Incidental Mutation 'R8742:Mslnl'
| ID |
663311 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Mslnl
|
| Ensembl Gene |
ENSMUSG00000041062 |
| Gene Name |
mesothelin-like |
| Synonyms |
|
| MMRRC Submission |
068587-MU
|
| Accession Numbers |
|
| Essential gene? |
Non essential
(E-score: 0.000)
|
| Stock # |
R8742 (G1)
|
| Quality Score |
164.009 |
|
Status
|
Validated
|
| Chromosome |
17 |
| Chromosomal Location |
25955016-25967304 bp(+) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
A to T
at 25964047 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Phenylalanine
at position 459
(I459F)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000049020
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000047098]
[ENSMUST00000075884]
|
| AlphaFold |
Q8C160 |
| Predicted Effect |
probably damaging
Transcript: ENSMUST00000047098
AA Change: I459F
PolyPhen 2
Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
|
| SMART Domains |
Protein: ENSMUSP00000049020
Gene: ENSMUSG00000041062
AA Change: I459F
| Domain | Start | End | E-Value | Type |
|---|
|
signal peptide
|
1 |
23 |
N/A |
INTRINSIC |
|
Pfam:Mesothelin
|
29 |
589 |
2.8e-70 |
PFAM |
|
low complexity region
|
633 |
653 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000075884
|
| SMART Domains |
Protein: ENSMUSP00000075279
Gene: ENSMUSG00000063011
| Domain | Start | End | E-Value | Type |
|---|
|
Pfam:Mesothelin
|
1 |
624 |
N/A |
PFAM |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.3%
- 20x: 97.0%
|
| Validation Efficiency |
100% (55/55) |
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 58 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Adgrb3 |
T |
C |
1: 25,265,835 (GRCm39) |
I893V |
probably benign |
Het |
| Adhfe1 |
A |
G |
1: 9,630,401 (GRCm39) |
I317V |
probably benign |
Het |
| Adnp2 |
A |
G |
18: 80,171,556 (GRCm39) |
V951A |
probably damaging |
Het |
| Ankrd35 |
T |
A |
3: 96,586,502 (GRCm39) |
H59Q |
probably damaging |
Het |
| Atg16l1 |
C |
T |
1: 87,694,620 (GRCm39) |
T161I |
probably damaging |
Het |
| Axl |
A |
G |
7: 25,463,861 (GRCm39) |
V591A |
probably damaging |
Het |
| Cdc40 |
C |
T |
10: 40,717,480 (GRCm39) |
D404N |
probably damaging |
Het |
| Cdcp3 |
A |
G |
7: 130,783,741 (GRCm39) |
I45V |
unknown |
Het |
| Ceacam13 |
T |
A |
7: 17,743,934 (GRCm39) |
S14T |
probably damaging |
Het |
| Cfh |
A |
T |
1: 140,029,390 (GRCm39) |
F986L |
probably damaging |
Het |
| Cfh |
G |
T |
1: 140,064,469 (GRCm39) |
T393K |
probably damaging |
Het |
| Clic1 |
A |
G |
17: 35,274,356 (GRCm39) |
N179S |
probably benign |
Het |
| Col6a3 |
C |
G |
1: 90,695,328 (GRCm39) |
|
probably benign |
Het |
| Dlat |
G |
T |
9: 50,560,967 (GRCm39) |
A360E |
probably damaging |
Het |
| Dst |
T |
A |
1: 34,251,425 (GRCm39) |
D2159E |
probably benign |
Het |
| Epn3 |
T |
G |
11: 94,386,921 (GRCm39) |
T150P |
probably damaging |
Het |
| Fgr |
T |
C |
4: 132,724,828 (GRCm39) |
Y310H |
probably damaging |
Het |
| Filip1l |
A |
G |
16: 57,391,593 (GRCm39) |
Y727C |
probably damaging |
Het |
| Fis1 |
G |
T |
5: 136,982,365 (GRCm39) |
|
probably benign |
Het |
| G530012D18Rik |
C |
G |
1: 85,504,935 (GRCm39) |
D113E |
unknown |
Het |
| Gdf10 |
A |
T |
14: 33,654,426 (GRCm39) |
H311L |
probably benign |
Het |
| Gphn |
C |
T |
12: 78,659,766 (GRCm39) |
R423C |
probably damaging |
Het |
| Gpr132 |
T |
C |
12: 112,819,517 (GRCm39) |
|
probably benign |
Het |
| Herc2 |
C |
A |
7: 55,744,143 (GRCm39) |
T406K |
probably benign |
Het |
| Hpf1 |
T |
C |
8: 61,346,748 (GRCm39) |
V21A |
probably benign |
Het |
| Ifitm6 |
A |
G |
7: 140,596,008 (GRCm39) |
I75T |
probably benign |
Het |
| Itgax |
A |
T |
7: 127,743,795 (GRCm39) |
H852L |
probably benign |
Het |
| Klhl3 |
T |
C |
13: 58,159,021 (GRCm39) |
Y546C |
probably damaging |
Het |
| Lbr |
A |
G |
1: 181,644,571 (GRCm39) |
L578P |
possibly damaging |
Het |
| Ltbp1 |
A |
G |
17: 75,617,217 (GRCm39) |
Y734C |
probably damaging |
Het |
| Mapre2 |
C |
A |
18: 24,016,688 (GRCm39) |
H281N |
probably benign |
Het |
| Mcm4 |
T |
C |
16: 15,443,430 (GRCm39) |
D831G |
possibly damaging |
Het |
| Mlf1 |
G |
A |
3: 67,305,119 (GRCm39) |
A207T |
probably damaging |
Het |
| Mtnr1a |
A |
G |
8: 45,540,720 (GRCm39) |
D227G |
probably benign |
Het |
| Ncapg |
T |
A |
5: 45,851,216 (GRCm39) |
L803Q |
probably damaging |
Het |
| Nr3c2 |
T |
G |
8: 77,635,210 (GRCm39) |
S104A |
probably damaging |
Het |
| Or4k52 |
A |
G |
2: 111,610,910 (GRCm39) |
I82V |
probably benign |
Het |
| Pard3 |
C |
T |
8: 128,050,592 (GRCm39) |
A218V |
possibly damaging |
Het |
| Poteg |
A |
T |
8: 27,984,957 (GRCm39) |
N439Y |
possibly damaging |
Het |
| Pramel34 |
T |
A |
5: 93,785,935 (GRCm39) |
D115V |
probably damaging |
Het |
| Ret |
A |
T |
6: 118,155,484 (GRCm39) |
L404Q |
probably damaging |
Het |
| Ripk4 |
A |
T |
16: 97,556,272 (GRCm39) |
V157D |
probably damaging |
Het |
| Rsf1 |
CGGCGGCGGCGGCGGCGGCGGC |
CGGCGGCGGCGGCGGCGGCGGCGGCGGCGGC |
7: 97,229,121 (GRCm39) |
|
probably benign |
Het |
| Serinc1 |
A |
T |
10: 57,395,895 (GRCm39) |
N298K |
probably benign |
Het |
| Sh3pxd2a |
G |
A |
19: 47,275,073 (GRCm39) |
S230L |
probably benign |
Het |
| Shb |
G |
C |
4: 45,458,319 (GRCm39) |
R282G |
probably benign |
Het |
| Skint11 |
T |
C |
4: 114,051,922 (GRCm39) |
I90T |
probably damaging |
Het |
| Slc36a4 |
A |
G |
9: 15,632,039 (GRCm39) |
T72A |
probably damaging |
Het |
| Slc38a9 |
T |
A |
13: 112,865,818 (GRCm39) |
I505K |
probably damaging |
Het |
| Sprr3 |
C |
T |
3: 92,364,307 (GRCm39) |
R179H |
possibly damaging |
Het |
| Syne1 |
A |
T |
10: 5,058,661 (GRCm39) |
I7284N |
probably benign |
Het |
| Timeless |
A |
T |
10: 128,083,107 (GRCm39) |
T648S |
probably benign |
Het |
| Trim44 |
A |
G |
2: 102,230,521 (GRCm39) |
M170T |
possibly damaging |
Het |
| Trpm7 |
A |
G |
2: 126,667,469 (GRCm39) |
F815L |
probably damaging |
Het |
| Uimc1 |
A |
G |
13: 55,240,971 (GRCm39) |
L39S |
possibly damaging |
Het |
| Vmn2r13 |
T |
C |
5: 109,304,263 (GRCm39) |
T723A |
probably benign |
Het |
| Vps11 |
A |
G |
9: 44,267,070 (GRCm39) |
|
probably benign |
Het |
| Zp3r |
A |
T |
1: 130,511,230 (GRCm39) |
C383S |
probably damaging |
Het |
|
| Other mutations in Mslnl |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01621:Mslnl
|
APN |
17 |
25,962,641 (GRCm39) |
unclassified |
probably benign |
|
|
IGL01629:Mslnl
|
APN |
17 |
25,963,749 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
IGL02084:Mslnl
|
APN |
17 |
25,965,125 (GRCm39) |
missense |
probably benign |
0.07 |
|
IGL02408:Mslnl
|
APN |
17 |
25,966,972 (GRCm39) |
missense |
possibly damaging |
0.80 |
|
IGL02726:Mslnl
|
APN |
17 |
25,963,077 (GRCm39) |
critical splice donor site |
probably null |
|
|
IGL03387:Mslnl
|
APN |
17 |
25,963,051 (GRCm39) |
missense |
probably benign |
0.06 |
|
R0561:Mslnl
|
UTSW |
17 |
25,962,177 (GRCm39) |
nonsense |
probably null |
|
|
R0881:Mslnl
|
UTSW |
17 |
25,961,939 (GRCm39) |
missense |
possibly damaging |
0.82 |
|
R1295:Mslnl
|
UTSW |
17 |
25,962,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1296:Mslnl
|
UTSW |
17 |
25,962,214 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1582:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1629:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1630:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1631:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1632:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1794:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1850:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1866:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1876:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1914:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2166:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2241:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2243:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2247:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2282:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2284:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2852:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2867:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2867:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2877:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2878:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2919:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R2920:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3026:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3405:Mslnl
|
UTSW |
17 |
25,965,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3406:Mslnl
|
UTSW |
17 |
25,965,155 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R3411:Mslnl
|
UTSW |
17 |
25,963,491 (GRCm39) |
missense |
probably benign |
0.05 |
|
R3434:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3546:Mslnl
|
UTSW |
17 |
25,963,943 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R3612:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3729:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3730:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3802:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3804:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3894:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R3895:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4454:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4455:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4456:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4457:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4561:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4562:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4564:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4600:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4601:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4610:Mslnl
|
UTSW |
17 |
25,961,908 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R4704:Mslnl
|
UTSW |
17 |
25,957,952 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5155:Mslnl
|
UTSW |
17 |
25,957,942 (GRCm39) |
nonsense |
probably null |
|
|
R5257:Mslnl
|
UTSW |
17 |
25,965,139 (GRCm39) |
missense |
probably benign |
0.00 |
|
R5456:Mslnl
|
UTSW |
17 |
25,962,133 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5645:Mslnl
|
UTSW |
17 |
25,956,816 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R6007:Mslnl
|
UTSW |
17 |
25,965,749 (GRCm39) |
missense |
probably benign |
0.00 |
|
R6083:Mslnl
|
UTSW |
17 |
25,956,876 (GRCm39) |
missense |
possibly damaging |
0.83 |
|
R6142:Mslnl
|
UTSW |
17 |
25,963,531 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R6761:Mslnl
|
UTSW |
17 |
25,965,047 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R7058:Mslnl
|
UTSW |
17 |
25,962,186 (GRCm39) |
missense |
probably benign |
0.03 |
|
R7156:Mslnl
|
UTSW |
17 |
25,962,184 (GRCm39) |
missense |
probably benign |
0.20 |
|
R7467:Mslnl
|
UTSW |
17 |
25,955,895 (GRCm39) |
start codon destroyed |
probably benign |
0.33 |
|
R7687:Mslnl
|
UTSW |
17 |
25,962,157 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R7807:Mslnl
|
UTSW |
17 |
25,965,751 (GRCm39) |
missense |
probably benign |
0.03 |
|
R8682:Mslnl
|
UTSW |
17 |
25,965,962 (GRCm39) |
missense |
probably benign |
|
|
R8735:Mslnl
|
UTSW |
17 |
25,964,062 (GRCm39) |
missense |
probably benign |
0.09 |
|
R9208:Mslnl
|
UTSW |
17 |
25,961,694 (GRCm39) |
missense |
possibly damaging |
0.94 |
|
R9264:Mslnl
|
UTSW |
17 |
25,961,506 (GRCm39) |
intron |
probably benign |
|
|
RF007:Mslnl
|
UTSW |
17 |
25,962,202 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
| Predicted Primers |
PCR Primer
(F):5'- GGTGATAGGGCTGGCAAC -3'
(R):5'- TCACTCAGTTTGTAATGCTTCTTTCA -3'
Sequencing Primer
(F):5'- TTGGACCACAATGGCAAG -3'
(R):5'- TGTTGCAAGCACTCTACAGG -3'
|
| Posted On |
2021-03-08 |
Incidental Mutation