Incidental Mutation 'R8746:Or6f1'
ID 663553
Institutional Source Beutler Lab
Gene Symbol Or6f1
Ensembl Gene ENSMUSG00000054498
Gene Name olfactory receptor family 6 subfamily F member 1
Synonyms Olfr308, GA_x6K02T2NHDJ-9786435-9787361, MOR104-1
MMRRC Submission 068590-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.120) question?
Stock # R8746 (G1)
Quality Score 225.009
Status Validated
Chromosome 7
Chromosomal Location 85970232-85971158 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 85970437 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Cysteine to Tyrosine at position 241 (C241Y)
Ref Sequence ENSEMBL: ENSMUSP00000150391 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000044256] [ENSMUST00000214977]
AlphaFold Q8VFP2
Predicted Effect probably damaging
Transcript: ENSMUST00000044256
AA Change: C241Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000049454
Gene: ENSMUSG00000054498
AA Change: C241Y

DomainStartEndE-ValueType
Pfam:7tm_4 31 308 2.3e-53 PFAM
Pfam:7tm_1 41 290 2.2e-21 PFAM
Predicted Effect probably damaging
Transcript: ENSMUST00000214977
AA Change: C241Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
Meta Mutation Damage Score 0.8260 question?
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 100.0%
  • 10x: 99.8%
  • 20x: 99.5%
Validation Efficiency 100% (52/52)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 54 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
2210408I21Rik T A 13: 77,451,529 (GRCm39) M871K probably benign Het
5530400C23Rik A C 6: 133,271,256 (GRCm39) E100A possibly damaging Het
Aatf A T 11: 84,402,338 (GRCm39) I116N probably benign Het
Abcb11 G T 2: 69,087,754 (GRCm39) probably benign Het
Adarb2 G T 13: 8,802,680 (GRCm39) A652S probably benign Het
Adgb C T 10: 10,281,028 (GRCm39) probably null Het
Ankrd34a C T 3: 96,504,791 (GRCm39) probably benign Het
Ano2 A G 6: 125,840,513 (GRCm39) I395V probably benign Het
Cadm2 C A 16: 66,581,696 (GRCm39) R203L probably damaging Het
Ccr2 T C 9: 123,906,448 (GRCm39) F243L probably benign Het
Ccr4 A G 9: 114,321,918 (GRCm39) V49A probably damaging Het
Cemip2 G A 19: 21,803,465 (GRCm39) G833R probably damaging Het
Corin T C 5: 72,592,695 (GRCm39) D234G probably benign Het
Drd5 G T 5: 38,477,433 (GRCm39) R142I probably benign Het
Dsg1b A G 18: 20,529,056 (GRCm39) D264G probably damaging Het
Ezh2 T C 6: 47,553,534 (GRCm39) K61R probably damaging Het
Frmd4b T A 6: 97,269,370 (GRCm39) T981S probably benign Het
Gcg T A 2: 62,305,325 (GRCm39) K180N probably damaging Het
Gm10840 G A 11: 106,051,742 (GRCm39) E23K unknown Het
Gm2696 T G 10: 77,651,037 (GRCm39) C174W unknown Het
Grin2b T C 6: 135,899,985 (GRCm39) I299V probably benign Het
Hepacam T A 9: 37,293,030 (GRCm39) V207E probably damaging Het
Igf1r T A 7: 67,864,745 (GRCm39) M1181K probably damaging Het
Lmo2 T C 2: 103,806,384 (GRCm39) S96P possibly damaging Het
Marf1 T A 16: 13,935,168 (GRCm39) E1533D probably benign Het
Megf9 A G 4: 70,353,511 (GRCm39) C432R probably damaging Het
Mpp2 A G 11: 101,954,040 (GRCm39) Y236H probably damaging Het
Neb T C 2: 52,172,613 (GRCm39) I1565V probably damaging Het
Or2y1f A G 11: 49,183,993 (GRCm39) probably benign Het
Or56b2j A T 7: 104,353,067 (GRCm39) I98F probably damaging Het
Or5ac21 T A 16: 59,123,973 (GRCm39) F152L probably benign Het
Or5b3 A G 19: 13,388,092 (GRCm39) D53G probably benign Het
Or5g24-ps1 T A 2: 85,464,221 (GRCm39) Y149* probably null Het
Or9k2b T C 10: 130,016,086 (GRCm39) Y221C probably damaging Het
Patj T A 4: 98,394,067 (GRCm39) probably benign Het
Pknox1 A T 17: 31,809,624 (GRCm39) Q76L possibly damaging Het
Plekhg1 C A 10: 3,907,777 (GRCm39) T953K Het
Plekhn1 C A 4: 156,316,682 (GRCm39) R333L probably damaging Het
Plk5 T A 10: 80,194,610 (GRCm39) V111D probably benign Het
Polr1b A G 2: 128,954,597 (GRCm39) I398M possibly damaging Het
Ranbp3 T C 17: 57,009,826 (GRCm39) V137A probably benign Het
Rc3h1 T A 1: 160,757,744 (GRCm39) F21I probably damaging Het
Rgs8 T C 1: 153,547,537 (GRCm39) S56P probably damaging Het
Rhpn1 G A 15: 75,585,425 (GRCm39) V593M probably damaging Het
Sdad1 A G 5: 92,437,784 (GRCm39) S589P probably benign Het
Skp1 A G 11: 52,136,843 (GRCm39) K163R probably damaging Het
Slf2 A G 19: 44,962,063 (GRCm39) Y1080C probably damaging Het
Tcf4 C T 18: 69,654,572 (GRCm39) probably benign Het
Tmem144 C T 3: 79,732,655 (GRCm39) V208M probably damaging Het
Tomm34 A T 2: 163,902,884 (GRCm39) L142Q probably benign Het
Unc13b T A 4: 43,176,120 (GRCm39) V2316D unknown Het
Yme1l1 T A 2: 23,052,543 (GRCm39) S66T probably benign Het
Zfc3h1 T C 10: 115,243,885 (GRCm39) S739P probably damaging Het
Zscan25 T A 5: 145,224,157 (GRCm39) V209E possibly damaging Het
Other mutations in Or6f1
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01113:Or6f1 APN 7 85,970,361 (GRCm39) missense probably benign
IGL03141:Or6f1 APN 7 85,970,909 (GRCm39) missense probably damaging 0.97
PIT4519001:Or6f1 UTSW 7 85,970,941 (GRCm39) missense probably damaging 1.00
R0206:Or6f1 UTSW 7 85,970,854 (GRCm39) missense probably benign 0.22
R0206:Or6f1 UTSW 7 85,970,854 (GRCm39) missense probably benign 0.22
R0401:Or6f1 UTSW 7 85,970,500 (GRCm39) missense probably benign 0.02
R2132:Or6f1 UTSW 7 85,970,687 (GRCm39) missense possibly damaging 0.94
R3983:Or6f1 UTSW 7 85,970,942 (GRCm39) missense probably damaging 1.00
R4596:Or6f1 UTSW 7 85,970,631 (GRCm39) missense probably damaging 1.00
R5532:Or6f1 UTSW 7 85,970,879 (GRCm39) missense possibly damaging 0.90
R7326:Or6f1 UTSW 7 85,970,782 (GRCm39) missense probably damaging 0.99
R7480:Or6f1 UTSW 7 85,970,888 (GRCm39) missense probably benign 0.18
R8811:Or6f1 UTSW 7 85,970,989 (GRCm39) missense probably damaging 0.98
R8971:Or6f1 UTSW 7 85,970,369 (GRCm39) missense possibly damaging 0.71
R9497:Or6f1 UTSW 7 85,970,989 (GRCm39) missense probably damaging 0.98
R9666:Or6f1 UTSW 7 85,970,444 (GRCm39) missense probably damaging 1.00
Predicted Primers PCR Primer
(F):5'- CTCTGACCTCCTTGTTACGAAGAG -3'
(R):5'- AGCACCTTGTCCTTCTGTGG -3'

Sequencing Primer
(F):5'- CCTCCTTGTTACGAAGAGTATAAATG -3'
(R):5'- GACATTGCACCCTGGATTGC -3'
Posted On 2021-03-08