Incidental Mutation 'R8754:Tox2'
ID 664016
Institutional Source Beutler Lab
Gene Symbol Tox2
Ensembl Gene ENSMUSG00000074607
Gene Name TOX high mobility group box family member 2
Synonyms LOC269389, RxHMG1
MMRRC Submission 068620-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8754 (G1)
Quality Score 225.009
Status Validated
Chromosome 2
Chromosomal Location 163045047-163166092 bp(+) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) A to G at 163163360 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Aspartic acid to Glycine at position 111 (D111G)
Gene Model predicted gene model for transcript(s): [ENSMUST00000099110] [ENSMUST00000109428] [ENSMUST00000165937]
AlphaFold A2A472
Predicted Effect probably benign
Transcript: ENSMUST00000099110
AA Change: D500G

PolyPhen 2 Score 0.005 (Sensitivity: 0.97; Specificity: 0.74)
SMART Domains Protein: ENSMUSP00000096710
Gene: ENSMUSG00000074607
AA Change: D500G

DomainStartEndE-ValueType
low complexity region 2 15 N/A INTRINSIC
low complexity region 20 35 N/A INTRINSIC
low complexity region 110 122 N/A INTRINSIC
low complexity region 232 248 N/A INTRINSIC
HMG 287 357 1.44e-18 SMART
low complexity region 424 451 N/A INTRINSIC
low complexity region 457 471 N/A INTRINSIC
low complexity region 499 524 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000109428
AA Change: D458G

PolyPhen 2 Score 0.000 (Sensitivity: 1.00; Specificity: 0.00)
SMART Domains Protein: ENSMUSP00000105055
Gene: ENSMUSG00000074607
AA Change: D458G

DomainStartEndE-ValueType
low complexity region 68 80 N/A INTRINSIC
low complexity region 190 206 N/A INTRINSIC
HMG 245 315 1.44e-18 SMART
low complexity region 382 409 N/A INTRINSIC
low complexity region 415 429 N/A INTRINSIC
low complexity region 457 482 N/A INTRINSIC
Predicted Effect
SMART Domains Protein: ENSMUSP00000118219
Gene: ENSMUSG00000074607
AA Change: D111G

DomainStartEndE-ValueType
low complexity region 36 63 N/A INTRINSIC
low complexity region 69 83 N/A INTRINSIC
low complexity region 111 136 N/A INTRINSIC
Predicted Effect probably benign
Transcript: ENSMUST00000165937
AA Change: D465G

PolyPhen 2 Score 0.016 (Sensitivity: 0.95; Specificity: 0.79)
SMART Domains Protein: ENSMUSP00000126243
Gene: ENSMUSG00000074607
AA Change: D465G

DomainStartEndE-ValueType
low complexity region 75 87 N/A INTRINSIC
low complexity region 197 213 N/A INTRINSIC
HMG 252 322 1.44e-18 SMART
low complexity region 389 416 N/A INTRINSIC
low complexity region 422 436 N/A INTRINSIC
low complexity region 464 489 N/A INTRINSIC
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.3%
  • 20x: 97.5%
Validation Efficiency 100% (67/67)
Allele List at MGI
Other mutations in this stock
Total: 70 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
1110002E22Rik T C 3: 137,771,798 (GRCm39) V329A probably benign Het
A830018L16Rik G T 1: 11,615,472 (GRCm39) K148N probably benign Het
Actn3 A G 19: 4,913,488 (GRCm39) F648L probably damaging Het
Amotl2 A G 9: 102,597,358 (GRCm39) D39G possibly damaging Het
Anks1 C A 17: 28,214,984 (GRCm39) T477K possibly damaging Het
Brix1 A T 15: 10,476,664 (GRCm39) S271T probably benign Het
Ccdc88b T C 19: 6,833,213 (GRCm39) E278G probably damaging Het
Cdc40 C T 10: 40,717,480 (GRCm39) D404N probably damaging Het
Chrna6 T C 8: 27,897,229 (GRCm39) H216R probably damaging Het
Col6a3 C G 1: 90,695,328 (GRCm39) probably benign Het
Copa C T 1: 171,935,926 (GRCm39) R423W probably damaging Het
Cttnbp2 A C 6: 18,434,037 (GRCm39) I607R possibly damaging Het
Depdc5 A T 5: 33,136,881 (GRCm39) T1384S probably benign Het
Dlat G T 9: 50,560,967 (GRCm39) A360E probably damaging Het
Dusp26 C T 8: 31,581,805 (GRCm39) probably benign Het
Eif1ad13 T A 12: 87,762,569 (GRCm39) N96K possibly damaging Het
Fam135a G A 1: 24,067,569 (GRCm39) T1100M probably benign Het
Fuca1 T C 4: 135,652,889 (GRCm39) L171P probably damaging Het
Gpr158 G A 2: 21,581,693 (GRCm39) V391I probably benign Het
Gtf2h5 C CA 17: 6,134,833 (GRCm39) probably null Het
Heatr1 T A 13: 12,428,175 (GRCm39) Y771N probably damaging Het
Il17ra A G 6: 120,458,417 (GRCm39) T523A probably benign Het
Kcnv1 G A 15: 44,977,865 (GRCm39) Q58* probably null Het
Kdm5d T C Y: 941,594 (GRCm39) V1265A probably damaging Het
Kifc3 A T 8: 95,829,024 (GRCm39) L726Q probably damaging Het
Klk1b21 T A 7: 43,755,912 (GRCm39) I247N probably benign Het
Kntc1 T A 5: 123,897,115 (GRCm39) N159K probably benign Het
Krtap4-7 G T 11: 99,534,667 (GRCm39) C65* probably null Het
Lama2 C T 10: 26,877,147 (GRCm39) V2680M possibly damaging Het
Lipe T A 7: 25,088,007 (GRCm39) M61L probably benign Het
Med17 A G 9: 15,188,896 (GRCm39) M123T possibly damaging Het
Mrpl37 T C 4: 106,921,611 (GRCm39) N206S probably benign Het
Muc4 A T 16: 32,602,356 (GRCm39) N1390Y Het
Muc5ac C T 7: 141,354,008 (GRCm39) A869V possibly damaging Het
Nckap5l A G 15: 99,327,290 (GRCm39) V133A probably benign Het
Nin A T 12: 70,077,787 (GRCm39) probably benign Het
Nr1h2 C T 7: 44,200,768 (GRCm39) A287T probably damaging Het
Or8c16 A T 9: 38,130,865 (GRCm39) I246L possibly damaging Het
Patl1 A G 19: 11,899,898 (GRCm39) E230G probably damaging Het
Pbxip1 T C 3: 89,355,235 (GRCm39) S585P probably damaging Het
Pde3b T A 7: 114,015,278 (GRCm39) W165R possibly damaging Het
Pdia4 A C 6: 47,773,464 (GRCm39) D628E probably benign Het
Pigo T A 4: 43,024,724 (GRCm39) H125L probably benign Het
Platr25 A T 13: 62,847,924 (GRCm39) *313K probably null Het
Plxdc1 A T 11: 97,846,337 (GRCm39) M169K possibly damaging Het
Pxk T C 14: 8,151,496 (GRCm38) I437T probably damaging Het
Rlf T C 4: 121,004,010 (GRCm39) T1767A possibly damaging Het
Rnf123 T A 9: 107,948,363 (GRCm39) D110V probably damaging Het
Rnf185 A T 11: 3,368,052 (GRCm39) F209I probably benign Het
Rpl4 A T 9: 64,082,242 (GRCm39) N47I probably damaging Het
Rsl1d1 A T 16: 11,017,512 (GRCm39) F151L probably damaging Het
Sema3d T C 5: 12,603,191 (GRCm39) probably null Het
Serhl A G 15: 82,986,126 (GRCm39) N80D probably benign Het
Sh3tc1 C A 5: 35,863,802 (GRCm39) R795L probably benign Het
Slc2a12 A T 10: 22,521,116 (GRCm39) T7S probably benign Het
Snrnp200 A G 2: 127,068,005 (GRCm39) Y834C probably damaging Het
Ss18 G C 18: 14,774,016 (GRCm39) Q258E probably damaging Het
Telo2 G A 17: 25,321,041 (GRCm39) L725F probably damaging Het
Tnxb A G 17: 34,934,882 (GRCm39) E2497G probably damaging Het
Trim16 G A 11: 62,731,763 (GRCm39) E545K probably benign Het
Trpm7 A G 2: 126,664,623 (GRCm39) W919R probably damaging Het
Ttbk1 G T 17: 46,756,127 (GRCm39) S1301* probably null Het
Txk T C 5: 72,889,122 (GRCm39) N144S probably damaging Het
Ubqln4 T A 3: 88,473,090 (GRCm39) V515E probably benign Het
Ush2a C T 1: 188,581,162 (GRCm39) R3681* probably null Het
Ythdf3 A T 3: 16,258,138 (GRCm39) N106I probably damaging Het
Zfp367 A T 13: 64,292,069 (GRCm39) C187* probably null Het
Zfp735 A G 11: 73,603,000 (GRCm39) D648G possibly damaging Het
Zic1 T C 9: 91,244,701 (GRCm39) probably benign Het
Zik1 A G 7: 10,223,826 (GRCm39) S424P probably damaging Het
Other mutations in Tox2
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL01444:Tox2 APN 2 163,067,386 (GRCm39) utr 5 prime probably benign
IGL01891:Tox2 APN 2 163,164,903 (GRCm39) missense possibly damaging 0.48
IGL02190:Tox2 APN 2 163,164,926 (GRCm39) missense possibly damaging 0.91
IGL02576:Tox2 APN 2 163,118,100 (GRCm39) missense probably damaging 0.99
R0881:Tox2 UTSW 2 163,163,365 (GRCm39) missense probably benign 0.18
R1739:Tox2 UTSW 2 163,089,705 (GRCm39) missense probably damaging 0.99
R1742:Tox2 UTSW 2 163,067,446 (GRCm39) missense probably benign 0.04
R1900:Tox2 UTSW 2 163,118,087 (GRCm39) missense probably damaging 1.00
R1937:Tox2 UTSW 2 163,067,476 (GRCm39) missense probably benign
R2345:Tox2 UTSW 2 163,161,518 (GRCm39) missense probably damaging 1.00
R2842:Tox2 UTSW 2 163,046,550 (GRCm39) intron probably benign
R3753:Tox2 UTSW 2 163,156,243 (GRCm39) missense probably damaging 1.00
R4614:Tox2 UTSW 2 163,162,567 (GRCm39) missense probably damaging 1.00
R4615:Tox2 UTSW 2 163,162,567 (GRCm39) missense probably damaging 1.00
R4616:Tox2 UTSW 2 163,162,567 (GRCm39) missense probably damaging 1.00
R4618:Tox2 UTSW 2 163,162,567 (GRCm39) missense probably damaging 1.00
R4625:Tox2 UTSW 2 163,156,336 (GRCm39) missense possibly damaging 0.71
R5410:Tox2 UTSW 2 163,162,293 (GRCm39) missense probably benign 0.04
R5493:Tox2 UTSW 2 163,046,649 (GRCm39) nonsense probably null
R6731:Tox2 UTSW 2 163,162,297 (GRCm39) missense probably damaging 1.00
R6965:Tox2 UTSW 2 163,164,930 (GRCm39) makesense probably null
R7038:Tox2 UTSW 2 163,156,264 (GRCm39) missense probably damaging 0.99
R7078:Tox2 UTSW 2 163,162,501 (GRCm39) missense
R7422:Tox2 UTSW 2 163,163,435 (GRCm39) missense
R7577:Tox2 UTSW 2 163,157,822 (GRCm39) nonsense probably null
R7829:Tox2 UTSW 2 163,162,296 (GRCm39) missense probably damaging 1.00
R8356:Tox2 UTSW 2 163,046,550 (GRCm39) missense unknown
R8456:Tox2 UTSW 2 163,046,550 (GRCm39) missense unknown
R9085:Tox2 UTSW 2 163,067,481 (GRCm39) missense probably benign 0.19
R9153:Tox2 UTSW 2 163,045,091 (GRCm39) missense
R9526:Tox2 UTSW 2 163,164,930 (GRCm39) makesense probably null
RF011:Tox2 UTSW 2 163,067,484 (GRCm39) missense probably benign 0.02
Predicted Primers PCR Primer
(F):5'- ACCCTCCCGACTTGTTTGAG -3'
(R):5'- TGGGCTGACAGTGACTTCTTC -3'

Sequencing Primer
(F):5'- AGGTAGTCCATTGCTGAGCTACAC -3'
(R):5'- ACCCCAGTGTCTCCCTGTG -3'
Posted On 2021-03-08