Incidental Mutation 'R8680:Vmn2r68'
ID |
661675 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Vmn2r68
|
Ensembl Gene |
ENSMUSG00000096861 |
Gene Name |
vomeronasal 2, receptor 68 |
Synonyms |
EG620697, Vmn2r68-ps |
MMRRC Submission |
068535-MU
|
Accession Numbers |
|
Essential gene? |
Probably non essential
(E-score: 0.085)
|
Stock # |
R8680 (G1)
|
Quality Score |
225.009 |
Status
|
Validated
|
Chromosome |
7 |
Chromosomal Location |
84870726-84886912 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
A to G
at 84871321 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Isoleucine to Threonine
at position 654
(I654T)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000129411
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000061074]
|
AlphaFold |
L7N2B3 |
Predicted Effect |
possibly damaging
Transcript: ENSMUST00000061074
AA Change: I654T
PolyPhen 2
Score 0.675 (Sensitivity: 0.86; Specificity: 0.92)
|
SMART Domains |
Protein: ENSMUSP00000129411 Gene: ENSMUSG00000096861 AA Change: I654T
Domain | Start | End | E-Value | Type |
signal peptide
|
1 |
18 |
N/A |
INTRINSIC |
Pfam:ANF_receptor
|
77 |
463 |
4.5e-28 |
PFAM |
Pfam:NCD3G
|
507 |
559 |
1.1e-18 |
PFAM |
Pfam:7tm_3
|
589 |
827 |
3.7e-53 |
PFAM |
|
Meta Mutation Damage Score |
0.1712 |
Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.4%
- 20x: 97.6%
|
Validation Efficiency |
99% (78/79) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 78 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
4932438H23Rik |
T |
C |
16: 90,852,551 (GRCm39) |
Y195C |
probably damaging |
Het |
Abcb1a |
T |
A |
5: 8,735,371 (GRCm39) |
F159L |
probably damaging |
Het |
Adam6b |
A |
G |
12: 113,454,371 (GRCm39) |
N396S |
probably benign |
Het |
Adamts15 |
T |
C |
9: 30,823,055 (GRCm39) |
M338V |
possibly damaging |
Het |
Adamts7 |
T |
A |
9: 90,077,321 (GRCm39) |
H1329Q |
probably damaging |
Het |
Aim2 |
C |
T |
1: 173,289,786 (GRCm39) |
P243L |
probably damaging |
Het |
Ankdd1a |
T |
C |
9: 65,412,418 (GRCm39) |
D311G |
probably damaging |
Het |
Apon |
A |
T |
10: 128,090,428 (GRCm39) |
E35D |
probably benign |
Het |
Atp1a4 |
T |
C |
1: 172,078,566 (GRCm39) |
D224G |
probably damaging |
Het |
Atp6v0a1 |
T |
A |
11: 100,953,229 (GRCm39) |
*839R |
probably null |
Het |
Bco2 |
A |
G |
9: 50,461,878 (GRCm39) |
L42P |
probably damaging |
Het |
Bicral |
T |
A |
17: 47,141,873 (GRCm39) |
|
probably benign |
Het |
Ccna1 |
T |
C |
3: 54,955,878 (GRCm39) |
Q306R |
probably benign |
Het |
Cep152 |
G |
T |
2: 125,406,131 (GRCm39) |
S1467* |
probably null |
Het |
Cfap44 |
T |
A |
16: 44,225,085 (GRCm39) |
V110E |
probably damaging |
Het |
Clip2 |
G |
A |
5: 134,531,462 (GRCm39) |
A781V |
probably benign |
Het |
Cps1 |
A |
T |
1: 67,243,772 (GRCm39) |
I1083F |
probably damaging |
Het |
Cux1 |
A |
G |
5: 136,336,710 (GRCm39) |
V934A |
possibly damaging |
Het |
Depdc5 |
T |
C |
5: 33,101,382 (GRCm39) |
F891L |
possibly damaging |
Het |
Dnai7 |
T |
A |
6: 145,127,542 (GRCm39) |
I456F |
probably benign |
Het |
Dnajc13 |
A |
G |
9: 104,057,338 (GRCm39) |
V1554A |
probably benign |
Het |
Echs1 |
A |
T |
7: 139,690,499 (GRCm39) |
M191K |
probably damaging |
Het |
Eif6 |
T |
A |
2: 155,664,772 (GRCm39) |
D238V |
probably benign |
Het |
Fat2 |
G |
A |
11: 55,144,692 (GRCm39) |
L4061F |
probably benign |
Het |
Fat3 |
T |
C |
9: 15,908,703 (GRCm39) |
D2433G |
probably damaging |
Het |
Flt3 |
A |
G |
5: 147,320,265 (GRCm39) |
V33A |
probably benign |
Het |
Garin2 |
TGATGTCACAGATGTCAC |
TGATGTCAC |
12: 78,762,057 (GRCm39) |
|
probably benign |
Het |
Gpr155 |
T |
C |
2: 73,174,039 (GRCm39) |
E790G |
probably damaging |
Het |
Ighv1-67 |
A |
T |
12: 115,567,861 (GRCm39) |
V17E |
probably damaging |
Het |
Klra9 |
T |
A |
6: 130,165,639 (GRCm39) |
R125S |
probably damaging |
Het |
Leo1 |
T |
C |
9: 75,353,277 (GRCm39) |
|
probably null |
Het |
Map2 |
G |
T |
1: 66,460,872 (GRCm39) |
R1556L |
probably damaging |
Het |
Megf8 |
A |
G |
7: 25,059,166 (GRCm39) |
|
probably null |
Het |
Meikin |
T |
C |
11: 54,317,477 (GRCm39) |
I426T |
possibly damaging |
Het |
Muc16 |
A |
T |
9: 18,556,015 (GRCm39) |
V3426E |
unknown |
Het |
Or4a15 |
T |
A |
2: 89,193,065 (GRCm39) |
Y236F |
probably benign |
Het |
Or51af1 |
G |
A |
7: 103,142,029 (GRCm39) |
L19F |
probably damaging |
Het |
Or52n2c |
A |
G |
7: 104,574,620 (GRCm39) |
L117P |
probably damaging |
Het |
Or7e168 |
T |
G |
9: 19,720,105 (GRCm39) |
S164A |
possibly damaging |
Het |
Or8k25 |
T |
C |
2: 86,243,935 (GRCm39) |
I154V |
probably benign |
Het |
Or9s13 |
T |
C |
1: 92,547,643 (GRCm39) |
V5A |
probably benign |
Het |
Otogl |
A |
G |
10: 107,747,936 (GRCm39) |
|
probably null |
Het |
Palm3 |
T |
C |
8: 84,756,504 (GRCm39) |
L672P |
probably damaging |
Het |
Perm1 |
A |
G |
4: 156,302,091 (GRCm39) |
T212A |
probably benign |
Het |
Poc1a |
T |
C |
9: 106,226,960 (GRCm39) |
M400T |
probably benign |
Het |
Pou6f2 |
T |
A |
13: 18,414,196 (GRCm39) |
Q193L |
unknown |
Het |
Ppl |
C |
T |
16: 4,905,300 (GRCm39) |
R1665H |
probably benign |
Het |
Ppp4r3b |
T |
C |
11: 29,123,449 (GRCm39) |
|
probably null |
Het |
Ptger1 |
T |
C |
8: 84,394,654 (GRCm39) |
S44P |
probably damaging |
Het |
Pzp |
T |
C |
6: 128,473,009 (GRCm39) |
T787A |
probably benign |
Het |
Rab44 |
A |
T |
17: 29,358,642 (GRCm39) |
R277* |
probably null |
Het |
Rasgef1a |
T |
A |
6: 118,064,088 (GRCm39) |
I334K |
probably damaging |
Het |
Rfx1 |
T |
C |
8: 84,818,084 (GRCm39) |
V554A |
possibly damaging |
Het |
Ripk1 |
T |
A |
13: 34,214,032 (GRCm39) |
I518K |
possibly damaging |
Het |
Rpl22 |
A |
G |
4: 152,416,763 (GRCm39) |
Y90C |
probably damaging |
Het |
Rps27a |
C |
A |
11: 29,495,998 (GRCm39) |
R118L |
probably benign |
Het |
Scmh1 |
T |
A |
4: 120,319,331 (GRCm39) |
S19T |
probably benign |
Het |
Scn10a |
C |
T |
9: 119,520,509 (GRCm39) |
|
probably null |
Het |
Sema4c |
A |
T |
1: 36,589,867 (GRCm39) |
S496T |
probably benign |
Het |
Serpina3i |
T |
C |
12: 104,231,387 (GRCm39) |
V8A |
possibly damaging |
Het |
Sis |
G |
A |
3: 72,867,628 (GRCm39) |
T139M |
probably damaging |
Het |
Skic3 |
A |
T |
13: 76,303,587 (GRCm39) |
H1227L |
probably benign |
Het |
Slc45a2 |
T |
A |
15: 11,000,972 (GRCm39) |
S24T |
probably benign |
Het |
Slc5a11 |
A |
G |
7: 122,866,975 (GRCm39) |
I423M |
probably benign |
Het |
Slc7a10 |
G |
A |
7: 34,885,997 (GRCm39) |
G31S |
probably benign |
Het |
Sowahc |
A |
G |
10: 59,059,001 (GRCm39) |
N379S |
probably benign |
Het |
Stat5a |
T |
C |
11: 100,774,714 (GRCm39) |
M741T |
unknown |
Het |
Tcf15 |
T |
C |
2: 151,986,020 (GRCm39) |
S159P |
probably benign |
Het |
Tdrd5 |
C |
A |
1: 156,098,788 (GRCm39) |
R669L |
possibly damaging |
Het |
Tln1 |
T |
C |
4: 43,553,041 (GRCm39) |
E350G |
possibly damaging |
Het |
Trim12c |
T |
G |
7: 103,997,271 (GRCm39) |
N95T |
|
Het |
Urb1 |
T |
C |
16: 90,571,513 (GRCm39) |
T1099A |
probably benign |
Het |
Vmn1r44 |
T |
A |
6: 89,870,578 (GRCm39) |
V108D |
probably damaging |
Het |
Vmn2r65 |
A |
G |
7: 84,589,388 (GRCm39) |
Y843H |
probably benign |
Het |
Vps13a |
T |
C |
19: 16,623,270 (GRCm39) |
N2797S |
possibly damaging |
Het |
Wscd2 |
T |
C |
5: 113,712,235 (GRCm39) |
Y385H |
probably damaging |
Het |
Xdh |
T |
C |
17: 74,229,500 (GRCm39) |
I318V |
probably benign |
Het |
Xrcc3 |
T |
A |
12: 111,774,313 (GRCm39) |
K172M |
probably damaging |
Het |
|
Other mutations in Vmn2r68 |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL01391:Vmn2r68
|
APN |
7 |
84,886,819 (GRCm39) |
missense |
probably benign |
|
IGL01477:Vmn2r68
|
APN |
7 |
84,882,691 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL01600:Vmn2r68
|
APN |
7 |
84,871,468 (GRCm39) |
missense |
probably benign |
0.39 |
IGL01979:Vmn2r68
|
APN |
7 |
84,871,325 (GRCm39) |
missense |
probably benign |
|
IGL01999:Vmn2r68
|
APN |
7 |
84,871,439 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02269:Vmn2r68
|
APN |
7 |
84,870,947 (GRCm39) |
missense |
possibly damaging |
0.84 |
IGL02517:Vmn2r68
|
APN |
7 |
84,871,153 (GRCm39) |
nonsense |
probably null |
|
IGL02827:Vmn2r68
|
APN |
7 |
84,886,800 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02852:Vmn2r68
|
APN |
7 |
84,882,595 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL02982:Vmn2r68
|
APN |
7 |
84,883,649 (GRCm39) |
missense |
probably benign |
0.12 |
IGL03099:Vmn2r68
|
APN |
7 |
84,871,448 (GRCm39) |
nonsense |
probably null |
|
IGL03166:Vmn2r68
|
APN |
7 |
84,871,331 (GRCm39) |
missense |
probably benign |
0.01 |
IGL03168:Vmn2r68
|
APN |
7 |
84,870,972 (GRCm39) |
missense |
probably damaging |
1.00 |
IGL03243:Vmn2r68
|
APN |
7 |
84,882,963 (GRCm39) |
missense |
possibly damaging |
0.66 |
F5770:Vmn2r68
|
UTSW |
7 |
84,871,088 (GRCm39) |
missense |
probably benign |
0.01 |
R0280:Vmn2r68
|
UTSW |
7 |
84,882,466 (GRCm39) |
critical splice donor site |
probably null |
|
R0280:Vmn2r68
|
UTSW |
7 |
84,882,457 (GRCm39) |
splice site |
probably benign |
|
R0281:Vmn2r68
|
UTSW |
7 |
84,882,466 (GRCm39) |
critical splice donor site |
probably null |
|
R0281:Vmn2r68
|
UTSW |
7 |
84,882,457 (GRCm39) |
splice site |
probably benign |
|
R0348:Vmn2r68
|
UTSW |
7 |
84,870,884 (GRCm39) |
missense |
possibly damaging |
0.50 |
R0390:Vmn2r68
|
UTSW |
7 |
84,882,466 (GRCm39) |
critical splice donor site |
probably null |
|
R0390:Vmn2r68
|
UTSW |
7 |
84,882,457 (GRCm39) |
splice site |
probably benign |
|
R0722:Vmn2r68
|
UTSW |
7 |
84,870,794 (GRCm39) |
missense |
possibly damaging |
0.95 |
R1129:Vmn2r68
|
UTSW |
7 |
84,886,712 (GRCm39) |
splice site |
probably null |
|
R1136:Vmn2r68
|
UTSW |
7 |
84,871,549 (GRCm39) |
missense |
possibly damaging |
0.81 |
R1319:Vmn2r68
|
UTSW |
7 |
84,881,700 (GRCm39) |
missense |
probably damaging |
0.96 |
R1614:Vmn2r68
|
UTSW |
7 |
84,870,946 (GRCm39) |
missense |
possibly damaging |
0.93 |
R1682:Vmn2r68
|
UTSW |
7 |
84,882,574 (GRCm39) |
missense |
possibly damaging |
0.68 |
R1837:Vmn2r68
|
UTSW |
7 |
84,882,886 (GRCm39) |
missense |
probably damaging |
0.96 |
R1893:Vmn2r68
|
UTSW |
7 |
84,883,867 (GRCm39) |
nonsense |
probably null |
|
R1908:Vmn2r68
|
UTSW |
7 |
84,883,260 (GRCm39) |
missense |
probably benign |
0.09 |
R1909:Vmn2r68
|
UTSW |
7 |
84,883,260 (GRCm39) |
missense |
probably benign |
0.09 |
R1951:Vmn2r68
|
UTSW |
7 |
84,883,102 (GRCm39) |
missense |
probably damaging |
1.00 |
R2177:Vmn2r68
|
UTSW |
7 |
84,871,123 (GRCm39) |
missense |
probably benign |
0.01 |
R2178:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
R2185:Vmn2r68
|
UTSW |
7 |
84,882,901 (GRCm39) |
nonsense |
probably null |
|
R2188:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
R2282:Vmn2r68
|
UTSW |
7 |
84,870,859 (GRCm39) |
missense |
possibly damaging |
0.65 |
R2567:Vmn2r68
|
UTSW |
7 |
84,883,803 (GRCm39) |
missense |
probably benign |
|
R2869:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
R2869:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
R2870:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
R2870:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
R2871:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
R2871:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
R2873:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
R2874:Vmn2r68
|
UTSW |
7 |
84,882,834 (GRCm39) |
missense |
probably benign |
0.25 |
R3149:Vmn2r68
|
UTSW |
7 |
84,886,875 (GRCm39) |
missense |
probably benign |
0.00 |
R3401:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
R3978:Vmn2r68
|
UTSW |
7 |
84,881,670 (GRCm39) |
missense |
probably benign |
0.00 |
R4399:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
R4401:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
R4421:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
R4478:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
R4479:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
R4495:Vmn2r68
|
UTSW |
7 |
84,870,758 (GRCm39) |
frame shift |
probably null |
|
R4628:Vmn2r68
|
UTSW |
7 |
84,883,673 (GRCm39) |
missense |
probably benign |
0.00 |
R4649:Vmn2r68
|
UTSW |
7 |
84,870,743 (GRCm39) |
missense |
probably benign |
|
R4654:Vmn2r68
|
UTSW |
7 |
84,882,769 (GRCm39) |
nonsense |
probably null |
|
R4793:Vmn2r68
|
UTSW |
7 |
84,883,648 (GRCm39) |
missense |
probably benign |
0.01 |
R5007:Vmn2r68
|
UTSW |
7 |
84,881,622 (GRCm39) |
missense |
probably benign |
|
R5021:Vmn2r68
|
UTSW |
7 |
84,882,942 (GRCm39) |
missense |
possibly damaging |
0.62 |
R5082:Vmn2r68
|
UTSW |
7 |
84,883,076 (GRCm39) |
missense |
probably benign |
0.12 |
R5177:Vmn2r68
|
UTSW |
7 |
84,871,199 (GRCm39) |
missense |
probably damaging |
0.99 |
R5221:Vmn2r68
|
UTSW |
7 |
84,871,085 (GRCm39) |
missense |
probably damaging |
1.00 |
R5514:Vmn2r68
|
UTSW |
7 |
84,886,767 (GRCm39) |
missense |
possibly damaging |
0.92 |
R5521:Vmn2r68
|
UTSW |
7 |
84,882,926 (GRCm39) |
missense |
probably benign |
0.03 |
R5563:Vmn2r68
|
UTSW |
7 |
84,871,283 (GRCm39) |
missense |
probably damaging |
1.00 |
R5664:Vmn2r68
|
UTSW |
7 |
84,882,978 (GRCm39) |
missense |
probably benign |
0.02 |
R5829:Vmn2r68
|
UTSW |
7 |
84,886,812 (GRCm39) |
missense |
probably benign |
0.00 |
R6016:Vmn2r68
|
UTSW |
7 |
84,871,453 (GRCm39) |
missense |
probably damaging |
0.99 |
R6356:Vmn2r68
|
UTSW |
7 |
84,883,048 (GRCm39) |
missense |
possibly damaging |
0.85 |
R6413:Vmn2r68
|
UTSW |
7 |
84,870,973 (GRCm39) |
missense |
probably damaging |
1.00 |
R6418:Vmn2r68
|
UTSW |
7 |
84,882,915 (GRCm39) |
missense |
probably benign |
|
R6699:Vmn2r68
|
UTSW |
7 |
84,881,583 (GRCm39) |
missense |
possibly damaging |
0.58 |
R7287:Vmn2r68
|
UTSW |
7 |
84,871,460 (GRCm39) |
missense |
probably benign |
0.33 |
R7319:Vmn2r68
|
UTSW |
7 |
84,883,042 (GRCm39) |
missense |
probably benign |
|
R7374:Vmn2r68
|
UTSW |
7 |
84,881,607 (GRCm39) |
missense |
possibly damaging |
0.66 |
R7585:Vmn2r68
|
UTSW |
7 |
84,881,587 (GRCm39) |
missense |
probably damaging |
1.00 |
R7605:Vmn2r68
|
UTSW |
7 |
84,883,116 (GRCm39) |
missense |
probably benign |
0.01 |
R7892:Vmn2r68
|
UTSW |
7 |
84,883,722 (GRCm39) |
missense |
probably benign |
|
R7979:Vmn2r68
|
UTSW |
7 |
84,883,625 (GRCm39) |
critical splice donor site |
probably null |
|
R8177:Vmn2r68
|
UTSW |
7 |
84,871,422 (GRCm39) |
nonsense |
probably null |
|
R8349:Vmn2r68
|
UTSW |
7 |
84,882,785 (GRCm39) |
missense |
probably damaging |
1.00 |
R8378:Vmn2r68
|
UTSW |
7 |
84,871,108 (GRCm39) |
missense |
probably benign |
0.00 |
R8397:Vmn2r68
|
UTSW |
7 |
84,886,722 (GRCm39) |
missense |
possibly damaging |
0.71 |
R8449:Vmn2r68
|
UTSW |
7 |
84,882,785 (GRCm39) |
missense |
probably damaging |
1.00 |
R8543:Vmn2r68
|
UTSW |
7 |
84,883,648 (GRCm39) |
missense |
probably benign |
0.01 |
R9056:Vmn2r68
|
UTSW |
7 |
84,871,420 (GRCm39) |
missense |
possibly damaging |
0.71 |
R9342:Vmn2r68
|
UTSW |
7 |
84,882,993 (GRCm39) |
missense |
probably benign |
0.39 |
R9734:Vmn2r68
|
UTSW |
7 |
84,882,757 (GRCm39) |
missense |
possibly damaging |
0.54 |
V7581:Vmn2r68
|
UTSW |
7 |
84,871,088 (GRCm39) |
missense |
probably benign |
0.01 |
Z1176:Vmn2r68
|
UTSW |
7 |
84,871,289 (GRCm39) |
missense |
probably benign |
0.27 |
Z1176:Vmn2r68
|
UTSW |
7 |
84,870,941 (GRCm39) |
missense |
probably damaging |
1.00 |
Z1176:Vmn2r68
|
UTSW |
7 |
84,871,307 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
Predicted Primers |
PCR Primer
(F):5'- GGAGAAGTTCCCAGCCAAATTC -3'
(R):5'- AAGGCTCTAGCTGGCATTGC -3'
Sequencing Primer
(F):5'- TTCCACAAAGAATCAGCTGAATCATG -3'
(R):5'- GCTCTAGCTGGCATTGCTCTATG -3'
|
Posted On |
2021-03-08 |