Incidental Mutation 'R8732:Vmn1r183'
ID 662804
Institutional Source Beutler Lab
Gene Symbol Vmn1r183
Ensembl Gene ENSMUSG00000066723
Gene Name vomeronasal 1 receptor 183
Synonyms V1rd15, LOC209824
MMRRC Submission 068580-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.050) question?
Stock # R8732 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 23754199-23755116 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 23754890 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamine to Arginine at position 231 (Q231R)
Ref Sequence ENSEMBL: ENSMUSP00000083176 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000086012]
AlphaFold no structure available at present
Predicted Effect possibly damaging
Transcript: ENSMUST00000086012
AA Change: Q231R

PolyPhen 2 Score 0.895 (Sensitivity: 0.82; Specificity: 0.94)
SMART Domains Protein: ENSMUSP00000083176
Gene: ENSMUSG00000066723
AA Change: Q231R

DomainStartEndE-ValueType
Pfam:TAS2R 8 297 5.6e-15 PFAM
Pfam:7tm_1 31 285 1.4e-9 PFAM
Pfam:V1R 41 296 2.5e-18 PFAM
Meta Mutation Damage Score 0.1712 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.0%
Validation Efficiency 98% (63/64)
Allele List at MGI
Other mutations in this stock
Total: 65 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adtrp A T 13: 41,981,622 (GRCm39) N82K probably damaging Het
Ankrd36 T A 11: 5,578,906 (GRCm39) S57T possibly damaging Het
Aoc3 A G 11: 101,222,643 (GRCm39) N293S probably benign Het
Aup1 A T 6: 83,033,602 (GRCm39) H302L probably damaging Het
Bptf G A 11: 106,931,206 (GRCm39) R277W probably damaging Het
Cald1 A G 6: 34,734,946 (GRCm39) I346V unknown Het
Cd44 T C 2: 102,664,645 (GRCm39) T519A possibly damaging Het
Cela1 A G 15: 100,580,766 (GRCm39) probably null Het
Ces2g T C 8: 105,689,195 (GRCm39) V57A possibly damaging Het
Cpt1b G C 15: 89,308,628 (GRCm39) T100S probably benign Het
D6Wsu163e A T 6: 126,932,859 (GRCm39) I361F possibly damaging Het
Dock5 A T 14: 68,083,449 (GRCm39) D153E possibly damaging Het
Dync2h1 G T 9: 7,168,326 (GRCm39) R430S probably damaging Het
Dync2i2 T A 2: 29,922,220 (GRCm39) T414S possibly damaging Het
Efcab3 T A 11: 104,695,100 (GRCm39) F1730L probably benign Het
Eml5 C T 12: 98,782,218 (GRCm39) G1405R probably damaging Het
Ergic2 G A 6: 148,102,975 (GRCm39) A91V probably damaging Het
Fancl A T 11: 26,419,754 (GRCm39) I336L probably benign Het
Fpr3 A G 17: 18,191,223 (GRCm39) T165A possibly damaging Het
Gon4l A G 3: 88,807,291 (GRCm39) I1662V possibly damaging Het
Gpr153 C T 4: 152,363,558 (GRCm39) probably benign Het
Hdac4 C A 1: 91,875,239 (GRCm39) A911S probably damaging Het
Ighd T C 12: 113,378,183 (GRCm39) N139D Het
Klhl22 T A 16: 17,589,690 (GRCm39) L117Q probably damaging Het
Kntc1 A G 5: 123,928,180 (GRCm39) S1226G probably benign Het
Lama5 A T 2: 179,828,481 (GRCm39) C2126S probably damaging Het
Ldlr A G 9: 21,650,985 (GRCm39) I468V probably benign Het
Lmtk3 G A 7: 45,447,712 (GRCm39) A1253T unknown Het
Lta T A 17: 35,423,045 (GRCm39) N93Y probably damaging Het
Macf1 A T 4: 123,403,563 (GRCm39) probably null Het
Mink1 A G 11: 70,500,902 (GRCm39) probably null Het
Myl10 G C 5: 136,726,825 (GRCm39) V70L probably benign Het
Ntpcr A G 8: 126,472,074 (GRCm39) M132V probably benign Het
Or14a257 A G 7: 86,138,061 (GRCm39) S233P probably damaging Het
Or52n1 A G 7: 104,383,115 (GRCm39) M152T probably benign Het
Or7g32 T C 9: 19,408,098 (GRCm39) I18T probably benign Het
Padi2 A G 4: 140,660,590 (GRCm39) I357V probably benign Het
Pax7 G T 4: 139,506,920 (GRCm39) H372Q probably benign Het
Paxip1 A G 5: 27,949,541 (GRCm39) Y966H probably damaging Het
Pde4b A C 4: 102,412,822 (GRCm39) D199A probably null Het
Pkd1l2 T C 8: 117,792,311 (GRCm39) N494D probably benign Het
Prdm2 G T 4: 142,862,580 (GRCm39) Q237K probably benign Het
Prune2 T C 19: 17,097,769 (GRCm39) L1091P probably damaging Het
Rab9 C T X: 165,240,754 (GRCm39) D186N probably benign Het
Rassf5 A G 1: 131,106,264 (GRCm39) *414Q probably null Het
Repin1 G T 6: 48,574,279 (GRCm39) E403* probably null Het
Rrp9 C A 9: 106,360,388 (GRCm39) T238K probably benign Het
Slc44a2 A G 9: 21,259,882 (GRCm39) D630G probably benign Het
Slc7a9 A G 7: 35,156,443 (GRCm39) D295G probably benign Het
Slco3a1 A T 7: 73,934,054 (GRCm39) M706K possibly damaging Het
Spag9 T C 11: 93,962,514 (GRCm39) probably null Het
Stam2 A T 2: 52,590,180 (GRCm39) Y394N probably damaging Het
Stard9 T C 2: 120,510,442 (GRCm39) L341P probably damaging Het
Steap3 A T 1: 120,171,624 (GRCm39) H160Q probably damaging Het
Stxbp5l A T 16: 37,061,809 (GRCm39) C334S probably benign Het
Tcof1 G C 18: 60,962,123 (GRCm39) A702G possibly damaging Het
Thap1 CAGCATCTGCTCGGAGCA CAGCA 8: 26,650,884 (GRCm39) probably null Het
Tmem74 A T 15: 43,731,456 (GRCm39) probably benign Het
Ttn T C 2: 76,537,480 (GRCm39) K34816R possibly damaging Het
Ttn T A 2: 76,627,735 (GRCm39) N14736I probably damaging Het
Vmn1r235 A G 17: 21,482,439 (GRCm39) T255A probably damaging Het
Wasl A T 6: 24,619,209 (GRCm39) I437K unknown Het
Ywhae A G 11: 75,642,769 (GRCm39) N43D probably damaging Het
Zfp583 A T 7: 6,320,210 (GRCm39) Y267* probably null Het
Zfp608 C T 18: 55,121,072 (GRCm39) G172R probably benign Het
Other mutations in Vmn1r183
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00987:Vmn1r183 APN 7 23,754,649 (GRCm39) missense probably damaging 1.00
IGL01813:Vmn1r183 APN 7 23,754,985 (GRCm39) missense probably benign 0.19
IGL03377:Vmn1r183 APN 7 23,754,817 (GRCm39) missense possibly damaging 0.70
PIT4791001:Vmn1r183 UTSW 7 23,754,266 (GRCm39) missense probably damaging 0.99
R0463:Vmn1r183 UTSW 7 23,754,926 (GRCm39) missense probably damaging 1.00
R0616:Vmn1r183 UTSW 7 23,754,250 (GRCm39) missense probably benign 0.03
R0666:Vmn1r183 UTSW 7 23,754,601 (GRCm39) missense probably benign
R3928:Vmn1r183 UTSW 7 23,754,997 (GRCm39) missense probably damaging 0.98
R4425:Vmn1r183 UTSW 7 23,754,973 (GRCm39) missense probably benign 0.00
R4767:Vmn1r183 UTSW 7 23,754,531 (GRCm39) frame shift probably null
R4835:Vmn1r183 UTSW 7 23,754,564 (GRCm39) missense probably benign 0.07
R5267:Vmn1r183 UTSW 7 23,754,971 (GRCm39) missense possibly damaging 0.90
R5693:Vmn1r183 UTSW 7 23,754,227 (GRCm39) missense possibly damaging 0.94
R6291:Vmn1r183 UTSW 7 23,754,982 (GRCm39) missense possibly damaging 0.70
R6439:Vmn1r183 UTSW 7 23,754,704 (GRCm39) missense possibly damaging 0.73
R7073:Vmn1r183 UTSW 7 23,754,926 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- AAGCAAGTTGTTCTGTTCCACTTC -3'
(R):5'- GGCTTTCAACAGCTGAAGAG -3'

Sequencing Primer
(F):5'- TCCACTTCTGGATTCAGTGTG -3'
(R):5'- TCTCTGAAGATCAACAGTAAGGG -3'
Posted On 2021-03-08