Mutagenetix > Incidental Mutation

Incidental Mutation 'R8771:Vmn1r142'

664408

Institutional Source

Beutler Lab

Gene Symbol

Vmn1r142

Ensembl Gene

ENSMUSG00000095273

Gene Name

vomeronasal 1 receptor 142

Synonyms

Gm8647

MMRRC Submission

068602-MU

Accession Numbers

Essential gene?

Not available question?

Stock #

R8771 (G1)

Quality Score

180.009

Status

Not validated

Chromosome

Chromosomal Location

21862543-21863460 bp(-) (GRCm39)

Type of Mutation

missense

DNA Base Change (assembly)

T to C at 21862737 bp (GRCm39)

Zygosity

Heterozygous

Amino Acid Change

Methionine to Valine at position 242 (M242V)

Ref Sequence

ENSEMBL: ENSMUSP00000126410 (fasta)

Gene Model

predicted gene model for transcript(s): [ENSMUST00000169697]

AlphaFold

K7N6U0

Predicted Effect

probably benign
Transcript: ENSMUST00000169697
AA Change: M242V

PolyPhen 2 Score 0.073 (Sensitivity: 0.93; Specificity: 0.84)

SMART Domains

Protein: ENSMUSP00000126410
Gene: ENSMUSG00000095273
AA Change: M242V

Domain	Start	End	E-Value	Type
Pfam:TAS2R	8	296	5.3e-16	PFAM
Pfam:7tm_1	40	289	2.4e-9	PFAM
Pfam:V1R	41	296	1.5e-14	PFAM

Coding Region Coverage

1x: 100.0%
3x: 99.9%
10x: 99.5%
20x: 98.3%

Validation Efficiency

100% (47/47)

Allele List at MGI

Other mutations in this stock

Total: 48 list
Gene	Ref	Var	Chr/Loc	Mutation	Predicted Effect	Zygosity
Abca4	T	C	3: 121,880,320 (GRCm39)	I451T	probably damaging	Het
Acin1	T	C	14: 54,880,496 (GRCm39)	K1236E	unknown	Het
AI661453	T	C	17: 47,777,683 (GRCm39)	S470P	unknown	Het
Ano5	C	A	7: 51,216,095 (GRCm39)	N357K	probably damaging	Het
Ano5	C	T	7: 51,220,047 (GRCm39)	Q396*	probably null	Het
Baz1b	T	A	5: 135,273,151 (GRCm39)	M1425K	probably benign	Het
Cdh22	A	T	2: 164,988,689 (GRCm39)	V222E	possibly damaging	Het
Celsr1	A	T	15: 85,788,175 (GRCm39)	S2692R	probably benign	Het
Ces5a	A	G	8: 94,255,249 (GRCm39)	I144T	possibly damaging	Het
D5Ertd579e	T	A	5: 36,761,940 (GRCm39)	N1309I	probably damaging	Het
Dnmt3b	C	T	2: 153,504,734 (GRCm39)	T112M	possibly damaging	Het
Eif4g3	C	T	4: 137,907,848 (GRCm39)	Q1283*	probably null	Het
Etnppl	T	A	3: 130,414,024 (GRCm39)	M41K	probably damaging	Het
Hhatl	G	A	9: 121,617,776 (GRCm39)	T271I	possibly damaging	Het
Igkv5-37	A	G	6: 69,940,423 (GRCm39)	S74P	probably damaging	Het
Krt87	A	G	15: 101,385,779 (GRCm39)	V272A	probably benign	Het
Lgr6	A	T	1: 134,933,429 (GRCm39)	L262*	probably null	Het
Lrriq3	G	A	3: 154,899,270 (GRCm39)	V590I	probably damaging	Het
Mfsd13a	T	C	19: 46,360,668 (GRCm39)	V382A	probably damaging	Het
Minar2	T	C	18: 59,200,052 (GRCm39)		probably benign	Het
Mrc2	A	G	11: 105,240,596 (GRCm39)	T1429A	probably benign	Het
Mroh5	A	T	15: 73,693,203 (GRCm39)	M79K	possibly damaging	Het
Myo1c	A	G	11: 75,556,709 (GRCm39)	K553R	probably benign	Het
Nbeal1	A	G	1: 60,300,743 (GRCm39)	T1488A	probably benign	Het
Or4c12	T	C	2: 89,773,565 (GRCm39)	K298R	probably benign	Het
Or5aq6	T	C	2: 86,923,294 (GRCm39)	Y149C	probably benign	Het
Or5m10b	T	G	2: 85,699,712 (GRCm39)	Y259D	probably damaging	Het
Or5p76	T	A	7: 108,122,632 (GRCm39)	N175I	possibly damaging	Het
Prl7a1	A	T	13: 27,819,811 (GRCm39)	W148R	probably damaging	Het
Ptpn2	G	T	18: 67,805,659 (GRCm39)	T402K	probably benign	Het
Ptprf	A	G	4: 118,068,987 (GRCm39)	M1665T	possibly damaging	Het
Raet1e	G	T	10: 22,057,041 (GRCm39)	V122F	probably damaging	Het
Serpina3m	A	G	12: 104,357,841 (GRCm39)	E255G	probably damaging	Het
Sorcs2	T	C	5: 36,188,624 (GRCm39)	Y828C	probably damaging	Het
Sprr1a	T	A	3: 92,391,989 (GRCm39)	H4L	probably benign	Het
Sptssa	A	G	12: 54,703,211 (GRCm39)	Y20H	probably damaging	Het
Synpo2l	A	G	14: 20,710,491 (GRCm39)	S939P	probably damaging	Het
Tdrd7	T	C	4: 46,010,800 (GRCm39)	V568A	probably damaging	Het
Tmem132c	C	T	5: 127,437,192 (GRCm39)	P227L	probably benign	Het
Tmtc3	A	G	10: 100,286,180 (GRCm39)	S548P	possibly damaging	Het
Trip12	A	T	1: 84,721,018 (GRCm39)		probably benign	Het
Ttll6	A	G	11: 96,042,762 (GRCm39)	Y436C	probably damaging	Het
Unc80	A	G	1: 66,685,554 (GRCm39)	D2226G	possibly damaging	Het
Vmn2r12	T	G	5: 109,239,952 (GRCm39)	T204P	possibly damaging	Het
Vmn2r16	C	T	5: 109,488,231 (GRCm39)	T368M	probably benign	Het
Vmn2r61	C	A	7: 41,916,194 (GRCm39)	A269D	probably damaging	Het
Zfp148	A	G	16: 33,317,656 (GRCm39)	D776G	possibly damaging	Het
Zfp775	A	T	6: 48,596,906 (GRCm39)	Q260L	probably benign	Het

Other mutations in Vmn1r142

Allele	Source	Chr	Coord	Type	Predicted Effect	PPH Score
R7468:Vmn1r142	UTSW	7	21,862,784 (GRCm39)	missense	possibly damaging	0.89
R8356:Vmn1r142	UTSW	7	21,862,748 (GRCm39)	missense	probably benign	0.18
R9008:Vmn1r142	UTSW	7	21,862,796 (GRCm39)	missense	probably damaging	1.00

Predicted Primers

PCR Primer
(F):5'- GTGAGCACCACACCTTGTTC -3'
(R):5'- CCACTTCTGGATTCATTGTAGGC -3'

Sequencing Primer
(F):5'- CCACACCTTGTTCATACAAAATGTTG -3'
(R):5'- CATTGTAGGCATTGTCTTCTTGCAG -3'

Posted On

2021-03-08