Mutagenetix > Incidental Mutation

Incidental Mutation 'R8751:Or8b55'

663852

Institutional Source

Beutler Lab

Gene Symbol

Or8b55

Ensembl Gene

ENSMUSG00000043911

Gene Name

olfactory receptor family 8 subfamily B member 55

Synonyms

MOR161-3, Olfr922, GA_x6K02T2PVTD-32518237-32519172

MMRRC Submission

068594-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.056) question?

Stock #

R8751 (G1)

Quality Score

225.009

Status

Not validated

Chromosome

Chromosomal Location

38726704-38727835 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to A at 38727335 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Cysteine to Serine at position 179 (C179S)

Ref Sequence

ENSEMBL: ENSMUSP00000149057 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000051004] [ENSMUST00000213164]

AlphaFold

Q8VG50

Predicted Effect

probably damaging
Transcript: ENSMUST00000051004
AA Change: C179S

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

SMART Domains

Protein: ENSMUSP00000057086
Gene: ENSMUSG00000043911
AA Change: C179S

Domain	Start	End	E-Value	Type
Pfam:7tm_4	31	308	9.3e-52	PFAM
Pfam:7tm_1	41	290	3.4e-26	PFAM

Predicted Effect

probably damaging
Transcript: ENSMUST00000213164
AA Change: C179S

PolyPhen 2 Score 0.993 (Sensitivity: 0.70; Specificity: 0.97)

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.1%
20x: 96.2%

Validation Efficiency

MGI Phenotype

FUNCTION: Olfactory receptors interact with odorant molecules in the nose, to initiate a neuronal response that triggers the perception of a smell. The olfactory receptor proteins are members of a large family of G-protein-coupled receptors (GPCR) arising from single coding-exon genes. Olfactory receptors share a 7-transmembrane domain structure with many neurotransmitter and hormone receptors and are responsible for the recognition and G protein-mediated transduction of odorant signals. The olfactory receptor gene family is the largest in the genome. The nomenclature assigned to the olfactory receptor genes and proteins for this organism is independent of other organisms. [provided by RefSeq, Jul 2008]

Allele List at MGI

Other mutations in this stock

Total: 73 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Adamts12	T	A	15: 11,215,813 (GRCm39)	I278N	probably damaging	Het
Adcy9	A	G	16: 4,129,492 (GRCm39)	W702R	probably damaging	Het
Adgrf5	G	A	17: 43,748,574 (GRCm39)	V468I	possibly damaging	Het
Ahnak	A	C	19: 8,987,509 (GRCm39)	K2931T	probably damaging	Het
Ank3	C	T	10: 69,761,849 (GRCm39)		probably benign	Het
Birc6	G	A	17: 74,955,135 (GRCm39)	V3480I	probably damaging	Het
Bpifa5	A	T	2: 154,007,432 (GRCm39)	I125L	probably benign	Het
Catsperg2	T	C	7: 29,404,744 (GRCm39)	D773G	possibly damaging	Het
Ccm2l	A	T	2: 152,909,695 (GRCm39)	I16F	probably benign	Het
Cep72	G	A	13: 74,198,303 (GRCm39)	S359F	possibly damaging	Het
Col1a1	A	G	11: 94,838,100 (GRCm39)	N844S	unknown	Het
Col7a1	C	T	9: 108,796,730 (GRCm39)	P1623S	possibly damaging	Het
Crybg1	T	C	10: 43,880,838 (GRCm39)	K117E	probably benign	Het
Csmd3	A	G	15: 47,845,402 (GRCm39)	C54R		Het
Dlg1	A	G	16: 31,600,648 (GRCm39)	T211A	probably benign	Het
Emc1	C	A	4: 139,097,279 (GRCm39)	H724N	possibly damaging	Het
Epg5	A	C	18: 78,008,223 (GRCm39)	N784H	probably benign	Het
Epg5	T	A	18: 78,008,225 (GRCm39)	N784K	probably benign	Het
Epg5	A	T	18: 78,008,224 (GRCm39)	N784I	possibly damaging	Het
Erc2	A	G	14: 27,802,145 (GRCm39)	E771G	possibly damaging	Het
Exo1	T	C	1: 175,719,678 (GRCm39)	V241A	probably benign	Het
Fat4	A	G	3: 38,946,002 (GRCm39)	T1632A	probably benign	Het
Fbxo21	T	A	5: 118,140,127 (GRCm39)	M529K	probably damaging	Het
Fhad1	T	C	4: 141,646,134 (GRCm39)	E276G	probably benign	Het
Frem1	G	A	4: 82,889,015 (GRCm39)	T1069I	probably damaging	Het
Gapvd1	A	C	2: 34,568,078 (GRCm39)	F1429V	probably damaging	Het
Gbp9	T	C	5: 105,229,117 (GRCm39)	E510G	possibly damaging	Het
Gm17087	A	T	17: 8,785,510 (GRCm39)	H64Q	probably damaging	Het
Gm19965	A	T	1: 116,749,867 (GRCm39)	Y516F	unknown	Het
Hdac5	A	T	11: 102,109,280 (GRCm39)	I38N	probably benign	Het
Hectd4	T	A	5: 121,501,838 (GRCm39)	C4190*	probably null	Het
Helb	A	T	10: 119,925,412 (GRCm39)	D988E	probably benign	Het
Herc6	C	T	6: 57,639,359 (GRCm39)	S909L	probably damaging	Het
Ice1	A	T	13: 70,751,010 (GRCm39)	V1692E	probably damaging	Het
Ino80	A	G	2: 119,237,389 (GRCm39)	Y1107H	probably benign	Het
Kif9	A	T	9: 110,330,724 (GRCm39)	Y350F	probably benign	Het
Lct	T	A	1: 128,221,534 (GRCm39)	T1570S	probably benign	Het
Lias	T	A	5: 65,557,193 (GRCm39)	N203K	probably benign	Het
Lrrtm4	A	G	6: 79,999,092 (GRCm39)	N168S	probably damaging	Het
Ltf	A	T	9: 110,860,192 (GRCm39)	K538*	probably null	Het
Lysmd4	A	G	7: 66,875,787 (GRCm39)	D150G	probably benign	Het
Magi2	A	G	5: 20,739,462 (GRCm39)	D572G	probably benign	Het
Meiob	T	C	17: 25,047,008 (GRCm39)		probably null	Het
Ncor2	T	C	5: 125,115,964 (GRCm39)	Y130C		Het
Ntmt2	T	A	1: 163,544,738 (GRCm39)	T82S	probably benign	Het
Ofcc1	A	G	13: 40,409,072 (GRCm39)	S118P	probably benign	Het
Or10g3	A	G	14: 52,610,420 (GRCm39)	F30S	probably benign	Het
Or2t45	A	G	11: 58,669,213 (GRCm39)	T87A	probably benign	Het
Parp14	A	T	16: 35,677,181 (GRCm39)	M929K	probably benign	Het
Pcdh8	T	C	14: 80,006,229 (GRCm39)	E778G	probably benign	Het
Pgls	T	C	8: 72,047,838 (GRCm39)	V211A	probably benign	Het
Pkd2	T	A	5: 104,637,151 (GRCm39)	M588K	probably damaging	Het
Pms1	T	C	1: 53,231,269 (GRCm39)	N860S	probably benign	Het
Psg19	C	T	7: 18,530,888 (GRCm39)	V89M	probably benign	Het
Reln	T	C	5: 22,147,672 (GRCm39)	H2426R	probably benign	Het
Ripor2	T	A	13: 24,885,050 (GRCm39)	N428K	possibly damaging	Het
Slc12a4	C	T	8: 106,676,285 (GRCm39)		probably null	Het
Slc25a3	T	C	10: 90,952,960 (GRCm39)	I314V	probably benign	Het
Slc29a1	C	A	17: 45,900,688 (GRCm39)	V125F	probably benign	Het
Slc9a5	T	A	8: 106,085,981 (GRCm39)	C583S	probably damaging	Het
Slco2b1	G	A	7: 99,309,259 (GRCm39)	Q691*	probably null	Het
Smg7	T	C	1: 152,719,129 (GRCm39)	D874G	probably damaging	Het
Spef2	T	A	15: 9,729,723 (GRCm39)	K132*	probably null	Het
Tap1	A	G	17: 34,412,133 (GRCm39)	K446R	probably benign	Het
Tcam1	A	T	11: 106,176,443 (GRCm39)	T390S	possibly damaging	Het
Tnik	A	G	3: 28,666,057 (GRCm39)	N687D	probably damaging	Het
Trim42	T	C	9: 97,251,852 (GRCm39)	R16G	possibly damaging	Het
Vcp	A	C	4: 42,984,658 (GRCm39)	L411W	probably damaging	Het
Vma21-ps	C	A	4: 52,496,973 (GRCm39)	G91V	probably damaging	Het
Vmn1r23	T	C	6: 57,903,452 (GRCm39)	T109A	probably benign	Het
Vmn2r67	C	T	7: 84,801,450 (GRCm39)	C162Y	probably benign	Het
Vmn2r-ps117	A	G	17: 19,044,021 (GRCm39)	T366A	probably benign	Het
Zfp804a	A	G	2: 82,066,190 (GRCm39)	K54E	probably damaging	Het

Other mutations in Or8b55

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL01631:Or8b55	APN	9	38,727,335 (GRCm39)	missense	probably damaging	0.99
IGL02445:Or8b55	APN	9	38,726,901 (GRCm39)	missense	possibly damaging	0.57
R1758:Or8b55	UTSW	9	38,726,871 (GRCm39)	missense	probably benign
R1759:Or8b55	UTSW	9	38,727,194 (GRCm39)	missense	probably damaging	1.00
R1809:Or8b55	UTSW	9	38,727,443 (GRCm39)	missense	probably benign
R1938:Or8b55	UTSW	9	38,727,146 (GRCm39)	missense	probably benign	0.33
R2177:Or8b55	UTSW	9	38,727,482 (GRCm39)	missense	possibly damaging	0.82
R3438:Or8b55	UTSW	9	38,727,512 (GRCm39)	missense	probably damaging	0.99
R3815:Or8b55	UTSW	9	38,727,722 (GRCm39)	missense	possibly damaging	0.47
R3816:Or8b55	UTSW	9	38,727,722 (GRCm39)	missense	possibly damaging	0.47
R3817:Or8b55	UTSW	9	38,727,722 (GRCm39)	missense	possibly damaging	0.47
R3819:Or8b55	UTSW	9	38,727,722 (GRCm39)	missense	possibly damaging	0.47
R3859:Or8b55	UTSW	9	38,727,443 (GRCm39)	missense	probably benign
R4768:Or8b55	UTSW	9	38,727,245 (GRCm39)	missense	probably damaging	1.00
R5082:Or8b55	UTSW	9	38,727,441 (GRCm39)	missense	possibly damaging	0.70
R5659:Or8b55	UTSW	9	38,727,072 (GRCm39)	missense	probably benign	0.01
R5813:Or8b55	UTSW	9	38,726,952 (GRCm39)	missense	probably benign	0.00
R6226:Or8b55	UTSW	9	38,727,666 (GRCm39)	missense	probably damaging	0.99
R7240:Or8b55	UTSW	9	38,727,009 (GRCm39)	missense	probably benign	0.01
R7966:Or8b55	UTSW	9	38,727,536 (GRCm39)	missense	probably benign	0.11
R8868:Or8b55	UTSW	9	38,727,285 (GRCm39)	missense	probably damaging	1.00
R9121:Or8b55	UTSW	9	38,726,976 (GRCm39)	missense	probably damaging	0.98

Predicted Primers

PCR Primer
(F):5'- ACTGCTTCTTTGTCAGTGCAG -3'
(R):5'- GCCTTAGATCTGCCTTCAGTGG -3'

Sequencing Primer
(F):5'- ACAGTGATGGCATATGATCGCTATG -3'
(R):5'- AGATCTGCCTTCAGTGGATCGG -3'

Posted On

2021-03-08