Mutagenetix > Incidental Mutation

Incidental Mutation 'R8747:Vmn1r238'

663628

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r238

Ensembl Gene

ENSMUSG00000091539

Gene Name

vomeronasal 1 receptor, 238

Synonyms

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.062) question?

Stock #

R8747 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

3122492-3123412 bp(-) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

T to G at 3123232 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Isoleucine to Leucine at position 61 (I61L)

Ref Sequence

ENSEMBL: ENSMUSP00000129804 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000165255]

AlphaFold

E9Q373

Predicted Effect

possibly damaging
Transcript: ENSMUST00000165255
AA Change: I61L

PolyPhen 2 Score 0.872 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000129804
Gene: ENSMUSG00000091539
AA Change: I61L

Domain	Start	End	E-Value	Type
Pfam:TAS2R	7	302	5.3e-8	PFAM
Pfam:7tm_1	27	292	8.8e-7	PFAM
Pfam:V1R	34	298	1.9e-33	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.5%

Validation Efficiency

100% (52/52)

Allele List at MGI

Other mutations in this stock

Total: 54 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700109H08Rik	A	G	5: 3,582,240	D190G	probably benign	Het
8430408G22Rik	T	A	6: 116,652,161	L155Q	possibly damaging	Het
Abhd11	A	G	5: 135,011,906	I271V	possibly damaging	Het
AI314180	C	T	4: 58,828,632	V934I	probably damaging	Het
Akap6	T	G	12: 53,142,216	S2138A	probably benign	Het
Amn	C	A	12: 111,275,006	P235H	probably damaging	Het
Arf2	A	T	11: 103,969,149	M18L	probably benign	Het
Asic2	A	T	11: 81,152,407	F20Y	possibly damaging	Het
Bok	T	C	1: 93,694,942		probably null	Het
Cachd1	T	A	4: 101,002,848		probably benign	Het
Casp8	A	G	1: 58,844,458	N308S	probably benign	Het
Cavin3	G	T	7: 105,481,947	H71Q	possibly damaging	Het
Ccdc87	A	G	19: 4,841,618	I713V	probably benign	Het
Clcn6	A	T	4: 148,008,897		probably null	Het
Cmas	T	C	6: 142,771,201	I273T	possibly damaging	Het
Ctxn3	A	T	18: 57,477,306	D65V	probably damaging	Het
D130040H23Rik	C	A	8: 69,303,053	N387K	probably benign	Het
Dnah9	T	C	11: 65,927,990	K3174R	possibly damaging	Het
Efcab14	A	G	4: 115,746,596	N157S	probably damaging	Het
Ets1	G	A	9: 32,730,178	G109D	probably damaging	Het
Fbln5	G	A	12: 101,768,495	R173C	probably damaging	Het
Fchsd1	G	A	18: 37,962,982	P525L	probably benign	Het
Gmppa	G	A	1: 75,439,381	V156I	probably damaging	Het
Gtpbp1	A	G	15: 79,719,281	D182G		Het
Ift140	T	A	17: 25,035,835	S430T	probably benign	Het
Kat7	G	C	11: 95,294,566	C161W	probably damaging	Het
Lipk	T	A	19: 34,018,784	M32K	probably damaging	Het
Lum	A	T	10: 97,568,489	D82V	possibly damaging	Het
Macf1	C	A	4: 123,355,151	A7196S	probably damaging	Het
Mroh2b	T	A	15: 4,935,300	S926T	probably damaging	Het
Nbn	G	T	4: 15,981,555	R549I	probably damaging	Het
Nfu1	T	C	6: 87,019,418	I117T	probably damaging	Het
Olfr1355	A	G	10: 78,879,321	T50A	probably benign	Het
Olfr566	T	C	7: 102,856,932	T117A	probably benign	Het
Parp1	T	C	1: 180,594,710	L778P	probably damaging	Het
Pbld2	G	T	10: 63,052,290	V125F	probably benign	Het
Prkag2	A	G	5: 24,880,682		probably null	Het
Prss54	A	G	8: 95,559,723	F241L	probably benign	Het
Rnf121	T	C	7: 102,029,109	D177G	probably damaging	Het
Slc12a7	G	A	13: 73,785,122	V100I	probably benign	Het
Slc28a1	C	T	7: 81,124,971	L189F	possibly damaging	Het
Slc35a3	T	C	3: 116,694,570	Q16R	probably damaging	Het
Snap91	A	G	9: 86,804,524	F354L	probably damaging	Het
Steap2	A	G	5: 5,673,539	I447T	probably benign	Het
Tagap	T	A	17: 7,928,770	I104N	probably damaging	Het
Tas1r2	A	G	4: 139,660,007	D259G	probably benign	Het
Tgm3	T	C	2: 130,044,532	S558P	probably benign	Het
Tuba3a	A	G	6: 125,281,055	V324A	probably damaging	Het
Vmn1r52	A	G	6: 90,179,469	T252A	probably benign	Het
Vmp1	A	G	11: 86,602,059	V308A	probably damaging	Het
Wdfy4	A	C	14: 33,152,654	V159G		Het
Zfp180	A	G	7: 24,105,262	T369A	possibly damaging	Het
Zfp827	A	G	8: 79,028,687	M1V	probably null	Het
Zmym4	A	G	4: 126,893,405	I1031T	probably damaging	Het

Other mutations in Vmn1r238

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00427:Vmn1r238	APN	18	3123243	missense	probably benign	0.01
IGL01385:Vmn1r238	APN	18	3122770	missense	possibly damaging	0.83
IGL02716:Vmn1r238	APN	18	3123124	missense	probably damaging	1.00
R1219:Vmn1r238	UTSW	18	3123135	missense	possibly damaging	0.81
R1568:Vmn1r238	UTSW	18	3123358	missense	probably benign	0.00
R1864:Vmn1r238	UTSW	18	3123040	nonsense	probably null
R3024:Vmn1r238	UTSW	18	3123305	missense	probably benign	0.13
R4291:Vmn1r238	UTSW	18	3123214	nonsense	probably null
R4304:Vmn1r238	UTSW	18	3123040	nonsense	probably null
R4586:Vmn1r238	UTSW	18	3123294	missense	probably damaging	1.00
R4664:Vmn1r238	UTSW	18	3123300	missense	probably damaging	0.99
R5123:Vmn1r238	UTSW	18	3123243	missense	probably benign
R5430:Vmn1r238	UTSW	18	3122521	missense	possibly damaging	0.63
R5834:Vmn1r238	UTSW	18	3123168	missense	probably benign
R7186:Vmn1r238	UTSW	18	3122661	missense	probably damaging	0.99
R7206:Vmn1r238	UTSW	18	3122623	missense	possibly damaging	0.94
R7308:Vmn1r238	UTSW	18	3122875	missense	probably benign	0.09
R7346:Vmn1r238	UTSW	18	3123151	missense	probably damaging	1.00
R7467:Vmn1r238	UTSW	18	3123393	missense	probably benign	0.10
R7571:Vmn1r238	UTSW	18	3122721	missense	probably damaging	1.00
R7808:Vmn1r238	UTSW	18	3123033	missense	probably benign	0.03
R8085:Vmn1r238	UTSW	18	3123151	missense	probably damaging	1.00
R8086:Vmn1r238	UTSW	18	3123250	missense	probably damaging	1.00
R8325:Vmn1r238	UTSW	18	3122529	missense	probably benign	0.00
R8423:Vmn1r238	UTSW	18	3123365	nonsense	probably null
R8930:Vmn1r238	UTSW	18	3123127	missense	probably benign	0.03
R8932:Vmn1r238	UTSW	18	3123127	missense	probably benign	0.03
R9279:Vmn1r238	UTSW	18	3122994	missense	probably damaging	0.99
R9382:Vmn1r238	UTSW	18	3122676	missense	probably damaging	0.99
R9644:Vmn1r238	UTSW	18	3122635	missense	probably benign	0.10
R9725:Vmn1r238	UTSW	18	3122577	missense	probably benign	0.00
Z1177:Vmn1r238	UTSW	18	3122505	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TCCACCTGGAGTTATTGGGG -3'
(R):5'- TCAAGTTCAGGGATTTTGGACC -3'

Sequencing Primer
(F):5'- GCTGATGGTGATTGCTTGGAAAC -3'
(R):5'- TTAATAGGAATGAAAATGGATCCTGG -3'

Posted On

2021-03-08