Incidental Mutation 'R8687:Gpr137b'
ID |
662092 |
Institutional Source |
Beutler Lab
|
Gene Symbol |
Gpr137b
|
Ensembl Gene |
ENSMUSG00000021306 |
Gene Name |
G protein-coupled receptor 137B |
Synonyms |
Tm7sf1, C80741, 2310041G17Rik |
MMRRC Submission |
068542-MU
|
Accession Numbers |
|
Essential gene? |
Non essential
(E-score: 0.000)
|
Stock # |
R8687 (G1)
|
Quality Score |
210.009 |
Status
|
Not validated
|
Chromosome |
13 |
Chromosomal Location |
13532205-13568599 bp(-) (GRCm39) |
Type of Mutation |
missense |
DNA Base Change (assembly) |
T to C
at 13533991 bp (GRCm39)
|
Zygosity |
Heterozygous |
Amino Acid Change |
Tyrosine to Cysteine
at position 355
(Y355C)
|
Ref Sequence |
ENSEMBL: ENSMUSP00000021738
(fasta)
|
Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000021738]
[ENSMUST00000220628]
[ENSMUST00000222958]
[ENSMUST00000223093]
|
AlphaFold |
no structure available at present |
Predicted Effect |
|
SMART Domains |
Protein: ENSMUSP00000021738 Gene: ENSMUSG00000021306 AA Change: Y355C
Domain | Start | End | E-Value | Type |
Blast:G_alpha
|
19 |
64 |
9e-7 |
BLAST |
Blast:G_alpha
|
80 |
264 |
2e-22 |
BLAST |
transmembrane domain
|
276 |
298 |
N/A |
INTRINSIC |
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000220628
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000222958
|
Predicted Effect |
probably benign
Transcript: ENSMUST00000223093
|
Meta Mutation Damage Score |
0.1203 |
Coding Region Coverage |
- 1x: 100.0%
- 3x: 100.0%
- 10x: 99.8%
- 20x: 99.3%
|
Validation Efficiency |
92% (22/24) |
Allele List at MGI |
|
Other mutations in this stock |
Total: 25 list
Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
Arhgap45 |
C |
T |
10: 79,852,621 (GRCm39) |
|
probably benign |
Het |
B3galt4 |
A |
G |
17: 34,169,819 (GRCm39) |
S140P |
probably damaging |
Het |
Cog6 |
C |
T |
3: 52,892,338 (GRCm39) |
V624I |
probably benign |
Het |
Cysrt1 |
A |
G |
2: 25,129,399 (GRCm39) |
S38P |
possibly damaging |
Het |
Eme2 |
C |
T |
17: 25,113,813 (GRCm39) |
V71M |
possibly damaging |
Het |
Eva1c |
C |
A |
16: 90,687,433 (GRCm39) |
T223K |
probably benign |
Het |
Gm3633 |
A |
T |
14: 42,462,648 (GRCm39) |
L81H |
|
Het |
Iqch |
A |
T |
9: 63,432,067 (GRCm39) |
W443R |
probably damaging |
Het |
Itgb1 |
T |
C |
8: 129,442,697 (GRCm39) |
V294A |
probably damaging |
Het |
Kif1b |
T |
A |
4: 149,345,620 (GRCm39) |
K407* |
probably null |
Het |
Kyat1 |
A |
G |
2: 30,075,759 (GRCm39) |
S377P |
probably benign |
Het |
Mical3 |
A |
G |
6: 120,936,438 (GRCm39) |
S1363P |
probably benign |
Het |
Muc4 |
C |
G |
16: 32,575,221 (GRCm39) |
Q1269E |
probably benign |
Het |
Naip6 |
T |
A |
13: 100,435,636 (GRCm39) |
R962S |
probably benign |
Het |
Pnma8a |
T |
G |
7: 16,694,520 (GRCm39) |
V125G |
probably damaging |
Het |
Ptpdc1 |
G |
A |
13: 48,740,136 (GRCm39) |
P432S |
possibly damaging |
Het |
Rhobtb2 |
G |
A |
14: 70,038,104 (GRCm39) |
T52I |
probably damaging |
Het |
Slco1a8 |
C |
T |
6: 141,939,991 (GRCm39) |
G171S |
probably damaging |
Het |
Spop |
G |
A |
11: 95,361,337 (GRCm39) |
|
probably benign |
Het |
Stam |
TGCTGCTGCTGCTGCCGCTGCTGCTGCTG |
TGCTGCTGCTGCTG |
2: 14,151,096 (GRCm39) |
|
probably benign |
Het |
Stam |
CCTGCTGCTGCTGCTGCTGCCGCTGCTGCTGCTG |
CCTGCCGCTGCTGCTGCTG |
2: 14,151,091 (GRCm39) |
|
probably benign |
Het |
Tmem102 |
T |
C |
11: 69,695,441 (GRCm39) |
H177R |
probably benign |
Het |
Trpc4ap |
T |
C |
2: 155,477,170 (GRCm39) |
T748A |
possibly damaging |
Het |
Ttc27 |
T |
A |
17: 75,046,679 (GRCm39) |
Y247N |
probably benign |
Het |
Ttc39a |
T |
C |
4: 109,288,776 (GRCm39) |
I292T |
probably damaging |
Het |
|
Other mutations in Gpr137b |
Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
IGL00336:Gpr137b
|
APN |
13 |
13,549,000 (GRCm39) |
splice site |
probably benign |
|
IGL00969:Gpr137b
|
APN |
13 |
13,539,650 (GRCm39) |
nonsense |
probably null |
|
R0276:Gpr137b
|
UTSW |
13 |
13,542,160 (GRCm39) |
splice site |
probably benign |
|
R1102:Gpr137b
|
UTSW |
13 |
13,539,616 (GRCm39) |
splice site |
probably benign |
|
R4012:Gpr137b
|
UTSW |
13 |
13,533,947 (GRCm39) |
missense |
probably benign |
|
R4712:Gpr137b
|
UTSW |
13 |
13,533,974 (GRCm39) |
missense |
probably benign |
0.07 |
R5892:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
R6269:Gpr137b
|
UTSW |
13 |
13,538,096 (GRCm39) |
missense |
probably damaging |
1.00 |
R6841:Gpr137b
|
UTSW |
13 |
13,538,094 (GRCm39) |
missense |
probably damaging |
1.00 |
R7165:Gpr137b
|
UTSW |
13 |
13,542,205 (GRCm39) |
missense |
probably damaging |
1.00 |
R7772:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
R7996:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
R7997:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
R7998:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
R7999:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
R8049:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
R8093:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
R8108:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
R8109:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
R8111:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
R8153:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
R8154:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
R8156:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
R8358:Gpr137b
|
UTSW |
13 |
13,533,929 (GRCm39) |
missense |
probably benign |
|
R8686:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
R8688:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
R8921:Gpr137b
|
UTSW |
13 |
13,533,991 (GRCm39) |
missense |
|
|
|
Predicted Primers |
|
Posted On |
2021-03-08 |