Incidental Mutation 'R8755:Lgals12'
ID 664142
Institutional Source Beutler Lab
Gene Symbol Lgals12
Ensembl Gene ENSMUSG00000024972
Gene Name lectin, galactose binding, soluble 12
Synonyms galectin-12, galectin-related inhibitor of proliferation, GRIP1
MMRRC Submission 068596-MU
Accession Numbers
Essential gene? Non essential (E-score: 0.000) question?
Stock # R8755 (G1)
Quality Score 225.009
Status Not validated
Chromosome 19
Chromosomal Location 7574025-7584558 bp(-) (GRCm39)
Type of Mutation missense
DNA Base Change (assembly) C to T at 7581345 bp (GRCm39)
Zygosity Heterozygous
Amino Acid Change Glutamic Acid to Lysine at position 121 (E121K)
Ref Sequence ENSEMBL: ENSMUSP00000097318 (fasta)
Gene Model predicted gene model for transcript(s): [ENSMUST00000079902] [ENSMUST00000099729] [ENSMUST00000159983]
AlphaFold Q91VD1
Predicted Effect probably damaging
Transcript: ENSMUST00000079902
AA Change: E121K

PolyPhen 2 Score 0.991 (Sensitivity: 0.71; Specificity: 0.97)
SMART Domains Protein: ENSMUSP00000078824
Gene: ENSMUSG00000024972
AA Change: E121K

DomainStartEndE-ValueType
GLECT 25 161 1.18e-33 SMART
Gal-bind_lectin 31 160 1.45e-48 SMART
Gal-bind_lectin 181 301 3.6e-12 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000099729
AA Change: E121K

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000097318
Gene: ENSMUSG00000024972
AA Change: E121K

DomainStartEndE-ValueType
GLECT 25 161 1.18e-33 SMART
Gal-bind_lectin 31 160 1.45e-48 SMART
Gal-bind_lectin 194 314 3.6e-12 SMART
Predicted Effect possibly damaging
Transcript: ENSMUST00000159983
AA Change: E121K

PolyPhen 2 Score 0.948 (Sensitivity: 0.79; Specificity: 0.95)
SMART Domains Protein: ENSMUSP00000124610
Gene: ENSMUSG00000024972
AA Change: E121K

DomainStartEndE-ValueType
GLECT 25 161 1.18e-33 SMART
Gal-bind_lectin 31 160 1.45e-48 SMART
Gal-bind_lectin 194 314 3.6e-12 SMART
Coding Region Coverage
  • 1x: 100.0%
  • 3x: 99.9%
  • 10x: 99.4%
  • 20x: 98.0%
Validation Efficiency
MGI Phenotype FUNCTION: [Summary is not available for the mouse gene. This summary is for the human ortholog.] This gene encodes a member of the galectin superfamily, a group of beta-galactoside-binding proteins with conserved carbohydrate recognition domains. The related mouse protein is a primary regulator of the early stages of adipose tissue development. Alternatively spliced transcript variants encoding different isoforms have been described. [provided by RefSeq, May 2010]
PHENOTYPE: Mice homozygous for a knock-out allele exhibit increased lipolysis, reduced adiposity, and enhanced insulin sensitivity. [provided by MGI curators]
Allele List at MGI
Other mutations in this stock
Total: 68 list
GeneRefVarChr/LocMutationPredicted EffectZygosity
Aaas A C 15: 102,255,520 (GRCm39) D86E probably benign Het
Akap3 A G 6: 126,843,130 (GRCm39) D583G possibly damaging Het
Alms1 T A 6: 85,598,556 (GRCm39) D1127E probably benign Het
Anks4b T A 7: 119,773,307 (GRCm39) probably null Het
Ano8 A T 8: 71,935,724 (GRCm39) F298Y probably benign Het
Arhgef2 C A 3: 88,536,850 (GRCm39) Q7K probably benign Het
Brd10 T C 19: 29,693,890 (GRCm39) I1868V probably benign Het
Cand2 T C 6: 115,769,941 (GRCm39) L917P probably damaging Het
Car8 T C 4: 8,238,083 (GRCm39) D44G probably benign Het
Cdk1 T C 10: 69,176,435 (GRCm39) N224S probably benign Het
Cep162 T C 9: 87,114,064 (GRCm39) E336G probably benign Het
Chd7 T C 4: 8,866,069 (GRCm39) M2792T probably benign Het
Cyp4f40 A T 17: 32,886,957 (GRCm39) K143* probably null Het
Cyth1 T A 11: 118,074,768 (GRCm39) M178L probably benign Het
Dcaf11 C T 14: 55,798,023 (GRCm39) probably benign Het
Dlec1 T G 9: 118,967,225 (GRCm39) W1203G probably damaging Het
Fgd4 A T 16: 16,302,133 (GRCm39) S141T probably benign Het
Firrm A G 1: 163,786,895 (GRCm39) S725P probably damaging Het
Flg2 T A 3: 93,108,120 (GRCm39) D49E probably damaging Het
Fyb2 T A 4: 104,861,086 (GRCm39) D647E unknown Het
Gstp1 T C 19: 4,086,698 (GRCm39) Y109C probably damaging Het
Gtf3c3 T C 1: 54,468,031 (GRCm39) E202G probably benign Het
Hephl1 A G 9: 14,985,563 (GRCm39) F698L probably benign Het
Hephl1 G T 9: 15,023,280 (GRCm39) P41T probably damaging Het
Hmcn1 T A 1: 150,509,371 (GRCm39) E3659V probably benign Het
Il27ra A T 8: 84,765,988 (GRCm39) D229E probably damaging Het
Itih2 T A 2: 10,103,369 (GRCm39) D706V probably damaging Het
Itpr2 A T 6: 146,133,926 (GRCm39) C1893S probably benign Het
Lama5 T C 2: 179,832,714 (GRCm39) N1646S probably benign Het
Laptm4b A G 15: 34,273,420 (GRCm39) D111G probably damaging Het
Ldb3 T A 14: 34,299,256 (GRCm39) S123C probably damaging Het
Mmp13 T A 9: 7,277,996 (GRCm39) S296R possibly damaging Het
Mpeg1 T C 19: 12,439,238 (GRCm39) F232S probably damaging Het
Ncapd2 A T 6: 125,148,817 (GRCm39) C990S possibly damaging Het
Nckap5 A T 1: 125,954,279 (GRCm39) C758S possibly damaging Het
Nwd1 A T 8: 73,394,192 (GRCm39) D485V probably damaging Het
Or13a21 T G 7: 139,999,417 (GRCm39) S90R probably benign Het
Or6c2 T C 10: 129,362,332 (GRCm39) F79L possibly damaging Het
Or8g50 T A 9: 39,648,786 (GRCm39) I225N probably damaging Het
Pcgf3 G A 5: 108,634,108 (GRCm39) R122Q probably benign Het
Pgm5 T A 19: 24,812,212 (GRCm39) I107F probably damaging Het
Pid1 G T 1: 84,016,066 (GRCm39) H114N probably damaging Het
Pkdrej T C 15: 85,703,807 (GRCm39) T710A probably benign Het
Plpbp T A 8: 27,535,165 (GRCm39) probably null Het
Ppfibp2 T G 7: 107,343,432 (GRCm39) F824V probably damaging Het
Ppp1r16b G A 2: 158,593,098 (GRCm39) D226N probably damaging Het
Psg17 T A 7: 18,550,836 (GRCm39) T340S possibly damaging Het
Pstpip2 T C 18: 77,961,133 (GRCm39) S239P probably damaging Het
Ralbp1 A C 17: 66,166,036 (GRCm39) S383A possibly damaging Het
Ranbp2 T A 10: 58,300,969 (GRCm39) L613* probably null Het
Rgs11 T C 17: 26,422,346 (GRCm39) V49A probably damaging Het
Ryr1 C T 7: 28,791,693 (GRCm39) V1404I probably benign Het
Secisbp2 G A 13: 51,833,869 (GRCm39) V670I possibly damaging Het
Slc22a13 T A 9: 119,038,126 (GRCm39) M1L probably damaging Het
Slc5a1 A T 5: 33,316,526 (GRCm39) I591L probably benign Het
Tacr2 T A 10: 62,088,733 (GRCm39) V46E possibly damaging Het
Tet2 C T 3: 133,194,039 (GRCm39) G132S probably damaging Het
Thsd7a G A 6: 12,408,851 (GRCm39) R724* probably null Het
Tmco3 A T 8: 13,341,782 (GRCm39) I19L probably benign Het
Tnfrsf1a T A 6: 125,334,768 (GRCm39) L14Q probably benign Het
Tpm1 A T 9: 66,935,371 (GRCm39) L248Q probably benign Het
Tprn T A 2: 25,154,027 (GRCm39) I443N probably benign Het
Unc80 A T 1: 66,651,290 (GRCm39) H1545L possibly damaging Het
Vmn2r97 T A 17: 19,168,104 (GRCm39) M786K probably damaging Het
Wipi1 C T 11: 109,494,645 (GRCm39) V63M probably damaging Het
Zcchc4 G A 5: 52,976,724 (GRCm39) R506H unknown Het
Zfand6 A T 7: 84,281,899 (GRCm39) V110E probably benign Het
Zfp866 A T 8: 70,219,381 (GRCm39) Y80N possibly damaging Het
Other mutations in Lgals12
AlleleSourceChrCoordTypePredicted EffectPPH Score
IGL02442:Lgals12 APN 19 7,584,019 (GRCm39) splice site probably benign
IGL02630:Lgals12 APN 19 7,578,607 (GRCm39) splice site probably benign
IGL02700:Lgals12 APN 19 7,575,455 (GRCm39) missense probably benign 0.01
R0129:Lgals12 UTSW 19 7,580,403 (GRCm39) missense probably damaging 0.99
R1398:Lgals12 UTSW 19 7,581,322 (GRCm39) splice site probably benign
R1421:Lgals12 UTSW 19 7,584,079 (GRCm39) missense probably benign 0.08
R1548:Lgals12 UTSW 19 7,581,677 (GRCm39) missense probably benign 0.12
R1697:Lgals12 UTSW 19 7,581,530 (GRCm39) missense possibly damaging 0.91
R2075:Lgals12 UTSW 19 7,576,210 (GRCm39) missense possibly damaging 0.81
R2192:Lgals12 UTSW 19 7,578,606 (GRCm39) splice site probably null
R2253:Lgals12 UTSW 19 7,584,130 (GRCm39) start gained probably benign
R4256:Lgals12 UTSW 19 7,584,081 (GRCm39) missense possibly damaging 0.93
R4738:Lgals12 UTSW 19 7,581,464 (GRCm39) missense probably benign 0.01
R5495:Lgals12 UTSW 19 7,581,495 (GRCm39) missense probably damaging 1.00
R5810:Lgals12 UTSW 19 7,584,085 (GRCm39) missense probably benign 0.00
R6139:Lgals12 UTSW 19 7,581,742 (GRCm39) missense probably benign 0.07
R7414:Lgals12 UTSW 19 7,581,335 (GRCm39) missense probably damaging 1.00
R8920:Lgals12 UTSW 19 7,576,166 (GRCm39) missense possibly damaging 0.55
R9334:Lgals12 UTSW 19 7,578,086 (GRCm39) missense probably benign 0.01
R9441:Lgals12 UTSW 19 7,581,356 (GRCm39) missense probably damaging 1.00
X0067:Lgals12 UTSW 19 7,581,329 (GRCm39) splice site probably null
Z1177:Lgals12 UTSW 19 7,575,445 (GRCm39) missense probably benign 0.03
Predicted Primers PCR Primer
(F):5'- AAGCATGGGTCTTCTGAGTG -3'
(R):5'- ATCCTCAGCCAGATGTTGCC -3'

Sequencing Primer
(F):5'- CTACTAGATCCAGGGACTTTTGCAG -3'
(R):5'- AGCCAGATGTTGCCTTCCG -3'
Posted On 2021-03-08