Incidental Mutation 'R8734:Pglyrp2'
ID 662942
Institutional Source Beutler Lab
Gene Symbol Pglyrp2
Ensembl Gene ENSMUSG00000079563
Gene Name peptidoglycan recognition protein 2
Synonyms tagL-alpha, C730002N09Rik, Pglyrpl, tagl-beta, tagL, PGRP-L
MMRRC Submission 068582-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8734 (G1)
Quality Score 225.009
Status Validated
Chromosome 17
Chromosomal Location 32631433-32643141 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 32634976 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Phenylalanine to Serine at position 462 (F462S)
Ref Sequence ENSEMBL: ENSMUSP00000110099 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000114455] [ENSMUST00000170392]
AlphaFold Q8VCS0
Predicted Effect probably damaging
Transcript: ENSMUST00000114455
AA Change: F462S

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000110099
Gene: ENSMUSG00000079563
AA Change: F462S

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 251 266 N/A INTRINSIC
low complexity region 270 281 N/A INTRINSIC
PGRP 360 506 6.61e-78 SMART
Ami_2 373 512 6.28e-10 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000170392
AA Change: F462S

PolyPhen 2 Score 0.986 (Sensitivity: 0.74; Specificity: 0.96)
SMART Domains Protein: ENSMUSP00000129964
Gene: ENSMUSG00000079563
AA Change: F462S

DomainStartEndE-ValueType
signal peptide 1 22 N/A INTRINSIC
low complexity region 251 266 N/A INTRINSIC
low complexity region 270 281 N/A INTRINSIC
PGRP 360 506 6.61e-78 SMART
Ami_2 373 512 6.28e-10 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.7%
  • 20x: 99.0%
Validation Efficiency 100% (61/61)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a peptidoglycan recognition protein, which belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. This protein hydrolyzes the link between N-acetylmuramoyl residues and L-amino acid residues in bacterial cell wall glycopeptides, and thus may play a scavenger role by digesting biologically active peptidoglycan into biologically inactive fragments. [provided by RefSeq, Sep 2011]
PHENOTYPE: Mice homozygous for disruption of this gene are viable and fertile with no gross developmental defects. Mice homozygous for a different knock-out allele are resistant to peptidoglycan- or muramyl dipeptide-induced arthritis and increased susceptibility to DSS-induced colitis. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 60 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abcc2 T A 19: 43,770,855 (GRCm39) C5S probably damaging Het
Actl6a G A 3: 32,774,104 (GRCm39) D275N probably benign Het
Ahctf1 C A 1: 179,608,430 (GRCm39) E681* probably null Het
Ankub1 G A 3: 57,599,706 (GRCm39) S21L probably benign Het
Apmap T A 2: 150,430,824 (GRCm39) K178N probably benign Het
Arhgap15 T A 2: 44,133,130 (GRCm39) N345K probably damaging Het
Armc8 A G 9: 99,402,538 (GRCm39) V379A probably benign Het
Atmin G A 8: 117,681,525 (GRCm39) D175N possibly damaging Het
Atp5pd T C 11: 115,307,689 (GRCm39) E94G possibly damaging Het
B3gnt3 G A 8: 72,146,145 (GRCm39) T128M probably damaging Het
Ccdc88c T A 12: 100,906,394 (GRCm39) T1040S probably damaging Het
Crot C T 5: 9,028,208 (GRCm39) R247Q probably benign Het
Cyp2b9 A G 7: 25,898,035 (GRCm39) probably benign Het
Dcaf8 T C 1: 172,021,427 (GRCm39) W540R probably benign Het
Galnt11 T C 5: 25,455,222 (GRCm39) I186T possibly damaging Het
Gne T A 4: 44,072,911 (GRCm39) probably benign Het
Gpr37 A T 6: 25,688,201 (GRCm39) F299I probably benign Het
Gpr37l1 C T 1: 135,095,167 (GRCm39) A26T probably benign Het
Grm4 A G 17: 27,657,765 (GRCm39) Y414H probably damaging Het
Kcnh1 T C 1: 192,188,320 (GRCm39) I954T possibly damaging Het
Lias T C 5: 65,561,552 (GRCm39) Y308H probably damaging Het
Lrrc27 T A 7: 138,796,515 (GRCm39) probably benign Het
Lrrc8a C T 2: 30,146,619 (GRCm39) H478Y probably benign Het
Mdh2 T A 5: 135,812,983 (GRCm39) probably benign Het
Mug1 T A 6: 121,848,340 (GRCm39) I688K probably benign Het
Nrp1 A G 8: 129,207,420 (GRCm39) D605G probably benign Het
Nt5dc3 A G 10: 86,669,863 (GRCm39) Y486C possibly damaging Het
Or5m13 T A 2: 85,748,993 (GRCm39) C241* probably null Het
Or8s16 A T 15: 98,210,954 (GRCm39) L159H probably damaging Het
Or9s23 T A 1: 92,501,121 (GRCm39) V76D possibly damaging Het
Pam A T 1: 97,762,127 (GRCm39) probably benign Het
Pcolce A G 5: 137,609,550 (GRCm39) L14P probably damaging Het
Pcsk6 T C 7: 65,581,481 (GRCm39) I254T probably benign Het
Pdzrn3 A T 6: 101,128,567 (GRCm39) C700S probably damaging Het
Plaat3 T A 19: 7,552,347 (GRCm39) Y21N possibly damaging Het
Plekhm1 A T 11: 103,285,778 (GRCm39) L219Q probably damaging Het
Prkch T A 12: 73,632,018 (GRCm39) S28T possibly damaging Het
Prrc2c A T 1: 162,507,081 (GRCm39) S2529R possibly damaging Het
Prss3 G T 6: 41,350,827 (GRCm39) A221D probably damaging Het
Rbm33 T A 5: 28,557,874 (GRCm39) probably benign Het
Retreg1 T C 15: 25,968,493 (GRCm39) L83S probably damaging Het
Robo2 C T 16: 73,764,651 (GRCm39) probably benign Het
Slc25a47 T A 12: 108,820,247 (GRCm39) F84I probably benign Het
Sntb2 A G 8: 107,728,320 (GRCm39) I423V probably benign Het
Spart A T 3: 55,032,300 (GRCm39) D378V possibly damaging Het
Spint2 A T 7: 28,958,835 (GRCm39) F127Y probably damaging Het
Stag3 A G 5: 138,310,050 (GRCm39) T1233A probably benign Het
Tenm3 A G 8: 48,802,391 (GRCm39) I390T probably benign Het
Tigd2 A G 6: 59,187,184 (GRCm39) D17G probably damaging Het
Tln2 C A 9: 67,179,936 (GRCm39) A812S probably benign Het
Tmem234 A G 4: 129,501,317 (GRCm39) T133A probably benign Het
Trnp1 A G 4: 133,225,380 (GRCm39) F130S possibly damaging Het
Tsr1 A G 11: 74,794,652 (GRCm39) S436G probably benign Het
Ttn T C 2: 76,541,032 (GRCm39) I33985V probably benign Het
Usp34 A C 11: 23,394,184 (GRCm39) D2278A Het
Vav3 T A 3: 109,565,285 (GRCm39) F727Y probably benign Het
Vcl T C 14: 21,060,236 (GRCm39) probably null Het
Vps13c T A 9: 67,880,685 (GRCm39) D3507E probably damaging Het
Vtn A G 11: 78,391,090 (GRCm39) probably benign Het
Zfp319 A G 8: 96,054,938 (GRCm39) S422P possibly damaging Het
Other mutations in Pglyrp2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01935:Pglyrp2 APN 17 32,637,551 (GRCm39) missense probably benign 0.14
IGL01949:Pglyrp2 APN 17 32,635,080 (GRCm39) splice site probably null
IGL02355:Pglyrp2 APN 17 32,635,996 (GRCm39) missense probably damaging 1.00
IGL02362:Pglyrp2 APN 17 32,635,996 (GRCm39) missense probably damaging 1.00
IGL02601:Pglyrp2 APN 17 32,634,835 (GRCm39) missense probably benign 0.04
IGL02965:Pglyrp2 APN 17 32,637,560 (GRCm39) missense probably benign 0.00
R0324:Pglyrp2 UTSW 17 32,637,302 (GRCm39) missense probably benign 0.00
R0386:Pglyrp2 UTSW 17 32,639,836 (GRCm39) start codon destroyed probably null 0.93
R2158:Pglyrp2 UTSW 17 32,637,222 (GRCm39) missense probably benign 0.12
R2181:Pglyrp2 UTSW 17 32,637,936 (GRCm39) missense probably damaging 1.00
R2191:Pglyrp2 UTSW 17 32,634,931 (GRCm39) missense probably benign 0.04
R2313:Pglyrp2 UTSW 17 32,637,673 (GRCm39) missense probably damaging 1.00
R4825:Pglyrp2 UTSW 17 32,637,235 (GRCm39) missense probably benign 0.00
R4852:Pglyrp2 UTSW 17 32,634,823 (GRCm39) missense probably benign 0.09
R4888:Pglyrp2 UTSW 17 32,637,771 (GRCm39) missense probably benign 0.26
R6941:Pglyrp2 UTSW 17 32,635,048 (GRCm39) missense probably damaging 1.00
R7014:Pglyrp2 UTSW 17 32,634,904 (GRCm39) missense probably damaging 0.98
R7327:Pglyrp2 UTSW 17 32,634,893 (GRCm39) missense probably benign 0.16
R7886:Pglyrp2 UTSW 17 32,637,735 (GRCm39) missense possibly damaging 0.53
R8179:Pglyrp2 UTSW 17 32,635,003 (GRCm39) missense possibly damaging 0.51
Predicted Primers PCR Primer
(F):5'- AAGTTGAAGAGCGCGTTCCC -3'
(R):5'- AGAAAGGTTTCCGGGTTTGCAC -3'

Sequencing Primer
(F):5'- CGTTCCCGGGGCAGTGG -3'
(R):5'- CAGAAGCAGTGTGTTGCAC -3'
Posted On 2021-03-08