Incidental Mutation 'R8680:Abcb1a'
| ID |
661661 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Abcb1a
|
| Ensembl Gene |
ENSMUSG00000040584 |
| Gene Name |
ATP-binding cassette, sub-family B member 1A |
| Synonyms |
Evi32, multiple drug resistant 1a, Pgp, MDR3, Pgy-3, Mdr1a, P-glycoprotein, P-gp, Pgy3, mdr-3 |
| MMRRC Submission |
068535-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.172)
|
| Stock # |
R8680 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Validated
|
| Chromosome |
5 |
| Chromosomal Location |
8710077-8798575 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to A
at 8735371 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Phenylalanine to Leucine
at position 159
(F159L)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000041204
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047753]
|
| AlphaFold |
P21447 |
| PDB Structure |
Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding [X-RAY DIFFRACTION]
Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding [X-RAY DIFFRACTION]
Structure of P-glycoprotein Reveals a Molecular Basis for Poly-Specific Drug Binding [X-RAY DIFFRACTION]
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain [X-RAY DIFFRACTION]
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain [X-RAY DIFFRACTION]
Structures of P-glycoprotein reveal its conformational flexibility and an epitope on the nucleotide-binding domain [X-RAY DIFFRACTION]
Structure of Mouse P-Glycoprotein [X-RAY DIFFRACTION]
Corrected Structure of Mouse P-glycoprotein [X-RAY DIFFRACTION]
Corrected Structure of Mouse P-glycoprotein bound to QZ59-RRR [X-RAY DIFFRACTION]
Corrected Structure of Mouse P-glycoprotein bound to QZ59-SSS [X-RAY DIFFRACTION]
>> 5 additional structures at PDB <<
|
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000047753
AA Change: F159L
PolyPhen 2
Score 0.994 (Sensitivity: 0.69; Specificity: 0.97)
|
| SMART Domains |
Protein: ENSMUSP00000041204
Gene: ENSMUSG00000040584
AA Change: F159L
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
16 |
30 |
N/A |
INTRINSIC |
|
Pfam:ABC_membrane
|
50 |
339 |
8.3e-97 |
PFAM |
|
AAA
|
415 |
607 |
1.22e-20 |
SMART |
|
Pfam:ABC_membrane
|
707 |
982 |
4.8e-79 |
PFAM |
|
AAA
|
1058 |
1246 |
8.85e-18 |
SMART |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.4%
- 20x: 97.6%
|
| Validation Efficiency |
99% (78/79) |
| MGI Phenotype |
FUNCTION: The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance as well as antigen presentation. This gene encodes a p-glycoprotein which actively transports a variety of hydrophobic amphipathic drugs and plays a major role in the blood-brain barrier permeability of certain drugs. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutations in this gene result in increased sensitivity to various drugs, including avermectins and vinblastine. Mice with a null allele develop spontanous colitis. [provided by MGI curators]
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 78 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| 4932438H23Rik |
T |
C |
16: 90,852,551 (GRCm39) |
Y195C |
probably damaging |
Het |
| Adam6b |
A |
G |
12: 113,454,371 (GRCm39) |
N396S |
probably benign |
Het |
| Adamts15 |
T |
C |
9: 30,823,055 (GRCm39) |
M338V |
possibly damaging |
Het |
| Adamts7 |
T |
A |
9: 90,077,321 (GRCm39) |
H1329Q |
probably damaging |
Het |
| Aim2 |
C |
T |
1: 173,289,786 (GRCm39) |
P243L |
probably damaging |
Het |
| Ankdd1a |
T |
C |
9: 65,412,418 (GRCm39) |
D311G |
probably damaging |
Het |
| Apon |
A |
T |
10: 128,090,428 (GRCm39) |
E35D |
probably benign |
Het |
| Atp1a4 |
T |
C |
1: 172,078,566 (GRCm39) |
D224G |
probably damaging |
Het |
| Atp6v0a1 |
T |
A |
11: 100,953,229 (GRCm39) |
*839R |
probably null |
Het |
| Bco2 |
A |
G |
9: 50,461,878 (GRCm39) |
L42P |
probably damaging |
Het |
| Bicral |
T |
A |
17: 47,141,873 (GRCm39) |
|
probably benign |
Het |
| Ccna1 |
T |
C |
3: 54,955,878 (GRCm39) |
Q306R |
probably benign |
Het |
| Cep152 |
G |
T |
2: 125,406,131 (GRCm39) |
S1467* |
probably null |
Het |
| Cfap44 |
T |
A |
16: 44,225,085 (GRCm39) |
V110E |
probably damaging |
Het |
| Clip2 |
G |
A |
5: 134,531,462 (GRCm39) |
A781V |
probably benign |
Het |
| Cps1 |
A |
T |
1: 67,243,772 (GRCm39) |
I1083F |
probably damaging |
Het |
| Cux1 |
A |
G |
5: 136,336,710 (GRCm39) |
V934A |
possibly damaging |
Het |
| Depdc5 |
T |
C |
5: 33,101,382 (GRCm39) |
F891L |
possibly damaging |
Het |
| Dnai7 |
T |
A |
6: 145,127,542 (GRCm39) |
I456F |
probably benign |
Het |
| Dnajc13 |
A |
G |
9: 104,057,338 (GRCm39) |
V1554A |
probably benign |
Het |
| Echs1 |
A |
T |
7: 139,690,499 (GRCm39) |
M191K |
probably damaging |
Het |
| Eif6 |
T |
A |
2: 155,664,772 (GRCm39) |
D238V |
probably benign |
Het |
| Fat2 |
G |
A |
11: 55,144,692 (GRCm39) |
L4061F |
probably benign |
Het |
| Fat3 |
T |
C |
9: 15,908,703 (GRCm39) |
D2433G |
probably damaging |
Het |
| Flt3 |
A |
G |
5: 147,320,265 (GRCm39) |
V33A |
probably benign |
Het |
| Garin2 |
TGATGTCACAGATGTCAC |
TGATGTCAC |
12: 78,762,057 (GRCm39) |
|
probably benign |
Het |
| Gpr155 |
T |
C |
2: 73,174,039 (GRCm39) |
E790G |
probably damaging |
Het |
| Ighv1-67 |
A |
T |
12: 115,567,861 (GRCm39) |
V17E |
probably damaging |
Het |
| Klra9 |
T |
A |
6: 130,165,639 (GRCm39) |
R125S |
probably damaging |
Het |
| Leo1 |
T |
C |
9: 75,353,277 (GRCm39) |
|
probably null |
Het |
| Map2 |
G |
T |
1: 66,460,872 (GRCm39) |
R1556L |
probably damaging |
Het |
| Megf8 |
A |
G |
7: 25,059,166 (GRCm39) |
|
probably null |
Het |
| Meikin |
T |
C |
11: 54,317,477 (GRCm39) |
I426T |
possibly damaging |
Het |
| Muc16 |
A |
T |
9: 18,556,015 (GRCm39) |
V3426E |
unknown |
Het |
| Or4a15 |
T |
A |
2: 89,193,065 (GRCm39) |
Y236F |
probably benign |
Het |
| Or51af1 |
G |
A |
7: 103,142,029 (GRCm39) |
L19F |
probably damaging |
Het |
| Or52n2c |
A |
G |
7: 104,574,620 (GRCm39) |
L117P |
probably damaging |
Het |
| Or7e168 |
T |
G |
9: 19,720,105 (GRCm39) |
S164A |
possibly damaging |
Het |
| Or8k25 |
T |
C |
2: 86,243,935 (GRCm39) |
I154V |
probably benign |
Het |
| Or9s13 |
T |
C |
1: 92,547,643 (GRCm39) |
V5A |
probably benign |
Het |
| Otogl |
A |
G |
10: 107,747,936 (GRCm39) |
|
probably null |
Het |
| Palm3 |
T |
C |
8: 84,756,504 (GRCm39) |
L672P |
probably damaging |
Het |
| Perm1 |
A |
G |
4: 156,302,091 (GRCm39) |
T212A |
probably benign |
Het |
| Poc1a |
T |
C |
9: 106,226,960 (GRCm39) |
M400T |
probably benign |
Het |
| Pou6f2 |
T |
A |
13: 18,414,196 (GRCm39) |
Q193L |
unknown |
Het |
| Ppl |
C |
T |
16: 4,905,300 (GRCm39) |
R1665H |
probably benign |
Het |
| Ppp4r3b |
T |
C |
11: 29,123,449 (GRCm39) |
|
probably null |
Het |
| Ptger1 |
T |
C |
8: 84,394,654 (GRCm39) |
S44P |
probably damaging |
Het |
| Pzp |
T |
C |
6: 128,473,009 (GRCm39) |
T787A |
probably benign |
Het |
| Rab44 |
A |
T |
17: 29,358,642 (GRCm39) |
R277* |
probably null |
Het |
| Rasgef1a |
T |
A |
6: 118,064,088 (GRCm39) |
I334K |
probably damaging |
Het |
| Rfx1 |
T |
C |
8: 84,818,084 (GRCm39) |
V554A |
possibly damaging |
Het |
| Ripk1 |
T |
A |
13: 34,214,032 (GRCm39) |
I518K |
possibly damaging |
Het |
| Rpl22 |
A |
G |
4: 152,416,763 (GRCm39) |
Y90C |
probably damaging |
Het |
| Rps27a |
C |
A |
11: 29,495,998 (GRCm39) |
R118L |
probably benign |
Het |
| Scmh1 |
T |
A |
4: 120,319,331 (GRCm39) |
S19T |
probably benign |
Het |
| Scn10a |
C |
T |
9: 119,520,509 (GRCm39) |
|
probably null |
Het |
| Sema4c |
A |
T |
1: 36,589,867 (GRCm39) |
S496T |
probably benign |
Het |
| Serpina3i |
T |
C |
12: 104,231,387 (GRCm39) |
V8A |
possibly damaging |
Het |
| Sis |
G |
A |
3: 72,867,628 (GRCm39) |
T139M |
probably damaging |
Het |
| Skic3 |
A |
T |
13: 76,303,587 (GRCm39) |
H1227L |
probably benign |
Het |
| Slc45a2 |
T |
A |
15: 11,000,972 (GRCm39) |
S24T |
probably benign |
Het |
| Slc5a11 |
A |
G |
7: 122,866,975 (GRCm39) |
I423M |
probably benign |
Het |
| Slc7a10 |
G |
A |
7: 34,885,997 (GRCm39) |
G31S |
probably benign |
Het |
| Sowahc |
A |
G |
10: 59,059,001 (GRCm39) |
N379S |
probably benign |
Het |
| Stat5a |
T |
C |
11: 100,774,714 (GRCm39) |
M741T |
unknown |
Het |
| Tcf15 |
T |
C |
2: 151,986,020 (GRCm39) |
S159P |
probably benign |
Het |
| Tdrd5 |
C |
A |
1: 156,098,788 (GRCm39) |
R669L |
possibly damaging |
Het |
| Tln1 |
T |
C |
4: 43,553,041 (GRCm39) |
E350G |
possibly damaging |
Het |
| Trim12c |
T |
G |
7: 103,997,271 (GRCm39) |
N95T |
|
Het |
| Urb1 |
T |
C |
16: 90,571,513 (GRCm39) |
T1099A |
probably benign |
Het |
| Vmn1r44 |
T |
A |
6: 89,870,578 (GRCm39) |
V108D |
probably damaging |
Het |
| Vmn2r65 |
A |
G |
7: 84,589,388 (GRCm39) |
Y843H |
probably benign |
Het |
| Vmn2r68 |
A |
G |
7: 84,871,321 (GRCm39) |
I654T |
possibly damaging |
Het |
| Vps13a |
T |
C |
19: 16,623,270 (GRCm39) |
N2797S |
possibly damaging |
Het |
| Wscd2 |
T |
C |
5: 113,712,235 (GRCm39) |
Y385H |
probably damaging |
Het |
| Xdh |
T |
C |
17: 74,229,500 (GRCm39) |
I318V |
probably benign |
Het |
| Xrcc3 |
T |
A |
12: 111,774,313 (GRCm39) |
K172M |
probably damaging |
Het |
|
| Other mutations in Abcb1a |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL00704:Abcb1a
|
APN |
5 |
8,736,257 (GRCm39) |
missense |
probably benign |
0.01 |
|
IGL00898:Abcb1a
|
APN |
5 |
8,783,690 (GRCm39) |
missense |
probably damaging |
0.97 |
|
IGL01064:Abcb1a
|
APN |
5 |
8,782,388 (GRCm39) |
missense |
possibly damaging |
0.65 |
|
IGL01118:Abcb1a
|
APN |
5 |
8,724,687 (GRCm39) |
missense |
probably damaging |
1.00 |
|
IGL01150:Abcb1a
|
APN |
5 |
8,752,550 (GRCm39) |
missense |
possibly damaging |
0.90 |
|
IGL01584:Abcb1a
|
APN |
5 |
8,748,637 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL01654:Abcb1a
|
APN |
5 |
8,765,065 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL01820:Abcb1a
|
APN |
5 |
8,765,896 (GRCm39) |
splice site |
probably benign |
|
|
IGL02499:Abcb1a
|
APN |
5 |
8,776,807 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
IGL02711:Abcb1a
|
APN |
5 |
8,773,245 (GRCm39) |
splice site |
probably null |
|
|
IGL02954:Abcb1a
|
APN |
5 |
8,782,341 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03018:Abcb1a
|
APN |
5 |
8,752,451 (GRCm39) |
missense |
probably damaging |
0.99 |
|
IGL03119:Abcb1a
|
APN |
5 |
8,764,887 (GRCm39) |
missense |
probably benign |
0.00 |
|
IGL03292:Abcb1a
|
APN |
5 |
8,765,827 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
IGL03338:Abcb1a
|
APN |
5 |
8,744,153 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0418:Abcb1a
|
UTSW |
5 |
8,763,281 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R0559:Abcb1a
|
UTSW |
5 |
8,748,535 (GRCm39) |
missense |
probably benign |
0.01 |
|
R0595:Abcb1a
|
UTSW |
5 |
8,790,417 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0599:Abcb1a
|
UTSW |
5 |
8,748,539 (GRCm39) |
missense |
probably benign |
0.13 |
|
R0811:Abcb1a
|
UTSW |
5 |
8,763,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0812:Abcb1a
|
UTSW |
5 |
8,763,229 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0894:Abcb1a
|
UTSW |
5 |
8,724,856 (GRCm39) |
splice site |
probably benign |
|
|
R0948:Abcb1a
|
UTSW |
5 |
8,790,621 (GRCm39) |
splice site |
probably null |
|
|
R1292:Abcb1a
|
UTSW |
5 |
8,763,343 (GRCm39) |
missense |
probably benign |
0.00 |
|
R1318:Abcb1a
|
UTSW |
5 |
8,751,621 (GRCm39) |
missense |
probably benign |
0.31 |
|
R1459:Abcb1a
|
UTSW |
5 |
8,752,920 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1489:Abcb1a
|
UTSW |
5 |
8,736,300 (GRCm39) |
critical splice donor site |
probably null |
|
|
R1514:Abcb1a
|
UTSW |
5 |
8,724,791 (GRCm39) |
missense |
possibly damaging |
0.88 |
|
R2100:Abcb1a
|
UTSW |
5 |
8,763,202 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R2409:Abcb1a
|
UTSW |
5 |
8,788,747 (GRCm39) |
missense |
probably benign |
0.30 |
|
R2844:Abcb1a
|
UTSW |
5 |
8,736,164 (GRCm39) |
missense |
probably benign |
0.02 |
|
R3709:Abcb1a
|
UTSW |
5 |
8,788,738 (GRCm39) |
missense |
probably benign |
0.03 |
|
R3755:Abcb1a
|
UTSW |
5 |
8,797,403 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R4193:Abcb1a
|
UTSW |
5 |
8,765,068 (GRCm39) |
splice site |
probably null |
|
|
R4401:Abcb1a
|
UTSW |
5 |
8,752,390 (GRCm39) |
missense |
possibly damaging |
0.54 |
|
R4463:Abcb1a
|
UTSW |
5 |
8,769,981 (GRCm39) |
splice site |
probably benign |
|
|
R4539:Abcb1a
|
UTSW |
5 |
8,765,793 (GRCm39) |
missense |
probably benign |
|
|
R4635:Abcb1a
|
UTSW |
5 |
8,764,927 (GRCm39) |
missense |
probably benign |
|
|
R4740:Abcb1a
|
UTSW |
5 |
8,752,280 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4757:Abcb1a
|
UTSW |
5 |
8,787,632 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R4764:Abcb1a
|
UTSW |
5 |
8,765,732 (GRCm39) |
splice site |
probably null |
|
|
R4792:Abcb1a
|
UTSW |
5 |
8,796,657 (GRCm39) |
critical splice donor site |
probably null |
|
|
R4829:Abcb1a
|
UTSW |
5 |
8,773,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4935:Abcb1a
|
UTSW |
5 |
8,787,773 (GRCm39) |
critical splice donor site |
probably null |
|
|
R5140:Abcb1a
|
UTSW |
5 |
8,752,154 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5181:Abcb1a
|
UTSW |
5 |
8,764,937 (GRCm39) |
missense |
probably benign |
|
|
R5355:Abcb1a
|
UTSW |
5 |
8,776,873 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R5406:Abcb1a
|
UTSW |
5 |
8,752,946 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R5496:Abcb1a
|
UTSW |
5 |
8,724,818 (GRCm39) |
missense |
probably benign |
|
|
R5557:Abcb1a
|
UTSW |
5 |
8,764,949 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5572:Abcb1a
|
UTSW |
5 |
8,765,108 (GRCm39) |
splice site |
probably null |
|
|
R5702:Abcb1a
|
UTSW |
5 |
8,787,752 (GRCm39) |
missense |
probably benign |
0.15 |
|
R5753:Abcb1a
|
UTSW |
5 |
8,773,160 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5769:Abcb1a
|
UTSW |
5 |
8,733,426 (GRCm39) |
missense |
probably benign |
0.01 |
|
R5895:Abcb1a
|
UTSW |
5 |
8,752,216 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6536:Abcb1a
|
UTSW |
5 |
8,769,030 (GRCm39) |
missense |
probably benign |
0.01 |
|
R6555:Abcb1a
|
UTSW |
5 |
8,752,468 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R6798:Abcb1a
|
UTSW |
5 |
8,782,364 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6875:Abcb1a
|
UTSW |
5 |
8,751,628 (GRCm39) |
missense |
probably benign |
0.28 |
|
R7000:Abcb1a
|
UTSW |
5 |
8,752,823 (GRCm39) |
missense |
probably benign |
0.19 |
|
R7102:Abcb1a
|
UTSW |
5 |
8,744,072 (GRCm39) |
missense |
probably benign |
0.01 |
|
R7172:Abcb1a
|
UTSW |
5 |
8,752,399 (GRCm39) |
missense |
probably benign |
0.00 |
|
R7313:Abcb1a
|
UTSW |
5 |
8,773,187 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7513:Abcb1a
|
UTSW |
5 |
8,765,771 (GRCm39) |
nonsense |
probably null |
|
|
R7718:Abcb1a
|
UTSW |
5 |
8,765,788 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7816:Abcb1a
|
UTSW |
5 |
8,736,132 (GRCm39) |
missense |
possibly damaging |
0.56 |
|
R7829:Abcb1a
|
UTSW |
5 |
8,748,623 (GRCm39) |
missense |
probably benign |
0.06 |
|
R7943:Abcb1a
|
UTSW |
5 |
8,736,222 (GRCm39) |
missense |
probably benign |
|
|
R8040:Abcb1a
|
UTSW |
5 |
8,765,035 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8086:Abcb1a
|
UTSW |
5 |
8,724,833 (GRCm39) |
missense |
probably benign |
|
|
R8271:Abcb1a
|
UTSW |
5 |
8,736,212 (GRCm39) |
missense |
probably benign |
0.41 |
|
R8367:Abcb1a
|
UTSW |
5 |
8,736,221 (GRCm39) |
missense |
probably benign |
0.00 |
|
R8520:Abcb1a
|
UTSW |
5 |
8,735,346 (GRCm39) |
missense |
possibly damaging |
0.67 |
|
R8820:Abcb1a
|
UTSW |
5 |
8,773,204 (GRCm39) |
missense |
possibly damaging |
0.69 |
|
R8996:Abcb1a
|
UTSW |
5 |
8,769,069 (GRCm39) |
missense |
probably benign |
0.00 |
|
R9114:Abcb1a
|
UTSW |
5 |
8,788,702 (GRCm39) |
nonsense |
probably null |
|
|
R9127:Abcb1a
|
UTSW |
5 |
8,724,707 (GRCm39) |
missense |
probably benign |
|
|
R9187:Abcb1a
|
UTSW |
5 |
8,765,016 (GRCm39) |
missense |
probably benign |
|
|
R9294:Abcb1a
|
UTSW |
5 |
8,736,171 (GRCm39) |
missense |
probably benign |
0.02 |
|
R9459:Abcb1a
|
UTSW |
5 |
8,735,414 (GRCm39) |
critical splice donor site |
probably null |
|
|
R9581:Abcb1a
|
UTSW |
5 |
8,790,428 (GRCm39) |
missense |
possibly damaging |
0.66 |
|
R9617:Abcb1a
|
UTSW |
5 |
8,797,353 (GRCm39) |
critical splice acceptor site |
probably null |
|
|
R9676:Abcb1a
|
UTSW |
5 |
8,714,548 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R9682:Abcb1a
|
UTSW |
5 |
8,752,507 (GRCm39) |
missense |
probably benign |
0.44 |
|
R9790:Abcb1a
|
UTSW |
5 |
8,748,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R9791:Abcb1a
|
UTSW |
5 |
8,748,604 (GRCm39) |
missense |
probably damaging |
1.00 |
|
Z1177:Abcb1a
|
UTSW |
5 |
8,796,544 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- AGGTGGATGCTAATCATTACAGCTC -3'
(R):5'- TCCACAGGGCTTTACTCTGC -3'
Sequencing Primer
(F):5'- GGATGCTAATCATTACAGCTCCATCC -3'
(R):5'- ACAGGGCTTTACTCTGCTCAGTTATG -3'
|
| Posted On |
2021-03-08 |
Incidental Mutation