Mutagenetix > Incidental Mutation

Incidental Mutation 'R8749:Prkdc'

663733

Institutional Source

Beutler Lab

Gene Symbol

Prkdc

Ensembl Gene

ENSMUSG00000022672

Gene Name

protein kinase, DNA activated, catalytic polypeptide

Synonyms

slip, DNA-PK, XRCC7, DNAPDcs, DOXNPH, dxnph, DNA-PKcs

MMRRC Submission

068592-MU

Accession Numbers

Essential gene?

Probably essential (E-score: 0.953) question?

Stock #

R8749 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

15455730-15660099 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

G to A at 15601029 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Alanine to Threonine at position 2897 (A2897T)

Ref Sequence

ENSEMBL: ENSMUSP00000023352 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000023352]

AlphaFold

no structure available at present

Predicted Effect

possibly damaging
Transcript: ENSMUST00000023352
AA Change: A2897T

PolyPhen 2 Score 0.850 (Sensitivity: 0.83; Specificity: 0.93)

SMART Domains

Protein: ENSMUSP00000023352
Gene: ENSMUSG00000022672
AA Change: A2897T

Domain	Start	End	E-Value	Type
low complexity region	125	138	N/A	INTRINSIC
low complexity region	1253	1263	N/A	INTRINSIC
low complexity region	1508	1522	N/A	INTRINSIC
NUC194	1810	2206	2.37e-246	SMART
SCOP:d1gw5a_	2210	2493	5e-3	SMART
low complexity region	2669	2681	N/A	INTRINSIC
low complexity region	2841	2855	N/A	INTRINSIC
Pfam:FAT	3024	3470	8.2e-75	PFAM
PI3Kc	3749	4068	3.67e-86	SMART
FATC	4096	4128	1.57e-9	SMART

Coding Region Coverage

1x: 100.0%
3x: 100.0%
10x: 99.9%
20x: 99.7%

Validation Efficiency

100% (59/59)

MGI Phenotype

FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes the catalytic subunit of the DNA-dependent protein kinase (DNA-PK). It functions with the Ku70/Ku80 heterodimer protein in DNA double strand break repair and recombination. The protein encoded is a member of the PI3/PI4-kinase family.[provided by RefSeq, Jul 2010]
PHENOTYPE: Mutations at this locus effect genome stability, radiation sensitivity and DNA repair. Nonsense (scid) and null homozygotes have severe combined immunodeficiency. A BALB/c variant allele reduces enzyme activity and predisposes to breast cancer. [provided by MGI curators]

Allele List at MGI

Other mutations in this stock

Total: 61 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Akr1c12	C	T	13: 4,320,155 (GRCm39)		probably benign	Het
Ap3b1	T	A	13: 94,664,725 (GRCm39)	M888K	unknown	Het
Arhgap23	T	A	11: 97,391,641 (GRCm39)	V223E	probably damaging	Het
Atm	C	T	9: 53,410,497 (GRCm39)	W1028*	probably null	Het
Atp7b	A	G	8: 22,518,334 (GRCm39)	V168A	probably damaging	Het
Bach1	G	A	16: 87,516,179 (GRCm39)	R240Q	probably benign	Het
Caskin1	C	T	17: 24,723,774 (GRCm39)	A854V	probably benign	Het
Cdcp1	T	C	9: 123,019,027 (GRCm39)	N84S	probably benign	Het
Cdh20	T	A	1: 110,027,009 (GRCm39)	I475N	probably damaging	Het
Ciz1	A	T	2: 32,255,848 (GRCm39)	Y107F	probably benign	Het
Creb3l4	T	C	3: 90,145,199 (GRCm39)	N318D	probably benign	Het
Dmrt3	G	A	19: 25,588,550 (GRCm39)	A130T	probably benign	Het
Dmxl1	A	T	18: 50,088,937 (GRCm39)	K2805N	probably damaging	Het
Dusp15	T	A	2: 152,788,209 (GRCm39)	I63F	probably damaging	Het
Dync2h1	T	C	9: 7,035,063 (GRCm39)	Q3462R	probably benign	Het
Evpl	A	G	11: 116,120,232 (GRCm39)	C569R	probably benign	Het
Fmnl3	A	T	15: 99,219,322 (GRCm39)	M766K	possibly damaging	Het
G6pc2	A	G	2: 69,057,140 (GRCm39)	N262S	probably damaging	Het
Galk1	A	T	11: 115,899,762 (GRCm39)	L325Q	probably damaging	Het
H3c3	T	C	13: 23,929,108 (GRCm39)	I125V	probably benign	Het
Hr	G	A	14: 70,795,510 (GRCm39)	G352R	probably damaging	Het
Il12b	A	T	11: 44,294,864 (GRCm39)	M1L	not run	Het
Lpar6	A	T	14: 73,476,950 (GRCm39)	M304L	probably benign	Het
Mpeg1	G	A	19: 12,439,291 (GRCm39)	A250T	probably benign	Het
Mtcl3	T	C	10: 29,072,721 (GRCm39)	I671T	possibly damaging	Het
Neb	T	C	2: 52,180,863 (GRCm39)	K1221R	probably benign	Het
Ogfrl1	T	A	1: 23,409,399 (GRCm39)	I276F	probably damaging	Het
Or4f62	A	G	2: 111,986,869 (GRCm39)	D191G	possibly damaging	Het
Or4k37	T	C	2: 111,158,817 (GRCm39)	C18R	possibly damaging	Het
Or4x12-ps1	T	C	2: 89,916,631 (GRCm39)	Y58C	probably damaging	Het
Oxr1	A	G	15: 41,574,260 (GRCm39)	N2S	probably benign	Het
P3h3	G	A	6: 124,822,940 (GRCm39)	R505C	probably damaging	Het
Pcdhb16	A	T	18: 37,612,392 (GRCm39)	I451F	possibly damaging	Het
Pet117	C	A	2: 144,215,122 (GRCm39)	D36E	probably benign	Het
Prf1	T	C	10: 61,138,948 (GRCm39)	V302A	probably damaging	Het
Prkra	A	G	2: 76,460,879 (GRCm39)	L273P	probably damaging	Het
Prr30	T	A	14: 101,436,365 (GRCm39)	T66S	probably benign	Het
Slc29a4	A	G	5: 142,700,819 (GRCm39)	Y188C	probably damaging	Het
Spink5	A	T	18: 44,122,425 (GRCm39)	K297*	probably null	Het
Tcof1	G	C	18: 60,962,123 (GRCm39)	A702G	possibly damaging	Het
Tmem100	G	A	11: 89,926,574 (GRCm39)	A134T	probably damaging	Het
Tmem132c	A	G	5: 127,437,003 (GRCm39)	D164G	possibly damaging	Het
Tnfsf18	A	G	1: 161,331,047 (GRCm39)	T66A	possibly damaging	Het
Ubr4	C	T	4: 139,129,935 (GRCm39)	T685I	probably damaging	Het
Uck1	T	C	2: 32,146,524 (GRCm39)	Y185C		Het
Umod	T	A	7: 119,070,639 (GRCm39)	I418F	probably benign	Het
Upp1	A	T	11: 9,079,561 (GRCm39)	S41C	probably damaging	Het
Vmn1r168	A	T	7: 23,240,428 (GRCm39)	Y95F	probably benign	Het
Vmn1r180	G	T	7: 23,652,415 (GRCm39)	D193Y	probably damaging	Het
Vmn2r11	A	G	5: 109,195,319 (GRCm39)	V669A	probably damaging	Het
Vmn2r55	T	A	7: 12,385,796 (GRCm39)	Y728F	probably damaging	Het
Vmn2r78	A	G	7: 86,603,513 (GRCm39)	T564A	possibly damaging	Het
Vps13d	T	A	4: 144,865,183 (GRCm39)	N2057I		Het
Wdfy3	C	T	5: 102,030,446 (GRCm39)	R2354Q	probably damaging	Het
Wdr77	T	A	3: 105,866,975 (GRCm39)	C26S	probably damaging	Het
Yif1b	C	T	7: 28,946,690 (GRCm39)	A267V	probably benign	Het
Zfp316	A	G	5: 143,248,565 (GRCm39)	V227A	unknown	Het
Zfp600	T	A	4: 146,133,151 (GRCm39)	H606Q	unknown	Het
Zfp804a	T	C	2: 82,087,919 (GRCm39)	W583R	probably benign	Het
Zfp961	T	C	8: 72,719,686 (GRCm39)	W39R	probably damaging	Het
Zfp990	T	A	4: 145,264,156 (GRCm39)	C385S	probably damaging	Het

Other mutations in Prkdc

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL00157:Prkdc	APN	16	15,515,090 (GRCm39)	missense	probably damaging	1.00
IGL00225:Prkdc	APN	16	15,627,508 (GRCm39)	missense	possibly damaging	0.64
IGL00481:Prkdc	APN	16	15,608,330 (GRCm39)	missense	probably benign	0.41
IGL00488:Prkdc	APN	16	15,593,711 (GRCm39)	splice site	probably null
IGL00489:Prkdc	APN	16	15,617,790 (GRCm39)	missense	possibly damaging	0.51
IGL00579:Prkdc	APN	16	15,482,103 (GRCm39)	missense	probably damaging	1.00
IGL00587:Prkdc	APN	16	15,470,222 (GRCm39)	splice site	probably benign
IGL00666:Prkdc	APN	16	15,554,699 (GRCm39)	missense	probably damaging	1.00
IGL00675:Prkdc	APN	16	15,605,022 (GRCm39)	missense	probably benign	0.05
IGL00708:Prkdc	APN	16	15,597,290 (GRCm39)	missense	probably damaging	0.97
IGL00725:Prkdc	APN	16	15,634,503 (GRCm39)	missense	probably benign	0.10
IGL00818:Prkdc	APN	16	15,577,618 (GRCm39)	missense	possibly damaging	0.92
IGL00917:Prkdc	APN	16	15,557,428 (GRCm39)	missense	probably damaging	0.98
IGL00990:Prkdc	APN	16	15,519,979 (GRCm39)	missense	probably benign	0.03
IGL01126:Prkdc	APN	16	15,487,185 (GRCm39)	missense	probably benign	0.01
IGL01141:Prkdc	APN	16	15,544,568 (GRCm39)	missense	probably damaging	0.99
IGL01306:Prkdc	APN	16	15,485,595 (GRCm39)	missense	possibly damaging	0.67
IGL01326:Prkdc	APN	16	15,647,556 (GRCm39)	missense	probably benign
IGL01335:Prkdc	APN	16	15,634,760 (GRCm39)	critical splice donor site	probably null
IGL01419:Prkdc	APN	16	15,653,030 (GRCm39)	missense	probably damaging	1.00
IGL01434:Prkdc	APN	16	15,531,451 (GRCm39)	missense	probably benign	0.00
IGL01554:Prkdc	APN	16	15,470,166 (GRCm39)	missense	probably benign	0.05
IGL01671:Prkdc	APN	16	15,485,609 (GRCm39)	missense	possibly damaging	0.90
IGL01871:Prkdc	APN	16	15,600,951 (GRCm39)	missense	probably benign	0.00
IGL01874:Prkdc	APN	16	15,552,858 (GRCm39)	missense	possibly damaging	0.89
IGL01930:Prkdc	APN	16	15,516,751 (GRCm39)	missense	probably damaging	1.00
IGL01984:Prkdc	APN	16	15,526,643 (GRCm39)	missense	probably benign
IGL02121:Prkdc	APN	16	15,535,048 (GRCm39)	missense	probably benign	0.18
IGL02152:Prkdc	APN	16	15,487,149 (GRCm39)	missense	probably benign	0.15
IGL02172:Prkdc	APN	16	15,627,623 (GRCm39)	missense	probably benign	0.10
IGL02336:Prkdc	APN	16	15,603,843 (GRCm39)	missense	probably benign	0.01
IGL02336:Prkdc	APN	16	15,603,842 (GRCm39)	missense	possibly damaging	0.47
IGL02393:Prkdc	APN	16	15,634,622 (GRCm39)	missense	probably benign	0.42
IGL02406:Prkdc	APN	16	15,488,399 (GRCm39)	missense	probably benign	0.00
IGL02500:Prkdc	APN	16	15,532,146 (GRCm39)	critical splice donor site	probably null
IGL02568:Prkdc	APN	16	15,544,406 (GRCm39)	missense	probably damaging	0.98
IGL02579:Prkdc	APN	16	15,488,465 (GRCm39)	missense	possibly damaging	0.83
IGL02652:Prkdc	APN	16	15,600,951 (GRCm39)	missense	probably benign	0.00
IGL02661:Prkdc	APN	16	15,587,689 (GRCm39)	missense	possibly damaging	0.92
IGL02685:Prkdc	APN	16	15,653,907 (GRCm39)	missense	possibly damaging	0.61
IGL02741:Prkdc	APN	16	15,570,590 (GRCm39)	splice site	probably benign
IGL02803:Prkdc	APN	16	15,651,530 (GRCm39)	splice site	probably benign
IGL02866:Prkdc	APN	16	15,649,191 (GRCm39)	missense	probably damaging	1.00
IGL02882:Prkdc	APN	16	15,469,383 (GRCm39)	nonsense	probably null
IGL02989:Prkdc	APN	16	15,617,880 (GRCm39)	missense	possibly damaging	0.67
IGL03053:Prkdc	APN	16	15,652,030 (GRCm39)	missense	probably benign	0.02
IGL03071:Prkdc	APN	16	15,617,848 (GRCm39)	missense	probably benign	0.01
IGL03091:Prkdc	APN	16	15,523,174 (GRCm39)	splice site	probably benign
IGL03100:Prkdc	APN	16	15,531,499 (GRCm39)	missense	probably benign	0.08
IGL03128:Prkdc	APN	16	15,518,608 (GRCm39)	splice site	probably benign
IGL03168:Prkdc	APN	16	15,652,030 (GRCm39)	missense	probably benign	0.02
IGL03204:Prkdc	APN	16	15,587,665 (GRCm39)	missense	probably benign	0.01
IGL03390:Prkdc	APN	16	15,488,490 (GRCm39)	nonsense	probably null
anhimid	UTSW	16	15,543,325 (GRCm39)	critical splice donor site	probably null
anhinga	UTSW	16	15,526,796 (GRCm39)	critical splice donor site	probably null
Bushtit	UTSW	16	15,570,628 (GRCm39)	missense	probably damaging	0.97
clover	UTSW	16	15,520,020 (GRCm39)	splice site	probably benign
crackle	UTSW	16	15,603,914 (GRCm39)	critical splice donor site	probably null
Daffy	UTSW	16	15,647,561 (GRCm39)	missense	possibly damaging	0.86
darter	UTSW	16	15,591,477 (GRCm39)	missense	possibly damaging	0.93
Elmer_fudd	UTSW	16	15,625,922 (GRCm39)	missense	probably benign	0.01
envenomation	UTSW	16	15,653,091 (GRCm39)	nonsense	probably null
hobgoblin	UTSW	16	15,633,850 (GRCm39)	missense	probably damaging	1.00
Incubus	UTSW	16	15,490,191 (GRCm39)	missense	probably damaging	1.00
liming	UTSW	16	15,570,693 (GRCm39)	nonsense	probably null
newt	UTSW	16	15,545,590 (GRCm39)	missense	probably benign	0.04
ornithorhynchus	UTSW	16	15,634,523 (GRCm39)	critical splice donor site	probably null
primitive	UTSW	16	15,653,022 (GRCm39)	frame shift	probably null
roadrunner	UTSW	16	15,651,751 (GRCm39)	missense	probably damaging	1.00
Schreier	UTSW	16	15,488,392 (GRCm39)	missense	probably benign	0.00
screamer	UTSW	16	15,649,146 (GRCm39)	nonsense	probably null
Screamer10	UTSW	16	15,585,889 (GRCm39)	missense	probably damaging	0.98
screamer2	UTSW	16	15,470,416 (GRCm39)	critical splice donor site	probably null
screamer3	UTSW	16	15,558,196 (GRCm39)	critical splice donor site	probably null
screamer4	UTSW	16	15,600,943 (GRCm39)	missense	probably benign	0.00
screamer5	UTSW	16	15,505,268 (GRCm39)	missense	probably benign
screamer6	UTSW	16	15,577,469 (GRCm39)	missense	probably damaging	1.00
screamer7	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
Screamer8	UTSW	16	15,537,297 (GRCm39)	missense	probably benign	0.00
Screamer9	UTSW	16	15,552,786 (GRCm39)	missense	probably benign	0.01
Tweetie	UTSW	16	15,535,665 (GRCm39)	missense	probably damaging	1.00
updock	UTSW	16	15,612,958 (GRCm39)	missense	probably benign
ANU23:Prkdc	UTSW	16	15,485,595 (GRCm39)	missense	possibly damaging	0.67
R0008:Prkdc	UTSW	16	15,526,565 (GRCm39)	splice site	probably benign
R0018:Prkdc	UTSW	16	15,544,406 (GRCm39)	missense	probably benign	0.03
R0018:Prkdc	UTSW	16	15,544,406 (GRCm39)	missense	probably benign	0.03
R0069:Prkdc	UTSW	16	15,544,368 (GRCm39)	missense	probably benign	0.03
R0125:Prkdc	UTSW	16	15,516,871 (GRCm39)	missense	probably damaging	0.98
R0131:Prkdc	UTSW	16	15,531,517 (GRCm39)	missense	probably benign	0.09
R0131:Prkdc	UTSW	16	15,531,517 (GRCm39)	missense	probably benign	0.09
R0132:Prkdc	UTSW	16	15,531,517 (GRCm39)	missense	probably benign	0.09
R0137:Prkdc	UTSW	16	15,558,196 (GRCm39)	critical splice donor site	probably null
R0334:Prkdc	UTSW	16	15,554,663 (GRCm39)	missense	probably benign	0.00
R0373:Prkdc	UTSW	16	15,609,791 (GRCm39)	missense	probably damaging	1.00
R0485:Prkdc	UTSW	16	15,651,604 (GRCm39)	missense	probably damaging	0.97
R0511:Prkdc	UTSW	16	15,649,146 (GRCm39)	nonsense	probably null
R0538:Prkdc	UTSW	16	15,651,652 (GRCm39)	missense	probably damaging	1.00
R0595:Prkdc	UTSW	16	15,625,952 (GRCm39)	missense	probably damaging	1.00
R0607:Prkdc	UTSW	16	15,589,921 (GRCm39)	missense	probably damaging	0.98
R0616:Prkdc	UTSW	16	15,508,271 (GRCm39)	missense	probably damaging	1.00
R0630:Prkdc	UTSW	16	15,628,665 (GRCm39)	missense	probably damaging	1.00
R0694:Prkdc	UTSW	16	15,586,501 (GRCm39)	missense	probably damaging	1.00
R0702:Prkdc	UTSW	16	15,603,835 (GRCm39)	missense	possibly damaging	0.95
R0965:Prkdc	UTSW	16	15,647,580 (GRCm39)	missense	probably benign
R1027:Prkdc	UTSW	16	15,468,576 (GRCm39)	missense	possibly damaging	0.80
R1029:Prkdc	UTSW	16	15,472,613 (GRCm39)	splice site	probably benign
R1033:Prkdc	UTSW	16	15,585,815 (GRCm39)	missense	probably damaging	1.00
R1067:Prkdc	UTSW	16	15,570,646 (GRCm39)	missense	probably damaging	0.99
R1116:Prkdc	UTSW	16	15,600,943 (GRCm39)	missense	probably benign	0.00
R1187:Prkdc	UTSW	16	15,577,610 (GRCm39)	missense	probably damaging	0.98
R1226:Prkdc	UTSW	16	15,491,861 (GRCm39)	missense	possibly damaging	0.80
R1279:Prkdc	UTSW	16	15,508,146 (GRCm39)	missense	probably damaging	1.00
R1304:Prkdc	UTSW	16	15,577,587 (GRCm39)	missense	probably damaging	0.99
R1314:Prkdc	UTSW	16	15,482,091 (GRCm39)	missense	possibly damaging	0.68
R1351:Prkdc	UTSW	16	15,485,564 (GRCm39)	missense	possibly damaging	0.62
R1509:Prkdc	UTSW	16	15,549,430 (GRCm39)	missense	probably damaging	1.00
R1512:Prkdc	UTSW	16	15,505,268 (GRCm39)	missense	probably benign
R1531:Prkdc	UTSW	16	15,589,970 (GRCm39)	missense	probably benign	0.01
R1579:Prkdc	UTSW	16	15,493,192 (GRCm39)	missense	probably benign	0.00
R1669:Prkdc	UTSW	16	15,551,922 (GRCm39)	missense	probably damaging	1.00
R1682:Prkdc	UTSW	16	15,494,853 (GRCm39)	missense	probably benign	0.19
R1713:Prkdc	UTSW	16	15,612,958 (GRCm39)	missense	probably benign
R1762:Prkdc	UTSW	16	15,455,825 (GRCm39)	missense	probably benign
R1789:Prkdc	UTSW	16	15,557,388 (GRCm39)	missense	probably damaging	1.00
R1822:Prkdc	UTSW	16	15,577,469 (GRCm39)	missense	probably damaging	1.00
R1848:Prkdc	UTSW	16	15,625,922 (GRCm39)	missense	probably benign	0.01
R1887:Prkdc	UTSW	16	15,647,499 (GRCm39)	missense	probably benign	0.00
R1891:Prkdc	UTSW	16	15,543,300 (GRCm39)	missense	probably benign	0.02
R1921:Prkdc	UTSW	16	15,532,079 (GRCm39)	missense	possibly damaging	0.80
R1922:Prkdc	UTSW	16	15,532,130 (GRCm39)	missense	probably benign	0.00
R1929:Prkdc	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
R1939:Prkdc	UTSW	16	15,653,777 (GRCm39)	missense	possibly damaging	0.95
R2021:Prkdc	UTSW	16	15,494,873 (GRCm39)	missense	probably benign	0.00
R2033:Prkdc	UTSW	16	15,505,216 (GRCm39)	splice site	probably benign
R2056:Prkdc	UTSW	16	15,545,469 (GRCm39)	missense	probably benign	0.03
R2057:Prkdc	UTSW	16	15,545,469 (GRCm39)	missense	probably benign	0.03
R2058:Prkdc	UTSW	16	15,545,469 (GRCm39)	missense	probably benign	0.03
R2082:Prkdc	UTSW	16	15,533,827 (GRCm39)	missense	probably damaging	1.00
R2109:Prkdc	UTSW	16	15,505,254 (GRCm39)	missense	probably benign	0.01
R2124:Prkdc	UTSW	16	15,537,297 (GRCm39)	missense	probably benign	0.00
R2164:Prkdc	UTSW	16	15,523,071 (GRCm39)	missense	probably damaging	1.00
R2174:Prkdc	UTSW	16	15,552,786 (GRCm39)	missense	probably benign	0.01
R2191:Prkdc	UTSW	16	15,516,688 (GRCm39)	missense	probably damaging	1.00
R2270:Prkdc	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
R2271:Prkdc	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
R2272:Prkdc	UTSW	16	15,472,681 (GRCm39)	splice site	probably null
R2356:Prkdc	UTSW	16	15,502,068 (GRCm39)	missense	probably benign
R2852:Prkdc	UTSW	16	15,470,416 (GRCm39)	critical splice donor site	probably null
R3115:Prkdc	UTSW	16	15,482,222 (GRCm39)	missense	probably benign	0.01
R3116:Prkdc	UTSW	16	15,482,222 (GRCm39)	missense	probably benign	0.01
R3499:Prkdc	UTSW	16	15,585,889 (GRCm39)	missense	probably damaging	0.98
R3687:Prkdc	UTSW	16	15,617,831 (GRCm39)	missense	probably benign
R3834:Prkdc	UTSW	16	15,609,810 (GRCm39)	missense	probably damaging	1.00
R3835:Prkdc	UTSW	16	15,609,810 (GRCm39)	missense	probably damaging	1.00
R3961:Prkdc	UTSW	16	15,647,475 (GRCm39)	splice site	probably null
R4151:Prkdc	UTSW	16	15,634,637 (GRCm39)	missense	probably benign
R4233:Prkdc	UTSW	16	15,653,783 (GRCm39)	missense	probably benign	0.11
R4281:Prkdc	UTSW	16	15,623,963 (GRCm39)	splice site	probably null
R4296:Prkdc	UTSW	16	15,555,769 (GRCm39)	missense	probably damaging	0.99
R4344:Prkdc	UTSW	16	15,585,886 (GRCm39)	missense	probably damaging	0.98
R4424:Prkdc	UTSW	16	15,653,946 (GRCm39)	missense	probably damaging	1.00
R4424:Prkdc	UTSW	16	15,591,603 (GRCm39)	missense	probably damaging	0.98
R4497:Prkdc	UTSW	16	15,518,517 (GRCm39)	missense	probably benign	0.43
R4549:Prkdc	UTSW	16	15,554,734 (GRCm39)	missense	possibly damaging	0.89
R4594:Prkdc	UTSW	16	15,585,830 (GRCm39)	missense	possibly damaging	0.64
R4603:Prkdc	UTSW	16	15,628,688 (GRCm39)	missense	probably damaging	0.98
R4615:Prkdc	UTSW	16	15,480,938 (GRCm39)	missense	probably damaging	0.99
R4648:Prkdc	UTSW	16	15,634,638 (GRCm39)	missense	probably benign	0.05
R4662:Prkdc	UTSW	16	15,551,916 (GRCm39)	missense	probably damaging	1.00
R4680:Prkdc	UTSW	16	15,589,894 (GRCm39)	missense	probably benign	0.00
R4700:Prkdc	UTSW	16	15,519,976 (GRCm39)	missense	probably damaging	1.00
R4716:Prkdc	UTSW	16	15,628,701 (GRCm39)	missense	probably benign	0.32
R4720:Prkdc	UTSW	16	15,485,579 (GRCm39)	missense	probably benign
R4785:Prkdc	UTSW	16	15,466,840 (GRCm39)	missense	probably benign	0.21
R4822:Prkdc	UTSW	16	15,468,576 (GRCm39)	missense	possibly damaging	0.80
R4829:Prkdc	UTSW	16	15,519,939 (GRCm39)	missense	possibly damaging	0.80
R4981:Prkdc	UTSW	16	15,496,173 (GRCm39)	missense	probably damaging	1.00
R4989:Prkdc	UTSW	16	15,491,861 (GRCm39)	missense	possibly damaging	0.80
R5059:Prkdc	UTSW	16	15,655,882 (GRCm39)	missense	probably damaging	1.00
R5074:Prkdc	UTSW	16	15,589,912 (GRCm39)	missense	probably damaging	1.00
R5115:Prkdc	UTSW	16	15,608,444 (GRCm39)	missense	probably benign
R5151:Prkdc	UTSW	16	15,533,899 (GRCm39)	missense	probably damaging	1.00
R5165:Prkdc	UTSW	16	15,496,136 (GRCm39)	missense	probably damaging	1.00
R5215:Prkdc	UTSW	16	15,589,985 (GRCm39)	missense	possibly damaging	0.64
R5270:Prkdc	UTSW	16	15,552,819 (GRCm39)	missense	probably damaging	1.00
R5278:Prkdc	UTSW	16	15,532,838 (GRCm39)	missense	probably damaging	1.00
R5351:Prkdc	UTSW	16	15,649,176 (GRCm39)	missense	probably benign	0.03
R5416:Prkdc	UTSW	16	15,623,814 (GRCm39)	missense	probably damaging	1.00
R5418:Prkdc	UTSW	16	15,612,961 (GRCm39)	missense	probably benign	0.20
R5437:Prkdc	UTSW	16	15,587,739 (GRCm39)	missense	possibly damaging	0.46
R5452:Prkdc	UTSW	16	15,586,501 (GRCm39)	missense	possibly damaging	0.96
R5518:Prkdc	UTSW	16	15,496,172 (GRCm39)	missense	probably damaging	1.00
R5538:Prkdc	UTSW	16	15,469,333 (GRCm39)	missense	probably damaging	1.00
R5589:Prkdc	UTSW	16	15,524,655 (GRCm39)	missense	probably benign	0.02
R5618:Prkdc	UTSW	16	15,627,476 (GRCm39)	missense	probably damaging	1.00
R5640:Prkdc	UTSW	16	15,647,633 (GRCm39)	missense	possibly damaging	0.86
R5661:Prkdc	UTSW	16	15,628,634 (GRCm39)	missense	possibly damaging	0.81
R5771:Prkdc	UTSW	16	15,482,097 (GRCm39)	missense	probably damaging	1.00
R5772:Prkdc	UTSW	16	15,597,252 (GRCm39)	missense	possibly damaging	0.49
R5783:Prkdc	UTSW	16	15,535,665 (GRCm39)	missense	probably damaging	1.00
R5792:Prkdc	UTSW	16	15,634,616 (GRCm39)	missense	probably damaging	1.00
R5797:Prkdc	UTSW	16	15,555,698 (GRCm39)	nonsense	probably null
R5826:Prkdc	UTSW	16	15,551,962 (GRCm39)	missense	probably benign
R5883:Prkdc	UTSW	16	15,533,778 (GRCm39)	missense	probably benign
R5895:Prkdc	UTSW	16	15,570,693 (GRCm39)	nonsense	probably null
R5998:Prkdc	UTSW	16	15,601,021 (GRCm39)	missense	probably damaging	1.00
R6000:Prkdc	UTSW	16	15,647,561 (GRCm39)	missense	possibly damaging	0.86
R6120:Prkdc	UTSW	16	15,557,335 (GRCm39)	missense	probably benign	0.00
R6145:Prkdc	UTSW	16	15,589,937 (GRCm39)	missense	probably damaging	1.00
R6209:Prkdc	UTSW	16	15,608,456 (GRCm39)	missense	probably damaging	1.00
R6293:Prkdc	UTSW	16	15,605,019 (GRCm39)	missense	probably benign	0.00
R6321:Prkdc	UTSW	16	15,532,783 (GRCm39)	missense	probably benign
R6376:Prkdc	UTSW	16	15,587,749 (GRCm39)	missense	probably benign	0.06
R6387:Prkdc	UTSW	16	15,516,679 (GRCm39)	missense	probably benign	0.01
R6406:Prkdc	UTSW	16	15,535,665 (GRCm39)	missense	probably damaging	1.00
R6469:Prkdc	UTSW	16	15,612,939 (GRCm39)	missense	probably benign	0.10
R6486:Prkdc	UTSW	16	15,570,628 (GRCm39)	missense	probably damaging	0.97
R6665:Prkdc	UTSW	16	15,603,914 (GRCm39)	critical splice donor site	probably null
R6703:Prkdc	UTSW	16	15,488,392 (GRCm39)	missense	probably benign	0.00
R6774:Prkdc	UTSW	16	15,543,325 (GRCm39)	critical splice donor site	probably null
R6854:Prkdc	UTSW	16	15,469,402 (GRCm39)	missense	probably damaging	1.00
R6878:Prkdc	UTSW	16	15,594,936 (GRCm39)	missense	probably benign	0.31
R6882:Prkdc	UTSW	16	15,626,020 (GRCm39)	missense	probably benign	0.33
R6882:Prkdc	UTSW	16	15,601,127 (GRCm39)	critical splice donor site	probably null
R6949:Prkdc	UTSW	16	15,617,853 (GRCm39)	missense	probably benign
R6950:Prkdc	UTSW	16	15,633,850 (GRCm39)	missense	probably damaging	1.00
R7019:Prkdc	UTSW	16	15,587,830 (GRCm39)	missense	probably benign	0.00
R7064:Prkdc	UTSW	16	15,608,317 (GRCm39)	missense	probably benign	0.00
R7097:Prkdc	UTSW	16	15,507,207 (GRCm39)	missense	probably damaging	1.00
R7201:Prkdc	UTSW	16	15,516,667 (GRCm39)	missense	probably benign	0.12
R7235:Prkdc	UTSW	16	15,532,127 (GRCm39)	missense	probably benign
R7283:Prkdc	UTSW	16	15,535,628 (GRCm39)	missense	probably benign	0.00
R7401:Prkdc	UTSW	16	15,466,602 (GRCm39)	missense	probably damaging	1.00
R7525:Prkdc	UTSW	16	15,490,191 (GRCm39)	missense	probably damaging	1.00
R7647:Prkdc	UTSW	16	15,555,807 (GRCm39)	missense	probably damaging	1.00
R7679:Prkdc	UTSW	16	15,649,183 (GRCm39)	missense	probably damaging	1.00
R7803:Prkdc	UTSW	16	15,623,960 (GRCm39)	missense	probably null	0.05
R7858:Prkdc	UTSW	16	15,507,141 (GRCm39)	missense	probably benign	0.11
R7872:Prkdc	UTSW	16	15,532,870 (GRCm39)	missense	probably benign	0.05
R7896:Prkdc	UTSW	16	15,526,767 (GRCm39)	missense	probably damaging	0.97
R8032:Prkdc	UTSW	16	15,597,315 (GRCm39)	missense	probably benign	0.00
R8055:Prkdc	UTSW	16	15,634,749 (GRCm39)	missense	probably benign	0.09
R8153:Prkdc	UTSW	16	15,482,108 (GRCm39)	missense	probably damaging	1.00
R8281:Prkdc	UTSW	16	15,523,117 (GRCm39)	missense	probably damaging	1.00
R8302:Prkdc	UTSW	16	15,653,946 (GRCm39)	missense	probably damaging	1.00
R8322:Prkdc	UTSW	16	15,532,005 (GRCm39)	splice site	probably benign
R8401:Prkdc	UTSW	16	15,591,477 (GRCm39)	missense	possibly damaging	0.93
R8440:Prkdc	UTSW	16	15,653,022 (GRCm39)	frame shift	probably null
R8458:Prkdc	UTSW	16	15,608,540 (GRCm39)	critical splice donor site	probably null
R8472:Prkdc	UTSW	16	15,469,400 (GRCm39)	missense	probably damaging	1.00
R8478:Prkdc	UTSW	16	15,466,788 (GRCm39)	missense	probably benign	0.00
R8515:Prkdc	UTSW	16	15,482,232 (GRCm39)	missense	probably damaging	1.00
R8546:Prkdc	UTSW	16	15,480,899 (GRCm39)	missense	probably damaging	1.00
R8678:Prkdc	UTSW	16	15,526,796 (GRCm39)	critical splice donor site	probably null
R8739:Prkdc	UTSW	16	15,626,068 (GRCm39)	missense	probably benign	0.01
R8836:Prkdc	UTSW	16	15,545,523 (GRCm39)	missense	probably damaging	1.00
R8904:Prkdc	UTSW	16	15,545,590 (GRCm39)	missense	probably benign	0.04
R8952:Prkdc	UTSW	16	15,491,624 (GRCm39)	intron	probably benign
R8971:Prkdc	UTSW	16	15,493,229 (GRCm39)	missense	probably null	0.99
R8974:Prkdc	UTSW	16	15,617,726 (GRCm39)	splice site	probably null
R9052:Prkdc	UTSW	16	15,508,160 (GRCm39)	missense	probably benign	0.05
R9069:Prkdc	UTSW	16	15,653,091 (GRCm39)	nonsense	probably null
R9200:Prkdc	UTSW	16	15,523,153 (GRCm39)	missense	probably damaging	1.00
R9235:Prkdc	UTSW	16	15,651,751 (GRCm39)	missense	probably damaging	1.00
R9278:Prkdc	UTSW	16	15,634,523 (GRCm39)	critical splice donor site	probably null
R9309:Prkdc	UTSW	16	15,526,792 (GRCm39)	nonsense	probably null
R9386:Prkdc	UTSW	16	15,496,136 (GRCm39)	missense	probably damaging	0.99
R9452:Prkdc	UTSW	16	15,485,465 (GRCm39)	missense	possibly damaging	0.90
R9500:Prkdc	UTSW	16	15,657,079 (GRCm39)	missense	possibly damaging	0.76
R9608:Prkdc	UTSW	16	15,548,335 (GRCm39)	missense	probably damaging	1.00
R9608:Prkdc	UTSW	16	15,548,334 (GRCm39)	missense	possibly damaging	0.96
R9636:Prkdc	UTSW	16	15,548,341 (GRCm39)	missense	probably benign	0.19
R9656:Prkdc	UTSW	16	15,617,818 (GRCm39)	missense	probably benign	0.00
R9674:Prkdc	UTSW	16	15,533,819 (GRCm39)	missense	probably damaging	0.98
R9760:Prkdc	UTSW	16	15,657,044 (GRCm39)	nonsense	probably null
X0023:Prkdc	UTSW	16	15,558,142 (GRCm39)	missense	probably benign
Z1176:Prkdc	UTSW	16	15,505,286 (GRCm39)	nonsense	probably null

Predicted Primers

PCR Primer
(F):5'- CTGCCTATTATTACAAGTCGGTTG -3'
(R):5'- TGGCCATTTTGAAACATGGG -3'

Sequencing Primer
(F):5'- TAAGTTGCCAACACCCAG -3'
(R):5'- GGCCTGTGATCTATCCAACATAGG -3'

Posted On

2021-03-08