Mutagenetix > Incidental Mutation

Incidental Mutation 'R0241:Zbtb37'

66164

Institutional Source

Beutler Lab

Gene Symbol

Zbtb37

Ensembl Gene

ENSMUSG00000043467

Gene Name

zinc finger and BTB domain containing 37

Synonyms

D430004I08Rik

MMRRC Submission

038479-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.123) question?

Stock #

R0241 (G1)

Quality Score

146

Status

Not validated

Chromosome

Chromosomal Location

160830492-160862419 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 160847939 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Valine to Glutamic Acid at position 356 (V356E)

Ref Sequence

ENSEMBL: ENSMUSP00000131576 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000159250] [ENSMUST00000160056] [ENSMUST00000162226] [ENSMUST00000163079] [ENSMUST00000171748] [ENSMUST00000172044]

AlphaFold

Q8C3U9

Predicted Effect

probably benign
Transcript: ENSMUST00000159250
AA Change: V356E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000125417
Gene: ENSMUSG00000043467
AA Change: V356E

Domain	Start	End	E-Value	Type
BTB	34	128	1.39e-23	SMART
ZnF_C2H2	375	397	5.99e-4	SMART
ZnF_C2H2	403	425	6.88e-4	SMART
ZnF_C2H2	431	454	1.16e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000160056
AA Change: V356E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000134769
Gene: ENSMUSG00000043467
AA Change: V356E

Domain	Start	End	E-Value	Type
BTB	34	128	1.39e-23	SMART
ZnF_C2H2	375	397	5.99e-4	SMART
ZnF_C2H2	403	425	6.88e-4	SMART
ZnF_C2H2	431	454	1.16e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000162226
AA Change: V356E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000125253
Gene: ENSMUSG00000043467
AA Change: V356E

Domain	Start	End	E-Value	Type
BTB	34	128	1.39e-23	SMART
ZnF_C2H2	375	397	5.99e-4	SMART
ZnF_C2H2	403	425	6.88e-4	SMART
ZnF_C2H2	431	454	1.16e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000163079
AA Change: V356E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000134753
Gene: ENSMUSG00000043467
AA Change: V356E

Domain	Start	End	E-Value	Type
BTB	34	128	1.39e-23	SMART
ZnF_C2H2	375	397	5.99e-4	SMART
ZnF_C2H2	403	425	6.88e-4	SMART
ZnF_C2H2	431	454	1.16e-1	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000171748

SMART Domains

Protein: ENSMUSP00000129965
Gene: ENSMUSG00000043467

Domain	Start	End	E-Value	Type
BTB	34	128	1.39e-23	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000172044
AA Change: V356E

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)

SMART Domains

Protein: ENSMUSP00000131576
Gene: ENSMUSG00000043467
AA Change: V356E

Domain	Start	End	E-Value	Type
BTB	34	128	1.39e-23	SMART
ZnF_C2H2	375	397	5.99e-4	SMART
ZnF_C2H2	403	425	6.88e-4	SMART
ZnF_C2H2	431	454	1.16e-1	SMART

Meta Mutation Damage Score

0.1024

Coding Region Coverage

1x: 98.6%
3x: 97.1%
10x: 89.8%
20x: 65.7%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 45 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adck2	T	A	6: 39,560,752 (GRCm39)	V380E	probably benign	Het
Anapc1	A	T	2: 128,470,549 (GRCm39)	M1527K	possibly damaging	Het
Bicra	A	T	7: 15,709,070 (GRCm39)	M1188K	probably damaging	Het
Brd7	G	A	8: 89,072,478 (GRCm39)	R331W	probably benign	Het
Cactin	A	G	10: 81,158,486 (GRCm39)	T151A	probably benign	Het
Cadps	G	A	14: 12,376,675 (GRCm38)	T1274M	probably damaging	Het
Catsper3	T	C	13: 55,952,667 (GRCm39)	M175T	probably damaging	Het
Chd5	A	G	4: 152,450,589 (GRCm39)	D605G	probably damaging	Het
Chst12	G	A	5: 140,510,054 (GRCm39)	R227H	possibly damaging	Het
Cobl	A	T	11: 12,204,524 (GRCm39)	V644E	probably benign	Het
Ddx31	A	G	2: 28,738,303 (GRCm39)	T155A	probably damaging	Het
Dnah3	T	C	7: 119,521,953 (GRCm39)	Q4069R	probably damaging	Het
Dnah8	T	C	17: 30,984,653 (GRCm39)	I3117T	probably damaging	Het
Doc2b	A	G	11: 75,663,387 (GRCm39)	V355A	probably damaging	Het
Dock10	A	T	1: 80,556,340 (GRCm39)	S578T	probably benign	Het
Fcer2a	A	G	8: 3,738,796 (GRCm39)		probably null	Het
Fmnl1	G	A	11: 103,072,996 (GRCm39)		probably null	Het
Git2	T	C	5: 114,871,290 (GRCm39)	E208G	probably damaging	Het
Hs6st3	T	C	14: 119,376,232 (GRCm39)	F136L	probably benign	Het
Hydin	G	A	8: 111,124,655 (GRCm39)	V555I	probably benign	Het
Kmt2b	A	G	7: 30,276,494 (GRCm39)	L1726S	probably damaging	Het
Loxl3	A	G	6: 83,027,114 (GRCm39)	D615G	probably damaging	Het
Nfasc	C	A	1: 132,564,731 (GRCm39)	A70S	probably benign	Het
Or4d1	T	A	11: 87,804,860 (GRCm39)	N291Y	probably damaging	Het
Or4p21	A	T	2: 88,276,889 (GRCm39)	M131K	possibly damaging	Het
Or52n4	A	G	7: 104,294,450 (GRCm39)	M41T	probably benign	Het
Or5g29	A	G	2: 85,421,154 (GRCm39)	K90R	probably benign	Het
Pde7b	A	G	10: 20,311,962 (GRCm39)	C239R	probably damaging	Het
Pdzd2	A	T	15: 12,368,027 (GRCm39)	L2654Q	probably damaging	Het
Pgap1	T	C	1: 54,575,110 (GRCm39)		probably null	Het
Proz	T	A	8: 13,115,356 (GRCm39)	M124K	probably benign	Het
Raet1d	A	G	10: 22,247,328 (GRCm39)	T135A	probably benign	Het
Rapgef1	A	G	2: 29,592,682 (GRCm39)	N558S	possibly damaging	Het
Sfi1	CCTCTC	CCTCTCTC	11: 3,127,419 (GRCm39)		probably benign	Het
Simc1	G	T	13: 54,698,338 (GRCm39)	L1319F	probably damaging	Het
Sspo	A	G	6: 48,438,429 (GRCm39)	E1499G	possibly damaging	Het
Tas2r118	T	C	6: 23,969,338 (GRCm39)	Y241C	probably damaging	Het
Tbck	A	G	3: 132,430,636 (GRCm39)	E344G	probably benign	Het
Tcam1	G	A	11: 106,174,904 (GRCm39)	E120K	probably benign	Het
Tmbim7	A	T	5: 3,716,866 (GRCm39)	Y66F	probably benign	Het
Vil1	T	C	1: 74,465,853 (GRCm39)	L548P	probably damaging	Het
Wdr3	A	G	3: 100,052,973 (GRCm39)	V593A	probably damaging	Het
Zan	T	C	5: 137,420,084 (GRCm39)	T2858A	unknown	Het
Zfp36	C	T	7: 28,077,759 (GRCm39)	V50I	probably damaging	Het
Zfp563	A	T	17: 33,323,659 (GRCm39)	S85C	possibly damaging	Het

Other mutations in Zbtb37

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R0241:Zbtb37	UTSW	1	160,847,939 (GRCm39)	missense	probably benign
R0330:Zbtb37	UTSW	1	160,860,066 (GRCm39)	missense	probably benign	0.01
R0442:Zbtb37	UTSW	1	160,859,918 (GRCm39)	missense	possibly damaging	0.51
R1370:Zbtb37	UTSW	1	160,859,592 (GRCm39)	missense	probably benign	0.32
R1716:Zbtb37	UTSW	1	160,847,814 (GRCm39)	missense	probably benign	0.07
R6644:Zbtb37	UTSW	1	160,859,643 (GRCm39)	nonsense	probably null
R7257:Zbtb37	UTSW	1	160,860,231 (GRCm39)	missense	probably damaging	1.00
R7718:Zbtb37	UTSW	1	160,859,802 (GRCm39)	missense	possibly damaging	0.90
R7934:Zbtb37	UTSW	1	160,857,305 (GRCm39)	missense	probably damaging	1.00
R8145:Zbtb37	UTSW	1	160,847,654 (GRCm39)	missense	probably damaging	0.98
R9095:Zbtb37	UTSW	1	160,847,941 (GRCm39)	nonsense	probably null
R9563:Zbtb37	UTSW	1	160,847,840 (GRCm39)	missense	possibly damaging	0.62
R9765:Zbtb37	UTSW	1	160,859,432 (GRCm39)	missense	probably damaging	0.99
Z1177:Zbtb37	UTSW	1	160,857,235 (GRCm39)	missense	probably benign	0.29

Predicted Primers

Posted On

2013-08-19