Mutagenetix > Incidental Mutation

Incidental Mutation 'R8752:Lcn11'

663893

Institutional Source

Beutler Lab

Gene Symbol

Lcn11

Ensembl Gene

ENSMUSG00000069080

Gene Name

lipocalin 11

Synonyms

MMRRC Submission

068595-MU

Accession Numbers

Essential gene?

Probably non essential (E-score: 0.066) question?

Stock #

R8752 (G1)

Quality Score

225.009

Status

Validated

Chromosome

Chromosomal Location

25667029-25670291 bp(+) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 25668138 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Tyrosine to Histidine at position 99 (Y99H)

Ref Sequence

ENSEMBL: ENSMUSP00000088822 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000091278] [ENSMUST00000211245]

AlphaFold

A2BHR2

Predicted Effect

probably damaging
Transcript: ENSMUST00000091278
AA Change: Y99H

PolyPhen 2 Score 1.000 (Sensitivity: 0.00; Specificity: 1.00)

SMART Domains

Protein: ENSMUSP00000088822
Gene: ENSMUSG00000069080
AA Change: Y99H

Domain	Start	End	E-Value	Type
signal peptide	1	24	N/A	INTRINSIC
Pfam:Lipocalin	34	172	7.5e-23	PFAM

Predicted Effect

probably benign
Transcript: ENSMUST00000211245

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.6%
20x: 98.8%

Validation Efficiency

100% (55/55)

Allele List at MGI

Other mutations in this stock

Total: 59 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
1700012B07Rik	T	C	11: 109,704,396 (GRCm39)	K82R	probably damaging	Het
Acad8	A	T	9: 26,896,853 (GRCm39)	M202K	probably damaging	Het
Adam29	A	T	8: 56,325,328 (GRCm39)	C375*	probably null	Het
Adat2	A	T	10: 13,432,604 (GRCm39)	E35D	probably benign	Het
Afm	A	C	5: 90,700,424 (GRCm39)	E600D	probably benign	Het
Ahnak	T	A	19: 8,992,901 (GRCm39)	D4728E	probably damaging	Het
Ak7	AAGGAG	AAG	12: 105,713,476 (GRCm39)		probably benign	Het
Ankrd28	C	A	14: 31,477,699 (GRCm39)		probably benign	Het
Ankrd31	A	T	13: 96,916,879 (GRCm39)	H131L	probably damaging	Het
Ano5	T	C	7: 51,196,617 (GRCm39)	F183L	probably damaging	Het
Asah1	G	A	8: 41,813,314 (GRCm39)	S33L	possibly damaging	Het
Catsperg2	T	C	7: 29,404,744 (GRCm39)	D773G	possibly damaging	Het
Ccdc47	A	G	11: 106,095,818 (GRCm39)	Y293H	probably damaging	Het
Cd302	A	G	2: 60,102,529 (GRCm39)	F30S	probably damaging	Het
Ces1c	C	G	8: 93,846,964 (GRCm39)	A243P	probably damaging	Het
Deptor	A	T	15: 55,044,280 (GRCm39)	T149S	probably benign	Het
Dnah14	G	A	1: 181,455,581 (GRCm39)	R902H	probably benign	Het
Dnah5	A	G	15: 28,290,365 (GRCm39)	I1252V	probably benign	Het
Dnah7c	A	G	1: 46,711,701 (GRCm39)	I2643V	probably benign	Het
Dnajc4	C	T	19: 6,966,801 (GRCm39)	V177I	probably benign	Het
Efhc1	A	T	1: 21,059,692 (GRCm39)	N581Y	probably benign	Het
Espl1	A	G	15: 102,214,759 (GRCm39)	T767A	probably damaging	Het
Etv6	A	G	6: 134,243,391 (GRCm39)	E382G	probably benign	Het
Foxd4	A	T	19: 24,878,094 (GRCm39)	D35E	probably damaging	Het
Gata2	T	C	6: 88,177,513 (GRCm39)	V181A	possibly damaging	Het
Gm5114	A	T	7: 39,057,927 (GRCm39)	M564K	probably damaging	Het
Gpr45	A	T	1: 43,071,842 (GRCm39)	I162F	possibly damaging	Het
Hic1	A	G	11: 75,060,206 (GRCm39)	F47S	probably benign	Het
Hsf1	C	A	15: 76,384,344 (GRCm39)	S417*	probably null	Het
Id4	A	T	13: 48,415,065 (GRCm39)	H31L	possibly damaging	Het
Il12rb2	T	C	6: 67,328,265 (GRCm39)	S322G	probably damaging	Het
Mipol1	G	A	12: 57,372,367 (GRCm39)	R142Q	probably damaging	Het
Mpp2	A	G	11: 101,976,129 (GRCm39)	S10P	probably benign	Het
Muc15	A	T	2: 110,561,758 (GRCm39)	N65Y	possibly damaging	Het
Nav3	T	C	10: 109,596,165 (GRCm39)		probably benign	Het
Ndst3	C	T	3: 123,342,684 (GRCm39)	R709Q	probably damaging	Het
Nek11	G	T	9: 105,225,207 (GRCm39)	Q102K	probably benign	Het
Nhsl1	A	G	10: 18,407,113 (GRCm39)	N1416D	probably benign	Het
Or13p3	A	C	4: 118,567,083 (GRCm39)	T160P	probably damaging	Het
Or2v1	T	A	11: 49,025,505 (GRCm39)	V162E	possibly damaging	Het
Or4c111	T	C	2: 88,844,231 (GRCm39)	Y59C	probably damaging	Het
Or5p72	T	C	7: 108,022,480 (GRCm39)	I234T	probably benign	Het
Or5w20	T	C	2: 87,726,591 (GRCm39)	I16T	possibly damaging	Het
Parp4	G	T	14: 56,886,073 (GRCm39)	E1717D	unknown	Het
Pla2g4d	A	T	2: 120,099,248 (GRCm39)		probably null	Het
Pramel52-ps	A	T	5: 94,529,354 (GRCm39)	R41S	possibly damaging	Het
Psmc2	A	G	5: 22,001,533 (GRCm39)	I107V	probably benign	Het
Rhod	G	T	19: 4,476,121 (GRCm39)	T210N	probably damaging	Het
Setx	A	T	2: 29,048,992 (GRCm39)	D2006V	probably damaging	Het
Sfpq	T	A	4: 126,919,969 (GRCm39)	M541K	possibly damaging	Het
Sorbs1	C	T	19: 40,349,872 (GRCm39)		probably null	Het
Sv2b	C	A	7: 74,855,842 (GRCm39)	M149I	possibly damaging	Het
Svil	T	A	18: 5,060,366 (GRCm39)		probably benign	Het
Vmn1r216	G	T	13: 23,283,880 (GRCm39)	V188F	probably damaging	Het
Vmn2r27	A	G	6: 124,201,018 (GRCm39)	F313S	probably benign	Het
Vmn2r44	A	G	7: 8,370,805 (GRCm39)	F747S	probably damaging	Het
Vmn2r95	T	C	17: 18,661,738 (GRCm39)	S495P	probably damaging	Het
Xpo5	C	T	17: 46,547,838 (GRCm39)		probably benign	Het
Zscan20	A	C	4: 128,479,480 (GRCm39)	C1004G	probably damaging	Het

Other mutations in Lcn11

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
IGL02904:Lcn11	APN	2	25,669,278 (GRCm39)	missense	probably null	0.00
R0220:Lcn11	UTSW	2	25,667,843 (GRCm39)	missense	probably benign	0.02
R0607:Lcn11	UTSW	2	25,669,305 (GRCm39)	missense	probably benign	0.00
R1104:Lcn11	UTSW	2	25,669,115 (GRCm39)	unclassified	probably benign
R2021:Lcn11	UTSW	2	25,668,097 (GRCm39)	missense	probably benign	0.34
R2331:Lcn11	UTSW	2	25,670,188 (GRCm39)	missense	possibly damaging	0.79
R4295:Lcn11	UTSW	2	25,668,111 (GRCm39)	missense	possibly damaging	0.83
R6109:Lcn11	UTSW	2	25,669,308 (GRCm39)	missense	possibly damaging	0.78
R6356:Lcn11	UTSW	2	25,668,132 (GRCm39)	nonsense	probably null
R6502:Lcn11	UTSW	2	25,669,103 (GRCm39)	missense	probably benign	0.08
R7754:Lcn11	UTSW	2	25,667,830 (GRCm39)	missense	probably benign	0.06
R7920:Lcn11	UTSW	2	25,669,343 (GRCm39)	missense	possibly damaging	0.70
R8389:Lcn11	UTSW	2	25,669,043 (GRCm39)	missense	probably damaging	0.97
R8765:Lcn11	UTSW	2	25,668,139 (GRCm39)	missense	probably damaging	1.00
R8881:Lcn11	UTSW	2	25,669,296 (GRCm39)	missense	probably benign	0.33
R8954:Lcn11	UTSW	2	25,669,265 (GRCm39)	missense	probably benign	0.01
Z1176:Lcn11	UTSW	2	25,667,736 (GRCm39)	missense	probably benign	0.00

Predicted Primers

PCR Primer
(F):5'- TCAGACTCTGAGAAGGCCTTG -3'
(R):5'- ACTGAGGGAGCACAGTTTG -3'

Sequencing Primer
(F):5'- ACTCTGAGAAGGCCTTGATGATCC -3'
(R):5'- ACAGTTTGGAGCCACATCGTG -3'

Posted On

2021-03-08