Incidental Mutation 'R8748:Or10d3'
ID 663659
Institutional Source Beutler Lab
Gene Symbol Or10d3
Ensembl Gene ENSMUSG00000050853
Gene Name olfactory receptor family 10 subfamily D member 3
Synonyms GA_x6K02T2PVTD-33247839-33246901, MOR224-9, Olfr958
MMRRC Submission 068591-MU
Accession Numbers
Essential gene? Probably non essential (E-score: 0.153) question?
Stock # R8748 (G1)
Quality Score 225.009
Status Not validated
Chromosome 9
Chromosomal Location 39461227-39462165 bp(-) (GRCm39)
Type of Mutation nonsense
DNA Base Change (assembly) C to A at 39461712 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glycine to Stop codon at position 152 (G152*)
Ref Sequence ENSEMBL: ENSMUSP00000149018 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000062545] [ENSMUST00000215505] [ENSMUST00000217227]
AlphaFold Q8VEY3
Predicted Effect probably null
Transcript: ENSMUST00000062545
AA Change: G152*
SMART Domains Protein: ENSMUSP00000049930
Gene: ENSMUSG00000050853
AA Change: G152*

DomainStartEndE-ValueType
Pfam:7tm_4 31 306 1.1e-49 PFAM
Pfam:7TM_GPCR_Srsx 36 236 1.5e-6 PFAM
Pfam:7tm_1 41 288 3.4e-21 PFAM
Predicted Effect probably null
Transcript: ENSMUST00000215505
AA Change: G152*
Predicted Effect probably null
Transcript: ENSMUST00000217227
AA Change: G152*
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.5%
  • 20x: 97.9%
Validation Efficiency 96% (43/45)
MGI Phenotype FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]
Allele List at MGI
Other mutations in this stock
Total: 45 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Abca8b A T 11: 109,836,597 (GRCm39) F1233I probably damaging Het
Acte1 T C 7: 143,445,556 (GRCm39) I201T probably benign Het
Adgrl2 A G 3: 148,532,026 (GRCm39) I87T Het
Atr A G 9: 95,814,476 (GRCm39) M2058V probably benign Het
Bach1 G A 16: 87,516,179 (GRCm39) R240Q probably benign Het
Bscl2 A G 19: 8,825,311 (GRCm39) E365G probably damaging Het
Casd1 T A 6: 4,608,634 (GRCm39) S77R probably benign Het
Ccdc91 T C 6: 147,464,194 (GRCm39) I214T unknown Het
Chpf2 T C 5: 24,796,821 (GRCm39) F589S probably damaging Het
Cmya5 T A 13: 93,226,229 (GRCm39) Y2953F probably damaging Het
Cts8 A T 13: 61,397,086 (GRCm39) V278D probably damaging Het
Cyp20a1 T C 1: 60,392,181 (GRCm39) V79A probably damaging Het
Dach1 G A 14: 98,065,770 (GRCm39) Q686* probably null Het
Daxx A G 17: 34,131,138 (GRCm39) D355G probably damaging Het
Dmrt3 G A 19: 25,588,550 (GRCm39) A130T probably benign Het
Eif4ebp2 A T 10: 61,270,806 (GRCm39) H74Q probably benign Het
Exoc3l T C 8: 106,016,777 (GRCm39) D679G probably damaging Het
Fam13c T A 10: 70,378,516 (GRCm39) W349R probably damaging Het
Fat3 A T 9: 15,834,161 (GRCm39) Y4144N possibly damaging Het
Gm37240 A G 3: 84,405,045 (GRCm39) *253Q probably null Het
Hycc1 T A 5: 24,170,320 (GRCm39) D343V probably benign Het
Ildr1 A C 16: 36,542,734 (GRCm39) E422A probably benign Het
Itsn2 A G 12: 4,751,337 (GRCm39) E1309G probably benign Het
Macf1 T C 4: 123,368,068 (GRCm39) D2231G probably benign Het
Mtnr1a T C 8: 45,538,675 (GRCm39) S38P probably benign Het
Or10v5 A G 19: 11,805,596 (GRCm39) S265P probably damaging Het
Or11h6 G T 14: 50,880,211 (GRCm39) V152F probably benign Het
Pate13 A C 9: 35,820,351 (GRCm39) D25A probably damaging Het
Pcdhb9 G A 18: 37,535,901 (GRCm39) G632S probably damaging Het
Pgr C A 9: 8,958,449 (GRCm39) L819I probably benign Het
Phrf1 T C 7: 140,838,148 (GRCm39) S448P unknown Het
Pip5k1a A G 3: 94,971,695 (GRCm39) M471T probably benign Het
Postn A G 3: 54,296,760 (GRCm39) D758G probably damaging Het
Rbmyf9 T A Y: 3,774,915 (GRCm39) probably null Het
Rpl3 T C 15: 79,963,902 (GRCm39) I280V probably benign Het
Rtl1 A T 12: 109,561,492 (GRCm39) S116T probably benign Het
Six5 A G 7: 18,829,049 (GRCm39) H163R probably benign Het
Smarca4 A G 9: 21,546,164 (GRCm39) D114G possibly damaging Het
Tex46 C T 4: 136,337,808 (GRCm39) probably benign Het
Tmem144 A G 3: 79,743,539 (GRCm39) probably null Het
Unc5d T C 8: 29,186,453 (GRCm39) T617A probably benign Het
Vmn1r74 T A 7: 11,580,903 (GRCm39) S68T probably benign Het
Zfp184 G A 13: 22,144,217 (GRCm39) R641Q probably benign Het
Zfp583 C T 7: 6,319,419 (GRCm39) R531H probably benign Het
Zfp764 T C 7: 127,003,862 (GRCm39) E423G possibly damaging Het
Other mutations in Or10d3
AlleleSourceChrCoordTypePredicted EffectPPH Score
R0446:Or10d3 UTSW 9 39,461,747 (GRCm39) missense probably damaging 0.96
R0539:Or10d3 UTSW 9 39,461,593 (GRCm39) missense probably damaging 0.99
R1512:Or10d3 UTSW 9 39,461,390 (GRCm39) missense probably damaging 1.00
R1521:Or10d3 UTSW 9 39,462,080 (GRCm39) missense possibly damaging 0.65
R1652:Or10d3 UTSW 9 39,461,591 (GRCm39) missense probably benign 0.03
R2099:Or10d3 UTSW 9 39,461,963 (GRCm39) missense probably benign 0.17
R2252:Or10d3 UTSW 9 39,461,273 (GRCm39) missense probably damaging 0.99
R2911:Or10d3 UTSW 9 39,462,117 (GRCm39) missense possibly damaging 0.76
R3722:Or10d3 UTSW 9 39,461,418 (GRCm39) missense probably damaging 1.00
R5745:Or10d3 UTSW 9 39,461,987 (GRCm39) missense probably damaging 1.00
R6460:Or10d3 UTSW 9 39,462,088 (GRCm39) frame shift probably null
R6504:Or10d3 UTSW 9 39,461,574 (GRCm39) missense probably damaging 1.00
R7063:Or10d3 UTSW 9 39,461,411 (GRCm39) missense possibly damaging 0.87
R7162:Or10d3 UTSW 9 39,461,525 (GRCm39) missense probably damaging 1.00
R8674:Or10d3 UTSW 9 39,461,675 (GRCm39) missense probably damaging 1.00
R8748:Or10d3 UTSW 9 39,461,711 (GRCm39) missense possibly damaging 0.95
R8822:Or10d3 UTSW 9 39,461,812 (GRCm39) missense probably benign 0.11
R9529:Or10d3 UTSW 9 39,461,723 (GRCm39) missense probably benign 0.28
R9631:Or10d3 UTSW 9 39,461,508 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- TAGCAATGAGGTGGGCACTG -3'
(R):5'- AAGACTGTGTCTCCCAGCTC -3'

Sequencing Primer
(F):5'- CAGTTGACTGAATACTCAAGATGG -3'
(R):5'- GACTGTGTCTCCCAGCTCTTCTTC -3'
Posted On 2021-03-08