Mutagenetix > Incidental Mutation

Incidental Mutation 'R8735:Myo15a'

662987

Institutional Source

Beutler Lab

Gene Symbol

Myo15a

Ensembl Gene

ENSMUSG00000042678

Gene Name

myosin XVA

Synonyms

Myo15

MMRRC Submission

068583-MU

Accession Numbers

Essential gene?

Non essential (E-score: 0.000) question?

Stock #

R8735 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

60360165-60419195 bp(+) (GRCm39)

Type of Mutation

critical splice acceptor site

DNA Base Change (assembly)

A to T at 60401679 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000071777 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000071880] [ENSMUST00000081823] [ENSMUST00000094135]

AlphaFold

no structure available at present

Predicted Effect

probably null
Transcript: ENSMUST00000071880

SMART Domains

Protein: ENSMUSP00000071777
Gene: ENSMUSG00000042678

Domain	Start	End	E-Value	Type
low complexity region	4	24	N/A	INTRINSIC
low complexity region	87	100	N/A	INTRINSIC
low complexity region	107	120	N/A	INTRINSIC
low complexity region	269	292	N/A	INTRINSIC
low complexity region	295	306	N/A	INTRINSIC
low complexity region	311	325	N/A	INTRINSIC
low complexity region	349	384	N/A	INTRINSIC
low complexity region	425	435	N/A	INTRINSIC
low complexity region	487	498	N/A	INTRINSIC
low complexity region	502	509	N/A	INTRINSIC
low complexity region	653	681	N/A	INTRINSIC
low complexity region	692	705	N/A	INTRINSIC
low complexity region	737	747	N/A	INTRINSIC
low complexity region	758	775	N/A	INTRINSIC
low complexity region	781	792	N/A	INTRINSIC
low complexity region	796	809	N/A	INTRINSIC
low complexity region	825	849	N/A	INTRINSIC
low complexity region	883	897	N/A	INTRINSIC
low complexity region	1067	1082	N/A	INTRINSIC
low complexity region	1115	1130	N/A	INTRINSIC
MYSc	1200	1884	N/A	SMART
IQ	1885	1907	1.63e-1	SMART
IQ	1908	1930	1.77e-2	SMART
IQ	1931	1953	2.97e2	SMART
low complexity region	1955	1974	N/A	INTRINSIC
low complexity region	1992	2006	N/A	INTRINSIC
MyTH4	2049	2195	1.8e-42	SMART
low complexity region	2396	2405	N/A	INTRINSIC
low complexity region	2451	2461	N/A	INTRINSIC
Blast:MYSc	2665	2848	2e-14	BLAST
SH3	2851	2933	1.55e-4	SMART
low complexity region	2949	2962	N/A	INTRINSIC
MyTH4	3031	3185	5.59e-48	SMART
B41	3188	3400	6.94e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000081823

SMART Domains

Protein: ENSMUSP00000080507
Gene: ENSMUSG00000042678

Domain	Start	End	E-Value	Type
MYSc	13	697	N/A	SMART
IQ	698	720	1.63e-1	SMART
IQ	721	743	1.77e-2	SMART
IQ	744	766	2.97e2	SMART
low complexity region	787	801	N/A	INTRINSIC
MyTH4	844	990	1.8e-42	SMART
low complexity region	1191	1200	N/A	INTRINSIC
low complexity region	1246	1256	N/A	INTRINSIC
Blast:MYSc	1460	1643	7e-15	BLAST
SH3	1646	1728	1.55e-4	SMART
low complexity region	1744	1757	N/A	INTRINSIC
MyTH4	1826	1980	5.59e-48	SMART
B41	1983	2195	6.94e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000094135

SMART Domains

Protein: ENSMUSP00000091686
Gene: ENSMUSG00000042678

Domain	Start	End	E-Value	Type
low complexity region	4	24	N/A	INTRINSIC
low complexity region	87	100	N/A	INTRINSIC
low complexity region	107	120	N/A	INTRINSIC
low complexity region	269	292	N/A	INTRINSIC
low complexity region	295	306	N/A	INTRINSIC
low complexity region	311	325	N/A	INTRINSIC
low complexity region	349	384	N/A	INTRINSIC
low complexity region	425	435	N/A	INTRINSIC
low complexity region	487	498	N/A	INTRINSIC
low complexity region	502	509	N/A	INTRINSIC
low complexity region	653	681	N/A	INTRINSIC
low complexity region	692	705	N/A	INTRINSIC
low complexity region	737	747	N/A	INTRINSIC
low complexity region	758	775	N/A	INTRINSIC
low complexity region	781	792	N/A	INTRINSIC
low complexity region	796	809	N/A	INTRINSIC
low complexity region	825	849	N/A	INTRINSIC
low complexity region	883	897	N/A	INTRINSIC
low complexity region	1067	1082	N/A	INTRINSIC
low complexity region	1115	1130	N/A	INTRINSIC
MYSc	1200	1884	N/A	SMART
IQ	1885	1907	1.63e-1	SMART
IQ	1908	1930	1.77e-2	SMART
IQ	1931	1953	2.97e2	SMART
low complexity region	1974	1988	N/A	INTRINSIC
MyTH4	2031	2177	1.8e-42	SMART
low complexity region	2378	2387	N/A	INTRINSIC
low complexity region	2433	2443	N/A	INTRINSIC
Blast:MYSc	2647	2830	2e-14	BLAST
SH3	2833	2915	1.55e-4	SMART
low complexity region	2931	2944	N/A	INTRINSIC
MyTH4	3013	3167	5.59e-48	SMART
B41	3170	3382	6.94e-3	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000126522

SMART Domains

Protein: ENSMUSP00000120839
Gene: ENSMUSG00000042678

Domain	Start	End	E-Value	Type
MYSc	34	716	N/A	SMART
IQ	717	739	1.63e-1	SMART
IQ	740	762	1.77e-2	SMART
IQ	763	785	2.97e2	SMART
low complexity region	806	820	N/A	INTRINSIC
MyTH4	863	1009	1.8e-42	SMART
low complexity region	1210	1219	N/A	INTRINSIC
low complexity region	1265	1275	N/A	INTRINSIC
Blast:MYSc	1479	1662	5e-15	BLAST
SH3	1665	1747	1.55e-4	SMART
low complexity region	1763	1776	N/A	INTRINSIC

Meta Mutation Damage Score

0.9497

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.7%

Validation Efficiency

99% (76/77)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes an unconventional myosin. This protein differs from other myosins in that it has a long N-terminal extension preceding the conserved motor domain. Studies in mice suggest that this protein is necessary for actin organization in the hair cells of the cochlea. Mutations in this gene have been associated with profound, congenital, neurosensory, nonsyndromal deafness. This gene is located within the Smith-Magenis syndrome region on chromosome 17. Read-through transcripts containing an upstream gene and this gene have been identified, but they are not thought to encode a fusion protein. Several alternatively spliced transcript variants have been described, but their full length sequences have not been determined. [provided by RefSeq, Jul 2008]
PHENOTYPE: Mutations in this gene result in profound deafness and neurological behavior. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 78 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
6430550D23Rik	A	G	2: 155,845,731 (GRCm39)	F9S	unknown	Het
Abhd10	A	G	16: 45,557,997 (GRCm39)	F101L	probably damaging	Het
Acp2	A	G	2: 91,034,651 (GRCm39)	T93A	probably benign	Het
Adamts9	C	T	6: 92,837,048 (GRCm39)		probably benign	Het
Aknad1	T	A	3: 108,682,615 (GRCm39)		probably benign	Het
Ank3	A	T	10: 69,822,785 (GRCm39)	T485S	probably benign	Het
Caly	G	A	7: 139,652,503 (GRCm39)	R82C	probably damaging	Het
Cfhr2	A	G	1: 139,786,343 (GRCm39)	L8P	probably damaging	Het
Cpeb2	T	A	5: 43,438,775 (GRCm39)	L869*	probably null	Het
Cxxc1	A	G	18: 74,350,331 (GRCm39)	K33E	possibly damaging	Het
Cyp17a1	T	C	19: 46,659,533 (GRCm39)		probably null	Het
Cyp4a30b	G	A	4: 115,309,976 (GRCm39)	W59*	probably null	Het
Dennd4b	T	C	3: 90,185,172 (GRCm39)	V1204A	probably damaging	Het
Dpyd	T	A	3: 118,935,565 (GRCm39)	D663E	possibly damaging	Het
Esrrg	A	T	1: 187,933,205 (GRCm39)		probably benign	Het
Exoc2	A	C	13: 31,090,822 (GRCm39)	L261V	probably damaging	Het
Exosc9	T	C	3: 36,609,662 (GRCm39)	L185S	probably damaging	Het
Gcnt3	T	C	9: 69,941,728 (GRCm39)	K280R	probably benign	Het
Ighv1-64	A	T	12: 115,471,217 (GRCm39)	M100K	probably benign	Het
Impdh2	G	A	9: 108,441,978 (GRCm39)		probably null	Het
Itsn2	T	A	12: 4,721,474 (GRCm39)	I1068K	probably damaging	Het
Kif5c	T	C	2: 49,584,783 (GRCm39)	C169R	probably damaging	Het
Kndc1	A	G	7: 139,490,130 (GRCm39)	S211G	probably benign	Het
Lama2	T	A	10: 27,066,530 (GRCm39)	E1117V	probably damaging	Het
Lgals4	C	T	7: 28,540,921 (GRCm39)	R282C	probably damaging	Het
Lsg1	T	A	16: 30,399,865 (GRCm39)		probably null	Het
Mab21l4	C	T	1: 93,082,208 (GRCm39)		probably null	Het
Msh3	A	G	13: 92,411,374 (GRCm39)	S608P	possibly damaging	Het
Mslnl	T	A	17: 25,964,062 (GRCm39)	F464I	probably benign	Het
Mycbp2	T	A	14: 103,460,586 (GRCm39)	K1493N	probably damaging	Het
Myo1b	A	T	1: 51,794,896 (GRCm39)	F1065I	probably benign	Het
Nf1	A	G	11: 79,345,136 (GRCm39)		probably benign	Het
Nup153	C	A	13: 46,881,027 (GRCm39)		probably benign	Het
Or4f4-ps1	T	A	2: 111,330,497 (GRCm39)	I300K	probably damaging	Het
Or5b97	A	G	19: 12,878,274 (GRCm39)	V290A	possibly damaging	Het
Osbpl7	A	G	11: 96,943,194 (GRCm39)	T149A	probably benign	Het
Parp1	A	G	1: 180,396,690 (GRCm39)	D31G	probably benign	Het
Pcdha6	T	A	18: 37,101,203 (GRCm39)	V132E	possibly damaging	Het
Pcdhb8	T	A	18: 37,489,975 (GRCm39)	L551Q	possibly damaging	Het
Pcsk9	T	A	4: 106,311,808 (GRCm39)	T190S	probably damaging	Het
Pdgfrb	A	T	18: 61,197,049 (GRCm39)	T162S	probably benign	Het
Pi4ka	C	T	16: 17,136,234 (GRCm39)	R908Q		Het
Pnpla8	A	G	12: 44,330,222 (GRCm39)	E258G	probably benign	Het
Prrc2c	A	T	1: 162,537,127 (GRCm39)	S643T	unknown	Het
Rnf20	T	G	4: 49,655,964 (GRCm39)	I970S	possibly damaging	Het
Robo2	A	T	16: 73,755,247 (GRCm39)	V758D	probably damaging	Het
Robo4	G	A	9: 37,319,577 (GRCm39)	S609N	possibly damaging	Het
Rrbp1	G	A	2: 143,830,920 (GRCm39)	Q416*	probably null	Het
Rsf1	GCG	GCGACGGCGACG	7: 97,229,114 (GRCm39)		probably benign	Het
Ryr2	C	A	13: 11,701,833 (GRCm39)	E2941D	probably damaging	Het
Scd2	G	T	19: 44,289,743 (GRCm39)	C246F	probably benign	Het
Sh3rf1	G	A	8: 61,825,687 (GRCm39)	V561I	probably benign	Het
Slc4a4	T	A	5: 89,280,301 (GRCm39)	D366E	probably damaging	Het
Slfn14	T	G	11: 83,174,715 (GRCm39)	Q92P	probably damaging	Het
Slfn4	A	T	11: 83,077,770 (GRCm39)	Y186F	probably damaging	Het
Smpd4	T	C	16: 17,453,410 (GRCm39)	L309P	possibly damaging	Het
Smyd3	G	T	1: 178,920,482 (GRCm39)	N217K	probably benign	Het
Spen	T	C	4: 141,197,129 (GRCm39)	T3547A	probably benign	Het
Suclg1	A	T	6: 73,253,729 (GRCm39)	I126F	unknown	Het
Tenm4	C	T	7: 96,555,148 (GRCm39)	P2618S	probably benign	Het
Tmprss15	A	T	16: 78,798,702 (GRCm39)	I660N	possibly damaging	Het
Trf	A	T	9: 103,087,723 (GRCm39)	V677D	probably damaging	Het
Trim36	T	C	18: 46,302,452 (GRCm39)	N532S	probably benign	Het
Trim37	T	C	11: 87,037,885 (GRCm39)		probably null	Het
Ttn	T	C	2: 76,570,454 (GRCm39)	N26813S	probably benign	Het
Vmn1r199	T	A	13: 22,567,537 (GRCm39)	V277D	probably damaging	Het
Wdfy3	T	C	5: 102,077,951 (GRCm39)	D873G	probably benign	Het
Wdr27	T	C	17: 15,103,929 (GRCm39)	T726A	probably damaging	Het
Wdr97	T	C	15: 76,240,775 (GRCm39)	Y488H		Het
Wdtc1	A	T	4: 133,031,511 (GRCm39)	C236*	probably null	Het
Wnk4	A	C	11: 101,167,092 (GRCm39)	S1083R	unknown	Het
Wwc1	A	T	11: 35,774,234 (GRCm39)	I342N	probably damaging	Het
Zbtb40	A	G	4: 136,725,957 (GRCm39)	L534P	probably damaging	Het
Zfp62	T	C	11: 49,108,227 (GRCm39)	C773R	probably damaging	Het
Zfp709	T	A	8: 72,643,027 (GRCm39)	I152N	probably benign	Het
Zfp738	T	C	13: 67,819,550 (GRCm39)	Y147C	probably damaging	Het
Zscan18	A	C	7: 12,503,625 (GRCm39)	S645A	probably benign	Het
Zw10	A	G	9: 48,988,861 (GRCm39)	Y709C	probably damaging	Het

Other mutations in Myo15a

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00845:Myo15a	APN	11	60,368,605 (GRCm39)	missense	probably damaging	1.00
IGL01011:Myo15a	APN	11	60,367,818 (GRCm39)	missense	probably benign	0.33
IGL01100:Myo15a	APN	11	60,401,984 (GRCm39)	missense	probably damaging	1.00
IGL01357:Myo15a	APN	11	60,393,115 (GRCm39)	splice site	probably benign
IGL01634:Myo15a	APN	11	60,386,298 (GRCm39)	missense	probably damaging	1.00
IGL01763:Myo15a	APN	11	60,412,564 (GRCm39)	missense	probably benign	0.07
IGL01901:Myo15a	APN	11	60,418,260 (GRCm39)	utr 3 prime	probably benign
IGL01931:Myo15a	APN	11	60,386,964 (GRCm39)	missense	probably damaging	1.00
IGL02006:Myo15a	APN	11	60,401,954 (GRCm39)	missense	probably damaging	1.00
IGL02041:Myo15a	APN	11	60,397,689 (GRCm39)	missense	probably damaging	0.99
IGL02094:Myo15a	APN	11	60,401,473 (GRCm39)	unclassified	probably benign
IGL02122:Myo15a	APN	11	60,374,292 (GRCm39)	missense	probably benign	0.23
IGL02153:Myo15a	APN	11	60,389,223 (GRCm39)	missense	probably damaging	1.00
IGL02328:Myo15a	APN	11	60,417,433 (GRCm39)	missense	probably benign	0.13
IGL02330:Myo15a	APN	11	60,367,987 (GRCm39)	missense	possibly damaging	0.94
IGL02431:Myo15a	APN	11	60,401,465 (GRCm39)	missense	possibly damaging	0.73
IGL02639:Myo15a	APN	11	60,369,447 (GRCm39)	missense	probably benign
IGL02659:Myo15a	APN	11	60,382,609 (GRCm39)	splice site	probably benign
IGL02800:Myo15a	APN	11	60,393,195 (GRCm39)	missense	probably damaging	1.00
IGL02812:Myo15a	APN	11	60,368,005 (GRCm39)	missense	probably benign	0.15
IGL02863:Myo15a	APN	11	60,368,953 (GRCm39)	missense	probably damaging	1.00
IGL02873:Myo15a	APN	11	60,374,308 (GRCm39)	missense	probably damaging	1.00
IGL02990:Myo15a	APN	11	60,370,266 (GRCm39)	missense	probably benign	0.02
IGL03011:Myo15a	APN	11	60,400,357 (GRCm39)	splice site	probably benign
IGL03243:Myo15a	APN	11	60,387,344 (GRCm39)	missense	probably damaging	1.00
IGL03297:Myo15a	APN	11	60,369,967 (GRCm39)	missense	probably damaging	1.00
novichok	UTSW	11	60,372,566 (GRCm39)	critical splice donor site	probably null
parker	UTSW	11	60,411,740 (GRCm39)	critical splice donor site	probably null
Typhoon	UTSW	11	60,378,251 (GRCm39)	critical splice donor site	probably null
PIT4131001:Myo15a	UTSW	11	60,386,280 (GRCm39)	missense	probably damaging	1.00
PIT4131001:Myo15a	UTSW	11	60,373,953 (GRCm39)	missense	probably damaging	1.00
R0133:Myo15a	UTSW	11	60,368,676 (GRCm39)	missense	possibly damaging	0.94
R0265:Myo15a	UTSW	11	60,405,723 (GRCm39)	critical splice acceptor site	probably null
R0389:Myo15a	UTSW	11	60,369,364 (GRCm39)	missense	probably benign
R0416:Myo15a	UTSW	11	60,402,000 (GRCm39)	missense	probably damaging	1.00
R0449:Myo15a	UTSW	11	60,400,422 (GRCm39)	missense	possibly damaging	0.92
R0477:Myo15a	UTSW	11	60,411,740 (GRCm39)	critical splice donor site	probably null
R0543:Myo15a	UTSW	11	60,369,877 (GRCm39)	missense	probably benign
R0546:Myo15a	UTSW	11	60,397,139 (GRCm39)	missense	probably damaging	1.00
R0555:Myo15a	UTSW	11	60,412,464 (GRCm39)	missense	probably damaging	1.00
R0639:Myo15a	UTSW	11	60,370,162 (GRCm39)	missense	probably benign	0.12
R0723:Myo15a	UTSW	11	60,369,803 (GRCm39)	missense	possibly damaging	0.94
R0837:Myo15a	UTSW	11	60,378,077 (GRCm39)	missense	probably damaging	0.98
R0865:Myo15a	UTSW	11	60,382,514 (GRCm39)	missense	probably damaging	1.00
R0899:Myo15a	UTSW	11	60,368,011 (GRCm39)	missense	possibly damaging	0.87
R1022:Myo15a	UTSW	11	60,370,442 (GRCm39)	missense	probably benign	0.00
R1024:Myo15a	UTSW	11	60,370,442 (GRCm39)	missense	probably benign	0.00
R1035:Myo15a	UTSW	11	60,401,384 (GRCm39)	unclassified	probably benign
R1109:Myo15a	UTSW	11	60,383,892 (GRCm39)	missense	probably damaging	1.00
R1170:Myo15a	UTSW	11	60,370,233 (GRCm39)	missense	probably benign	0.04
R1241:Myo15a	UTSW	11	60,390,256 (GRCm39)	missense	possibly damaging	0.58
R1392:Myo15a	UTSW	11	60,368,800 (GRCm39)	missense	possibly damaging	0.95
R1392:Myo15a	UTSW	11	60,368,800 (GRCm39)	missense	possibly damaging	0.95
R1434:Myo15a	UTSW	11	60,395,157 (GRCm39)	missense	probably benign	0.00
R1450:Myo15a	UTSW	11	60,386,308 (GRCm39)	missense	probably damaging	1.00
R1456:Myo15a	UTSW	11	60,399,028 (GRCm39)	missense	probably damaging	1.00
R1468:Myo15a	UTSW	11	60,396,832 (GRCm39)	missense	probably damaging	1.00
R1468:Myo15a	UTSW	11	60,396,832 (GRCm39)	missense	probably damaging	1.00
R1548:Myo15a	UTSW	11	60,379,064 (GRCm39)	missense	probably damaging	1.00
R1551:Myo15a	UTSW	11	60,383,791 (GRCm39)	missense	possibly damaging	0.70
R1571:Myo15a	UTSW	11	60,409,290 (GRCm39)	missense	probably damaging	1.00
R1662:Myo15a	UTSW	11	60,392,527 (GRCm39)	missense	probably damaging	1.00
R1777:Myo15a	UTSW	11	60,405,762 (GRCm39)	missense	probably benign
R1778:Myo15a	UTSW	11	60,369,238 (GRCm39)	missense	possibly damaging	0.57
R1847:Myo15a	UTSW	11	60,390,321 (GRCm39)	nonsense	probably null
R1875:Myo15a	UTSW	11	60,398,354 (GRCm39)	missense	probably damaging	0.99
R1944:Myo15a	UTSW	11	60,392,909 (GRCm39)	missense	probably damaging	0.99
R1945:Myo15a	UTSW	11	60,392,909 (GRCm39)	missense	probably damaging	0.99
R2013:Myo15a	UTSW	11	60,385,057 (GRCm39)	missense	probably damaging	1.00
R2107:Myo15a	UTSW	11	60,382,636 (GRCm39)	missense	probably damaging	1.00
R2108:Myo15a	UTSW	11	60,382,636 (GRCm39)	missense	probably damaging	1.00
R2112:Myo15a	UTSW	11	60,384,994 (GRCm39)	missense	probably damaging	0.99
R2147:Myo15a	UTSW	11	60,401,055 (GRCm39)	missense	possibly damaging	0.66
R2196:Myo15a	UTSW	11	60,400,847 (GRCm39)	nonsense	probably null
R2207:Myo15a	UTSW	11	60,396,860 (GRCm39)	missense	probably benign	0.01
R2245:Myo15a	UTSW	11	60,399,925 (GRCm39)	missense	probably damaging	1.00
R2367:Myo15a	UTSW	11	60,408,064 (GRCm39)	missense	probably damaging	0.99
R2374:Myo15a	UTSW	11	60,369,669 (GRCm39)	missense	possibly damaging	0.88
R2438:Myo15a	UTSW	11	60,373,878 (GRCm39)	missense	probably damaging	1.00
R3154:Myo15a	UTSW	11	60,370,186 (GRCm39)	splice site	probably null
R3423:Myo15a	UTSW	11	60,401,126 (GRCm39)	critical splice donor site	probably null
R3551:Myo15a	UTSW	11	60,400,489 (GRCm39)	missense	possibly damaging	0.93
R3552:Myo15a	UTSW	11	60,400,489 (GRCm39)	missense	possibly damaging	0.93
R3612:Myo15a	UTSW	11	60,368,505 (GRCm39)	missense	probably damaging	1.00
R3620:Myo15a	UTSW	11	60,369,468 (GRCm39)	missense	possibly damaging	0.63
R3713:Myo15a	UTSW	11	60,370,057 (GRCm39)	missense	possibly damaging	0.55
R3714:Myo15a	UTSW	11	60,370,057 (GRCm39)	missense	possibly damaging	0.55
R3715:Myo15a	UTSW	11	60,370,057 (GRCm39)	missense	possibly damaging	0.55
R3783:Myo15a	UTSW	11	60,368,398 (GRCm39)	missense	probably damaging	0.97
R3784:Myo15a	UTSW	11	60,368,398 (GRCm39)	missense	probably damaging	0.97
R3785:Myo15a	UTSW	11	60,368,398 (GRCm39)	missense	probably damaging	0.97
R3786:Myo15a	UTSW	11	60,368,398 (GRCm39)	missense	probably damaging	0.97
R3787:Myo15a	UTSW	11	60,368,398 (GRCm39)	missense	probably damaging	0.97
R3894:Myo15a	UTSW	11	60,395,145 (GRCm39)	missense	probably benign	0.00
R3962:Myo15a	UTSW	11	60,370,654 (GRCm39)	missense	probably benign	0.00
R4082:Myo15a	UTSW	11	60,378,022 (GRCm39)	missense	possibly damaging	0.92
R4555:Myo15a	UTSW	11	60,387,763 (GRCm39)	missense	probably damaging	1.00
R4641:Myo15a	UTSW	11	60,393,867 (GRCm39)	missense	probably damaging	1.00
R4665:Myo15a	UTSW	11	60,395,705 (GRCm39)	critical splice acceptor site	probably null
R4713:Myo15a	UTSW	11	60,370,756 (GRCm39)	missense	probably benign	0.21
R4820:Myo15a	UTSW	11	60,367,741 (GRCm39)	missense	probably damaging	0.98
R5013:Myo15a	UTSW	11	60,382,493 (GRCm39)	missense	probably damaging	1.00
R5051:Myo15a	UTSW	11	60,378,251 (GRCm39)	critical splice donor site	probably null
R5187:Myo15a	UTSW	11	60,394,440 (GRCm39)	missense	probably damaging	1.00
R5230:Myo15a	UTSW	11	60,393,674 (GRCm39)	missense	possibly damaging	0.68
R5277:Myo15a	UTSW	11	60,367,940 (GRCm39)	nonsense	probably null
R5345:Myo15a	UTSW	11	60,388,364 (GRCm39)	missense	probably damaging	0.99
R5349:Myo15a	UTSW	11	60,384,409 (GRCm39)	missense	probably damaging	1.00
R5356:Myo15a	UTSW	11	60,389,192 (GRCm39)	missense	probably damaging	1.00
R5445:Myo15a	UTSW	11	60,411,603 (GRCm39)	nonsense	probably null
R5477:Myo15a	UTSW	11	60,368,503 (GRCm39)	missense	probably damaging	1.00
R5629:Myo15a	UTSW	11	60,370,578 (GRCm39)	missense	probably benign
R5728:Myo15a	UTSW	11	60,379,722 (GRCm39)	missense	probably damaging	1.00
R5818:Myo15a	UTSW	11	60,388,777 (GRCm39)	missense	probably benign	0.06
R5952:Myo15a	UTSW	11	60,370,246 (GRCm39)	missense	possibly damaging	0.50
R6338:Myo15a	UTSW	11	60,368,959 (GRCm39)	missense	probably damaging	0.99
R6467:Myo15a	UTSW	11	60,417,487 (GRCm39)	critical splice donor site	probably null
R6488:Myo15a	UTSW	11	60,369,313 (GRCm39)	missense	possibly damaging	0.86
R6521:Myo15a	UTSW	11	60,393,195 (GRCm39)	missense	probably damaging	1.00
R6645:Myo15a	UTSW	11	60,368,118 (GRCm39)	missense	probably benign	0.00
R6702:Myo15a	UTSW	11	60,383,818 (GRCm39)	missense	probably benign	0.16
R6703:Myo15a	UTSW	11	60,383,818 (GRCm39)	missense	probably benign	0.16
R6821:Myo15a	UTSW	11	60,415,301 (GRCm39)	missense	probably damaging	1.00
R6882:Myo15a	UTSW	11	60,414,832 (GRCm39)	missense	probably damaging	1.00
R6908:Myo15a	UTSW	11	60,396,832 (GRCm39)	missense	probably damaging	1.00
R6932:Myo15a	UTSW	11	60,390,320 (GRCm39)	missense	probably damaging	1.00
R6958:Myo15a	UTSW	11	60,394,451 (GRCm39)	missense	probably benign	0.07
R7041:Myo15a	UTSW	11	60,396,832 (GRCm39)	missense	probably damaging	1.00
R7149:Myo15a	UTSW	11	60,400,836 (GRCm39)	missense	possibly damaging	0.56
R7163:Myo15a	UTSW	11	60,389,195 (GRCm39)	missense
R7229:Myo15a	UTSW	11	60,387,321 (GRCm39)	missense	probably benign	0.08
R7347:Myo15a	UTSW	11	60,368,787 (GRCm39)	missense	probably benign
R7368:Myo15a	UTSW	11	60,381,741 (GRCm39)	splice site	probably null
R7392:Myo15a	UTSW	11	60,396,802 (GRCm39)	missense
R7414:Myo15a	UTSW	11	60,374,309 (GRCm39)	missense
R7461:Myo15a	UTSW	11	60,395,978 (GRCm39)	missense
R7609:Myo15a	UTSW	11	60,379,637 (GRCm39)	missense
R7613:Myo15a	UTSW	11	60,395,978 (GRCm39)	missense
R7734:Myo15a	UTSW	11	60,401,108 (GRCm39)	missense	probably benign
R7748:Myo15a	UTSW	11	60,395,727 (GRCm39)	missense
R7767:Myo15a	UTSW	11	60,392,922 (GRCm39)	missense
R7769:Myo15a	UTSW	11	60,399,975 (GRCm39)	missense
R7894:Myo15a	UTSW	11	60,381,963 (GRCm39)	missense
R7919:Myo15a	UTSW	11	60,417,356 (GRCm39)	missense	probably damaging	1.00
R8100:Myo15a	UTSW	11	60,408,016 (GRCm39)	missense	probably damaging	1.00
R8124:Myo15a	UTSW	11	60,398,279 (GRCm39)	missense
R8129:Myo15a	UTSW	11	60,399,026 (GRCm39)	missense
R8428:Myo15a	UTSW	11	60,387,241 (GRCm39)	missense	probably damaging	1.00
R8706:Myo15a	UTSW	11	60,370,443 (GRCm39)	missense	probably benign
R8739:Myo15a	UTSW	11	60,368,088 (GRCm39)	missense	probably benign	0.06
R8790:Myo15a	UTSW	11	60,378,047 (GRCm39)	missense
R8790:Myo15a	UTSW	11	60,367,362 (GRCm39)	missense	possibly damaging	0.73
R8822:Myo15a	UTSW	11	60,367,740 (GRCm39)	missense	probably damaging	0.99
R8907:Myo15a	UTSW	11	60,417,434 (GRCm39)	missense
R8931:Myo15a	UTSW	11	60,368,020 (GRCm39)	missense	probably benign
R9061:Myo15a	UTSW	11	60,393,692 (GRCm39)	missense
R9124:Myo15a	UTSW	11	60,369,952 (GRCm39)	missense	probably benign	0.37
R9297:Myo15a	UTSW	11	60,385,899 (GRCm39)	missense	probably null
R9347:Myo15a	UTSW	11	60,374,555 (GRCm39)	missense
R9417:Myo15a	UTSW	11	60,378,243 (GRCm39)	missense
R9456:Myo15a	UTSW	11	60,392,668 (GRCm39)	missense
R9460:Myo15a	UTSW	11	60,372,566 (GRCm39)	critical splice donor site	probably null
R9615:Myo15a	UTSW	11	60,374,320 (GRCm39)	missense
R9630:Myo15a	UTSW	11	60,407,988 (GRCm39)	missense	probably damaging	1.00
R9746:Myo15a	UTSW	11	60,378,234 (GRCm39)	nonsense	probably null
X0021:Myo15a	UTSW	11	60,373,185 (GRCm39)	nonsense	probably null
X0066:Myo15a	UTSW	11	60,369,046 (GRCm39)	missense	probably damaging	1.00
X0067:Myo15a	UTSW	11	60,369,444 (GRCm39)	missense	possibly damaging	0.88
Z1176:Myo15a	UTSW	11	60,389,229 (GRCm39)	missense
Z1176:Myo15a	UTSW	11	60,379,084 (GRCm39)	missense
Z1176:Myo15a	UTSW	11	60,415,267 (GRCm39)	missense	probably damaging	1.00
Z1177:Myo15a	UTSW	11	60,386,301 (GRCm39)	missense
Z1177:Myo15a	UTSW	11	60,379,663 (GRCm39)	missense
Z1177:Myo15a	UTSW	11	60,368,349 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- TCAACAAGATGGCGGTTGAC -3'
(R):5'- GTAAGAGGTTTCCCAGTGCAC -3'

Sequencing Primer
(F):5'- AACAAGATGGCGGTTGACATGTTTG -3'
(R):5'- GAGGTTTCCCAGTGCACCATAAC -3'

Posted On

2021-03-08