Incidental Mutation 'R8685:Or1f19'
ID 662007
Institutional Source Beutler Lab
Gene Symbol Or1f19
Ensembl Gene ENSMUSG00000051003
Gene Name olfactory receptor family 1 subfamily F member 19
Synonyms GA_x54KRFPKG5P-112942-113883, Olfr161, MOR131-1
MMRRC Submission 068540-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.357) question?
Stock # R8685 (G1)
Quality Score 225.009
Status Validated
Chromosome 16
Chromosomal Location 3410262-3411203 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to T at 3410904 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Phenylalanine at position 215 (I215F)
Ref Sequence ENSEMBL: ENSMUSP00000150825 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000061541] [ENSMUST00000216259]
AlphaFold Q8VGB9
Predicted Effect probably damaging
Transcript: ENSMUST00000061541
AA Change: I215F

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000058956
Gene: ENSMUSG00000051003
AA Change: I215F

DomainStartEndE-ValueType
Pfam:7tm_4 32 308 6.4e-60 PFAM
Pfam:7TM_GPCR_Srsx 36 220 7.2e-6 PFAM
Pfam:7tm_1 42 291 2.9e-25 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000216259
AA Change: I215F

PolyPhen 2 Score 0.985 (Sensitivity: 0.74; Specificity: 0.96)
Meta Mutation Damage Score 0.1831 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.9%
  • 20x: 99.7%
Validation Efficiency 100% (44/44)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 43 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2310057J18Rik T C 10: 28,862,140 (GRCm39) Y50C probably damaging Het
Adgrl3 G T 5: 81,874,708 (GRCm39) D1002Y possibly damaging Het
Aoc3 G A 11: 101,223,042 (GRCm39) R426H probably benign Het
Atf6b A G 17: 34,869,320 (GRCm39) H179R probably benign Het
Bbs4 T C 9: 59,247,138 (GRCm39) T121A probably benign Het
Brca1 T C 11: 101,380,672 (GRCm39) Y1787C probably benign Het
Cbx2 T A 11: 118,918,746 (GRCm39) S104T possibly damaging Het
Cdh10 T A 15: 18,899,851 (GRCm39) N59K possibly damaging Het
Clstn3 C T 6: 124,433,867 (GRCm39) R431H probably damaging Het
Cylc2 C T 4: 51,229,651 (GRCm39) T331M unknown Het
Dcpp3 T C 17: 24,138,096 (GRCm39) S85P probably benign Het
Dip2c A G 13: 9,687,161 (GRCm39) T1262A probably benign Het
Dlgap2 A G 8: 14,881,628 (GRCm39) E900G possibly damaging Het
Dtx4 C T 19: 12,446,995 (GRCm39) D566N probably benign Het
Elmo1 T A 13: 20,474,594 (GRCm39) N339K possibly damaging Het
Gm11596 C A 11: 99,683,816 (GRCm39) R101S unknown Het
Hk1 T C 10: 62,132,453 (GRCm39) probably benign Het
Hrnr T A 3: 93,230,205 (GRCm39) S148T unknown Het
Hyls1 A G 9: 35,472,724 (GRCm39) Y231H probably damaging Het
Il17rb T A 14: 29,726,297 (GRCm39) Y97F probably benign Het
Lamc1 G T 1: 153,109,288 (GRCm39) T1168K probably benign Het
Larp6 A T 9: 60,631,495 (GRCm39) D89V probably damaging Het
Muc4 C G 16: 32,575,221 (GRCm39) Q1269E probably benign Het
Myo18a A G 11: 77,745,520 (GRCm39) T1953A probably benign Het
Myo5c A G 9: 75,192,229 (GRCm39) D1127G possibly damaging Het
Myo7a T C 7: 97,746,334 (GRCm39) D266G probably benign Het
Naa35 T A 13: 59,734,036 (GRCm39) M22K probably benign Het
Niban2 T G 2: 32,809,101 (GRCm39) L229R probably benign Het
Pcdha8 T A 18: 37,127,003 (GRCm39) V495E probably damaging Het
Per2 T G 1: 91,378,402 (GRCm39) D49A possibly damaging Het
Plau G A 14: 20,889,627 (GRCm39) probably benign Het
Plekhg6 T A 6: 125,352,755 (GRCm39) I131L possibly damaging Het
Pnma8b T A 7: 16,679,965 (GRCm39) D316E unknown Het
Ppp4r3b T C 11: 29,159,436 (GRCm39) Y597H possibly damaging Het
Psmd2 T C 16: 20,474,161 (GRCm39) V288A probably benign Het
Slc6a15 T C 10: 103,245,556 (GRCm39) V513A possibly damaging Het
Smarcd3 G A 5: 24,800,988 (GRCm39) R140W probably damaging Het
Srrm4 T C 5: 116,585,380 (GRCm39) R440G unknown Het
Tpsg1 A T 17: 25,592,241 (GRCm39) Y105F possibly damaging Het
Trbv26 C A 6: 41,204,693 (GRCm39) A38E probably damaging Het
Ush2a T A 1: 188,198,401 (GRCm39) N1488K probably damaging Het
Vill A T 9: 118,895,795 (GRCm39) R502S probably benign Het
Zbed6 A T 1: 133,584,754 (GRCm39) L861* probably null Het
Other mutations in Or1f19
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01447:Or1f19 APN 16 3,410,848 (GRCm39) missense possibly damaging 0.55
IGL01519:Or1f19 APN 16 3,410,398 (GRCm39) missense probably damaging 1.00
IGL02727:Or1f19 APN 16 3,411,190 (GRCm39) missense probably benign 0.04
IGL03278:Or1f19 APN 16 3,410,971 (GRCm39) missense possibly damaging 0.55
F6893:Or1f19 UTSW 16 3,411,027 (GRCm39) missense possibly damaging 0.55
R1634:Or1f19 UTSW 16 3,411,073 (GRCm39) missense probably benign 0.19
R2345:Or1f19 UTSW 16 3,411,003 (GRCm39) missense probably damaging 0.99
R4858:Or1f19 UTSW 16 3,410,706 (GRCm39) missense probably damaging 1.00
R4930:Or1f19 UTSW 16 3,410,299 (GRCm39) missense probably damaging 1.00
R6774:Or1f19 UTSW 16 3,410,380 (GRCm39) missense probably damaging 1.00
R7480:Or1f19 UTSW 16 3,410,493 (GRCm39) missense probably benign 0.03
R7712:Or1f19 UTSW 16 3,410,295 (GRCm39) missense probably damaging 1.00
R9042:Or1f19 UTSW 16 3,411,132 (GRCm39) missense probably damaging 1.00
R9084:Or1f19 UTSW 16 3,410,617 (GRCm39) missense probably damaging 1.00
R9534:Or1f19 UTSW 16 3,410,937 (GRCm39) missense probably benign 0.00
R9561:Or1f19 UTSW 16 3,410,725 (GRCm39) missense probably damaging 1.00
Z1176:Or1f19 UTSW 16 3,410,997 (GRCm39) missense probably benign 0.16
Z1176:Or1f19 UTSW 16 3,410,404 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TGACCCATCAGCTTTGTGCC -3'
(R):5'- GTGTACATCATGGCAGCTGC -3'

Sequencing Primer
(F):5'- AGCCAGTCTGAATGCTCTG -3'
(R):5'- CCATGTCCCTCCCAGCTGAG -3'
Posted On 2021-03-08