Incidental Mutation 'R8685:Hrnr'
ID 661977
Institutional Source Beutler Lab
Gene Symbol Hrnr
Ensembl Gene ENSMUSG00000041991
Gene Name hornerin
Synonyms 1110033K19Rik, A530063N20Rik, S100a18
MMRRC Submission 068540-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8685 (G1)
Quality Score 225.009
Status Validated
Chromosome 3
Chromosomal Location 93227056-93240877 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 93230205 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Threonine at position 148 (S148T)
Ref Sequence ENSEMBL: ENSMUSP00000091288 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000090856] [ENSMUST00000093774]
AlphaFold no structure available at present
Predicted Effect unknown
Transcript: ENSMUST00000090856
AA Change: S148T
SMART Domains Protein: ENSMUSP00000088369
Gene: ENSMUSG00000041991
AA Change: S148T

DomainStartEndE-ValueType
Pfam:S_100 4 47 4.8e-15 PFAM
Blast:EFh 53 81 6e-9 BLAST
internal_repeat_5 95 129 7.19e-7 PROSPERO
low complexity region 135 155 N/A INTRINSIC
low complexity region 157 168 N/A INTRINSIC
low complexity region 183 197 N/A INTRINSIC
low complexity region 200 246 N/A INTRINSIC
low complexity region 255 287 N/A INTRINSIC
internal_repeat_2 288 341 5.7e-19 PROSPERO
internal_repeat_1 291 354 5.27e-23 PROSPERO
internal_repeat_3 301 355 9.03e-17 PROSPERO
internal_repeat_5 309 343 7.19e-7 PROSPERO
low complexity region 358 379 N/A INTRINSIC
low complexity region 394 415 N/A INTRINSIC
low complexity region 421 498 N/A INTRINSIC
low complexity region 501 523 N/A INTRINSIC
low complexity region 527 593 N/A INTRINSIC
low complexity region 598 675 N/A INTRINSIC
low complexity region 679 713 N/A INTRINSIC
low complexity region 723 764 N/A INTRINSIC
low complexity region 769 846 N/A INTRINSIC
low complexity region 849 871 N/A INTRINSIC
low complexity region 875 941 N/A INTRINSIC
low complexity region 946 1023 N/A INTRINSIC
low complexity region 1027 1061 N/A INTRINSIC
low complexity region 1084 1112 N/A INTRINSIC
low complexity region 1117 1194 N/A INTRINSIC
low complexity region 1197 1219 N/A INTRINSIC
low complexity region 1223 1289 N/A INTRINSIC
low complexity region 1294 1371 N/A INTRINSIC
low complexity region 1375 1409 N/A INTRINSIC
low complexity region 1419 1460 N/A INTRINSIC
low complexity region 1465 1542 N/A INTRINSIC
low complexity region 1545 1567 N/A INTRINSIC
low complexity region 1571 1637 N/A INTRINSIC
low complexity region 1642 1719 N/A INTRINSIC
low complexity region 1723 1757 N/A INTRINSIC
low complexity region 1767 1808 N/A INTRINSIC
low complexity region 1813 1890 N/A INTRINSIC
low complexity region 1893 1915 N/A INTRINSIC
low complexity region 1919 1985 N/A INTRINSIC
low complexity region 1990 2067 N/A INTRINSIC
low complexity region 2071 2105 N/A INTRINSIC
low complexity region 2115 2156 N/A INTRINSIC
low complexity region 2161 2238 N/A INTRINSIC
low complexity region 2242 2327 N/A INTRINSIC
low complexity region 2332 2409 N/A INTRINSIC
low complexity region 2413 2447 N/A INTRINSIC
low complexity region 2457 2498 N/A INTRINSIC
low complexity region 2503 2580 N/A INTRINSIC
low complexity region 2583 2605 N/A INTRINSIC
low complexity region 2609 2675 N/A INTRINSIC
low complexity region 2680 2757 N/A INTRINSIC
low complexity region 2761 2795 N/A INTRINSIC
low complexity region 2805 2846 N/A INTRINSIC
low complexity region 2851 2896 N/A INTRINSIC
internal_repeat_4 2897 2968 4.19e-13 PROSPERO
internal_repeat_3 2901 2955 9.03e-17 PROSPERO
internal_repeat_2 2920 2967 5.7e-19 PROSPERO
low complexity region 2969 2985 N/A INTRINSIC
low complexity region 3016 3034 N/A INTRINSIC
internal_repeat_1 3039 3101 5.27e-23 PROSPERO
internal_repeat_4 3045 3103 4.19e-13 PROSPERO
low complexity region 3140 3153 N/A INTRINSIC
low complexity region 3163 3174 N/A INTRINSIC
Predicted Effect unknown
Transcript: ENSMUST00000093774
AA Change: S148T
SMART Domains Protein: ENSMUSP00000091288
Gene: ENSMUSG00000041991
AA Change: S148T

DomainStartEndE-ValueType
Pfam:S_100 4 46 3.1e-17 PFAM
Blast:EFh 53 81 6e-9 BLAST
internal_repeat_5 95 129 5.9e-7 PROSPERO
low complexity region 135 155 N/A INTRINSIC
low complexity region 157 168 N/A INTRINSIC
low complexity region 183 197 N/A INTRINSIC
low complexity region 200 246 N/A INTRINSIC
low complexity region 255 287 N/A INTRINSIC
internal_repeat_2 288 341 3.49e-19 PROSPERO
internal_repeat_1 291 354 2.93e-23 PROSPERO
internal_repeat_3 301 355 5.83e-17 PROSPERO
internal_repeat_5 309 343 5.9e-7 PROSPERO
low complexity region 358 379 N/A INTRINSIC
low complexity region 394 415 N/A INTRINSIC
low complexity region 421 498 N/A INTRINSIC
low complexity region 501 523 N/A INTRINSIC
low complexity region 527 593 N/A INTRINSIC
low complexity region 598 675 N/A INTRINSIC
low complexity region 679 713 N/A INTRINSIC
low complexity region 723 764 N/A INTRINSIC
low complexity region 769 846 N/A INTRINSIC
low complexity region 849 871 N/A INTRINSIC
low complexity region 875 941 N/A INTRINSIC
low complexity region 946 1023 N/A INTRINSIC
low complexity region 1027 1061 N/A INTRINSIC
low complexity region 1084 1112 N/A INTRINSIC
low complexity region 1117 1194 N/A INTRINSIC
low complexity region 1197 1219 N/A INTRINSIC
low complexity region 1223 1289 N/A INTRINSIC
low complexity region 1294 1371 N/A INTRINSIC
low complexity region 1375 1409 N/A INTRINSIC
low complexity region 1419 1460 N/A INTRINSIC
low complexity region 1465 1542 N/A INTRINSIC
low complexity region 1545 1567 N/A INTRINSIC
low complexity region 1571 1637 N/A INTRINSIC
low complexity region 1642 1719 N/A INTRINSIC
low complexity region 1723 1757 N/A INTRINSIC
low complexity region 1767 1808 N/A INTRINSIC
low complexity region 1813 1890 N/A INTRINSIC
low complexity region 1893 1915 N/A INTRINSIC
low complexity region 1919 1985 N/A INTRINSIC
low complexity region 1990 2067 N/A INTRINSIC
low complexity region 2071 2105 N/A INTRINSIC
low complexity region 2115 2156 N/A INTRINSIC
low complexity region 2161 2238 N/A INTRINSIC
low complexity region 2242 2276 N/A INTRINSIC
low complexity region 2286 2327 N/A INTRINSIC
low complexity region 2332 2409 N/A INTRINSIC
low complexity region 2412 2434 N/A INTRINSIC
low complexity region 2438 2504 N/A INTRINSIC
low complexity region 2509 2586 N/A INTRINSIC
low complexity region 2590 2624 N/A INTRINSIC
low complexity region 2634 2675 N/A INTRINSIC
low complexity region 2680 2757 N/A INTRINSIC
low complexity region 2760 2782 N/A INTRINSIC
low complexity region 2786 2852 N/A INTRINSIC
low complexity region 2857 2934 N/A INTRINSIC
low complexity region 2938 2972 N/A INTRINSIC
low complexity region 2982 3023 N/A INTRINSIC
low complexity region 3028 3073 N/A INTRINSIC
internal_repeat_4 3074 3145 2.96e-13 PROSPERO
internal_repeat_3 3078 3132 5.83e-17 PROSPERO
internal_repeat_2 3097 3144 3.49e-19 PROSPERO
low complexity region 3146 3162 N/A INTRINSIC
low complexity region 3193 3211 N/A INTRINSIC
internal_repeat_1 3216 3278 2.93e-23 PROSPERO
internal_repeat_4 3222 3280 2.96e-13 PROSPERO
low complexity region 3317 3330 N/A INTRINSIC
low complexity region 3340 3351 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.9%
  • 20x: 99.7%
Validation Efficiency 100% (44/44)
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057J18Rik T C 10: 28,862,140 (GRCm39) Y50C probably damaging Het
Adgrl3 G T 5: 81,874,708 (GRCm39) D1002Y possibly damaging Het
Aoc3 G A 11: 101,223,042 (GRCm39) R426H probably benign Het
Atf6b A G 17: 34,869,320 (GRCm39) H179R probably benign Het
Bbs4 T C 9: 59,247,138 (GRCm39) T121A probably benign Het
Brca1 T C 11: 101,380,672 (GRCm39) Y1787C probably benign Het
Cbx2 T A 11: 118,918,746 (GRCm39) S104T possibly damaging Het
Cdh10 T A 15: 18,899,851 (GRCm39) N59K possibly damaging Het
Clstn3 C T 6: 124,433,867 (GRCm39) R431H probably damaging Het
Cylc2 C T 4: 51,229,651 (GRCm39) T331M unknown Het
Dcpp3 T C 17: 24,138,096 (GRCm39) S85P probably benign Het
Dip2c A G 13: 9,687,161 (GRCm39) T1262A probably benign Het
Dlgap2 A G 8: 14,881,628 (GRCm39) E900G possibly damaging Het
Dtx4 C T 19: 12,446,995 (GRCm39) D566N probably benign Het
Elmo1 T A 13: 20,474,594 (GRCm39) N339K possibly damaging Het
Gm11596 C A 11: 99,683,816 (GRCm39) R101S unknown Het
Hk1 T C 10: 62,132,453 (GRCm39) probably benign Het
Hyls1 A G 9: 35,472,724 (GRCm39) Y231H probably damaging Het
Il17rb T A 14: 29,726,297 (GRCm39) Y97F probably benign Het
Lamc1 G T 1: 153,109,288 (GRCm39) T1168K probably benign Het
Larp6 A T 9: 60,631,495 (GRCm39) D89V probably damaging Het
Muc4 C G 16: 32,575,221 (GRCm39) Q1269E probably benign Het
Myo18a A G 11: 77,745,520 (GRCm39) T1953A probably benign Het
Myo5c A G 9: 75,192,229 (GRCm39) D1127G possibly damaging Het
Myo7a T C 7: 97,746,334 (GRCm39) D266G probably benign Het
Naa35 T A 13: 59,734,036 (GRCm39) M22K probably benign Het
Niban2 T G 2: 32,809,101 (GRCm39) L229R probably benign Het
Or1f19 A T 16: 3,410,904 (GRCm39) I215F probably damaging Het
Pcdha8 T A 18: 37,127,003 (GRCm39) V495E probably damaging Het
Per2 T G 1: 91,378,402 (GRCm39) D49A possibly damaging Het
Plau G A 14: 20,889,627 (GRCm39) probably benign Het
Plekhg6 T A 6: 125,352,755 (GRCm39) I131L possibly damaging Het
Pnma8b T A 7: 16,679,965 (GRCm39) D316E unknown Het
Ppp4r3b T C 11: 29,159,436 (GRCm39) Y597H possibly damaging Het
Psmd2 T C 16: 20,474,161 (GRCm39) V288A probably benign Het
Slc6a15 T C 10: 103,245,556 (GRCm39) V513A possibly damaging Het
Smarcd3 G A 5: 24,800,988 (GRCm39) R140W probably damaging Het
Srrm4 T C 5: 116,585,380 (GRCm39) R440G unknown Het
Tpsg1 A T 17: 25,592,241 (GRCm39) Y105F possibly damaging Het
Trbv26 C A 6: 41,204,693 (GRCm39) A38E probably damaging Het
Ush2a T A 1: 188,198,401 (GRCm39) N1488K probably damaging Het
Vill A T 9: 118,895,795 (GRCm39) R502S probably benign Het
Zbed6 A T 1: 133,584,754 (GRCm39) L861* probably null Het
Other mutations in Hrnr
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00848:Hrnr APN 3 93,230,204 (GRCm39) missense unknown
IGL02326:Hrnr APN 3 93,231,052 (GRCm39) missense unknown
IGL03030:Hrnr APN 3 93,227,908 (GRCm39) missense possibly damaging 0.91
IGL03281:Hrnr APN 3 93,230,158 (GRCm39) missense probably benign 0.04
R0140:Hrnr UTSW 3 93,238,800 (GRCm39) nonsense probably null
R0709:Hrnr UTSW 3 93,239,815 (GRCm39) missense unknown
R1179:Hrnr UTSW 3 93,239,850 (GRCm39) missense unknown
R1528:Hrnr UTSW 3 93,230,101 (GRCm39) missense possibly damaging 0.56
R1640:Hrnr UTSW 3 93,239,823 (GRCm39) missense unknown
R1987:Hrnr UTSW 3 93,239,911 (GRCm39) missense unknown
R1988:Hrnr UTSW 3 93,239,911 (GRCm39) missense unknown
R3846:Hrnr UTSW 3 93,239,464 (GRCm39) missense unknown
R3871:Hrnr UTSW 3 93,239,181 (GRCm39) missense unknown
R3938:Hrnr UTSW 3 93,230,162 (GRCm39) missense probably benign 0.35
R4569:Hrnr UTSW 3 93,230,875 (GRCm39) missense unknown
R4690:Hrnr UTSW 3 93,230,959 (GRCm39) missense unknown
R4761:Hrnr UTSW 3 93,230,062 (GRCm39) missense probably damaging 0.96
R5182:Hrnr UTSW 3 93,239,450 (GRCm39) missense unknown
R5292:Hrnr UTSW 3 93,239,199 (GRCm39) missense unknown
R5739:Hrnr UTSW 3 93,230,436 (GRCm39) missense unknown
R5845:Hrnr UTSW 3 93,239,944 (GRCm39) missense unknown
R5994:Hrnr UTSW 3 93,239,607 (GRCm39) missense unknown
R6169:Hrnr UTSW 3 93,233,062 (GRCm39) nonsense probably null
R6216:Hrnr UTSW 3 93,239,469 (GRCm39) missense unknown
R6256:Hrnr UTSW 3 93,229,918 (GRCm39) missense probably damaging 1.00
R6670:Hrnr UTSW 3 93,239,192 (GRCm39) missense unknown
R6790:Hrnr UTSW 3 93,236,382 (GRCm39) missense unknown
R6936:Hrnr UTSW 3 93,239,667 (GRCm39) missense unknown
R7049:Hrnr UTSW 3 93,230,461 (GRCm39) nonsense probably null
R7358:Hrnr UTSW 3 93,230,448 (GRCm39) nonsense probably null
R7383:Hrnr UTSW 3 93,239,098 (GRCm39) missense unknown
R7724:Hrnr UTSW 3 93,230,323 (GRCm39) missense unknown
R7762:Hrnr UTSW 3 93,239,506 (GRCm39) missense unknown
R7945:Hrnr UTSW 3 93,239,506 (GRCm39) missense unknown
R8086:Hrnr UTSW 3 93,230,728 (GRCm39) missense unknown
R8115:Hrnr UTSW 3 93,231,039 (GRCm39) missense unknown
R8383:Hrnr UTSW 3 93,239,653 (GRCm39) missense unknown
R8809:Hrnr UTSW 3 93,239,443 (GRCm39) missense unknown
R9123:Hrnr UTSW 3 93,238,863 (GRCm39) missense unknown
R9125:Hrnr UTSW 3 93,238,863 (GRCm39) missense unknown
R9129:Hrnr UTSW 3 93,231,277 (GRCm39) missense unknown
R9572:Hrnr UTSW 3 93,239,467 (GRCm39) missense unknown
R9627:Hrnr UTSW 3 93,233,235 (GRCm39) missense unknown
R9698:Hrnr UTSW 3 93,233,094 (GRCm39) missense unknown
R9717:Hrnr UTSW 3 93,227,987 (GRCm39) missense probably damaging 1.00
R9749:Hrnr UTSW 3 93,231,384 (GRCm39) missense unknown
R9781:Hrnr UTSW 3 93,239,696 (GRCm39) missense unknown
R9785:Hrnr UTSW 3 93,238,861 (GRCm39) missense unknown
Predicted Primers PCR Primer
(F):5'- AAAGATTACTGCCAAGCTTCAGG -3'
(R):5'- AACATTCGCCAGATCCTTTTGTAC -3'

Sequencing Primer
(F):5'- CTGCCAAGCTTCAGGGTCAAAG -3'
(R):5'- CCAGATCCTTTTGTACTGGAGCTAG -3'
Posted On 2021-03-08