Incidental Mutation 'R8735:Lama2'
ID 662983
Institutional Source Beutler Lab
Gene Symbol Lama2
Ensembl Gene ENSMUSG00000019899
Gene Name laminin, alpha 2
Synonyms mer, merosin
MMRRC Submission 068583-MU
Accession Numbers
Essential gene? Possibly non essential (E-score: 0.320) question?
Stock # R8735 (G1)
Quality Score 225.009
Status Validated
Chromosome 10
Chromosomal Location 26857281-27493021 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) T to A at 27066530 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Valine at position 1117 (E1117V)
Ref Sequence ENSEMBL: ENSMUSP00000090304 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000092639] [ENSMUST00000189575]
AlphaFold no structure available at present
PDB Structure LAMININ ALPHA 2 CHAIN LG4-5 DOMAIN PAIR [X-RAY DIFFRACTION]
LAMININ ALPHA 2 CHAIN LG4-5 DOMAIN PAIR, CA1 SITE MUTANT [X-RAY DIFFRACTION]
CRYSTAL STRUCTURE OF THE FIFTH LAMININ G-LIKE MODULE OF THE MOUSE LAMININ ALPHA2 CHAIN [X-RAY DIFFRACTION]
CRYSTAL STRUCTURE OF THE LG1-3 REGION OF THE LAMININ ALPHA2 CHAIN [X-RAY DIFFRACTION]
Predicted Effect probably damaging
Transcript: ENSMUST00000092639
AA Change: E1117V

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000090304
Gene: ENSMUSG00000019899
AA Change: E1117V

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
LamNT 29 281 5.35e-129 SMART
EGF_Lam 283 337 2.11e-4 SMART
EGF_Lam 340 407 1.59e-8 SMART
EGF_Lam 410 462 5.44e-7 SMART
EGF_Lam 465 511 9.05e-4 SMART
LamB 574 706 2.26e-44 SMART
Pfam:Laminin_EGF 715 745 2.8e-4 PFAM
EGF_Lam 753 800 4.03e-10 SMART
EGF_Lam 803 858 3.01e-9 SMART
EGF_Lam 861 911 1.35e-11 SMART
EGF_Lam 914 960 7.23e-12 SMART
EGF_Lam 963 1007 5.87e-12 SMART
EGF_Lam 1010 1053 1.28e-12 SMART
EGF_Lam 1056 1099 2.37e-7 SMART
EGF_Lam 1102 1159 3.22e-9 SMART
LamB 1225 1360 1.95e-57 SMART
EGF_like 1364 1413 8.13e-1 SMART
EGF_Lam 1416 1462 5.48e-12 SMART
EGF_Lam 1465 1520 1.27e-7 SMART
EGF_Lam 1523 1567 2.4e-8 SMART
Pfam:Laminin_I 1584 1849 2e-92 PFAM
Blast:MA 1881 2113 1e-112 BLAST
LamG 2162 2307 1.28e-25 SMART
LamG 2356 2500 2.2e-33 SMART
LamG 2542 2688 3.31e-28 SMART
low complexity region 2725 2741 N/A INTRINSIC
LamG 2781 2914 2.25e-39 SMART
LamG 2956 3092 1.53e-32 SMART
Predicted Effect probably damaging
Transcript: ENSMUST00000189575
AA Change: E1117V

PolyPhen 2 Score 0.997 (Sensitivity: 0.41; Specificity: 0.98)
SMART Domains Protein: ENSMUSP00000140716
Gene: ENSMUSG00000019899
AA Change: E1117V

DomainStartEndE-ValueType
signal peptide 1 19 N/A INTRINSIC
LamNT 29 281 2.5e-131 SMART
EGF_Lam 283 337 1e-6 SMART
EGF_Lam 340 407 7.7e-11 SMART
EGF_Lam 410 462 2.6e-9 SMART
EGF_Lam 465 511 4.5e-6 SMART
LamB 574 706 1.4e-46 SMART
Pfam:Laminin_EGF 715 745 1.7e-2 PFAM
EGF_Lam 753 800 1.9e-12 SMART
EGF_Lam 803 858 1.4e-11 SMART
EGF_Lam 861 911 6.7e-14 SMART
EGF_Lam 914 960 3.6e-14 SMART
EGF_Lam 963 1007 2.9e-14 SMART
EGF_Lam 1010 1053 6.1e-15 SMART
EGF_Lam 1056 1099 1.1e-9 SMART
EGF_Lam 1102 1159 1.5e-11 SMART
LamB 1225 1349 1.4e-45 SMART
Meta Mutation Damage Score 0.1176 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.7%
Validation Efficiency 99% (76/77)
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] Laminin, an extracellular protein, is a major component of the basement membrane. It is thought to mediate the attachment, migration, and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components. It is composed of three subunits, alpha, beta, and gamma, which are bound to each other by disulfide bonds into a cross-shaped molecule. This gene encodes the alpha 2 chain, which constitutes one of the subunits of laminin 2 (merosin) and laminin 4 (s-merosin). Mutations in this gene have been identified as the cause of congenital merosin-deficient muscular dystrophy. Two transcript variants encoding different proteins have been found for this gene. [provided by RefSeq, Jul 2008]
PHENOTYPE: Homozygotes for targeted and spontaneous mutations exhibit progressive growth retardation, ataxia, muscle atrophy and degeneration, infertility, and premature lethality. Muscle fiber degeneration is evident as early as the first week of life. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 78 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
6430550D23Rik A G 2: 155,845,731 (GRCm39) F9S unknown Het
Abhd10 A G 16: 45,557,997 (GRCm39) F101L probably damaging Het
Acp2 A G 2: 91,034,651 (GRCm39) T93A probably benign Het
Adamts9 C T 6: 92,837,048 (GRCm39) probably benign Het
Aknad1 T A 3: 108,682,615 (GRCm39) probably benign Het
Ank3 A T 10: 69,822,785 (GRCm39) T485S probably benign Het
Caly G A 7: 139,652,503 (GRCm39) R82C probably damaging Het
Cfhr2 A G 1: 139,786,343 (GRCm39) L8P probably damaging Het
Cpeb2 T A 5: 43,438,775 (GRCm39) L869* probably null Het
Cxxc1 A G 18: 74,350,331 (GRCm39) K33E possibly damaging Het
Cyp17a1 T C 19: 46,659,533 (GRCm39) probably null Het
Cyp4a30b G A 4: 115,309,976 (GRCm39) W59* probably null Het
Dennd4b T C 3: 90,185,172 (GRCm39) V1204A probably damaging Het
Dpyd T A 3: 118,935,565 (GRCm39) D663E possibly damaging Het
Esrrg A T 1: 187,933,205 (GRCm39) probably benign Het
Exoc2 A C 13: 31,090,822 (GRCm39) L261V probably damaging Het
Exosc9 T C 3: 36,609,662 (GRCm39) L185S probably damaging Het
Gcnt3 T C 9: 69,941,728 (GRCm39) K280R probably benign Het
Ighv1-64 A T 12: 115,471,217 (GRCm39) M100K probably benign Het
Impdh2 G A 9: 108,441,978 (GRCm39) probably null Het
Itsn2 T A 12: 4,721,474 (GRCm39) I1068K probably damaging Het
Kif5c T C 2: 49,584,783 (GRCm39) C169R probably damaging Het
Kndc1 A G 7: 139,490,130 (GRCm39) S211G probably benign Het
Lgals4 C T 7: 28,540,921 (GRCm39) R282C probably damaging Het
Lsg1 T A 16: 30,399,865 (GRCm39) probably null Het
Mab21l4 C T 1: 93,082,208 (GRCm39) probably null Het
Msh3 A G 13: 92,411,374 (GRCm39) S608P possibly damaging Het
Mslnl T A 17: 25,964,062 (GRCm39) F464I probably benign Het
Mycbp2 T A 14: 103,460,586 (GRCm39) K1493N probably damaging Het
Myo15a A T 11: 60,401,679 (GRCm39) probably null Het
Myo1b A T 1: 51,794,896 (GRCm39) F1065I probably benign Het
Nf1 A G 11: 79,345,136 (GRCm39) probably benign Het
Nup153 C A 13: 46,881,027 (GRCm39) probably benign Het
Or4f4-ps1 T A 2: 111,330,497 (GRCm39) I300K probably damaging Het
Or5b97 A G 19: 12,878,274 (GRCm39) V290A possibly damaging Het
Osbpl7 A G 11: 96,943,194 (GRCm39) T149A probably benign Het
Parp1 A G 1: 180,396,690 (GRCm39) D31G probably benign Het
Pcdha6 T A 18: 37,101,203 (GRCm39) V132E possibly damaging Het
Pcdhb8 T A 18: 37,489,975 (GRCm39) L551Q possibly damaging Het
Pcsk9 T A 4: 106,311,808 (GRCm39) T190S probably damaging Het
Pdgfrb A T 18: 61,197,049 (GRCm39) T162S probably benign Het
Pi4ka C T 16: 17,136,234 (GRCm39) R908Q Het
Pnpla8 A G 12: 44,330,222 (GRCm39) E258G probably benign Het
Prrc2c A T 1: 162,537,127 (GRCm39) S643T unknown Het
Rnf20 T G 4: 49,655,964 (GRCm39) I970S possibly damaging Het
Robo2 A T 16: 73,755,247 (GRCm39) V758D probably damaging Het
Robo4 G A 9: 37,319,577 (GRCm39) S609N possibly damaging Het
Rrbp1 G A 2: 143,830,920 (GRCm39) Q416* probably null Het
Rsf1 GCG GCGACGGCGACG 7: 97,229,114 (GRCm39) probably benign Het
Ryr2 C A 13: 11,701,833 (GRCm39) E2941D probably damaging Het
Scd2 G T 19: 44,289,743 (GRCm39) C246F probably benign Het
Sh3rf1 G A 8: 61,825,687 (GRCm39) V561I probably benign Het
Slc4a4 T A 5: 89,280,301 (GRCm39) D366E probably damaging Het
Slfn14 T G 11: 83,174,715 (GRCm39) Q92P probably damaging Het
Slfn4 A T 11: 83,077,770 (GRCm39) Y186F probably damaging Het
Smpd4 T C 16: 17,453,410 (GRCm39) L309P possibly damaging Het
Smyd3 G T 1: 178,920,482 (GRCm39) N217K probably benign Het
Spen T C 4: 141,197,129 (GRCm39) T3547A probably benign Het
Suclg1 A T 6: 73,253,729 (GRCm39) I126F unknown Het
Tenm4 C T 7: 96,555,148 (GRCm39) P2618S probably benign Het
Tmprss15 A T 16: 78,798,702 (GRCm39) I660N possibly damaging Het
Trf A T 9: 103,087,723 (GRCm39) V677D probably damaging Het
Trim36 T C 18: 46,302,452 (GRCm39) N532S probably benign Het
Trim37 T C 11: 87,037,885 (GRCm39) probably null Het
Ttn T C 2: 76,570,454 (GRCm39) N26813S probably benign Het
Vmn1r199 T A 13: 22,567,537 (GRCm39) V277D probably damaging Het
Wdfy3 T C 5: 102,077,951 (GRCm39) D873G probably benign Het
Wdr27 T C 17: 15,103,929 (GRCm39) T726A probably damaging Het
Wdr97 T C 15: 76,240,775 (GRCm39) Y488H Het
Wdtc1 A T 4: 133,031,511 (GRCm39) C236* probably null Het
Wnk4 A C 11: 101,167,092 (GRCm39) S1083R unknown Het
Wwc1 A T 11: 35,774,234 (GRCm39) I342N probably damaging Het
Zbtb40 A G 4: 136,725,957 (GRCm39) L534P probably damaging Het
Zfp62 T C 11: 49,108,227 (GRCm39) C773R probably damaging Het
Zfp709 T A 8: 72,643,027 (GRCm39) I152N probably benign Het
Zfp738 T C 13: 67,819,550 (GRCm39) Y147C probably damaging Het
Zscan18 A C 7: 12,503,625 (GRCm39) S645A probably benign Het
Zw10 A G 9: 48,988,861 (GRCm39) Y709C probably damaging Het
Other mutations in Lama2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00392:Lama2 APN 10 27,064,261 (GRCm39) missense probably benign 0.01
IGL00467:Lama2 APN 10 27,343,193 (GRCm39) splice site probably benign
IGL00470:Lama2 APN 10 27,119,738 (GRCm39) missense probably benign 0.22
IGL00517:Lama2 APN 10 27,073,326 (GRCm39) missense probably benign 0.01
IGL00541:Lama2 APN 10 27,064,302 (GRCm39) missense probably benign 0.14
IGL00931:Lama2 APN 10 26,882,772 (GRCm39) missense possibly damaging 0.92
IGL00951:Lama2 APN 10 26,906,281 (GRCm39) missense probably benign 0.03
IGL00988:Lama2 APN 10 27,245,011 (GRCm39) nonsense probably null
IGL01098:Lama2 APN 10 26,907,108 (GRCm39) missense possibly damaging 0.66
IGL01152:Lama2 APN 10 27,084,425 (GRCm39) missense probably benign 0.00
IGL01293:Lama2 APN 10 27,107,632 (GRCm39) missense probably benign 0.38
IGL01338:Lama2 APN 10 27,064,268 (GRCm39) missense probably benign 0.13
IGL01609:Lama2 APN 10 27,220,417 (GRCm39) missense probably benign 0.03
IGL01643:Lama2 APN 10 26,946,368 (GRCm39) splice site probably benign
IGL01675:Lama2 APN 10 27,064,050 (GRCm39) missense possibly damaging 0.77
IGL01681:Lama2 APN 10 27,141,041 (GRCm39) missense probably benign 0.33
IGL01694:Lama2 APN 10 26,882,738 (GRCm39) missense possibly damaging 0.75
IGL01705:Lama2 APN 10 27,065,270 (GRCm39) splice site probably benign
IGL01885:Lama2 APN 10 26,981,135 (GRCm39) nonsense probably null
IGL01935:Lama2 APN 10 27,298,600 (GRCm39) missense probably damaging 0.98
IGL01994:Lama2 APN 10 27,343,199 (GRCm39) critical splice donor site probably null
IGL02041:Lama2 APN 10 26,860,322 (GRCm39) missense probably damaging 1.00
IGL02067:Lama2 APN 10 27,052,792 (GRCm39) missense probably benign 0.02
IGL02097:Lama2 APN 10 27,014,956 (GRCm39) missense probably benign 0.09
IGL02179:Lama2 APN 10 26,946,360 (GRCm39) missense probably benign 0.01
IGL02268:Lama2 APN 10 26,877,112 (GRCm39) splice site probably benign
IGL02302:Lama2 APN 10 27,088,039 (GRCm39) missense probably benign 0.06
IGL02363:Lama2 APN 10 27,242,062 (GRCm39) missense probably damaging 1.00
IGL02378:Lama2 APN 10 26,919,652 (GRCm39) missense probably damaging 0.99
IGL02642:Lama2 APN 10 27,343,269 (GRCm39) missense probably damaging 1.00
IGL02676:Lama2 APN 10 26,994,489 (GRCm39) missense probably benign 0.00
IGL02695:Lama2 APN 10 26,876,771 (GRCm39) missense probably benign
IGL02735:Lama2 APN 10 26,980,124 (GRCm39) missense probably damaging 1.00
IGL02794:Lama2 APN 10 26,917,227 (GRCm39) missense possibly damaging 0.73
IGL02823:Lama2 APN 10 26,877,141 (GRCm39) missense probably damaging 1.00
IGL02869:Lama2 APN 10 26,891,534 (GRCm39) missense probably damaging 0.99
IGL02942:Lama2 APN 10 26,917,216 (GRCm39) missense probably damaging 1.00
IGL03201:Lama2 APN 10 27,220,566 (GRCm39) nonsense probably null
IGL03268:Lama2 APN 10 27,298,649 (GRCm39) missense probably damaging 1.00
IGL03288:Lama2 APN 10 27,245,047 (GRCm39) missense probably damaging 1.00
IGL03380:Lama2 APN 10 26,926,261 (GRCm39) missense probably damaging 1.00
IGL03407:Lama2 APN 10 27,223,017 (GRCm39) missense probably damaging 1.00
cowboy UTSW 10 26,919,639 (GRCm39) frame shift probably null
petri UTSW 10 26,869,394 (GRCm39) splice site probably null
PIT4362001:Lama2 UTSW 10 27,245,132 (GRCm39) missense probably damaging 1.00
PIT4382001:Lama2 UTSW 10 27,080,901 (GRCm39) missense probably damaging 1.00
PIT4431001:Lama2 UTSW 10 26,977,426 (GRCm39) missense probably damaging 1.00
R0038:Lama2 UTSW 10 26,862,793 (GRCm39) missense probably benign 0.02
R0038:Lama2 UTSW 10 26,862,793 (GRCm39) missense probably benign 0.02
R0114:Lama2 UTSW 10 26,869,064 (GRCm39) nonsense probably null
R0142:Lama2 UTSW 10 27,063,841 (GRCm39) missense probably benign
R0313:Lama2 UTSW 10 26,869,394 (GRCm39) splice site probably null
R0376:Lama2 UTSW 10 26,891,542 (GRCm39) missense possibly damaging 0.68
R0412:Lama2 UTSW 10 27,066,621 (GRCm39) missense possibly damaging 0.58
R0472:Lama2 UTSW 10 26,866,863 (GRCm39) missense probably damaging 1.00
R0607:Lama2 UTSW 10 27,065,127 (GRCm39) missense probably benign 0.34
R0648:Lama2 UTSW 10 26,865,372 (GRCm39) missense probably benign 0.00
R0667:Lama2 UTSW 10 27,220,406 (GRCm39) splice site probably null
R0760:Lama2 UTSW 10 26,920,429 (GRCm39) critical splice donor site probably null
R1240:Lama2 UTSW 10 26,917,120 (GRCm39) missense probably damaging 1.00
R1385:Lama2 UTSW 10 27,100,039 (GRCm39) missense probably benign 0.11
R1433:Lama2 UTSW 10 27,063,750 (GRCm39) missense probably damaging 1.00
R1434:Lama2 UTSW 10 27,084,366 (GRCm39) missense probably damaging 1.00
R1574:Lama2 UTSW 10 27,200,750 (GRCm39) missense possibly damaging 0.65
R1574:Lama2 UTSW 10 27,200,750 (GRCm39) missense possibly damaging 0.65
R1645:Lama2 UTSW 10 27,244,981 (GRCm39) missense probably damaging 1.00
R1702:Lama2 UTSW 10 27,066,525 (GRCm39) missense probably benign
R1703:Lama2 UTSW 10 27,142,667 (GRCm39) missense probably damaging 1.00
R1769:Lama2 UTSW 10 27,084,403 (GRCm39) missense probably benign
R1769:Lama2 UTSW 10 27,084,402 (GRCm39) missense probably damaging 1.00
R1846:Lama2 UTSW 10 27,088,092 (GRCm39) missense probably damaging 1.00
R1859:Lama2 UTSW 10 26,907,078 (GRCm39) missense possibly damaging 0.51
R1871:Lama2 UTSW 10 26,860,490 (GRCm39) missense probably damaging 1.00
R1903:Lama2 UTSW 10 27,064,395 (GRCm39) missense probably damaging 1.00
R1906:Lama2 UTSW 10 26,932,523 (GRCm39) critical splice donor site probably null
R1958:Lama2 UTSW 10 26,857,594 (GRCm39) missense probably damaging 0.97
R1959:Lama2 UTSW 10 27,298,614 (GRCm39) missense probably damaging 1.00
R1977:Lama2 UTSW 10 26,866,796 (GRCm39) splice site probably null
R2063:Lama2 UTSW 10 27,040,922 (GRCm39) missense probably damaging 1.00
R2079:Lama2 UTSW 10 27,245,049 (GRCm39) missense probably damaging 0.99
R2085:Lama2 UTSW 10 27,080,837 (GRCm39) nonsense probably null
R2125:Lama2 UTSW 10 26,920,449 (GRCm39) nonsense probably null
R2140:Lama2 UTSW 10 26,930,690 (GRCm39) splice site probably null
R2219:Lama2 UTSW 10 26,919,565 (GRCm39) missense probably damaging 0.99
R2259:Lama2 UTSW 10 26,907,123 (GRCm39) missense probably benign 0.00
R2265:Lama2 UTSW 10 26,868,932 (GRCm39) missense probably damaging 1.00
R2266:Lama2 UTSW 10 26,862,793 (GRCm39) missense probably benign 0.02
R2267:Lama2 UTSW 10 26,868,932 (GRCm39) missense probably damaging 1.00
R2268:Lama2 UTSW 10 26,868,932 (GRCm39) missense probably damaging 1.00
R2269:Lama2 UTSW 10 26,868,932 (GRCm39) missense probably damaging 1.00
R2862:Lama2 UTSW 10 27,298,608 (GRCm39) nonsense probably null
R2912:Lama2 UTSW 10 26,876,799 (GRCm39) missense probably benign
R2999:Lama2 UTSW 10 26,865,417 (GRCm39) missense probably benign 0.18
R3034:Lama2 UTSW 10 26,877,231 (GRCm39) missense probably benign 0.11
R3081:Lama2 UTSW 10 26,877,231 (GRCm39) missense probably benign 0.11
R3107:Lama2 UTSW 10 26,877,231 (GRCm39) missense probably benign 0.11
R3109:Lama2 UTSW 10 26,877,231 (GRCm39) missense probably benign 0.11
R3436:Lama2 UTSW 10 26,877,231 (GRCm39) missense probably benign 0.11
R3437:Lama2 UTSW 10 26,877,231 (GRCm39) missense probably benign 0.11
R3706:Lama2 UTSW 10 27,014,992 (GRCm39) missense probably damaging 1.00
R3780:Lama2 UTSW 10 27,335,335 (GRCm39) missense probably damaging 1.00
R3807:Lama2 UTSW 10 27,066,661 (GRCm39) frame shift probably null
R3919:Lama2 UTSW 10 26,994,501 (GRCm39) missense probably damaging 1.00
R4014:Lama2 UTSW 10 26,860,372 (GRCm39) missense probably damaging 1.00
R4131:Lama2 UTSW 10 26,917,170 (GRCm39) missense probably benign 0.00
R4190:Lama2 UTSW 10 27,142,660 (GRCm39) missense probably damaging 0.96
R4273:Lama2 UTSW 10 27,223,050 (GRCm39) missense probably damaging 1.00
R4358:Lama2 UTSW 10 26,860,489 (GRCm39) missense probably damaging 1.00
R4407:Lama2 UTSW 10 27,088,124 (GRCm39) small deletion probably benign
R4415:Lama2 UTSW 10 26,865,340 (GRCm39) nonsense probably null
R4426:Lama2 UTSW 10 27,298,554 (GRCm39) missense probably damaging 1.00
R4590:Lama2 UTSW 10 26,865,410 (GRCm39) missense probably benign 0.00
R4615:Lama2 UTSW 10 26,857,520 (GRCm39) missense probably damaging 0.99
R4736:Lama2 UTSW 10 27,080,925 (GRCm39) missense probably damaging 1.00
R4754:Lama2 UTSW 10 26,994,527 (GRCm39) missense possibly damaging 0.58
R4791:Lama2 UTSW 10 27,343,267 (GRCm39) missense probably damaging 1.00
R4834:Lama2 UTSW 10 26,882,745 (GRCm39) missense probably benign 0.30
R4856:Lama2 UTSW 10 26,919,639 (GRCm39) frame shift probably null
R4858:Lama2 UTSW 10 26,919,639 (GRCm39) frame shift probably null
R4859:Lama2 UTSW 10 26,919,639 (GRCm39) frame shift probably null
R4897:Lama2 UTSW 10 26,919,639 (GRCm39) frame shift probably null
R4898:Lama2 UTSW 10 26,919,639 (GRCm39) frame shift probably null
R4899:Lama2 UTSW 10 26,919,639 (GRCm39) frame shift probably null
R4907:Lama2 UTSW 10 27,040,942 (GRCm39) missense probably benign 0.11
R4911:Lama2 UTSW 10 27,014,923 (GRCm39) missense probably damaging 1.00
R4924:Lama2 UTSW 10 27,245,137 (GRCm39) missense probably damaging 0.98
R5023:Lama2 UTSW 10 27,066,500 (GRCm39) missense probably damaging 0.97
R5057:Lama2 UTSW 10 27,040,982 (GRCm39) missense probably damaging 1.00
R5070:Lama2 UTSW 10 27,226,247 (GRCm39) critical splice donor site probably null
R5116:Lama2 UTSW 10 26,994,556 (GRCm39) missense probably benign 0.08
R5177:Lama2 UTSW 10 27,066,699 (GRCm39) missense possibly damaging 0.94
R5198:Lama2 UTSW 10 27,222,999 (GRCm39) missense probably damaging 0.96
R5289:Lama2 UTSW 10 27,088,069 (GRCm39) nonsense probably null
R5327:Lama2 UTSW 10 27,014,942 (GRCm39) missense probably benign
R5424:Lama2 UTSW 10 26,860,392 (GRCm39) missense probably damaging 1.00
R5469:Lama2 UTSW 10 26,917,185 (GRCm39) missense possibly damaging 0.92
R5620:Lama2 UTSW 10 26,866,876 (GRCm39) missense probably damaging 0.99
R5667:Lama2 UTSW 10 27,066,540 (GRCm39) missense probably damaging 1.00
R5671:Lama2 UTSW 10 27,066,540 (GRCm39) missense probably damaging 1.00
R5815:Lama2 UTSW 10 26,862,847 (GRCm39) missense probably damaging 1.00
R5917:Lama2 UTSW 10 27,066,693 (GRCm39) missense probably damaging 1.00
R5935:Lama2 UTSW 10 26,891,494 (GRCm39) missense probably benign
R5976:Lama2 UTSW 10 27,066,672 (GRCm39) missense probably benign 0.00
R5979:Lama2 UTSW 10 27,111,728 (GRCm39) missense probably damaging 0.99
R6004:Lama2 UTSW 10 27,111,781 (GRCm39) missense probably benign 0.01
R6180:Lama2 UTSW 10 26,857,495 (GRCm39) missense probably benign 0.03
R6198:Lama2 UTSW 10 27,064,018 (GRCm39) missense probably damaging 1.00
R6257:Lama2 UTSW 10 26,862,895 (GRCm39) missense possibly damaging 0.85
R6271:Lama2 UTSW 10 26,899,325 (GRCm39) missense possibly damaging 0.67
R6322:Lama2 UTSW 10 27,066,543 (GRCm39) missense probably damaging 0.96
R6354:Lama2 UTSW 10 27,088,064 (GRCm39) missense probably damaging 1.00
R6431:Lama2 UTSW 10 26,929,027 (GRCm39) missense possibly damaging 0.50
R6499:Lama2 UTSW 10 26,907,154 (GRCm39) missense probably damaging 1.00
R6535:Lama2 UTSW 10 26,980,127 (GRCm39) missense probably damaging 1.00
R6545:Lama2 UTSW 10 27,052,793 (GRCm39) missense probably benign
R6636:Lama2 UTSW 10 27,000,564 (GRCm39) missense probably benign 0.13
R6891:Lama2 UTSW 10 27,204,078 (GRCm39) nonsense probably null
R6891:Lama2 UTSW 10 27,204,068 (GRCm39) nonsense probably null
R6902:Lama2 UTSW 10 26,857,625 (GRCm39) missense probably damaging 1.00
R6908:Lama2 UTSW 10 26,907,192 (GRCm39) splice site probably null
R7168:Lama2 UTSW 10 27,242,148 (GRCm39) critical splice acceptor site probably null
R7233:Lama2 UTSW 10 27,107,659 (GRCm39) missense probably damaging 1.00
R7272:Lama2 UTSW 10 27,000,552 (GRCm39) missense probably damaging 1.00
R7274:Lama2 UTSW 10 26,995,976 (GRCm39) missense probably damaging 0.99
R7419:Lama2 UTSW 10 27,142,630 (GRCm39) missense probably benign
R7423:Lama2 UTSW 10 27,088,222 (GRCm39) missense probably benign 0.00
R7554:Lama2 UTSW 10 27,031,492 (GRCm39) missense probably damaging 1.00
R7569:Lama2 UTSW 10 27,141,046 (GRCm39) missense probably damaging 1.00
R7574:Lama2 UTSW 10 26,882,726 (GRCm39) missense probably benign 0.03
R7584:Lama2 UTSW 10 26,980,257 (GRCm39) missense possibly damaging 0.78
R7586:Lama2 UTSW 10 26,977,389 (GRCm39) missense probably benign 0.00
R7603:Lama2 UTSW 10 27,142,676 (GRCm39) missense possibly damaging 0.55
R7691:Lama2 UTSW 10 27,084,389 (GRCm39) missense possibly damaging 0.67
R7750:Lama2 UTSW 10 26,866,920 (GRCm39) missense probably damaging 0.97
R7841:Lama2 UTSW 10 27,031,529 (GRCm39) missense probably benign 0.00
R7864:Lama2 UTSW 10 26,932,611 (GRCm39) missense probably benign 0.08
R7960:Lama2 UTSW 10 26,869,094 (GRCm39) missense probably benign 0.04
R7964:Lama2 UTSW 10 27,099,977 (GRCm39) critical splice donor site probably null
R7980:Lama2 UTSW 10 27,239,609 (GRCm39) missense probably damaging 0.98
R8013:Lama2 UTSW 10 27,220,494 (GRCm39) missense probably benign 0.00
R8028:Lama2 UTSW 10 27,204,145 (GRCm39) missense probably benign 0.13
R8097:Lama2 UTSW 10 27,066,660 (GRCm39) nonsense probably null
R8100:Lama2 UTSW 10 26,917,113 (GRCm39) missense probably benign 0.03
R8110:Lama2 UTSW 10 26,866,866 (GRCm39) missense probably damaging 1.00
R8122:Lama2 UTSW 10 26,930,592 (GRCm39) missense possibly damaging 0.87
R8264:Lama2 UTSW 10 27,343,218 (GRCm39) missense probably benign 0.07
R8315:Lama2 UTSW 10 27,298,655 (GRCm39) missense probably damaging 1.00
R8318:Lama2 UTSW 10 26,860,334 (GRCm39) missense probably damaging 1.00
R8419:Lama2 UTSW 10 27,298,559 (GRCm39) missense probably benign 0.26
R8475:Lama2 UTSW 10 26,977,369 (GRCm39) missense possibly damaging 0.69
R8754:Lama2 UTSW 10 26,877,147 (GRCm39) missense possibly damaging 0.83
R8817:Lama2 UTSW 10 27,063,869 (GRCm39) missense probably damaging 1.00
R8851:Lama2 UTSW 10 27,242,119 (GRCm39) missense possibly damaging 0.94
R8859:Lama2 UTSW 10 27,335,384 (GRCm39) missense possibly damaging 0.58
R8886:Lama2 UTSW 10 27,245,157 (GRCm39) splice site probably benign
R8937:Lama2 UTSW 10 26,862,816 (GRCm39) missense probably damaging 1.00
R8993:Lama2 UTSW 10 27,298,710 (GRCm39) missense possibly damaging 0.91
R9025:Lama2 UTSW 10 26,860,367 (GRCm39) missense probably benign 0.00
R9027:Lama2 UTSW 10 27,080,881 (GRCm39) missense probably damaging 1.00
R9047:Lama2 UTSW 10 26,882,697 (GRCm39) missense possibly damaging 0.50
R9075:Lama2 UTSW 10 26,857,588 (GRCm39) missense probably damaging 1.00
R9135:Lama2 UTSW 10 27,298,515 (GRCm39) missense probably damaging 1.00
R9165:Lama2 UTSW 10 26,929,022 (GRCm39) critical splice donor site probably null
R9192:Lama2 UTSW 10 27,204,181 (GRCm39) missense possibly damaging 0.95
R9254:Lama2 UTSW 10 27,298,685 (GRCm39) missense probably damaging 0.96
R9326:Lama2 UTSW 10 26,906,193 (GRCm39) missense probably benign 0.04
R9356:Lama2 UTSW 10 27,088,186 (GRCm39) missense probably damaging 0.99
R9358:Lama2 UTSW 10 27,492,761 (GRCm39) missense unknown
R9358:Lama2 UTSW 10 27,064,378 (GRCm39) missense possibly damaging 0.95
R9376:Lama2 UTSW 10 26,994,620 (GRCm39) missense probably benign 0.11
R9381:Lama2 UTSW 10 27,064,023 (GRCm39) nonsense probably null
R9397:Lama2 UTSW 10 26,981,117 (GRCm39) missense probably benign 0.01
R9460:Lama2 UTSW 10 27,298,475 (GRCm39) missense probably damaging 1.00
R9478:Lama2 UTSW 10 26,891,478 (GRCm39) missense probably damaging 0.98
R9503:Lama2 UTSW 10 26,865,440 (GRCm39) missense possibly damaging 0.57
R9514:Lama2 UTSW 10 27,100,015 (GRCm39) missense probably benign 0.00
R9515:Lama2 UTSW 10 26,877,170 (GRCm39) missense probably benign 0.23
R9516:Lama2 UTSW 10 27,100,015 (GRCm39) missense probably benign 0.00
R9533:Lama2 UTSW 10 26,862,871 (GRCm39) missense probably damaging 1.00
R9619:Lama2 UTSW 10 27,064,282 (GRCm39) missense probably damaging 1.00
R9721:Lama2 UTSW 10 27,343,338 (GRCm39) missense possibly damaging 0.58
Predicted Primers PCR Primer
(F):5'- TCTGTATGCCAATGAGCATACATC -3'
(R):5'- TTTGTAACTGCAGCACTGTGG -3'

Sequencing Primer
(F):5'- AAAACCTGTGTCTGGCCATG -3'
(R):5'- CAGCACTGTGGGGTCCTTG -3'
Posted On 2021-03-08