Mutagenetix > Incidental Mutation

Incidental Mutation 'R8722:Gm10800'

662149

Institutional Source

Beutler Lab

Gene Symbol

Gm10800

Ensembl Gene

ENSMUSG00000075014

Gene Name

predicted gene 10800

Synonyms

MMRRC Submission

068572-MU

Accession Numbers

Essential gene?

Possibly non essential (E-score: 0.285) question?

Stock #

R8722 (G1)

Quality Score

128.467

Status

Not validated

Chromosome

Chromosomal Location

98496892-98497646 bp(-) (GRCm39)

Type of Mutation

unclassified

DNA Base Change (assembly)

AAGAAAACTGAAAATCAT to A at 98497379 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000097276 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000099683] [ENSMUST00000099684]

AlphaFold

D3Z496

Predicted Effect

probably benign
Transcript: ENSMUST00000099683

SMART Domains

Protein: ENSMUSP00000097275
Gene: ENSMUSG00000075014

Domain	Start	End	E-Value	Type
internal_repeat_1	1	41	1.13e-5	PROSPERO
internal_repeat_2	26	49	4.11e-5	PROSPERO
transmembrane domain	78	96	N/A	INTRINSIC
internal_repeat_1	114	174	1.13e-5	PROSPERO
low complexity region	177	188	N/A	INTRINSIC
internal_repeat_2	197	219	4.11e-5	PROSPERO

Predicted Effect

probably benign
Transcript: ENSMUST00000099684

SMART Domains

Protein: ENSMUSP00000097276
Gene: ENSMUSG00000075015

Domain	Start	End	E-Value	Type
internal_repeat_1	2	73	1.19e-13	PROSPERO
internal_repeat_1	80	167	1.19e-13	PROSPERO

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.2%
20x: 96.8%

Validation Efficiency

100% (54/54)

Allele List at MGI

Other mutations in this stock

Total: 56 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
4931422A03Rik	A	G	2: 103,823,101 (GRCm39)	C61R	probably benign	Het
4933427D14Rik	A	G	11: 72,080,422 (GRCm39)	F415L	probably benign	Het
Abcc2	G	A	19: 43,825,052 (GRCm39)	G1446D	possibly damaging	Het
Acaca	A	T	11: 84,229,283 (GRCm39)	E1703D	possibly damaging	Het
Acap3	T	C	4: 155,990,415 (GRCm39)	*834Q	probably null	Het
Adam22	A	G	5: 8,166,554 (GRCm39)	S726P	probably benign	Het
Adamtsl3	T	C	7: 82,244,745 (GRCm39)		probably null	Het
Adgrg6	T	A	10: 14,296,188 (GRCm39)	I1071F	probably benign	Het
Agxt2	A	T	15: 10,373,825 (GRCm39)	D77V	probably benign	Het
Ahnak	C	A	19: 8,990,710 (GRCm39)	S3998*	probably null	Het
Asns	T	A	6: 7,676,085 (GRCm39)	I462F	probably damaging	Het
Barx2	G	C	9: 31,824,280 (GRCm39)	C36W	probably damaging	Het
Bnc2	A	G	4: 84,211,883 (GRCm39)	V162A	possibly damaging	Het
Bptf	A	G	11: 107,022,295 (GRCm39)	S152P	unknown	Het
Brpf3	T	C	17: 29,029,510 (GRCm39)	L490P	probably benign	Het
Carmil1	T	C	13: 24,220,568 (GRCm39)	D1052G	probably benign	Het
Ccn1	T	A	3: 145,354,584 (GRCm39)	N109I	probably damaging	Het
Cdk17	A	G	10: 93,064,565 (GRCm39)	H311R	probably damaging	Het
Cenpj	G	A	14: 56,772,975 (GRCm39)	R1022C	probably damaging	Het
Cog5	A	G	12: 31,969,703 (GRCm39)	D741G	possibly damaging	Het
Csmd2	T	A	4: 128,445,743 (GRCm39)		probably benign	Het
Dnah17	G	A	11: 117,961,283 (GRCm39)	Q2568*	probably null	Het
Dspp	A	G	5: 104,326,433 (GRCm39)	D932G	unknown	Het
Dtwd2	T	C	18: 49,833,385 (GRCm39)	T223A	probably damaging	Het
Fzd8	A	G	18: 9,213,686 (GRCm39)	N256S	possibly damaging	Het
Gm9936	T	C	5: 114,995,515 (GRCm39)	Y34C	unknown	Het
Gstcd	T	A	3: 132,777,822 (GRCm39)	K330*	probably null	Het
Igf2bp1	A	G	11: 95,861,606 (GRCm39)	V277A	possibly damaging	Het
Kidins220	G	A	12: 25,051,593 (GRCm39)	V332I	probably benign	Het
Kif24	T	C	4: 41,394,233 (GRCm39)	H1014R	probably benign	Het
Lrrc43	T	C	5: 123,646,142 (GRCm39)	Y639H	possibly damaging	Het
Med22	T	C	2: 26,800,313 (GRCm39)	T39A	probably benign	Het
Morn3	T	C	5: 123,179,177 (GRCm39)	Y91C	probably damaging	Het
Myo1a	T	C	10: 127,542,707 (GRCm39)	M115T	probably damaging	Het
Or10w3	T	C	19: 13,704,033 (GRCm39)	M136T	possibly damaging	Het
Or1e32	T	A	11: 73,705,882 (GRCm39)	I9F	probably benign	Het
Or52n2b	C	T	7: 104,565,708 (GRCm39)	R265H	probably benign	Het
Pdcl	T	C	2: 37,247,317 (GRCm39)	D24G	probably benign	Het
Pde10a	G	A	17: 9,163,772 (GRCm39)	C250Y	probably benign	Het
Pla2g10	A	T	16: 13,548,254 (GRCm39)	L8M	unknown	Het
Plch2	A	T	4: 155,069,860 (GRCm39)		probably benign	Het
Ppp1r42	T	C	1: 10,055,894 (GRCm39)	K198R	probably benign	Het
Prlh	G	T	1: 90,880,897 (GRCm39)	R23L	possibly damaging	Het
Ranbp2	C	A	10: 58,312,049 (GRCm39)	T923K	probably damaging	Het
Rps11	T	C	7: 44,772,616 (GRCm39)	N65S	probably benign	Het
Ryr3	T	C	2: 112,603,116 (GRCm39)	T2463A	probably benign	Het
Shank2	C	T	7: 143,729,485 (GRCm39)		probably benign	Het
Slc12a1	T	A	2: 125,002,518 (GRCm39)	V166E	probably damaging	Het
Slc6a9	C	T	4: 117,714,452 (GRCm39)	R97C	unknown	Het
Slpi	A	C	2: 164,197,975 (GRCm39)	M1R	probably null	Het
Syne2	T	A	12: 75,972,095 (GRCm39)	V994D	probably benign	Het
Tacc3	T	C	5: 33,825,553 (GRCm39)	Y435H	probably damaging	Het
Tpgs2	T	A	18: 25,274,679 (GRCm39)	Q132L	probably benign	Het
Usp13	T	A	3: 32,956,114 (GRCm39)	I462N	probably benign	Het
Zfp281	C	T	1: 136,553,334 (GRCm39)	A104V	probably benign	Het
Zfp40	A	G	17: 23,395,157 (GRCm39)	C477R	probably damaging	Het

Other mutations in Gm10800

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01022:Gm10800	APN	2	98,497,576 (GRCm39)	unclassified	probably benign
BB012:Gm10800	UTSW	2	98,497,378 (GRCm39)	frame shift	probably null
FR4976:Gm10800	UTSW	2	98,497,378 (GRCm39)	frame shift	probably null
PIT4131001:Gm10800	UTSW	2	98,497,250 (GRCm39)	missense	probably benign
PIT4131001:Gm10800	UTSW	2	98,497,163 (GRCm39)	missense	probably benign
PIT4131001:Gm10800	UTSW	2	98,496,893 (GRCm39)	missense	probably benign	0.11
PIT4142001:Gm10800	UTSW	2	98,497,250 (GRCm39)	missense	probably benign
PIT4142001:Gm10800	UTSW	2	98,497,163 (GRCm39)	missense	probably benign
PIT4142001:Gm10800	UTSW	2	98,496,893 (GRCm39)	missense	probably benign	0.11
PIT4142001:Gm10800	UTSW	2	98,497,361 (GRCm39)	frame shift	probably null
PIT4402001:Gm10800	UTSW	2	98,497,361 (GRCm39)	frame shift	probably null
PIT4498001:Gm10800	UTSW	2	98,497,361 (GRCm39)	frame shift	probably null
R0025:Gm10800	UTSW	2	98,496,925 (GRCm39)	missense	probably benign	0.05
R5077:Gm10800	UTSW	2	98,497,379 (GRCm39)	missense	probably benign	0.01
R5687:Gm10800	UTSW	2	98,496,965 (GRCm39)	missense	probably benign
R7146:Gm10800	UTSW	2	98,497,378 (GRCm39)	frame shift	probably null
R7206:Gm10800	UTSW	2	98,497,378 (GRCm39)	frame shift	probably null
R7619:Gm10800	UTSW	2	98,497,378 (GRCm39)	frame shift	probably null
R7930:Gm10800	UTSW	2	98,497,379 (GRCm39)	unclassified	probably benign
R7931:Gm10800	UTSW	2	98,497,379 (GRCm39)	unclassified	probably benign
R7998:Gm10800	UTSW	2	98,497,378 (GRCm39)	frame shift	probably null
R8019:Gm10800	UTSW	2	98,497,378 (GRCm39)	frame shift	probably null
R8110:Gm10800	UTSW	2	98,497,361 (GRCm39)	frame shift	probably null
R8111:Gm10800	UTSW	2	98,497,361 (GRCm39)	frame shift	probably null
R8488:Gm10800	UTSW	2	98,497,379 (GRCm39)	unclassified	probably benign
R8509:Gm10800	UTSW	2	98,497,379 (GRCm39)	unclassified	probably benign
R8692:Gm10800	UTSW	2	98,497,379 (GRCm39)	unclassified	probably benign
R8789:Gm10800	UTSW	2	98,497,361 (GRCm39)	frame shift	probably null
R8902:Gm10800	UTSW	2	98,497,361 (GRCm39)	frame shift	probably null
R8903:Gm10800	UTSW	2	98,497,361 (GRCm39)	frame shift	probably null
R8935:Gm10800	UTSW	2	98,497,378 (GRCm39)	frame shift	probably null
R9104:Gm10800	UTSW	2	98,497,379 (GRCm39)	unclassified	probably benign
R9571:Gm10800	UTSW	2	98,497,378 (GRCm39)	frame shift	probably null

Predicted Primers

Posted On

2021-03-08