Mutagenetix > Incidental Mutation

Incidental Mutation 'R8721:Morn4'

662143

Institutional Source

Beutler Lab

Gene Symbol

Morn4

Ensembl Gene

ENSMUSG00000049670

Gene Name

MORN repeat containing 4

Synonyms

MMRRC Submission

068717-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.205) question?

Stock #

R8721 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

42063378-42074796 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 42066439 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Asparagine to Lysine at position 49 (N49K)

Ref Sequence

ENSEMBL: ENSMUSP00000062887 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051772]

AlphaFold

Q6PGF2

Predicted Effect

possibly damaging
Transcript: ENSMUST00000051772
AA Change: N49K

PolyPhen 2 Score 0.847 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000062887
Gene: ENSMUSG00000049670
AA Change: N49K

Domain	Start	End	E-Value	Type
MORN	14	35	1.64e-5	SMART
MORN	37	58	4.15e-2	SMART
MORN	60	81	1.86e-4	SMART
MORN	83	104	1.84e0	SMART

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.1%
20x: 96.1%

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 41 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca9	T	C	11: 110,035,115 (GRCm39)	D684G	possibly damaging	Het
Abhd16a	T	C	17: 35,310,571 (GRCm39)	V94A	possibly damaging	Het
Acly	A	T	11: 100,412,806 (GRCm39)		probably null	Het
Adamts1	G	T	16: 85,594,775 (GRCm39)	T621K	probably damaging	Het
Arhgap24	A	T	5: 103,023,565 (GRCm39)	T200S	possibly damaging	Het
Arhgap31	A	G	16: 38,427,058 (GRCm39)	V598A	probably benign	Het
Ascc1	T	C	10: 59,933,928 (GRCm39)	F323S	possibly damaging	Het
Cdcp3	T	C	7: 130,879,335 (GRCm39)	S1785P	unknown	Het
Ces2b	T	A	8: 105,560,527 (GRCm39)	V114D	possibly damaging	Het
Cfap73	T	C	5: 120,768,089 (GRCm39)	E223G	probably benign	Het
Csnk1e	T	C	15: 79,314,015 (GRCm39)	N78S	possibly damaging	Het
Cyp7a1	G	T	4: 6,268,273 (GRCm39)	A484E	probably damaging	Het
Dnah9	G	T	11: 65,986,124 (GRCm39)	T1170K	probably damaging	Het
Fam83d	G	T	2: 158,627,522 (GRCm39)	V404L	probably benign	Het
Fbxw28	C	T	9: 109,157,382 (GRCm39)	V289I	probably benign	Het
Frs2	T	G	10: 116,909,935 (GRCm39)	I476L	probably benign	Het
Gbp2b	A	T	3: 142,312,705 (GRCm39)	I363F	possibly damaging	Het
Gm8267	A	T	14: 44,959,507 (GRCm39)	F186I	possibly damaging	Het
Hand1	A	G	11: 57,722,605 (GRCm39)	L3P	probably damaging	Het
Hmcn2	C	T	2: 31,315,189 (GRCm39)	L3671F	probably damaging	Het
Hspa12b	A	G	2: 130,982,922 (GRCm39)	D260G	probably benign	Het
Itih2	T	C	2: 10,111,619 (GRCm39)	K440E	probably damaging	Het
Mtmr6	T	G	14: 60,527,128 (GRCm39)		probably null	Het
Mylk	A	T	16: 34,817,176 (GRCm39)	D1848V	probably damaging	Het
Myo7b	A	G	18: 32,140,064 (GRCm39)	V242A	probably damaging	Het
Or4a74	T	C	2: 89,440,186 (GRCm39)	K87E	probably benign	Het
Or8g19	T	G	9: 39,055,386 (GRCm39)		probably benign	Het
Rmdn3	T	A	2: 118,969,846 (GRCm39)	Q405L	possibly damaging	Het
Robo2	A	G	16: 73,703,798 (GRCm39)	S30P		Het
Suclg1	G	T	6: 73,246,362 (GRCm39)	L218F	probably damaging	Het
Tas2r134	T	C	2: 51,517,571 (GRCm39)	S17P	probably damaging	Het
Tdrd9	T	C	12: 112,002,889 (GRCm39)	L846P	probably damaging	Het
Tgfbi	A	G	13: 56,773,599 (GRCm39)	N199S	probably benign	Het
Traj35	C	T	14: 54,421,272 (GRCm39)	T14I		Het
Tril	A	G	6: 53,797,183 (GRCm39)	V13A	probably benign	Het
Tshz2	T	A	2: 169,727,278 (GRCm39)	S625T	probably benign	Het
Ttll12	A	G	15: 83,464,784 (GRCm39)	F464L	probably damaging	Het
Wdr35	T	C	12: 9,075,044 (GRCm39)		probably null	Het
Zfp346	A	G	13: 55,261,491 (GRCm39)	S94G	possibly damaging	Het
Zfp429	T	A	13: 67,538,331 (GRCm39)	Y371F	probably damaging	Het
Zscan4-ps2	A	T	7: 11,251,522 (GRCm39)	E186V	probably benign	Het

Other mutations in Morn4

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00971:Morn4	APN	19	42,064,559 (GRCm39)	missense	possibly damaging	0.53
IGL02572:Morn4	APN	19	42,064,886 (GRCm39)	splice site	probably benign
IGL02933:Morn4	APN	19	42,064,661 (GRCm39)	missense	probably benign	0.01
FR4449:Morn4	UTSW	19	42,064,548 (GRCm39)	small insertion	probably benign
FR4548:Morn4	UTSW	19	42,064,548 (GRCm39)	small insertion	probably benign
R1997:Morn4	UTSW	19	42,064,977 (GRCm39)	missense	possibly damaging	0.71
R2239:Morn4	UTSW	19	42,066,471 (GRCm39)	missense	possibly damaging	0.93
R4409:Morn4	UTSW	19	42,066,986 (GRCm39)	missense	possibly damaging	0.53
R5544:Morn4	UTSW	19	42,064,686 (GRCm39)	missense	possibly damaging	0.71
R5695:Morn4	UTSW	19	42,064,556 (GRCm39)	missense	possibly damaging	0.96
R6986:Morn4	UTSW	19	42,066,453 (GRCm39)	missense	possibly damaging	0.71
R7024:Morn4	UTSW	19	42,066,483 (GRCm39)	missense	possibly damaging	0.92
RF025:Morn4	UTSW	19	42,064,550 (GRCm39)	nonsense	probably null
RF030:Morn4	UTSW	19	42,064,550 (GRCm39)	nonsense	probably null
RF036:Morn4	UTSW	19	42,064,553 (GRCm39)	nonsense	probably null
RF040:Morn4	UTSW	19	42,064,550 (GRCm39)	nonsense	probably null
RF042:Morn4	UTSW	19	42,064,550 (GRCm39)	nonsense	probably null
RF044:Morn4	UTSW	19	42,064,553 (GRCm39)	nonsense	probably null
RF057:Morn4	UTSW	19	42,064,545 (GRCm39)	nonsense	probably null
X0063:Morn4	UTSW	19	42,066,407 (GRCm39)	missense	possibly damaging	0.71

Predicted Primers

PCR Primer
(F):5'- TCCCACCATCATAAGCATGTGG -3'
(R):5'- TTCCATACTCACAGGGGCAAAG -3'

Sequencing Primer
(F):5'- CATGTGGTGCACCCTCC -3'
(R):5'- GCAAAGGGCAGCTTTTGG -3'

Posted On

2021-03-08