Mutagenetix > Incidental Mutation

Incidental Mutation 'R8746:Or2y1f'

663564

Institutional Source

Beutler Lab

Gene Symbol

Or2y1f

Ensembl Gene

ENSMUSG00000101750

Gene Name

olfactory receptor family 2 subfamily Y member 1F

Synonyms

GA_x6K02T2QP88-6141322-6140387, MOR256-25, Olfr1392

MMRRC Submission

068590-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.129) question?

Stock #

R8746 (G1)

Quality Score

202.009

Status

Validated

Chromosome

Chromosomal Location

49184124-49185149 bp(+) (GRCm39)

Type of Mutation

intron

DNA Base Change (assembly)

A to G at 49183993 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Ref Sequence

ENSEMBL: ENSMUSP00000149746 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000189851] [ENSMUST00000214170] [ENSMUST00000214598] [ENSMUST00000215861] [ENSMUST00000217275]

AlphaFold

Q8VFA6

Predicted Effect

probably benign
Transcript: ENSMUST00000189851

SMART Domains

Protein: ENSMUSP00000140904
Gene: ENSMUSG00000101750

Domain	Start	End	E-Value	Type
Pfam:7TM_GPCR_Srsx	35	222	7.1e-8	PFAM
Pfam:7tm_1	41	289	2.4e-32	PFAM
Pfam:7tm_4	139	282	1.8e-42	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000214170

Predicted Effect

probably benign
Transcript: ENSMUST00000214598

Predicted Effect

probably benign
Transcript: ENSMUST00000215861

Predicted Effect

probably benign
Transcript: ENSMUST00000217275

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.8%
20x: 99.5%

Validation Efficiency

100% (52/52)

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
2210408I21Rik	T	A	13: 77,451,529 (GRCm39)	M871K	probably benign	Het
5530400C23Rik	A	C	6: 133,271,256 (GRCm39)	E100A	possibly damaging	Het
Aatf	A	T	11: 84,402,338 (GRCm39)	I116N	probably benign	Het
Abcb11	G	T	2: 69,087,754 (GRCm39)		probably benign	Het
Adarb2	G	T	13: 8,802,680 (GRCm39)	A652S	probably benign	Het
Adgb	C	T	10: 10,281,028 (GRCm39)		probably null	Het
Ankrd34a	C	T	3: 96,504,791 (GRCm39)		probably benign	Het
Ano2	A	G	6: 125,840,513 (GRCm39)	I395V	probably benign	Het
Cadm2	C	A	16: 66,581,696 (GRCm39)	R203L	probably damaging	Het
Ccr2	T	C	9: 123,906,448 (GRCm39)	F243L	probably benign	Het
Ccr4	A	G	9: 114,321,918 (GRCm39)	V49A	probably damaging	Het
Cemip2	G	A	19: 21,803,465 (GRCm39)	G833R	probably damaging	Het
Corin	T	C	5: 72,592,695 (GRCm39)	D234G	probably benign	Het
Drd5	G	T	5: 38,477,433 (GRCm39)	R142I	probably benign	Het
Dsg1b	A	G	18: 20,529,056 (GRCm39)	D264G	probably damaging	Het
Ezh2	T	C	6: 47,553,534 (GRCm39)	K61R	probably damaging	Het
Frmd4b	T	A	6: 97,269,370 (GRCm39)	T981S	probably benign	Het
Gcg	T	A	2: 62,305,325 (GRCm39)	K180N	probably damaging	Het
Gm10840	G	A	11: 106,051,742 (GRCm39)	E23K	unknown	Het
Gm2696	T	G	10: 77,651,037 (GRCm39)	C174W	unknown	Het
Grin2b	T	C	6: 135,899,985 (GRCm39)	I299V	probably benign	Het
Hepacam	T	A	9: 37,293,030 (GRCm39)	V207E	probably damaging	Het
Igf1r	T	A	7: 67,864,745 (GRCm39)	M1181K	probably damaging	Het
Lmo2	T	C	2: 103,806,384 (GRCm39)	S96P	possibly damaging	Het
Marf1	T	A	16: 13,935,168 (GRCm39)	E1533D	probably benign	Het
Megf9	A	G	4: 70,353,511 (GRCm39)	C432R	probably damaging	Het
Mpp2	A	G	11: 101,954,040 (GRCm39)	Y236H	probably damaging	Het
Neb	T	C	2: 52,172,613 (GRCm39)	I1565V	probably damaging	Het
Or56b2j	A	T	7: 104,353,067 (GRCm39)	I98F	probably damaging	Het
Or5ac21	T	A	16: 59,123,973 (GRCm39)	F152L	probably benign	Het
Or5b3	A	G	19: 13,388,092 (GRCm39)	D53G	probably benign	Het
Or5g24-ps1	T	A	2: 85,464,221 (GRCm39)	Y149*	probably null	Het
Or6f1	C	T	7: 85,970,437 (GRCm39)	C241Y	probably damaging	Het
Or9k2b	T	C	10: 130,016,086 (GRCm39)	Y221C	probably damaging	Het
Patj	T	A	4: 98,394,067 (GRCm39)		probably benign	Het
Pknox1	A	T	17: 31,809,624 (GRCm39)	Q76L	possibly damaging	Het
Plekhg1	C	A	10: 3,907,777 (GRCm39)	T953K		Het
Plekhn1	C	A	4: 156,316,682 (GRCm39)	R333L	probably damaging	Het
Plk5	T	A	10: 80,194,610 (GRCm39)	V111D	probably benign	Het
Polr1b	A	G	2: 128,954,597 (GRCm39)	I398M	possibly damaging	Het
Ranbp3	T	C	17: 57,009,826 (GRCm39)	V137A	probably benign	Het
Rc3h1	T	A	1: 160,757,744 (GRCm39)	F21I	probably damaging	Het
Rgs8	T	C	1: 153,547,537 (GRCm39)	S56P	probably damaging	Het
Rhpn1	G	A	15: 75,585,425 (GRCm39)	V593M	probably damaging	Het
Sdad1	A	G	5: 92,437,784 (GRCm39)	S589P	probably benign	Het
Skp1	A	G	11: 52,136,843 (GRCm39)	K163R	probably damaging	Het
Slf2	A	G	19: 44,962,063 (GRCm39)	Y1080C	probably damaging	Het
Tcf4	C	T	18: 69,654,572 (GRCm39)		probably benign	Het
Tmem144	C	T	3: 79,732,655 (GRCm39)	V208M	probably damaging	Het
Tomm34	A	T	2: 163,902,884 (GRCm39)	L142Q	probably benign	Het
Unc13b	T	A	4: 43,176,120 (GRCm39)	V2316D	unknown	Het
Yme1l1	T	A	2: 23,052,543 (GRCm39)	S66T	probably benign	Het
Zfc3h1	T	C	10: 115,243,885 (GRCm39)	S739P	probably damaging	Het
Zscan25	T	A	5: 145,224,157 (GRCm39)	V209E	possibly damaging	Het

Other mutations in Or2y1f

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01066:Or2y1f	APN	11	49,184,457 (GRCm39)	missense	possibly damaging	0.55
IGL02530:Or2y1f	APN	11	49,184,555 (GRCm39)	missense	possibly damaging	0.78
IGL03026:Or2y1f	APN	11	49,184,285 (GRCm39)	missense	probably damaging	0.99
IGL03106:Or2y1f	APN	11	49,184,988 (GRCm39)	missense	probably damaging	0.99
R0357:Or2y1f	UTSW	11	49,184,613 (GRCm39)	missense	probably damaging	0.96
R0396:Or2y1f	UTSW	11	49,184,165 (GRCm39)	missense	probably benign	0.00
R2281:Or2y1f	UTSW	11	49,184,459 (GRCm39)	missense	probably benign	0.04
R4319:Or2y1f	UTSW	11	49,184,503 (GRCm39)	missense	probably damaging	1.00
R4320:Or2y1f	UTSW	11	49,184,503 (GRCm39)	missense	probably damaging	1.00
R4322:Or2y1f	UTSW	11	49,184,503 (GRCm39)	missense	probably damaging	1.00
R4323:Or2y1f	UTSW	11	49,184,503 (GRCm39)	missense	probably damaging	1.00
R5327:Or2y1f	UTSW	11	49,184,493 (GRCm39)	missense	probably damaging	1.00
R6749:Or2y1f	UTSW	11	49,184,877 (GRCm39)	missense	probably damaging	1.00
R7779:Or2y1f	UTSW	11	49,185,048 (GRCm39)	missense	probably damaging	1.00
R8122:Or2y1f	UTSW	11	49,184,401 (GRCm39)	missense	probably damaging	0.99
R8356:Or2y1f	UTSW	11	49,184,385 (GRCm39)	missense	probably damaging	1.00
R8456:Or2y1f	UTSW	11	49,184,385 (GRCm39)	missense	probably damaging	1.00
R8737:Or2y1f	UTSW	11	49,184,965 (GRCm39)	missense	probably damaging	1.00
R9375:Or2y1f	UTSW	11	49,184,902 (GRCm39)	nonsense	probably null
X0012:Or2y1f	UTSW	11	49,184,760 (GRCm39)	missense	probably benign	0.36
X0025:Or2y1f	UTSW	11	49,184,780 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TGTGAGTGGGACTCCAGAATG -3'
(R):5'- GAAGCTTTCCATAGCCAAAGAC -3'

Sequencing Primer
(F):5'- GTGTACAGACAATATCCATGGTGC -3'
(R):5'- GCCAAAGACAATTTAATGCATCTG -3'

Posted On

2021-03-08