Incidental Mutation 'R8681:Cyp2c38'
ID 661776
Institutional Source Beutler Lab
Gene Symbol Cyp2c38
Ensembl Gene ENSMUSG00000032808
Gene Name cytochrome P450, family 2, subfamily c, polypeptide 38
Synonyms
MMRRC Submission 068536-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.082) question?
Stock # R8681 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 39379109-39451519 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to C at 39390135 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Valine to Glycine at position 355 (V355G)
Ref Sequence ENSEMBL: ENSMUSP00000044722 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000035488]
AlphaFold P56655
Predicted Effect possibly damaging
Transcript: ENSMUST00000035488
AA Change: V355G

PolyPhen 2 Score 0.699 (Sensitivity: 0.86; Specificity: 0.92)
SMART Domains Protein: ENSMUSP00000044722
Gene: ENSMUSG00000032808
AA Change: V355G

DomainStartEndE-ValueType
signal peptide 1 20 N/A INTRINSIC
Pfam:p450 30 487 1.5e-161 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.2%
  • 20x: 97.0%
Validation Efficiency
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc12 A G 8: 87,231,908 (GRCm39) V1347A possibly damaging Het
Adam32 G A 8: 25,327,811 (GRCm39) T750I unknown Het
Adcy1 T C 11: 7,111,328 (GRCm39) I873T probably damaging Het
Aebp1 A G 11: 5,817,899 (GRCm39) D438G probably null Het
Anks1b T A 10: 89,885,868 (GRCm39) M188K probably damaging Het
Aopep T C 13: 63,338,373 (GRCm39) F583S probably damaging Het
Arhgef18 A G 8: 3,439,074 (GRCm39) Y477C unknown Het
Cep112 T C 11: 108,316,478 (GRCm39) probably null Het
Clu T C 14: 66,218,406 (GRCm39) V422A probably damaging Het
Cntrl T C 2: 35,038,600 (GRCm39) L1050P probably damaging Het
Col23a1 A T 11: 51,458,756 (GRCm39) T298S possibly damaging Het
Cyp26c1 A T 19: 37,675,065 (GRCm39) T129S probably damaging Het
Cyp4a30b G A 4: 115,314,942 (GRCm39) V175M possibly damaging Het
Cyp7a1 A T 4: 6,271,207 (GRCm39) N316K probably benign Het
Dcaf17 T A 2: 70,886,913 (GRCm39) Y67* probably null Het
Dll3 T C 7: 27,994,270 (GRCm39) D389G probably damaging Het
Fbxo33 A G 12: 59,265,830 (GRCm39) F146L probably benign Het
Gm10118 C T 10: 63,762,756 (GRCm39) V61M unknown Het
Gm9611 T C 14: 42,118,026 (GRCm39) D102G Het
Grik5 G A 7: 24,709,897 (GRCm39) A946V probably benign Het
Il17c A G 8: 123,150,207 (GRCm39) D150G possibly damaging Het
Ino80e A G 7: 126,460,893 (GRCm39) L22P probably damaging Het
Kcnh2 G T 5: 24,536,981 (GRCm39) T201K probably benign Het
Klrb1 A C 6: 128,687,012 (GRCm39) N173K possibly damaging Het
Kmt2d T A 15: 98,743,948 (GRCm39) Q3737H unknown Het
Lemd3 T C 10: 120,767,728 (GRCm39) D682G possibly damaging Het
Lilra5 T C 7: 4,241,216 (GRCm39) V51A probably benign Het
Lrrc25 G A 8: 71,070,314 (GRCm39) V32I possibly damaging Het
Mdh1b T A 1: 63,754,360 (GRCm39) M403L probably benign Het
Mms19 G A 19: 41,937,915 (GRCm39) L765F probably damaging Het
Msx3 T A 7: 139,628,900 (GRCm39) T5S probably benign Het
Myh13 A C 11: 67,242,960 (GRCm39) I958L possibly damaging Het
Myo18b T A 5: 113,021,429 (GRCm39) probably null Het
Myo9a G A 9: 59,775,394 (GRCm39) V1002I probably benign Het
Neb T C 2: 52,127,048 (GRCm39) K379R probably damaging Het
Nsmce2 A G 15: 59,473,208 (GRCm39) S216G probably benign Het
Odad1 A G 7: 45,591,263 (GRCm39) E246G probably damaging Het
Or11h7 A T 14: 50,890,801 (GRCm39) M36L probably benign Het
Or5aq6 A T 2: 86,923,390 (GRCm39) M117K possibly damaging Het
Pkp2 A T 16: 16,048,545 (GRCm39) M317L probably benign Het
Pogz T A 3: 94,768,234 (GRCm39) H137Q probably damaging Het
Prrx2 G T 2: 30,735,519 (GRCm39) D25Y unknown Het
Ptprf T C 4: 118,088,844 (GRCm39) D653G probably benign Het
Rps6kl1 T A 12: 85,194,629 (GRCm39) E94V probably damaging Het
Slc44a1 A T 4: 53,481,510 (GRCm39) D27V probably damaging Het
Slc44a4 A G 17: 35,147,253 (GRCm39) I549V possibly damaging Het
Slc8a3 T C 12: 81,361,914 (GRCm39) T302A probably benign Het
Spic T A 10: 88,511,847 (GRCm39) K136N possibly damaging Het
Stk36 T C 1: 74,661,392 (GRCm39) L473P probably damaging Het
Syce1 G A 7: 140,361,987 (GRCm39) T32I possibly damaging Het
Tars2 G A 3: 95,658,199 (GRCm39) Q209* probably null Het
Tmem9b A G 7: 109,344,527 (GRCm39) V100A probably benign Het
Vmn1r67 A G 7: 10,181,128 (GRCm39) I131V probably benign Het
Vmn2r26 C T 6: 124,001,877 (GRCm39) T54I probably benign Het
Zfp142 T C 1: 74,610,747 (GRCm39) E1016G probably damaging Het
Zfp773 T C 7: 7,139,482 (GRCm39) T56A possibly damaging Het
Other mutations in Cyp2c38
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00508:Cyp2c38 APN 19 39,449,169 (GRCm39) nonsense probably null
IGL01109:Cyp2c38 APN 19 39,451,329 (GRCm39) critical splice donor site probably null
IGL01521:Cyp2c38 APN 19 39,449,114 (GRCm39) missense probably damaging 0.99
IGL02036:Cyp2c38 APN 19 39,448,760 (GRCm39) missense probably null 0.97
IGL02187:Cyp2c38 APN 19 39,424,649 (GRCm39) missense probably benign 0.14
IGL02954:Cyp2c38 APN 19 39,379,520 (GRCm39) missense probably damaging 0.99
R0479:Cyp2c38 UTSW 19 39,451,449 (GRCm39) missense probably damaging 0.99
R0684:Cyp2c38 UTSW 19 39,379,500 (GRCm39) missense probably damaging 0.99
R0919:Cyp2c38 UTSW 19 39,393,113 (GRCm39) missense probably benign 0.07
R1462:Cyp2c38 UTSW 19 39,380,632 (GRCm39) missense probably damaging 0.96
R1462:Cyp2c38 UTSW 19 39,380,632 (GRCm39) missense probably damaging 0.96
R1642:Cyp2c38 UTSW 19 39,390,153 (GRCm39) missense probably damaging 1.00
R1715:Cyp2c38 UTSW 19 39,393,239 (GRCm39) missense probably benign 0.25
R1900:Cyp2c38 UTSW 19 39,426,756 (GRCm39) missense probably benign 0.40
R1954:Cyp2c38 UTSW 19 39,393,131 (GRCm39) missense probably damaging 0.99
R1955:Cyp2c38 UTSW 19 39,393,131 (GRCm39) missense probably damaging 0.99
R2860:Cyp2c38 UTSW 19 39,449,138 (GRCm39) missense probably benign 0.01
R2861:Cyp2c38 UTSW 19 39,449,138 (GRCm39) missense probably benign 0.01
R2862:Cyp2c38 UTSW 19 39,449,138 (GRCm39) missense probably benign 0.01
R3084:Cyp2c38 UTSW 19 39,390,145 (GRCm39) missense probably benign 0.00
R3727:Cyp2c38 UTSW 19 39,380,739 (GRCm39) splice site probably benign
R4648:Cyp2c38 UTSW 19 39,449,132 (GRCm39) missense probably benign 0.05
R5119:Cyp2c38 UTSW 19 39,449,065 (GRCm39) missense probably damaging 1.00
R5636:Cyp2c38 UTSW 19 39,426,750 (GRCm39) nonsense probably null
R5651:Cyp2c38 UTSW 19 39,449,156 (GRCm39) missense probably damaging 0.99
R6263:Cyp2c38 UTSW 19 39,380,659 (GRCm39) missense probably damaging 1.00
R6384:Cyp2c38 UTSW 19 39,380,737 (GRCm39) splice site probably null
R6853:Cyp2c38 UTSW 19 39,426,748 (GRCm39) missense probably benign 0.02
R6915:Cyp2c38 UTSW 19 39,424,512 (GRCm39) missense probably damaging 0.99
R7201:Cyp2c38 UTSW 19 39,390,220 (GRCm39) missense probably damaging 1.00
R7570:Cyp2c38 UTSW 19 39,393,187 (GRCm39) missense possibly damaging 0.76
R7625:Cyp2c38 UTSW 19 39,451,368 (GRCm39) missense possibly damaging 0.78
R7666:Cyp2c38 UTSW 19 39,426,686 (GRCm39) missense possibly damaging 0.52
Predicted Primers PCR Primer
(F):5'- GTAGATCTGCCCTCTGAACC -3'
(R):5'- ATTGCGTTGTGTATAGCCTGAC -3'

Sequencing Primer
(F):5'- GTAGATCTGCCCTCTGAACCATAAAG -3'
(R):5'- CGTTGTGTATAGCCTGACATTGTAAC -3'
Posted On 2021-03-08