Mutagenetix > Incidental Mutation

Incidental Mutation 'R8749:Vmn1r180'

663708

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r180

Ensembl Gene

ENSMUSG00000092473

Gene Name

vomeronasal 1 receptor 180

Synonyms

LOC232962, V1rd16

MMRRC Submission

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.063) question?

Stock #

R8749 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

23950632-23955691 bp(+) (GRCm38)

Type of Mutation

missense

DNA Base Change (assembly)

G to T at 23952990 bp (GRCm38)

Zygosity

Heterozygous

Amino Acid Change

Aspartic acid to Tyrosine at position 193 (D193Y)

Ref Sequence

ENSEMBL: ENSMUSP00000134362 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000173816]

AlphaFold

B9EK86

Predicted Effect

probably damaging
Transcript: ENSMUST00000173816
AA Change: D193Y

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000134362
Gene: ENSMUSG00000092473
AA Change: D193Y

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	298	2.9e-15	PFAM
Pfam:7tm_1	31	286	6.7e-9	PFAM
Pfam:V1R	41	297	1.4e-17	PFAM

Meta Mutation Damage Score

0.7540

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.9%
20x: 99.7%

Validation Efficiency

100% (59/59)

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akr1c12	C	T	13: 4,270,156		probably benign	Het
Ap3b1	T	A	13: 94,528,217	M888K	unknown	Het
Arhgap23	T	A	11: 97,500,815	V223E	probably damaging	Het
Atm	C	T	9: 53,499,197	W1028*	probably null	Het
Atp7b	A	G	8: 22,028,318	V168A	probably damaging	Het
Bach1	G	A	16: 87,719,291	R240Q	probably benign	Het
Caskin1	C	T	17: 24,504,800	A854V	probably benign	Het
Cdcp1	T	C	9: 123,189,962	N84S	probably benign	Het
Cdh7	T	A	1: 110,099,279	I475N	probably damaging	Het
Ciz1	A	T	2: 32,365,836	Y107F	probably benign	Het
Creb3l4	T	C	3: 90,237,892	N318D	probably benign	Het
Dmrt3	G	A	19: 25,611,186	A130T	probably benign	Het
Dmxl1	A	T	18: 49,955,870	K2805N	probably damaging	Het
Dusp15	T	A	2: 152,946,289	I63F	probably damaging	Het
Dync2h1	T	C	9: 7,035,063	Q3462R	probably benign	Het
Evpl	A	G	11: 116,229,406	C569R	probably benign	Het
Fmnl3	A	T	15: 99,321,441	M766K	possibly damaging	Het
G6pc2	A	G	2: 69,226,796	N262S	probably damaging	Het
Galk1	A	T	11: 116,008,936	L325Q	probably damaging	Het
Hist1h3c	T	C	13: 23,745,125	I125V	probably benign	Het
Hr	G	A	14: 70,558,070	G352R	probably damaging	Het
Il12b	A	T	11: 44,404,037	M1L	not run	Het
Lpar6	A	T	14: 73,239,510	M304L	probably benign	Het
Mpeg1	G	A	19: 12,461,927	A250T	probably benign	Het
Neb	T	C	2: 52,290,851	K1221R	probably benign	Het
Ogfrl1	T	A	1: 23,370,318	I276F	probably damaging	Het
Olfr1267-ps1	T	C	2: 90,086,287	Y58C	probably damaging	Het
Olfr1281	T	C	2: 111,328,472	C18R	possibly damaging	Het
Olfr1318	A	G	2: 112,156,524	D191G	possibly damaging	Het
Oxr1	A	G	15: 41,710,864	N2S	probably benign	Het
P3h3	G	A	6: 124,845,977	R505C	probably damaging	Het
Pcdhb16	A	T	18: 37,479,339	I451F	possibly damaging	Het
Pet117	C	A	2: 144,373,202	D36E	probably benign	Het
Prf1	T	C	10: 61,303,169	V302A	probably damaging	Het
Prkdc	G	A	16: 15,783,165	A2897T	possibly damaging	Het
Prkra	A	G	2: 76,630,535	L273P	probably damaging	Het
Prr30	T	A	14: 101,198,929	T66S	probably benign	Het
Slc29a4	A	G	5: 142,715,064	Y188C	probably damaging	Het
Soga3	T	C	10: 29,196,725	I671T	possibly damaging	Het
Spink5	A	T	18: 43,989,358	K297*	probably null	Het
Tcof1	G	C	18: 60,829,051	A702G	possibly damaging	Het
Tmem100	G	A	11: 90,035,748	A134T	probably damaging	Het
Tmem132c	A	G	5: 127,359,939	D164G	possibly damaging	Het
Tnfsf18	A	G	1: 161,503,478	T66A	possibly damaging	Het
Ubr4	C	T	4: 139,402,624	T685I	probably damaging	Het
Uck1	T	C	2: 32,256,512	Y185C		Het
Umod	T	A	7: 119,471,416	I418F	probably benign	Het
Upp1	A	T	11: 9,129,561	S41C	probably damaging	Het
Vmn1r168	A	T	7: 23,541,003	Y95F	probably benign	Het
Vmn2r11	A	G	5: 109,047,453	V669A	probably damaging	Het
Vmn2r55	T	A	7: 12,651,869	Y728F	probably damaging	Het
Vmn2r78	A	G	7: 86,954,305	T564A	possibly damaging	Het
Vps13d	T	A	4: 145,138,613	N2057I		Het
Wdfy3	C	T	5: 101,882,580	R2354Q	probably damaging	Het
Wdr77	T	A	3: 105,959,659	C26S	probably damaging	Het
Yif1b	C	T	7: 29,247,265	A267V	probably benign	Het
Zfp316	A	G	5: 143,262,810	V227A	unknown	Het
Zfp600	T	A	4: 146,196,581	H606Q	unknown	Het
Zfp804a	T	C	2: 82,257,575	W583R	probably benign	Het
Zfp961	T	C	8: 71,965,842	W39R	probably damaging	Het
Zfp990	T	A	4: 145,537,586	C385S	probably damaging	Het

Other mutations in Vmn1r180

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00487:Vmn1r180	APN	7	23952523	missense	probably benign	0.36
IGL01309:Vmn1r180	APN	7	23952999	missense	probably damaging	1.00
IGL01793:Vmn1r180	APN	7	23953243	missense	probably benign	0.00
IGL02653:Vmn1r180	APN	7	23953075	missense	probably damaging	1.00
IGL03277:Vmn1r180	APN	7	23953285	missense	probably damaging	0.99
IGL03352:Vmn1r180	APN	7	23952652	nonsense	probably null
R1298:Vmn1r180	UTSW	7	23953147	missense	possibly damaging	0.84
R1701:Vmn1r180	UTSW	7	23952970	missense	possibly damaging	0.84
R1702:Vmn1r180	UTSW	7	23952969	missense	possibly damaging	0.52
R2122:Vmn1r180	UTSW	7	23953141	missense	probably damaging	1.00
R4241:Vmn1r180	UTSW	7	23952873	missense	probably damaging	1.00
R5683:Vmn1r180	UTSW	7	23953210	missense	possibly damaging	0.58
R7241:Vmn1r180	UTSW	7	23952466	missense	probably damaging	0.96
R7522:Vmn1r180	UTSW	7	23953260	missense	probably damaging	1.00
R8991:Vmn1r180	UTSW	7	23952651	missense	probably benign	0.06
R9442:Vmn1r180	UTSW	7	23952195	start gained	probably benign

Predicted Primers

PCR Primer
(F):5'- ACTCATACTCAGAGCAAGTGTC -3'
(R):5'- CTGCAATGCCTCACAAAGAG -3'

Sequencing Primer
(F):5'- CTCAGAGCAAGTGTCCCAAATTTG -3'
(R):5'- AGAAGATGAAAGCTAACAAATGTGAC -3'

Posted On

2021-03-08