Incidental Mutation 'R8723:Stk25'
ID 662204
Institutional Source Beutler Lab
Gene Symbol Stk25
Ensembl Gene ENSMUSG00000026277
Gene Name serine/threonine kinase 25 (yeast)
Synonyms SOK-1, Ste20-like, 1500019J11Rik, Ysk1
MMRRC Submission 068615-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8723 (G1)
Quality Score 225.009
Status Validated
Chromosome 1
Chromosomal Location 93548473-93581937 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 93553666 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Isoleucine to Threonine at position 203 (I203T)
Ref Sequence ENSEMBL: ENSMUSP00000027498 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000027498] [ENSMUST00000120301] [ENSMUST00000133769] [ENSMUST00000186287]
AlphaFold Q9Z2W1
Predicted Effect probably damaging
Transcript: ENSMUST00000027498
AA Change: I203T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000027498
Gene: ENSMUSG00000026277
AA Change: I203T

DomainStartEndE-ValueType
S_TKc 20 270 2.92e-98 SMART
low complexity region 292 314 N/A INTRINSIC
PDB:3W8H|B 355 426 8e-43 PDB
Predicted Effect probably benign
Transcript: ENSMUST00000120301
SMART Domains Protein: ENSMUSP00000112725
Gene: ENSMUSG00000034066

DomainStartEndE-ValueType
B41 40 234 1.48e-66 SMART
FERM_C 238 328 3.29e-35 SMART
FA 332 378 1.13e-15 SMART
low complexity region 409 421 N/A INTRINSIC
low complexity region 440 459 N/A INTRINSIC
low complexity region 462 473 N/A INTRINSIC
low complexity region 478 492 N/A INTRINSIC
RhoGEF 542 728 1.57e-56 SMART
PH 759 857 1.45e-19 SMART
low complexity region 879 890 N/A INTRINSIC
PH 931 1029 2.62e-17 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000133769
AA Change: I203T

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000117765
Gene: ENSMUSG00000026277
AA Change: I203T

DomainStartEndE-ValueType
Pfam:Pkinase 20 233 1.7e-63 PFAM
Pfam:Pkinase_Tyr 20 233 2.1e-47 PFAM
Predicted Effect probably benign
Transcript: ENSMUST00000186287
SMART Domains Protein: ENSMUSP00000140396
Gene: ENSMUSG00000026277

DomainStartEndE-ValueType
STYKc 20 107 1.9e-4 SMART
Meta Mutation Damage Score 0.8470 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.7%
  • 20x: 99.2%
Validation Efficiency 100% (55/55)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the germinal centre kinase III (GCK III) subfamily of the sterile 20 superfamily of kinases. The encoded enzyme plays a role in serine-threonine liver kinase B1 (LKB1) signaling pathway to regulate neuronal polarization and morphology of the Golgi apparatus. The protein is translocated from the Golgi apparatus to the nucleus in response to chemical anoxia and plays a role in regulation of cell death. A pseudogene associated with this gene is located on chromosome 18. Multiple alternatively spliced transcript variants have been observed for this gene. [provided by RefSeq, Dec 2012]
PHENOTYPE: Germ line null mutants display normal cortical layers and neuronal migration. Acute loss of expression results in impaired neuronal migration. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 56 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca12 A T 1: 71,360,897 (GRCm39) H465Q probably benign Het
Adam29 T C 8: 56,324,513 (GRCm39) H647R probably damaging Het
Adamtsl4 C T 3: 95,584,426 (GRCm39) R990Q possibly damaging Het
Adgrg7 T G 16: 56,582,282 (GRCm39) R285S probably benign Het
Alkbh1 A G 12: 87,485,278 (GRCm39) V115A probably benign Het
Ankrd50 A C 3: 38,511,453 (GRCm39) F305V probably damaging Het
Anpep A G 7: 79,488,686 (GRCm39) S414P probably damaging Het
Anxa3 A G 5: 96,986,206 (GRCm39) I282V probably benign Het
Aoah T G 13: 21,184,180 (GRCm39) Y415D possibly damaging Het
Cacna1b A G 2: 24,548,510 (GRCm39) V1188A probably damaging Het
Cnot1 A G 8: 96,462,907 (GRCm39) I1651T probably benign Het
Col6a3 C G 1: 90,695,328 (GRCm39) probably benign Het
Ctnnd1 G A 2: 84,450,384 (GRCm39) P279S probably benign Het
Dnah10 A T 5: 124,891,685 (GRCm39) E3298V probably damaging Het
Ear14 C T 14: 51,441,513 (GRCm39) T123I possibly damaging Het
Elf3 A G 1: 135,185,385 (GRCm39) L43P possibly damaging Het
Exoc3l4 T A 12: 111,397,092 (GRCm39) probably benign Het
Figla A G 6: 85,997,724 (GRCm39) T151A probably benign Het
Fsd1l A G 4: 53,647,001 (GRCm39) E56G unknown Het
Gm49359 A T 13: 62,602,410 (GRCm39) H263Q probably damaging Het
Gprc6a A T 10: 51,491,518 (GRCm39) C744S probably damaging Het
Grhl1 G A 12: 24,662,244 (GRCm39) probably benign Het
Gtf2h5 C CA 17: 6,134,833 (GRCm39) probably null Het
Itih3 T A 14: 30,630,761 (GRCm39) Q850L probably damaging Het
Kcnq5 A G 1: 21,575,591 (GRCm39) V285A probably damaging Het
Klc4 T G 17: 46,951,626 (GRCm39) E165A probably benign Het
Lrp2 T C 2: 69,316,648 (GRCm39) Y2111C probably damaging Het
Lyst A G 13: 13,887,342 (GRCm39) E3057G possibly damaging Het
Macf1 G A 4: 123,348,910 (GRCm39) Q4006* probably null Het
Map4k1 G A 7: 28,686,542 (GRCm39) D155N probably damaging Het
Ms4a20 A G 19: 11,083,055 (GRCm39) Y122H probably damaging Het
Myh14 A G 7: 44,272,407 (GRCm39) F1466S probably damaging Het
Nrip1 T C 16: 76,089,553 (GRCm39) D668G probably damaging Het
Or5w17 T C 2: 87,583,501 (GRCm39) T279A possibly damaging Het
Or8k3 A T 2: 86,058,786 (GRCm39) H176Q probably damaging Het
P2rx1 C A 11: 72,899,756 (GRCm39) N120K probably benign Het
Pif1 T A 9: 65,501,673 (GRCm39) M569K probably damaging Het
Prkd2 G A 7: 16,591,702 (GRCm39) V578I possibly damaging Het
Rhobtb1 A G 10: 69,106,101 (GRCm39) Y284C probably damaging Het
Rps6kb1 T C 11: 86,410,757 (GRCm39) T164A possibly damaging Het
Rxfp1 T C 3: 79,557,802 (GRCm39) T559A probably benign Het
Sag G A 1: 87,751,175 (GRCm39) probably null Het
Smoc1 G A 12: 81,182,586 (GRCm39) V138I possibly damaging Het
Spag5 T A 11: 78,212,215 (GRCm39) I1081N probably damaging Het
Strip2 T A 6: 29,941,863 (GRCm39) V611E probably damaging Het
Sulf1 A T 1: 12,856,911 (GRCm39) D54V probably damaging Het
Tacr2 A G 10: 62,094,107 (GRCm39) D188G probably damaging Het
Tmem237 A T 1: 59,145,731 (GRCm39) Y358N probably damaging Het
Trim27 A C 13: 21,374,807 (GRCm39) probably benign Het
Tsen34 A G 7: 3,698,149 (GRCm39) E139G probably benign Het
Ttc39a T A 4: 109,300,700 (GRCm39) probably benign Het
Tubgcp3 A T 8: 12,671,899 (GRCm39) I781N probably damaging Het
Uqcc1 C T 2: 155,729,100 (GRCm39) W21* probably null Het
Vmn2r117 A T 17: 23,696,343 (GRCm39) W355R probably damaging Het
Vmn2r89 T C 14: 51,693,910 (GRCm39) V420A probably benign Het
Zdhhc21 A T 4: 82,762,439 (GRCm39) I52K probably benign Het
Other mutations in Stk25
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01291:Stk25 APN 1 93,551,145 (GRCm39) splice site probably null
IGL02952:Stk25 APN 1 93,553,798 (GRCm39) missense probably damaging 1.00
IGL03144:Stk25 APN 1 93,556,858 (GRCm39) missense probably damaging 1.00
ANU05:Stk25 UTSW 1 93,551,145 (GRCm39) splice site probably null
IGL02980:Stk25 UTSW 1 93,555,390 (GRCm39) missense probably damaging 1.00
PIT4531001:Stk25 UTSW 1 93,552,346 (GRCm39) missense probably benign
R0240:Stk25 UTSW 1 93,554,782 (GRCm39) missense probably damaging 1.00
R0240:Stk25 UTSW 1 93,554,782 (GRCm39) missense probably damaging 1.00
R0555:Stk25 UTSW 1 93,552,313 (GRCm39) missense probably benign 0.00
R1178:Stk25 UTSW 1 93,551,111 (GRCm39) unclassified probably benign
R1406:Stk25 UTSW 1 93,552,875 (GRCm39) unclassified probably benign
R1493:Stk25 UTSW 1 93,553,322 (GRCm39) missense probably benign 0.04
R2875:Stk25 UTSW 1 93,556,973 (GRCm39) missense possibly damaging 0.91
R4657:Stk25 UTSW 1 93,553,378 (GRCm39) unclassified probably benign
R4668:Stk25 UTSW 1 93,553,205 (GRCm39) missense probably damaging 1.00
R4686:Stk25 UTSW 1 93,551,142 (GRCm39) splice site probably null
R5089:Stk25 UTSW 1 93,552,330 (GRCm39) missense probably benign 0.05
R5493:Stk25 UTSW 1 93,563,031 (GRCm39) missense probably benign
R6013:Stk25 UTSW 1 93,553,181 (GRCm39) critical splice donor site probably null
R8905:Stk25 UTSW 1 93,556,929 (GRCm39) missense probably damaging 1.00
R9249:Stk25 UTSW 1 93,552,806 (GRCm39) missense probably benign
R9274:Stk25 UTSW 1 93,552,806 (GRCm39) missense probably benign
X0063:Stk25 UTSW 1 93,553,683 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- TATAGGCCTTACGAATCGTGG -3'
(R):5'- TGTGAAGCTGGCAGACTTCG -3'

Sequencing Primer
(F):5'- GGTCCTTATTGAGGCAGGCC -3'
(R):5'- TGGGCAGCTCACAGACAC -3'
Posted On 2021-03-08