16	UTSW	6	57,300,175 (GRCm39)	missense	probably benign	0.03
R6658:Vmn1r16	UTSW	6	57,300,091 (GRCm39)	nonsense	probably null
R6981:Vmn1r16	UTSW	6	57,300,473 (GRCm39)	missense	probably benign	0.30
R6991:Vmn1r16	UTSW	6	57,299,869 (GRCm39)	nonsense	probably null
R7915:Vmn1r16	UTSW	6	57,300,380 (GRCm39)	missense	probably damaging	1.00
R8214:Vmn1r16	UTSW	6	57,300,424 (GRCm39)	missense	noncoding transcript
R8459:Vmn1r16	UTSW	6	57,300,347 (GRCm39)	missense	probably benign	0.12
R8531:Vmn1r16	UTSW	6	57,299,900 (GRCm39)	missense	probably damaging	1.00
R9096:Vmn1r16	UTSW	6	57,300,250 (GRCm39)	missense	probably benign	0.02
R9097:Vmn1r16	UTSW	6	57,300,250 (GRCm39)	missense	probably benign	0.02
X0061:Vmn1r16	UTSW	6	57,300,349 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GGCACTGGGAATATACAATGC -3'
(R):5'- TCAGGCATCAGAGGCAATGC -3'

Sequencing Primer
(F):5'- CACTGGGAATATACAATGCATGCATG -3'
(R):5'- TGCAAGCATCTTCATAGCATCAGG -3'

Posted On

2021-03-08