Incidental Mutation 'R8750:Dpyd'
ID 663752
Institutional Source Beutler Lab
Gene Symbol Dpyd
Ensembl Gene ENSMUSG00000033308
Gene Name dihydropyrimidine dehydrogenase
Synonyms E330028L06Rik, DPD
MMRRC Submission 068593-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8750 (G1)
Quality Score 225.009
Status Not validated
Chromosome 3
Chromosomal Location 118355778-119226573 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 118935585 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Serine to Leucine at position 670 (S670L)
Ref Sequence ENSEMBL: ENSMUSP00000039429 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000039177]
AlphaFold Q8CHR6
Predicted Effect probably damaging
Transcript: ENSMUST00000039177
AA Change: S670L

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)
SMART Domains Protein: ENSMUSP00000039429
Gene: ENSMUSG00000033308
AA Change: S670L

DomainStartEndE-ValueType
Pfam:Fer4_20 55 168 4.6e-35 PFAM
Pfam:Pyr_redox_2 188 499 1.5e-15 PFAM
Pfam:NAD_binding_8 193 249 5.5e-8 PFAM
Pfam:DHO_dh 532 838 8.1e-36 PFAM
Pfam:Dus 617 822 7.5e-8 PFAM
Pfam:Fer4_10 945 997 7.4e-9 PFAM
Pfam:Fer4_21 946 1004 1.3e-26 PFAM
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.6%
  • 20x: 98.6%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] The protein encoded by this gene is a pyrimidine catabolic enzyme and the initial and rate-limiting factor in the pathway of uracil and thymidine catabolism. Mutations in this gene result in dihydropyrimidine dehydrogenase deficiency, an error in pyrimidine metabolism associated with thymine-uraciluria and an increased risk of toxicity in cancer patients receiving 5-fluorouracil chemotherapy. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, May 2009]
Allele List at MGI

All alleles(1) : Targeted, other(1)

Other mutations in this stock
Total: 72 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Adam21 G A 12: 81,607,247 (GRCm39) Q172* probably null Het
Ankib1 A G 5: 3,752,890 (GRCm39) probably null Het
Avpr1b C T 1: 131,527,674 (GRCm39) R66C probably damaging Het
Bbs7 A T 3: 36,661,744 (GRCm39) C152S possibly damaging Het
Cacna1a C A 8: 85,285,784 (GRCm39) R810S probably damaging Het
Ccdc17 G A 4: 116,457,129 (GRCm39) A538T possibly damaging Het
Cd93 T C 2: 148,285,080 (GRCm39) M89V probably benign Het
Clec11a G T 7: 43,955,323 (GRCm39) D157E probably benign Het
Crtam A C 9: 40,895,641 (GRCm39) D228E probably benign Het
Cyp2a4 A G 7: 26,012,209 (GRCm39) I331V probably benign Het
Cysltr2 T C 14: 73,267,078 (GRCm39) I211V probably benign Het
Dcaf13 T C 15: 38,982,836 (GRCm39) S123P probably damaging Het
Dctn1 T G 6: 83,160,108 (GRCm39) V116G possibly damaging Het
Dmrt3 G A 19: 25,588,550 (GRCm39) A130T probably benign Het
Dnah1 A T 14: 31,026,924 (GRCm39) L700Q probably benign Het
Dnajc1 T C 2: 18,313,645 (GRCm39) T159A probably damaging Het
Dsg2 A T 18: 20,708,069 (GRCm39) I57F possibly damaging Het
Dzip3 A C 16: 48,801,338 (GRCm39) I62S probably damaging Het
Ern1 A T 11: 106,312,776 (GRCm39) S202T probably damaging Het
Foxm1 T A 6: 128,350,206 (GRCm39) C517* probably null Het
Galnt16 G A 12: 80,644,879 (GRCm39) V501I probably benign Het
Gmip A T 8: 70,273,134 (GRCm39) R840S probably benign Het
Gna14 A C 19: 16,585,458 (GRCm39) I279L Het
Irak2 T C 6: 113,663,783 (GRCm39) M444T probably benign Het
Itfg2 T C 6: 128,389,755 (GRCm39) probably null Het
Kif5a T A 10: 127,083,909 (GRCm39) H94L probably damaging Het
Kmt2e A G 5: 23,698,215 (GRCm39) T636A probably benign Het
Krba1 T C 6: 48,382,212 (GRCm39) S152P probably damaging Het
Mad1l1 T A 5: 140,300,822 (GRCm39) M25L probably benign Het
Map7d1 T C 4: 126,132,315 (GRCm39) N286D probably benign Het
Mfrp A G 9: 44,014,802 (GRCm39) K280E probably benign Het
Mlh3 G T 12: 85,308,488 (GRCm39) L1100I probably damaging Het
Mrgprx2 T C 7: 48,131,778 (GRCm39) I347V probably benign Het
Mtnr1b A T 9: 15,785,724 (GRCm39) C11* probably null Het
Mx1 T C 16: 97,252,917 (GRCm39) E401G probably damaging Het
Mypn T C 10: 63,003,036 (GRCm39) D367G probably benign Het
Nherf2 T C 17: 24,861,233 (GRCm39) I176V probably damaging Het
Or52a33 T A 7: 103,289,059 (GRCm39) D96V probably damaging Het
Or6c5b T C 10: 129,245,649 (GRCm39) V138A probably benign Het
Or8s8 T G 15: 98,354,929 (GRCm39) I246R probably damaging Het
Or9g19 T A 2: 85,600,307 (GRCm39) L54H probably damaging Het
Plcb1 T G 2: 135,177,369 (GRCm39) M567R probably damaging Het
Plekhd1 A T 12: 80,752,861 (GRCm39) D109V probably damaging Het
Polr2e A G 10: 79,875,424 (GRCm39) I17T probably benign Het
Pot1b T C 17: 55,973,537 (GRCm39) D421G probably benign Het
Prkar1b A T 5: 139,036,451 (GRCm39) W224R probably damaging Het
Psmd1 C A 1: 86,016,585 (GRCm39) R490S probably damaging Het
Pwp2 A G 10: 78,013,659 (GRCm39) W521R probably damaging Het
Rhpn2 C A 7: 35,075,680 (GRCm39) Q286K probably benign Het
Rnf103 T A 6: 71,486,602 (GRCm39) M411K probably benign Het
Scpep1 A C 11: 88,835,298 (GRCm39) V125G probably damaging Het
Serpinb9c C T 13: 33,335,793 (GRCm39) V248M probably null Het
Snx15 T A 19: 6,170,593 (GRCm39) N282I probably benign Het
Spaca3 A T 11: 80,758,514 (GRCm39) D159V probably benign Het
Srrm4 A G 5: 116,605,567 (GRCm39) V230A unknown Het
Ssu2 T A 6: 112,359,312 (GRCm39) I103F possibly damaging Het
Strip2 T A 6: 29,931,815 (GRCm39) F453I probably damaging Het
Tac2 C T 10: 127,564,319 (GRCm39) P72L possibly damaging Het
Tiparp T G 3: 65,460,125 (GRCm39) S473R probably damaging Het
Tmem135 C T 7: 88,956,456 (GRCm39) R53Q probably damaging Het
Tmem200b T A 4: 131,649,406 (GRCm39) F109I probably damaging Het
Tmem245 A T 4: 56,886,141 (GRCm39) I825N probably damaging Het
Tmem63c G T 12: 87,103,306 (GRCm39) V27F probably damaging Het
Tshz1 T C 18: 84,033,162 (GRCm39) I415M probably damaging Het
Tut4 C G 4: 108,407,940 (GRCm39) A1403G probably damaging Het
Wfdc2 T A 2: 164,407,818 (GRCm39) N162K probably damaging Het
Zeb2 T A 2: 44,887,939 (GRCm39) I373F probably damaging Het
Zfp27 T C 7: 29,594,804 (GRCm39) N387S possibly damaging Het
Zfp760 A T 17: 21,941,356 (GRCm39) H177L possibly damaging Het
Zg16 A G 7: 126,649,518 (GRCm39) S148P possibly damaging Het
Zic2 A G 14: 122,714,129 (GRCm39) N348D probably benign Het
Zswim4 A T 8: 84,939,313 (GRCm39) D856E possibly damaging Het
Other mutations in Dpyd
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL00418:Dpyd APN 3 118,737,891 (GRCm39) missense probably damaging 1.00
IGL00508:Dpyd APN 3 118,858,636 (GRCm39) missense probably benign 0.06
IGL02113:Dpyd APN 3 118,792,868 (GRCm39) missense probably benign 0.06
IGL02177:Dpyd APN 3 118,858,559 (GRCm39) missense possibly damaging 0.76
IGL03001:Dpyd APN 3 118,710,891 (GRCm39) missense probably benign 0.07
IGL03106:Dpyd APN 3 118,988,783 (GRCm39) missense probably benign 0.03
IGL03399:Dpyd APN 3 119,108,426 (GRCm39) missense probably damaging 0.98
F5770:Dpyd UTSW 3 118,690,775 (GRCm39) nonsense probably null
F6893:Dpyd UTSW 3 118,597,783 (GRCm39) critical splice donor site probably null
R0014:Dpyd UTSW 3 118,935,584 (GRCm39) missense probably damaging 1.00
R0081:Dpyd UTSW 3 118,737,904 (GRCm39) missense probably benign 0.00
R0267:Dpyd UTSW 3 118,710,921 (GRCm39) missense probably benign
R0349:Dpyd UTSW 3 118,710,748 (GRCm39) nonsense probably null
R0387:Dpyd UTSW 3 119,220,875 (GRCm39) missense probably benign 0.21
R0523:Dpyd UTSW 3 118,692,852 (GRCm39) missense probably benign
R0555:Dpyd UTSW 3 119,225,191 (GRCm39) missense probably damaging 1.00
R0652:Dpyd UTSW 3 119,220,924 (GRCm39) missense probably damaging 1.00
R0741:Dpyd UTSW 3 118,468,154 (GRCm39) missense possibly damaging 0.79
R1313:Dpyd UTSW 3 118,692,810 (GRCm39) splice site probably benign
R1554:Dpyd UTSW 3 118,858,695 (GRCm39) splice site probably null
R1610:Dpyd UTSW 3 118,858,655 (GRCm39) missense probably benign
R1710:Dpyd UTSW 3 118,404,092 (GRCm39) critical splice acceptor site probably null
R1861:Dpyd UTSW 3 118,710,780 (GRCm39) missense probably damaging 1.00
R2103:Dpyd UTSW 3 118,858,601 (GRCm39) missense probably benign 0.02
R2130:Dpyd UTSW 3 118,468,217 (GRCm39) missense probably benign
R2131:Dpyd UTSW 3 118,468,217 (GRCm39) missense probably benign
R2882:Dpyd UTSW 3 118,858,679 (GRCm39) missense probably damaging 0.99
R3771:Dpyd UTSW 3 119,205,927 (GRCm39) critical splice donor site probably null
R3978:Dpyd UTSW 3 118,690,738 (GRCm39) critical splice acceptor site probably benign
R3978:Dpyd UTSW 3 118,690,737 (GRCm39) critical splice acceptor site probably benign
R4030:Dpyd UTSW 3 118,690,815 (GRCm39) missense probably benign 0.03
R4065:Dpyd UTSW 3 118,690,738 (GRCm39) critical splice acceptor site probably benign
R4066:Dpyd UTSW 3 118,690,738 (GRCm39) critical splice acceptor site probably benign
R4234:Dpyd UTSW 3 119,225,233 (GRCm39) missense probably damaging 1.00
R4502:Dpyd UTSW 3 118,591,186 (GRCm39) missense probably damaging 1.00
R4638:Dpyd UTSW 3 119,059,726 (GRCm39) missense probably benign 0.03
R4980:Dpyd UTSW 3 118,710,767 (GRCm39) missense probably damaging 0.99
R5262:Dpyd UTSW 3 118,591,071 (GRCm39) nonsense probably null
R5348:Dpyd UTSW 3 118,575,592 (GRCm39) missense probably benign
R5587:Dpyd UTSW 3 118,858,600 (GRCm39) missense probably damaging 1.00
R5611:Dpyd UTSW 3 118,987,942 (GRCm39) missense probably benign
R5665:Dpyd UTSW 3 118,710,741 (GRCm39) missense probably damaging 1.00
R5716:Dpyd UTSW 3 118,692,828 (GRCm39) missense probably damaging 1.00
R5786:Dpyd UTSW 3 119,220,886 (GRCm39) missense probably damaging 0.97
R6046:Dpyd UTSW 3 119,225,224 (GRCm39) missense probably benign 0.01
R6404:Dpyd UTSW 3 119,059,606 (GRCm39) missense probably benign 0.02
R6703:Dpyd UTSW 3 118,690,849 (GRCm39) splice site probably null
R7037:Dpyd UTSW 3 118,692,938 (GRCm39) missense probably benign 0.00
R7215:Dpyd UTSW 3 119,059,681 (GRCm39) missense probably benign 0.11
R7301:Dpyd UTSW 3 118,692,933 (GRCm39) missense possibly damaging 0.90
R7336:Dpyd UTSW 3 118,858,570 (GRCm39) missense probably damaging 1.00
R7714:Dpyd UTSW 3 118,597,780 (GRCm39) missense probably benign 0.01
R8238:Dpyd UTSW 3 118,988,842 (GRCm39) splice site probably null
R8306:Dpyd UTSW 3 119,205,822 (GRCm39) missense probably benign
R8315:Dpyd UTSW 3 119,108,534 (GRCm39) missense probably benign 0.09
R8321:Dpyd UTSW 3 118,575,573 (GRCm39) missense possibly damaging 0.84
R8342:Dpyd UTSW 3 119,108,452 (GRCm39) missense possibly damaging 0.60
R8735:Dpyd UTSW 3 118,935,565 (GRCm39) missense possibly damaging 0.74
R8874:Dpyd UTSW 3 118,792,981 (GRCm39) missense probably damaging 1.00
R8910:Dpyd UTSW 3 118,404,167 (GRCm39) missense probably benign 0.17
R8973:Dpyd UTSW 3 119,108,582 (GRCm39) critical splice donor site probably null
R9070:Dpyd UTSW 3 118,792,892 (GRCm39) missense probably damaging 0.98
R9132:Dpyd UTSW 3 118,710,897 (GRCm39) missense probably damaging 1.00
R9198:Dpyd UTSW 3 118,553,303 (GRCm39) critical splice acceptor site probably null
R9260:Dpyd UTSW 3 119,108,447 (GRCm39) missense possibly damaging 0.95
R9307:Dpyd UTSW 3 119,108,560 (GRCm39) missense probably benign
V7581:Dpyd UTSW 3 118,690,775 (GRCm39) nonsense probably null
V7582:Dpyd UTSW 3 118,690,775 (GRCm39) nonsense probably null
V7583:Dpyd UTSW 3 118,690,775 (GRCm39) nonsense probably null
Predicted Primers PCR Primer
(F):5'- CAAGAGCAGTTTCTACAGAAGTCG -3'
(R):5'- TCTTCAGCCAGTCATCAGATCC -3'

Sequencing Primer
(F):5'- AGACAAAGTGTGGTCCCTTATG -3'
(R):5'- GTCATCAGATCCACACATCTCCTCG -3'
Posted On 2021-03-08