Incidental Mutation 'R8755:Brd10'
| ID |
664145 |
| Institutional Source |
Beutler Lab
|
| Gene Symbol |
Brd10
|
| Ensembl Gene |
ENSMUSG00000046138 |
| Gene Name |
bromodomain containing 10 |
| Synonyms |
9930021J03Rik, Gm9832 |
| MMRRC Submission |
068596-MU
|
| Accession Numbers |
|
| Essential gene? |
Probably non essential
(E-score: 0.138)
|
| Stock # |
R8755 (G1)
|
| Quality Score |
225.009 |
|
Status
|
Not validated
|
| Chromosome |
19 |
| Chromosomal Location |
29691802-29783389 bp(-) (GRCm39) |
| Type of Mutation |
missense |
| DNA Base Change (assembly) |
T to C
at 29693890 bp (GRCm39)
|
| Zygosity |
Heterozygous |
| Amino Acid Change |
Isoleucine to Valine
at position 1868
(I1868V)
|
| Ref Sequence |
ENSEMBL: ENSMUSP00000135473
(fasta)
|
| Gene Model |
predicted gene model for transcript(s):
[ENSMUST00000177155]
|
| AlphaFold |
H3BKP8 |
| Predicted Effect |
|
| Predicted Effect |
|
| SMART Domains |
Protein: ENSMUSP00000135031
Gene: ENSMUSG00000046138
AA Change: I1167V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
2 |
19 |
N/A |
INTRINSIC |
|
low complexity region
|
379 |
393 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
397 |
526 |
2.65e-5 |
PROSPERO |
|
low complexity region
|
528 |
537 |
N/A |
INTRINSIC |
|
low complexity region
|
619 |
648 |
N/A |
INTRINSIC |
|
low complexity region
|
701 |
716 |
N/A |
INTRINSIC |
|
low complexity region
|
835 |
857 |
N/A |
INTRINSIC |
|
low complexity region
|
880 |
896 |
N/A |
INTRINSIC |
|
low complexity region
|
965 |
978 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
999 |
1143 |
2.65e-5 |
PROSPERO |
|
low complexity region
|
1220 |
1226 |
N/A |
INTRINSIC |
|
low complexity region
|
1246 |
1260 |
N/A |
INTRINSIC |
|
low complexity region
|
1286 |
1304 |
N/A |
INTRINSIC |
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000176773
|
| Predicted Effect |
probably benign
Transcript: ENSMUST00000177155
AA Change: I1868V
PolyPhen 2
Score 0.029 (Sensitivity: 0.95; Specificity: 0.82)
|
| SMART Domains |
Protein: ENSMUSP00000135473
Gene: ENSMUSG00000046138
AA Change: I1868V
| Domain | Start | End | E-Value | Type |
|---|
|
low complexity region
|
4 |
66 |
N/A |
INTRINSIC |
|
BROMO
|
75 |
198 |
1.22e-3 |
SMART |
|
low complexity region
|
205 |
219 |
N/A |
INTRINSIC |
|
low complexity region
|
280 |
298 |
N/A |
INTRINSIC |
|
low complexity region
|
428 |
441 |
N/A |
INTRINSIC |
|
coiled coil region
|
606 |
638 |
N/A |
INTRINSIC |
|
low complexity region
|
655 |
689 |
N/A |
INTRINSIC |
|
coiled coil region
|
697 |
729 |
N/A |
INTRINSIC |
|
low complexity region
|
1079 |
1093 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1097 |
1226 |
1.32e-7 |
PROSPERO |
|
low complexity region
|
1228 |
1237 |
N/A |
INTRINSIC |
|
low complexity region
|
1319 |
1348 |
N/A |
INTRINSIC |
|
low complexity region
|
1401 |
1416 |
N/A |
INTRINSIC |
|
low complexity region
|
1535 |
1557 |
N/A |
INTRINSIC |
|
low complexity region
|
1580 |
1596 |
N/A |
INTRINSIC |
|
low complexity region
|
1665 |
1678 |
N/A |
INTRINSIC |
|
internal_repeat_1
|
1699 |
1843 |
1.32e-7 |
PROSPERO |
|
low complexity region
|
1920 |
1926 |
N/A |
INTRINSIC |
|
low complexity region
|
1946 |
1960 |
N/A |
INTRINSIC |
|
low complexity region
|
1986 |
2004 |
N/A |
INTRINSIC |
|
| Coding Region Coverage |
- 1x: 100.0%
- 3x: 99.9%
- 10x: 99.4%
- 20x: 98.0%
|
| Validation Efficiency |
|
| Allele List at MGI |
|
| Other mutations in this stock |
Total: 68 list
| Gene | Ref | Var | Chr/Loc | Mutation | Predicted Effect | Zygosity |
|---|
| Aaas |
A |
C |
15: 102,255,520 (GRCm39) |
D86E |
probably benign |
Het |
| Akap3 |
A |
G |
6: 126,843,130 (GRCm39) |
D583G |
possibly damaging |
Het |
| Alms1 |
T |
A |
6: 85,598,556 (GRCm39) |
D1127E |
probably benign |
Het |
| Anks4b |
T |
A |
7: 119,773,307 (GRCm39) |
|
probably null |
Het |
| Ano8 |
A |
T |
8: 71,935,724 (GRCm39) |
F298Y |
probably benign |
Het |
| Arhgef2 |
C |
A |
3: 88,536,850 (GRCm39) |
Q7K |
probably benign |
Het |
| Cand2 |
T |
C |
6: 115,769,941 (GRCm39) |
L917P |
probably damaging |
Het |
| Car8 |
T |
C |
4: 8,238,083 (GRCm39) |
D44G |
probably benign |
Het |
| Cdk1 |
T |
C |
10: 69,176,435 (GRCm39) |
N224S |
probably benign |
Het |
| Cep162 |
T |
C |
9: 87,114,064 (GRCm39) |
E336G |
probably benign |
Het |
| Chd7 |
T |
C |
4: 8,866,069 (GRCm39) |
M2792T |
probably benign |
Het |
| Cyp4f40 |
A |
T |
17: 32,886,957 (GRCm39) |
K143* |
probably null |
Het |
| Cyth1 |
T |
A |
11: 118,074,768 (GRCm39) |
M178L |
probably benign |
Het |
| Dcaf11 |
C |
T |
14: 55,798,023 (GRCm39) |
|
probably benign |
Het |
| Dlec1 |
T |
G |
9: 118,967,225 (GRCm39) |
W1203G |
probably damaging |
Het |
| Fgd4 |
A |
T |
16: 16,302,133 (GRCm39) |
S141T |
probably benign |
Het |
| Firrm |
A |
G |
1: 163,786,895 (GRCm39) |
S725P |
probably damaging |
Het |
| Flg2 |
T |
A |
3: 93,108,120 (GRCm39) |
D49E |
probably damaging |
Het |
| Fyb2 |
T |
A |
4: 104,861,086 (GRCm39) |
D647E |
unknown |
Het |
| Gstp1 |
T |
C |
19: 4,086,698 (GRCm39) |
Y109C |
probably damaging |
Het |
| Gtf3c3 |
T |
C |
1: 54,468,031 (GRCm39) |
E202G |
probably benign |
Het |
| Hephl1 |
A |
G |
9: 14,985,563 (GRCm39) |
F698L |
probably benign |
Het |
| Hephl1 |
G |
T |
9: 15,023,280 (GRCm39) |
P41T |
probably damaging |
Het |
| Hmcn1 |
T |
A |
1: 150,509,371 (GRCm39) |
E3659V |
probably benign |
Het |
| Il27ra |
A |
T |
8: 84,765,988 (GRCm39) |
D229E |
probably damaging |
Het |
| Itih2 |
T |
A |
2: 10,103,369 (GRCm39) |
D706V |
probably damaging |
Het |
| Itpr2 |
A |
T |
6: 146,133,926 (GRCm39) |
C1893S |
probably benign |
Het |
| Lama5 |
T |
C |
2: 179,832,714 (GRCm39) |
N1646S |
probably benign |
Het |
| Laptm4b |
A |
G |
15: 34,273,420 (GRCm39) |
D111G |
probably damaging |
Het |
| Ldb3 |
T |
A |
14: 34,299,256 (GRCm39) |
S123C |
probably damaging |
Het |
| Lgals12 |
C |
T |
19: 7,581,345 (GRCm39) |
E121K |
possibly damaging |
Het |
| Mmp13 |
T |
A |
9: 7,277,996 (GRCm39) |
S296R |
possibly damaging |
Het |
| Mpeg1 |
T |
C |
19: 12,439,238 (GRCm39) |
F232S |
probably damaging |
Het |
| Ncapd2 |
A |
T |
6: 125,148,817 (GRCm39) |
C990S |
possibly damaging |
Het |
| Nckap5 |
A |
T |
1: 125,954,279 (GRCm39) |
C758S |
possibly damaging |
Het |
| Nwd1 |
A |
T |
8: 73,394,192 (GRCm39) |
D485V |
probably damaging |
Het |
| Or13a21 |
T |
G |
7: 139,999,417 (GRCm39) |
S90R |
probably benign |
Het |
| Or6c2 |
T |
C |
10: 129,362,332 (GRCm39) |
F79L |
possibly damaging |
Het |
| Or8g50 |
T |
A |
9: 39,648,786 (GRCm39) |
I225N |
probably damaging |
Het |
| Pcgf3 |
G |
A |
5: 108,634,108 (GRCm39) |
R122Q |
probably benign |
Het |
| Pgm5 |
T |
A |
19: 24,812,212 (GRCm39) |
I107F |
probably damaging |
Het |
| Pid1 |
G |
T |
1: 84,016,066 (GRCm39) |
H114N |
probably damaging |
Het |
| Pkdrej |
T |
C |
15: 85,703,807 (GRCm39) |
T710A |
probably benign |
Het |
| Plpbp |
T |
A |
8: 27,535,165 (GRCm39) |
|
probably null |
Het |
| Ppfibp2 |
T |
G |
7: 107,343,432 (GRCm39) |
F824V |
probably damaging |
Het |
| Ppp1r16b |
G |
A |
2: 158,593,098 (GRCm39) |
D226N |
probably damaging |
Het |
| Psg17 |
T |
A |
7: 18,550,836 (GRCm39) |
T340S |
possibly damaging |
Het |
| Pstpip2 |
T |
C |
18: 77,961,133 (GRCm39) |
S239P |
probably damaging |
Het |
| Ralbp1 |
A |
C |
17: 66,166,036 (GRCm39) |
S383A |
possibly damaging |
Het |
| Ranbp2 |
T |
A |
10: 58,300,969 (GRCm39) |
L613* |
probably null |
Het |
| Rgs11 |
T |
C |
17: 26,422,346 (GRCm39) |
V49A |
probably damaging |
Het |
| Ryr1 |
C |
T |
7: 28,791,693 (GRCm39) |
V1404I |
probably benign |
Het |
| Secisbp2 |
G |
A |
13: 51,833,869 (GRCm39) |
V670I |
possibly damaging |
Het |
| Slc22a13 |
T |
A |
9: 119,038,126 (GRCm39) |
M1L |
probably damaging |
Het |
| Slc5a1 |
A |
T |
5: 33,316,526 (GRCm39) |
I591L |
probably benign |
Het |
| Tacr2 |
T |
A |
10: 62,088,733 (GRCm39) |
V46E |
possibly damaging |
Het |
| Tet2 |
C |
T |
3: 133,194,039 (GRCm39) |
G132S |
probably damaging |
Het |
| Thsd7a |
G |
A |
6: 12,408,851 (GRCm39) |
R724* |
probably null |
Het |
| Tmco3 |
A |
T |
8: 13,341,782 (GRCm39) |
I19L |
probably benign |
Het |
| Tnfrsf1a |
T |
A |
6: 125,334,768 (GRCm39) |
L14Q |
probably benign |
Het |
| Tpm1 |
A |
T |
9: 66,935,371 (GRCm39) |
L248Q |
probably benign |
Het |
| Tprn |
T |
A |
2: 25,154,027 (GRCm39) |
I443N |
probably benign |
Het |
| Unc80 |
A |
T |
1: 66,651,290 (GRCm39) |
H1545L |
possibly damaging |
Het |
| Vmn2r97 |
T |
A |
17: 19,168,104 (GRCm39) |
M786K |
probably damaging |
Het |
| Wipi1 |
C |
T |
11: 109,494,645 (GRCm39) |
V63M |
probably damaging |
Het |
| Zcchc4 |
G |
A |
5: 52,976,724 (GRCm39) |
R506H |
unknown |
Het |
| Zfand6 |
A |
T |
7: 84,281,899 (GRCm39) |
V110E |
probably benign |
Het |
| Zfp866 |
A |
T |
8: 70,219,381 (GRCm39) |
Y80N |
possibly damaging |
Het |
|
| Other mutations in Brd10 |
| Allele | Source | Chr | Coord | Type | Predicted Effect | PPH Score |
|---|
|
IGL01311:Brd10
|
APN |
19 |
29,731,420 (GRCm39) |
missense |
probably benign |
0.33 |
|
IGL01535:Brd10
|
APN |
19 |
29,731,212 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
IGL02019:Brd10
|
APN |
19 |
29,694,463 (GRCm39) |
missense |
probably benign |
0.28 |
|
IGL02034:Brd10
|
APN |
19 |
29,694,259 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
IGL03114:Brd10
|
APN |
19 |
29,694,532 (GRCm39) |
missense |
probably benign |
0.18 |
|
IGL03382:Brd10
|
APN |
19 |
29,694,676 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0020:Brd10
|
UTSW |
19 |
29,693,597 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0020:Brd10
|
UTSW |
19 |
29,693,597 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R0142:Brd10
|
UTSW |
19 |
29,695,654 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R0178:Brd10
|
UTSW |
19 |
29,732,188 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0453:Brd10
|
UTSW |
19 |
29,731,068 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0730:Brd10
|
UTSW |
19 |
29,695,381 (GRCm39) |
missense |
probably benign |
0.00 |
|
R0735:Brd10
|
UTSW |
19 |
29,695,038 (GRCm39) |
missense |
possibly damaging |
0.92 |
|
R0891:Brd10
|
UTSW |
19 |
29,695,053 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R0894:Brd10
|
UTSW |
19 |
29,697,974 (GRCm39) |
splice site |
probably benign |
|
|
R1289:Brd10
|
UTSW |
19 |
29,700,852 (GRCm39) |
missense |
probably benign |
0.07 |
|
R1368:Brd10
|
UTSW |
19 |
29,693,796 (GRCm39) |
missense |
probably damaging |
0.97 |
|
R1387:Brd10
|
UTSW |
19 |
29,700,853 (GRCm39) |
missense |
probably benign |
0.15 |
|
R1483:Brd10
|
UTSW |
19 |
29,696,745 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R1526:Brd10
|
UTSW |
19 |
29,712,545 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R1612:Brd10
|
UTSW |
19 |
29,695,245 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R1721:Brd10
|
UTSW |
19 |
29,720,998 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1764:Brd10
|
UTSW |
19 |
29,696,560 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1822:Brd10
|
UTSW |
19 |
29,693,814 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1824:Brd10
|
UTSW |
19 |
29,693,814 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1859:Brd10
|
UTSW |
19 |
29,732,323 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R1868:Brd10
|
UTSW |
19 |
29,720,998 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R1880:Brd10
|
UTSW |
19 |
29,695,523 (GRCm39) |
missense |
probably benign |
0.06 |
|
R1898:Brd10
|
UTSW |
19 |
29,712,532 (GRCm39) |
missense |
possibly damaging |
0.74 |
|
R1936:Brd10
|
UTSW |
19 |
29,731,077 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1939:Brd10
|
UTSW |
19 |
29,731,077 (GRCm39) |
missense |
possibly damaging |
0.87 |
|
R1969:Brd10
|
UTSW |
19 |
29,694,075 (GRCm39) |
missense |
possibly damaging |
0.95 |
|
R2153:Brd10
|
UTSW |
19 |
29,694,229 (GRCm39) |
missense |
probably benign |
0.01 |
|
R2366:Brd10
|
UTSW |
19 |
29,731,035 (GRCm39) |
missense |
probably damaging |
0.99 |
|
R2379:Brd10
|
UTSW |
19 |
29,696,275 (GRCm39) |
missense |
probably benign |
0.01 |
|
R3107:Brd10
|
UTSW |
19 |
29,700,847 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4012:Brd10
|
UTSW |
19 |
29,720,990 (GRCm39) |
missense |
probably damaging |
1.00 |
|
R4222:Brd10
|
UTSW |
19 |
29,696,149 (GRCm39) |
missense |
probably benign |
0.18 |
|
R4328:Brd10
|
UTSW |
19 |
29,720,961 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4329:Brd10
|
UTSW |
19 |
29,720,961 (GRCm39) |
missense |
probably benign |
0.00 |
|
R4387:Brd10
|
UTSW |
19 |
29,782,715 (GRCm39) |
unclassified |
probably benign |
|
|
R4688:Brd10
|
UTSW |
19 |
29,694,501 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4796:Brd10
|
UTSW |
19 |
29,731,018 (GRCm39) |
missense |
probably benign |
0.33 |
|
R4820:Brd10
|
UTSW |
19 |
29,695,809 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R4832:Brd10
|
UTSW |
19 |
29,694,616 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R5056:Brd10
|
UTSW |
19 |
29,694,759 (GRCm39) |
missense |
probably benign |
|
|
R5150:Brd10
|
UTSW |
19 |
29,782,950 (GRCm39) |
missense |
probably damaging |
0.96 |
|
R5224:Brd10
|
UTSW |
19 |
29,696,450 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5306:Brd10
|
UTSW |
19 |
29,707,230 (GRCm39) |
intron |
probably benign |
|
|
R5460:Brd10
|
UTSW |
19 |
29,732,250 (GRCm39) |
missense |
probably damaging |
0.98 |
|
R5477:Brd10
|
UTSW |
19 |
29,731,518 (GRCm39) |
missense |
probably benign |
0.33 |
|
R5531:Brd10
|
UTSW |
19 |
29,731,072 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5559:Brd10
|
UTSW |
19 |
29,694,363 (GRCm39) |
missense |
possibly damaging |
0.91 |
|
R5647:Brd10
|
UTSW |
19 |
29,731,210 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R5886:Brd10
|
UTSW |
19 |
29,696,677 (GRCm39) |
missense |
probably benign |
0.03 |
|
R6029:Brd10
|
UTSW |
19 |
29,732,367 (GRCm39) |
unclassified |
probably benign |
|
|
R6240:Brd10
|
UTSW |
19 |
29,694,640 (GRCm39) |
missense |
probably benign |
0.18 |
|
R6331:Brd10
|
UTSW |
19 |
29,695,147 (GRCm39) |
missense |
probably benign |
0.33 |
|
R6456:Brd10
|
UTSW |
19 |
29,693,914 (GRCm39) |
missense |
possibly damaging |
0.93 |
|
R6584:Brd10
|
UTSW |
19 |
29,696,128 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6661:Brd10
|
UTSW |
19 |
29,700,864 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R6991:Brd10
|
UTSW |
19 |
29,696,508 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R7059:Brd10
|
UTSW |
19 |
29,696,945 (GRCm39) |
missense |
probably benign |
0.33 |
|
R7128:Brd10
|
UTSW |
19 |
29,693,881 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R7211:Brd10
|
UTSW |
19 |
29,763,712 (GRCm39) |
missense |
|
|
|
R7471:Brd10
|
UTSW |
19 |
29,707,139 (GRCm39) |
splice site |
probably null |
|
|
R7686:Brd10
|
UTSW |
19 |
29,694,870 (GRCm39) |
missense |
probably benign |
0.34 |
|
R8012:Brd10
|
UTSW |
19 |
29,695,534 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R8203:Brd10
|
UTSW |
19 |
29,693,443 (GRCm39) |
missense |
probably benign |
0.18 |
|
R8353:Brd10
|
UTSW |
19 |
29,731,242 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8672:Brd10
|
UTSW |
19 |
29,731,564 (GRCm39) |
missense |
probably benign |
|
|
R8918:Brd10
|
UTSW |
19 |
29,696,841 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R8954:Brd10
|
UTSW |
19 |
29,696,126 (GRCm39) |
missense |
possibly damaging |
0.72 |
|
R9038:Brd10
|
UTSW |
19 |
29,731,900 (GRCm39) |
missense |
possibly damaging |
0.86 |
|
R9195:Brd10
|
UTSW |
19 |
29,763,703 (GRCm39) |
missense |
|
|
|
R9204:Brd10
|
UTSW |
19 |
29,696,938 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
R9518:Brd10
|
UTSW |
19 |
29,731,541 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
R9743:Brd10
|
UTSW |
19 |
29,694,261 (GRCm39) |
missense |
probably benign |
|
|
R9747:Brd10
|
UTSW |
19 |
29,731,911 (GRCm39) |
missense |
possibly damaging |
0.73 |
|
RF011:Brd10
|
UTSW |
19 |
29,721,009 (GRCm39) |
missense |
possibly damaging |
0.53 |
|
X0027:Brd10
|
UTSW |
19 |
29,712,599 (GRCm39) |
missense |
probably damaging |
0.99 |
|
| Predicted Primers |
PCR Primer
(F):5'- TACTGAAGTCAACGCTGCC -3'
(R):5'- GCTCCGTTCAGTGAACCTTG -3'
Sequencing Primer
(F):5'- CGGTGGTGCAGGTGGAAC -3'
(R):5'- AGTACACCTTTGGCACCAGG -3'
|
| Posted On |
2021-03-08 |
Incidental Mutation