Incidental Mutation 'R8687:Gpr137b'
ID 662092
Institutional Source Beutler Lab
Gene Symbol Gpr137b
Ensembl Gene ENSMUSG00000021306
Gene Name G protein-coupled receptor 137B
Synonyms Tm7sf1, C80741, 2310041G17Rik
MMRRC Submission 068542-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8687 (G1)
Quality Score 210.009
Status Not validated
Chromosome 13
Chromosomal Location 13532205-13568599 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to C at 13533991 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Tyrosine to Cysteine at position 355 (Y355C)
Ref Sequence ENSEMBL: ENSMUSP00000021738 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000021738] [ENSMUST00000220628] [ENSMUST00000222958] [ENSMUST00000223093]
AlphaFold no structure available at present
Predicted Effect
SMART Domains Protein: ENSMUSP00000021738
Gene: ENSMUSG00000021306
AA Change: Y355C

DomainStartEndE-ValueType
Blast:G_alpha 19 64 9e-7 BLAST
Blast:G_alpha 80 264 2e-22 BLAST
transmembrane domain 276 298 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000220628
Predicted Effect probably benign
Transcript: ENSMUST00000222958
Predicted Effect probably benign
Transcript: ENSMUST00000223093
Meta Mutation Damage Score 0.1203 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.3%
Validation Efficiency 92% (22/24)
Allele List at MGI
Other mutations in this stock
Total: 25 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Arhgap45 C T 10: 79,852,621 (GRCm39) probably benign Het
B3galt4 A G 17: 34,169,819 (GRCm39) S140P probably damaging Het
Cog6 C T 3: 52,892,338 (GRCm39) V624I probably benign Het
Cysrt1 A G 2: 25,129,399 (GRCm39) S38P possibly damaging Het
Eme2 C T 17: 25,113,813 (GRCm39) V71M possibly damaging Het
Eva1c C A 16: 90,687,433 (GRCm39) T223K probably benign Het
Gm3633 A T 14: 42,462,648 (GRCm39) L81H Het
Iqch A T 9: 63,432,067 (GRCm39) W443R probably damaging Het
Itgb1 T C 8: 129,442,697 (GRCm39) V294A probably damaging Het
Kif1b T A 4: 149,345,620 (GRCm39) K407* probably null Het
Kyat1 A G 2: 30,075,759 (GRCm39) S377P probably benign Het
Mical3 A G 6: 120,936,438 (GRCm39) S1363P probably benign Het
Muc4 C G 16: 32,575,221 (GRCm39) Q1269E probably benign Het
Naip6 T A 13: 100,435,636 (GRCm39) R962S probably benign Het
Pnma8a T G 7: 16,694,520 (GRCm39) V125G probably damaging Het
Ptpdc1 G A 13: 48,740,136 (GRCm39) P432S possibly damaging Het
Rhobtb2 G A 14: 70,038,104 (GRCm39) T52I probably damaging Het
Slco1a8 C T 6: 141,939,991 (GRCm39) G171S probably damaging Het
Spop G A 11: 95,361,337 (GRCm39) probably benign Het
Stam TGCTGCTGCTGCTGCCGCTGCTGCTGCTG TGCTGCTGCTGCTG 2: 14,151,096 (GRCm39) probably benign Het
Stam CCTGCTGCTGCTGCTGCTGCCGCTGCTGCTGCTG CCTGCCGCTGCTGCTGCTG 2: 14,151,091 (GRCm39) probably benign Het
Tmem102 T C 11: 69,695,441 (GRCm39) H177R probably benign Het
Trpc4ap T C 2: 155,477,170 (GRCm39) T748A possibly damaging Het
Ttc27 T A 17: 75,046,679 (GRCm39) Y247N probably benign Het
Ttc39a T C 4: 109,288,776 (GRCm39) I292T probably damaging Het
Other mutations in Gpr137b
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00336:Gpr137b APN 13 13,549,000 (GRCm39) splice site probably benign
IGL00969:Gpr137b APN 13 13,539,650 (GRCm39) nonsense probably null
R0276:Gpr137b UTSW 13 13,542,160 (GRCm39) splice site probably benign
R1102:Gpr137b UTSW 13 13,539,616 (GRCm39) splice site probably benign
R4012:Gpr137b UTSW 13 13,533,947 (GRCm39) missense probably benign
R4712:Gpr137b UTSW 13 13,533,974 (GRCm39) missense probably benign 0.07
R5892:Gpr137b UTSW 13 13,533,991 (GRCm39) missense
R6269:Gpr137b UTSW 13 13,538,096 (GRCm39) missense probably damaging 1.00
R6841:Gpr137b UTSW 13 13,538,094 (GRCm39) missense probably damaging 1.00
R7165:Gpr137b UTSW 13 13,542,205 (GRCm39) missense probably damaging 1.00
R7772:Gpr137b UTSW 13 13,533,991 (GRCm39) missense
R7996:Gpr137b UTSW 13 13,533,991 (GRCm39) missense
R7997:Gpr137b UTSW 13 13,533,991 (GRCm39) missense
R7998:Gpr137b UTSW 13 13,533,991 (GRCm39) missense
R7999:Gpr137b UTSW 13 13,533,991 (GRCm39) missense
R8049:Gpr137b UTSW 13 13,533,991 (GRCm39) missense
R8093:Gpr137b UTSW 13 13,533,991 (GRCm39) missense
R8108:Gpr137b UTSW 13 13,533,991 (GRCm39) missense
R8109:Gpr137b UTSW 13 13,533,991 (GRCm39) missense
R8111:Gpr137b UTSW 13 13,533,991 (GRCm39) missense
R8153:Gpr137b UTSW 13 13,533,991 (GRCm39) missense
R8154:Gpr137b UTSW 13 13,533,991 (GRCm39) missense
R8156:Gpr137b UTSW 13 13,533,991 (GRCm39) missense
R8358:Gpr137b UTSW 13 13,533,929 (GRCm39) missense probably benign
R8686:Gpr137b UTSW 13 13,533,991 (GRCm39) missense
R8688:Gpr137b UTSW 13 13,533,991 (GRCm39) missense
R8921:Gpr137b UTSW 13 13,533,991 (GRCm39) missense
Predicted Primers
Posted On 2021-03-08