Mutagenetix > Incidental Mutation

Incidental Mutation 'IGL00597:Ifna7'

6634

Institutional Source

Australian Phenomics Network (link to record)

Gene Symbol

Ifna7

Ensembl Gene

ENSMUSG00000100713

Gene Name

interferon alpha 7

Synonyms

Ifa7

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.100) question?

Stock #

IGL00597

Quality Score

Status

Chromosome

Chromosomal Location

88734465-88735037 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

A to T at 88734675 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Phenylalanine at position 71 (I71F)

Ref Sequence

ENSEMBL: ENSMUSP00000100774 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000105143] [ENSMUST00000170428]

AlphaFold

no structure available at present

Predicted Effect

probably benign
Transcript: ENSMUST00000105143
AA Change: I71F

PolyPhen 2 Score 0.003 (Sensitivity: 0.98; Specificity: 0.44)

SMART Domains

Protein: ENSMUSP00000100774
Gene: ENSMUSG00000100713
AA Change: I71F

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
IFabd	58	175	2.32e-70	SMART

Predicted Effect

probably benign
Transcript: ENSMUST00000170428

SMART Domains

Protein: ENSMUSP00000127921
Gene: ENSMUSG00000100549

Domain	Start	End	E-Value	Type
signal peptide	1	23	N/A	INTRINSIC
IFabd	58	175	5.54e-68	SMART

Coding Region Coverage

Validation Efficiency

Allele List at MGI

Other mutations in this stock

Total: 17 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Bdkrb1	A	T	12: 105,571,210 (GRCm39)	I259F	probably damaging	Het
Chac1	A	G	2: 119,184,040 (GRCm39)	Y214C	probably benign	Het
Ctnnd2	A	C	15: 30,647,287 (GRCm39)	T328P	possibly damaging	Het
Gart	A	G	16: 91,435,677 (GRCm39)	S179P	possibly damaging	Het
Gbp9	A	G	5: 105,242,364 (GRCm39)	V125A	probably damaging	Het
Gpc6	T	A	14: 118,188,646 (GRCm39)	S427T	probably benign	Het
Kcnip1	A	T	11: 33,593,289 (GRCm39)		probably benign	Het
Kcnip1	A	T	11: 33,593,294 (GRCm39)		probably null	Het
Krt86	A	G	15: 101,374,107 (GRCm39)	K222R	probably benign	Het
Nacad	G	A	11: 6,550,921 (GRCm39)	P757S	probably benign	Het
Obox7	C	A	7: 14,397,957 (GRCm39)		probably benign	Het
Pam	T	A	1: 97,762,169 (GRCm39)	T805S	probably benign	Het
Pgam2	G	A	11: 5,753,442 (GRCm39)	R83C	probably damaging	Het
Prtg	T	A	9: 72,716,926 (GRCm39)	I89N	probably damaging	Het
Rpusd4	T	A	9: 35,179,738 (GRCm39)	V77E	probably benign	Het
Sirpb1a	T	C	3: 15,481,977 (GRCm39)	Y50C	probably damaging	Het
Whamm	T	C	7: 81,228,014 (GRCm39)	V87A	probably damaging	Het

Other mutations in Ifna7

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R1326:Ifna7	UTSW	4	88,734,931 (GRCm39)	missense	possibly damaging	0.87
R1352:Ifna7	UTSW	4	88,734,897 (GRCm39)	missense	possibly damaging	0.76
R1420:Ifna7	UTSW	4	88,734,906 (GRCm39)	missense	probably damaging	0.98
R1655:Ifna7	UTSW	4	88,734,897 (GRCm39)	missense	probably benign	0.06
R3767:Ifna7	UTSW	4	88,734,964 (GRCm39)	missense	probably damaging	1.00
R3768:Ifna7	UTSW	4	88,734,964 (GRCm39)	missense	probably damaging	1.00
R3769:Ifna7	UTSW	4	88,734,964 (GRCm39)	missense	probably damaging	1.00
R3770:Ifna7	UTSW	4	88,734,964 (GRCm39)	missense	probably damaging	1.00
R7478:Ifna7	UTSW	4	88,734,913 (GRCm39)	missense	probably damaging	1.00
R7549:Ifna7	UTSW	4	88,734,664 (GRCm39)	missense	possibly damaging	0.47
R9636:Ifna7	UTSW	4	88,734,733 (GRCm39)	missense	possibly damaging	0.90

Posted On

2012-04-20