Mutagenetix > Incidental Mutation

Incidental Mutation 'R8681:Vmn2r26'

661737

Institutional Source

Beutler Lab

Gene Symbol

Vmn2r26

Ensembl Gene

ENSMUSG00000096630

Gene Name

vomeronasal 2, receptor 26

Synonyms

V2r1b

MMRRC Submission

Accession Numbers

Is this an essential gene?

Probably non essential (E-score: 0.089) question?

Stock #

R8681 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

124024758-124062035 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

C to T at 124024918 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Threonine to Isoleucine at position 54 (T54I)

Ref Sequence

ENSEMBL: ENSMUSP00000032238 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000032238]

AlphaFold

Q6TAC4

Predicted Effect

probably benign
Transcript: ENSMUST00000032238
AA Change: T54I

PolyPhen 2 Score 0.004 (Sensitivity: 0.98; Specificity: 0.59)

SMART Domains

Protein: ENSMUSP00000032238
Gene: ENSMUSG00000096630
AA Change: T54I

Domain	Start	End	E-Value	Type
signal peptide	1	22	N/A	INTRINSIC
Pfam:ANF_receptor	82	471	1.5e-31	PFAM
Pfam:NCD3G	519	572	4.6e-25	PFAM
Pfam:7tm_3	603	840	1.5e-55	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.2%
20x: 97.0%

Validation Efficiency

MGI Phenotype

PHENOTYPE: Mice homozygous for a knock-out allele exhibit abnormal vomeronasal sensory neuron physiology and avnosmia. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2010111I01Rik	T	C	13: 63,190,559	F583S	probably damaging	Het
A430078G23Rik	A	G	8: 3,389,074	Y477C	unknown	Het
Abcc12	A	G	8: 86,505,279	V1347A	possibly damaging	Het
Adam32	G	A	8: 24,837,795	T750I	unknown	Het
Adcy1	T	C	11: 7,161,328	I873T	probably damaging	Het
Aebp1	A	G	11: 5,867,899	D438G	probably null	Het
Anks1b	T	A	10: 90,050,006	M188K	probably damaging	Het
Ccdc114	A	G	7: 45,941,839	E246G	probably damaging	Het
Cep112	T	C	11: 108,425,652		probably null	Het
Clu	T	C	14: 65,980,957	V422A	probably damaging	Het
Cntrl	T	C	2: 35,148,588	L1050P	probably damaging	Het
Col23a1	A	T	11: 51,567,929	T298S	possibly damaging	Het
Cyp26c1	A	T	19: 37,686,617	T129S	probably damaging	Het
Cyp2c38	A	C	19: 39,401,691	V355G	possibly damaging	Het
Cyp4a30b	G	A	4: 115,457,745	V175M	possibly damaging	Het
Cyp7a1	A	T	4: 6,271,207	N316K	probably benign	Het
Dcaf17	T	A	2: 71,056,569	Y67*	probably null	Het
Dll3	T	C	7: 28,294,845	D389G	probably damaging	Het
Fbxo33	A	G	12: 59,219,044	F146L	probably benign	Het
Gm10118	C	T	10: 63,926,977	V61M	unknown	Het
Gm9611	T	C	14: 42,296,069	D102G		Het
Grik5	G	A	7: 25,010,472	A946V	probably benign	Het
Il17c	A	G	8: 122,423,468	D150G	possibly damaging	Het
Ino80e	A	G	7: 126,861,721	L22P	probably damaging	Het
Kcnh2	G	T	5: 24,331,983	T201K	probably benign	Het
Klrb1	A	C	6: 128,710,049	N173K	possibly damaging	Het
Kmt2d	T	A	15: 98,846,067	Q3737H	unknown	Het
Lemd3	T	C	10: 120,931,823	D682G	possibly damaging	Het
Lilra5	T	C	7: 4,238,217	V51A	probably benign	Het
Lrrc25	G	A	8: 70,617,664	V32I	possibly damaging	Het
Mdh1b	T	A	1: 63,715,201	M403L	probably benign	Het
Mms19	G	A	19: 41,949,476	L765F	probably damaging	Het
Msx3	T	A	7: 140,048,987	T5S	probably benign	Het
Myh13	A	C	11: 67,352,134	I958L	possibly damaging	Het
Myo18b	T	A	5: 112,873,563		probably null	Het
Myo9a	G	A	9: 59,868,111	V1002I	probably benign	Het
Neb	T	C	2: 52,237,036	K379R	probably damaging	Het
Nsmce2	A	G	15: 59,601,359	S216G	probably benign	Het
Olfr1109	A	T	2: 87,093,046	M117K	possibly damaging	Het
Olfr746	A	T	14: 50,653,344	M36L	probably benign	Het
Pkp2	A	T	16: 16,230,681	M317L	probably benign	Het
Pogz	T	A	3: 94,860,923	H137Q	probably damaging	Het
Prrx2	G	T	2: 30,845,507	D25Y	unknown	Het
Ptprf	T	C	4: 118,231,647	D653G	probably benign	Het
Rps6kl1	T	A	12: 85,147,855	E94V	probably damaging	Het
Slc44a1	A	T	4: 53,481,510	D27V	probably damaging	Het
Slc44a4	A	G	17: 34,928,277	I549V	possibly damaging	Het
Slc8a3	T	C	12: 81,315,140	T302A	probably benign	Het
Spic	T	A	10: 88,675,985	K136N	possibly damaging	Het
Stk36	T	C	1: 74,622,233	L473P	probably damaging	Het
Syce1	G	A	7: 140,782,074	T32I	possibly damaging	Het
Tars2	G	A	3: 95,750,887	Q209*	probably null	Het
Tmem9b	A	G	7: 109,745,320	V100A	probably benign	Het
Vmn1r67	A	G	7: 10,447,201	I131V	probably benign	Het
Zfp142	T	C	1: 74,571,588	E1016G	probably damaging	Het
Zfp773	T	C	7: 7,136,483	T56A	possibly damaging	Het

Other mutations in Vmn2r26

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01070:Vmn2r26	APN	6	124061607	missense	probably benign	0.00
IGL01370:Vmn2r26	APN	6	124061756	missense	probably benign	0.08
IGL01603:Vmn2r26	APN	6	124053874	missense	probably damaging	1.00
IGL01651:Vmn2r26	APN	6	124050673	missense	probably benign	0.01
IGL02282:Vmn2r26	APN	6	124061625	missense	probably damaging	1.00
IGL02425:Vmn2r26	APN	6	124061818	missense	probably damaging	1.00
IGL02551:Vmn2r26	APN	6	124026141	missense	probably benign	0.11
IGL02690:Vmn2r26	APN	6	124026132	missense	probably benign	0.14
IGL03002:Vmn2r26	APN	6	124039795	missense	possibly damaging	0.78
IGL03270:Vmn2r26	APN	6	124050819	missense	probably benign	0.16
R0032:Vmn2r26	UTSW	6	124039899	missense	possibly damaging	0.72
R0052:Vmn2r26	UTSW	6	124062033	makesense	probably null
R0083:Vmn2r26	UTSW	6	124053981	splice site	probably null
R0682:Vmn2r26	UTSW	6	124061170	missense	probably damaging	0.97
R1061:Vmn2r26	UTSW	6	124061644	missense	probably benign	0.12
R1077:Vmn2r26	UTSW	6	124053913	missense	probably benign	0.00
R1263:Vmn2r26	UTSW	6	124050708	missense	probably benign
R1579:Vmn2r26	UTSW	6	124039747	missense	probably benign	0.00
R1741:Vmn2r26	UTSW	6	124061472	missense	probably damaging	1.00
R1834:Vmn2r26	UTSW	6	124061410	missense	possibly damaging	0.54
R1838:Vmn2r26	UTSW	6	124024771	missense	probably benign
R1956:Vmn2r26	UTSW	6	124053887	missense	probably damaging	1.00
R1996:Vmn2r26	UTSW	6	124061185	missense	probably damaging	1.00
R2140:Vmn2r26	UTSW	6	124061237	missense	probably benign	0.01
R2327:Vmn2r26	UTSW	6	124039749	missense	probably benign	0.07
R2417:Vmn2r26	UTSW	6	124061350	missense	probably damaging	1.00
R3930:Vmn2r26	UTSW	6	124025979	missense	probably benign
R4490:Vmn2r26	UTSW	6	124050738	missense	possibly damaging	0.47
R4629:Vmn2r26	UTSW	6	124061191	missense	possibly damaging	0.50
R4655:Vmn2r26	UTSW	6	124061416	missense	probably damaging	1.00
R4709:Vmn2r26	UTSW	6	124053965	missense	probably damaging	1.00
R4992:Vmn2r26	UTSW	6	124026111	missense	probably benign	0.00
R5297:Vmn2r26	UTSW	6	124061873	missense	probably damaging	1.00
R5482:Vmn2r26	UTSW	6	124061326	missense	possibly damaging	0.88
R5517:Vmn2r26	UTSW	6	124050717	missense	probably damaging	1.00
R5737:Vmn2r26	UTSW	6	124039449	missense	probably benign	0.00
R5739:Vmn2r26	UTSW	6	124025966	missense	probably benign	0.00
R5873:Vmn2r26	UTSW	6	124061674	missense	probably benign	0.01
R5907:Vmn2r26	UTSW	6	124039871	missense	probably benign	0.00
R6086:Vmn2r26	UTSW	6	124039560	missense	possibly damaging	0.48
R6134:Vmn2r26	UTSW	6	124061485	missense	probably damaging	0.97
R6391:Vmn2r26	UTSW	6	124061389	missense	probably damaging	1.00
R6428:Vmn2r26	UTSW	6	124026080	missense	probably benign	0.17
R6637:Vmn2r26	UTSW	6	124061691	missense	probably damaging	1.00
R6927:Vmn2r26	UTSW	6	124039098	missense	possibly damaging	0.93
R6953:Vmn2r26	UTSW	6	124039782	missense	probably benign	0.00
R7173:Vmn2r26	UTSW	6	124061296	missense	probably benign	0.16
R7206:Vmn2r26	UTSW	6	124039768	missense	probably benign	0.17
R7208:Vmn2r26	UTSW	6	124061989	missense	probably damaging	1.00
R7283:Vmn2r26	UTSW	6	124025955	missense	probably damaging	0.97
R7506:Vmn2r26	UTSW	6	124039741	missense	probably benign	0.00
R7672:Vmn2r26	UTSW	6	124039647	missense	probably benign	0.25
R7674:Vmn2r26	UTSW	6	124039362	missense	probably benign
R7696:Vmn2r26	UTSW	6	124061535	missense	possibly damaging	0.94
R7716:Vmn2r26	UTSW	6	124061745	missense	probably damaging	1.00
R7831:Vmn2r26	UTSW	6	124039799	nonsense	probably null
R8063:Vmn2r26	UTSW	6	124024955	missense	probably benign	0.00
R8331:Vmn2r26	UTSW	6	124061928	missense	probably benign	0.22
R8352:Vmn2r26	UTSW	6	124039618	missense	probably benign	0.09
R8445:Vmn2r26	UTSW	6	124026036	missense	probably damaging	0.97
R8452:Vmn2r26	UTSW	6	124039618	missense	probably benign	0.09
R8914:Vmn2r26	UTSW	6	124062024	missense	probably benign
R9333:Vmn2r26	UTSW	6	124026050	missense	probably benign	0.13
R9351:Vmn2r26	UTSW	6	124039374	missense	probably benign
R9436:Vmn2r26	UTSW	6	124025867	missense	probably damaging	1.00
R9515:Vmn2r26	UTSW	6	124061178	missense	probably damaging	1.00
RF010:Vmn2r26	UTSW	6	124039489	missense	possibly damaging	0.90

Predicted Primers

PCR Primer
(F):5'- CCCAAGATTCTCAACTGAACAGATATC -3'
(R):5'- CAAAGTCTTTTCAACAATGTCTTACA -3'

Sequencing Primer
(F):5'- CAGATATCTGGGTCTTATCGATT -3'
(R):5'- AGCTTGTCTACACTCTAGAAGGTGTC -3'

Posted On

2021-03-08